Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZY5KP)

• DTT Name: Caspase (CASP) DTT Info
• Gene Name: CASP

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NCX-1000	DM2YIZH	Cardiovascular disease	BA00-BE2Z	Phase 2	[1]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VX-166	DMZKY56	Hepatic fibrosis	DB93.0	Preclinical	[2]
Z-VAD-fmk	DMTDG7L	Pulmonary fibrosis	CB03.4	Preclinical	[3]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALS-769	DMGBT9Z	Solid tumour/cancer	2A00-2F9Z	Terminated	[4]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-aminophenoxazine-3-one	DMBVGAO	T-cell leukaemia	2A90	Investigative	[5]
Ac-DEVD-CHO	DMW02H7	Discovery agent	N.A.	Investigative	[6]
IDN-1965	DMRQSN2	Discovery agent	N.A.	Investigative	[7]
Isoquinoline-1,3,4(2H)-trione	DMT4RI2	Discovery agent	N.A.	Investigative	[8]

References

• [1] Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol. 2004 Sep;143(1):33-42.
• [2] VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care. 2009;13(5):R146.
• [3] Clinical pipeline report, company report or official report of InvivoGen.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025089)
• [5] Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
• [6] Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63.
• [7] Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic ... Circulation. 2003 Dec 16;108(24):3036-41.
• [8] Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.