DrugMAP Full Data Download File Title - DrugMAP drug to drug transporter (DTP) mapping information in raw format Version 1.01 (2022.07.20) Provided by Lab of Innovative Drug Reasearch and Bioinformatics (IDRB) College of Pharmaceutical Sciences Zhejiang University https://idrblab.org/ Any question about data provided here, please contact with: Dr. Li (lifengcheng@zju.edu.cn) and Dr. Yin (yinjiayi@zju.edu.cn) TI: DTP_ID TN: DTP_Name DI: Drug_ID DN: Drug_Name MA: MOA RA: Reference_Name RU: Reference_URL DT01CKS TI DT01CKS DT01CKS TN Lymphocyte activation antigen 4F2 DT01CKS DI DMUXEBQ DT01CKS DN Polyamine DT01CKS MA Substrate DT01CKS RA Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma. DT01CKS RU http://www.ncbi.nlm.nih.gov/pubmed/30700572 DT021JD TI DT021JD DT021JD TN Organic anion transporting polypeptide 2A1 DT021JD DI DM4XAU7 DT021JD DN Prostaglandin f2Alpha DT021JD MA Substrate DT021JD RA Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. DT021JD RU http://www.ncbi.nlm.nih.gov/pubmed/8787677 DT021JD TI DT021JD DT021JD TN Organic anion transporting polypeptide 2A1 DT021JD DI DMVPZBE DT021JD DN Iloprost DT021JD MA Substrate DT021JD RA Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. DT021JD RU http://www.ncbi.nlm.nih.gov/pubmed/8787677 DT021JD TI DT021JD DT021JD TN Organic anion transporting polypeptide 2A1 DT021JD DI DMTYOPD DT021JD DN Dinoprostone DT021JD MA Substrate DT021JD RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DT021JD RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DT021JD TI DT021JD DT021JD TN Organic anion transporting polypeptide 2A1 DT021JD DI DMI5OXG DT021JD DN Latanoprost DT021JD MA Substrate DT021JD RA The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. DT021JD RU http://www.ncbi.nlm.nih.gov/pubmed/20019365 DT021JD TI DT021JD DT021JD TN Organic anion transporting polypeptide 2A1 DT021JD DI DMWH7NQ DT021JD DN Alprostadil DT021JD MA Substrate DT021JD RA Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. DT021JD RU http://www.ncbi.nlm.nih.gov/pubmed/8787677 DT03V27 TI DT03V27 DT03V27 TN Sodium bicarbonate cotransporter 3 DT03V27 DI DMMU6BJ DT03V27 DN Sodium bicarbonate DT03V27 MA Substrate DT03V27 RA The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. DT03V27 RU http://www.ncbi.nlm.nih.gov/pubmed/17071329 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DM4PUDW DT06JWZ DN L-glutamic acid DT06JWZ MA Substrate DT06JWZ RA The role of the intracellular glutamate gradient in driving organic anion transporter function. DT06JWZ RU http://www.physoc.org/proceedings/abstract/Proc%20Physiol%20Soc%2034C12 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DM4XAU7 DT06JWZ DN Prostaglandin f2Alpha DT06JWZ MA Substrate DT06JWZ RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DM4KI7O DT06JWZ DN Zidovudine DT06JWZ MA Substrate DT06JWZ RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DM6A0X7 DT06JWZ DN Pravastatin DT06JWZ MA Substrate DT06JWZ RA Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica. 2007 Apr;37(4):416-26. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/17455113 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DMTYOPD DT06JWZ DN Dinoprostone DT06JWZ MA Substrate DT06JWZ RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DMZA017 DT06JWZ DN Tetracycline DT06JWZ MA Substrate DT06JWZ RA Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/11855680 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DMA1MKT DT06JWZ DN Uric acid DT06JWZ MA Substrate DT06JWZ RA Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/17674156 