Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZBRVL)

• DTT Name: Staphylococcus Enoyl ACP reductase (Stap-coc fabI) DTT Info
• Gene Name: Stap-coc fabI

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Afabicin	DMFO2G5	Acute bacterial skin infection	1C41	Phase 2	[1]
AFN-1252	DMTFE9Y	Staphylococcus infection	1B5Y	Phase 2	[2]
CG-400549	DMFAKGR	Bacterial infection	1A00-1C4Z	Phase 2	[3]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MUT-056399	DMC3NSK	Methicillin-resistant staphylococci infection	1A00-1A09	Preclinical	[4]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics. J Chemother. 2013 Feb;25(1):32-5.
• [3] In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Antimicrob Agents Chemother. 2007 Jul;51(7):2591-3.
• [4] The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.