Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZOEBC)

• DTT Name: Phosphodiesterase 9 (PDE9) DTT Info
• Gene Name: PDE9A

Molecule-Related Drug & Molecule List

7 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASP-4901	DMZUAH2	Genitourinary disease	GA0Z-GC8Z	Phase 2	[1]
BI-409306	DMJFDS0	Alzheimer disease	8A20	Phase 2	[2]
CRD-740	DMRTX0K	Heart failure	BD10-BD13	Phase 2	[3]
E2027	DMK8SY6	Lewy body dementia	6D82	Phase 2	[4]
IMR-687	DM15MRZ	Sickle-cell disorder	3A51	Phase 2	[5]
PF-4447943	DM81D4I	Alzheimer disease	8A20	Phase 2	[6]
TT-00920	DMP6G0P	Heart failure	BD10-BD13	Phase 1	[7]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-4181366	DMC8G4S	Cognitive impairment	6D71	Investigative	[8]
SCH51866	DMCWSJP	Discovery agent	N.A.	Investigative	[9]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033070)
• [2] Clinical pipeline report, company report or official report of Boehringer Ingelheim pipeline.
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Clinical pipeline report, company report or official report of Imara.
• [6] A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease. Curr Alzheimer Res. 2014;11(5):413-21.
• [7] Clinical pipeline report, company report or official report of TransThera Biosciences
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).
• [9] Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64.