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DM2KEW6 DT06JWZ DN Ochratoxin A DT06JWZ MA Substrate DT06JWZ RA Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/12063169 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DMRV7H0 DT06JWZ DN Bumetanide DT06JWZ MA Substrate DT06JWZ RA Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DM2TEOL DT06JWZ DN Methotrexate DT06JWZ MA Substrate DT06JWZ RA Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/12130730 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DMVBIZL DT06JWZ DN Estrone sulfate DT06JWZ MA Substrate DT06JWZ RA Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol. 2006 Nov;58(11):1499-505. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/17132213 DT06JWZ TI DT06JWZ DT06JWZ TN Organic anion transporter 4 DT06JWZ DI DMQYLGP DT06JWZ DN Levocetirizine DT06JWZ MA Substrate DT06JWZ RA Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 Sep;106(9):2895-2898. DT06JWZ RU http://www.ncbi.nlm.nih.gov/pubmed/28385546 DT0EQPW TI DT0EQPW DT0EQPW TN Concentrative nucleoside transporter 1 DT0EQPW DI DMSE3I7 DT0EQPW DN Gemcitabine DT0EQPW MA Substrate DT0EQPW RA Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers (Basel). 2017 Nov 16;9(11). DT0EQPW RU http://www.ncbi.nlm.nih.gov/pubmed/29144412 DT0EQPW TI DT0EQPW DT0EQPW TN Concentrative nucleoside transporter 1 DT0EQPW DI DMG2YBD DT0EQPW DN Trifluridine DT0EQPW MA Substrate DT0EQPW RA Lonsurf, INN-trifluridine/tipiracil. DT0EQPW RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/649/original/WC500206246.pdf?1531845997 DT0EQPW TI DT0EQPW DT0EQPW TN Concentrative nucleoside transporter 1 DT0EQPW DI DMZD5QR DT0EQPW DN Cytarabine DT0EQPW MA Substrate DT0EQPW RA FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799. DT0EQPW RU http://www.ncbi.nlm.nih.gov/pubmed/27391351 DT0EQPW TI DT0EQPW DT0EQPW TN Concentrative nucleoside transporter 1 DT0EQPW DI DMQTREB DT0EQPW DN Uridine DT0EQPW MA Substrate DT0EQPW RA Electrophysiological recordings of CNT1 (SLC28A1) activity on Nanions SURFE2R N1. DT0EQPW RU https://www.nanion.de/images/phocadownloadpap/Application_Notes/Nanion_APP_Note_SURFE2R_CNT1_09003.pdf DT0KQND TI DT0KQND DT0KQND TN ATP-binding cassette sub-family B member 8 DT0KQND DI DMVP5YE DT0KQND DN Doxorubicin DT0KQND MA Substrate DT0KQND RA ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol Cancer Res. 2009 Jan;7(1):79-87. DT0KQND RU http://www.ncbi.nlm.nih.gov/pubmed/19147539 DT0OA2B TI DT0OA2B DT0OA2B TN Cation-chloride cotransporter 9 DT0OA2B DI DMW1LKP DT0OA2B DN Nicotinamide mononucleotide DT0OA2B MA Substrate DT0OA2B RA Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolismvolume 1, pages4757 (2019). DT0OA2B RU https://www.nature.com/articles/s42255-018-0009-4 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM4XAU7 DT0OC1Q DN Prostaglandin f2Alpha DT0OC1Q MA Substrate DT0OC1Q RA Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/12023506 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM4KI7O DT0OC1Q DN Zidovudine DT0OC1Q MA Substrate DT0OC1Q RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM4K7GQ DT0OC1Q DN Erythromycin DT0OC1Q MA Substrate DT0OC1Q RA Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/15708966 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMLPAOB DT0OC1Q DN Allopurinol DT0OC1Q MA Substrate DT0OC1Q RA Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/12065749 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMUM7HZ DT0OC1Q DN Fluorouracil DT0OC1Q MA Substrate DT0OC1Q RA Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/15901346 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMTYOPD DT0OC1Q DN Dinoprostone DT0OC1Q MA Substrate DT0OC1Q RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMOUMDV DT0OC1Q DN Penciclovir DT0OC1Q MA Substrate DT0OC1Q RA In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2018 Oct;48(10):1037-1049. