General Information of DTT (ID: TTZBFA0)

DTT Name Protease unspecific (PRO) DTT Info
Gene Name PRO

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prolastin DMYSCIL Alpha-1 antitrypsin deficiency 5C5A Approved [1]
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3 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ONO-3307 DMQGO74 Coagulation defect 3B10.0 Phase 2 [2]
SRD-441 DM5GAC4 Atopic dermatitis EA80 Phase 2 [3]
AZD-2551 DMZQEDY Chronic obstructive pulmonary disease CA22 Phase 1 [4]
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6 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aprosulate sodium DMRLHNW Coagulation defect 3B10.0 Discontinued in Phase 1 [5]
AZD-3342 DMUCQPB Chronic obstructive pulmonary disease CA22 Discontinued in Phase 1 [6]
ALP-242 DM592WE Cystic fibrosis CA25 Terminated [7]
CEP-431 DMDH0AM Alzheimer disease 8A20 Terminated [8]
EP-2060 DMZA5Q4 Solid tumour/cancer 2A00-2F9Z Terminated [9]
WY-48989 DMGJNQW Rheumatoid arthritis FA20 Terminated [10]
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⏷ Show the Full List of 6 Discontinued Drug(s)
Molecule Interaction Atlas

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51(4):455-63.
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029807)
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029854)
5 Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model. Pol J Pharmacol. 1996 May-Jun;48(3):317-22.
6 New Drugs and Targets for Asthma and COPD. Trevor T. Hansel, Peter J. Barnes. 2010. Page(227).
7 Oxidation resistant muteins of antileukoproteinase as potential therapeutic agents. Agents Actions Suppl. 1993;42:111-21.
8 US patent application no. 7,935,815, Imidazoyl pyridine compounds and salts thereof.
9 Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents. Anticancer Agents Med Chem. 2009 May;9(4):437-56.
10 Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989. Agents Actions. 1991 Sep;34(1-2):223-5.