Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZ3COY)

DTT Name	COVID-19 spike glycoprotein (S) DTT Info
Gene Name	COVID-19 S

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK4182136	DMYH2FI	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved in EU	[1]
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[2]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[3]
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6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY-CoV555	DM6LVCQ	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[4]
REGN-COV2	DM0KBML	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[5]
JS016	DMGEZVF	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1/2	[6]
GSK4182137	DMJJW2Y	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1	[1]
REGN3048	DM0E3ZG	Coronavirus infection	1D92	Phase 1	[7]
REGN3051	DM7LIV2	Coronavirus infection	1D92	Phase 1	[7]
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⏷ Show the Full List of 6 Clinical Trial Drug(s)

3 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
m337	DM7HUVB	Coronavirus infection	1D92	Preclinical	[8]
MERS-27	DMVGIB4	Coronavirus infection	1D92	Preclinical	[8]
MERS-4	DMS6KT8	Coronavirus infection	1D92	Preclinical	[8]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Clinical pipeline report, company report or official report of GlaxoSmithKline
2	Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
3	Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2. June 5, 2020.
4	Neutralizing Antibody LY-CoV555 for Outpatient Covid-19. Reply. N Engl J Med. 2021 Jan 14;384(2):189.
5	REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N Engl J Med. 2021 Jan 21;384(3):238-251.
6	Clinical pipeline report, company report or official report of Lilly.
7	Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets. Antiviral Res. 2018 Aug;156:64-71.
8	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.