Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZ8C5Q)

• DTT Name: Sphingosine-1-phosphate receptor 4 (S1PR4) DTT Info
• Gene Name: S1PR4

Molecule-Related Drug & Molecule List

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AFD(R)	DME9Y8Q	Discovery agent	N.A.	Investigative	[1]
AUY954	DMVGIO5	Discovery agent	N.A.	Investigative	[2]
dihydrosphingosine-1-phosphate	DM58KHY	N. A.	N. A.	Investigative	[3]
FTY720-phosphate	DMDZBQH	Discovery agent	N.A.	Investigative	[4]
KRP 203-phosphate	DMLIK7X	Discovery agent	N.A.	Investigative	[5]
phytosphingosine 1-phosphate	DMWJCST	Discovery agent	N.A.	Investigative	[3]
VPC03090-P	DMIXUM3	Discovery agent	N.A.	Investigative	[6]

References

• [1] Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48.
• [2] A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34.
• [3] Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem Biophys Res Commun. 2002 Sep 27;297(3):600-6.
• [4] The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7.
• [5] A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-d... J Pharmacol Exp Ther. 2008 Jan;324(1):276-83.
• [6] Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89.