Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZSJHV)

DTT Name	Tryptophan 5-hydroxylase 1 (TPH1) DTT Info
Gene Name	TPH1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGN-2979	DMLQRFO	Psychotic disorder	6A20-6A25	Phase 2	[1]
KAR5585	DMXYN1H	Pulmonary arterial hypertension	BB01.0	Phase 1	[2]
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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-fluorotryptophan	DM6YD3U	Discovery agent	N.A.	Investigative	[3]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[4]
fenclonine	DMUBO3E	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).