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/28945155 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMZA017 DT0OC1Q DN Tetracycline DT0OC1Q MA Substrate DT0OC1Q RA Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/11855680 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMYLOVR DT0OC1Q DN Acyclovir DT0OC1Q MA Substrate DT0OC1Q RA Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol. 2008 Apr;73(4):1151-8. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/18216183 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM0GUSX DT0OC1Q DN Ranitidine DT0OC1Q MA Substrate DT0OC1Q RA A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMRJFN9 DT0OC1Q DN Theophylline DT0OC1Q MA Substrate DT0OC1Q RA Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/15708966 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM672AH DT0OC1Q DN Aspirin DT0OC1Q MA Substrate DT0OC1Q RA Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/9650585 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM7VTQO DT0OC1Q DN Entecavir DT0OC1Q MA Substrate DT0OC1Q RA Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter. Drug Metab Pharmacokinet. 2017 Feb;32(1):116-119. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/27916488 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMRV7H0 DT0OC1Q DN Bumetanide DT0OC1Q MA Substrate DT0OC1Q RA Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/15901346 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DM2TEOL DT0OC1Q DN Methotrexate DT0OC1Q MA Substrate DT0OC1Q RA Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/12605306 DT0OC1Q TI DT0OC1Q DT0OC1Q TN Organic anion transporter 2 DT0OC1Q DI DMLB81S DT0OC1Q DN Paclitaxel DT0OC1Q MA Substrate DT0OC1Q RA Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. DT0OC1Q RU http://www.ncbi.nlm.nih.gov/pubmed/15901346 DT0TZPS TI DT0TZPS DT0TZPS TN Anion transporter/exchanger protein 9 DT0TZPS DI DMT5E36 DT0TZPS DN Bicarbonate DT0TZPS MA Substrate DT0TZPS RA SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol. 2005 Aug;289(2):C493-505. DT0TZPS RU http://www.ncbi.nlm.nih.gov/pubmed/15800055 DT0UQDA TI DT0UQDA DT0UQDA TN Putative sodium-coupled neutral amino acid transporter 8 DT0UQDA DI DM4PUDW DT0UQDA DN L-glutamic acid DT0UQDA MA Substrate DT0UQDA RA Structural modeling of a novel SLC38A8 mutation that causes foveal hypoplasia. Mol Genet Genomic Med. 2017 Feb 26;5(3):202-209. DT0UQDA RU http://www.ncbi.nlm.nih.gov/pubmed/28546991 DT0VAI5 TI DT0VAI5 DT0VAI5 TN Excitatory amino acid transporter 2 DT0VAI5 DI DM4PUDW DT0VAI5 DN L-glutamic acid DT0VAI5 MA Substrate DT0VAI5 RA EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake. J Neurosci. 2014 Oct 1;34(40):13472-85. DT0VAI5 RU http://www.ncbi.nlm.nih.gov/pubmed/25274824 DT0YAUQ TI DT0YAUQ DT0YAUQ TN Mitochondrial 2-oxoglutarate/malate carrier DT0YAUQ DI DM5LFYN DT0YAUQ DN Alpha-ketoglutaric acid DT0YAUQ MA Substrate DT0YAUQ RA The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione. FEBS Lett. 2015 Feb 27;589(5):621-8. DT0YAUQ RU http://www.ncbi.nlm.nih.gov/pubmed/25637873 DT18YD9 TI DT18YD9 DT18YD9 TN Glucose transporter type 14 DT18YD9 DI DMIAHVU DT18YD9 DN 2-Deoxyglucose DT18YD9 MA Substrate DT18YD9 RA The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513. DT18YD9 RU http://www.ncbi.nlm.nih.gov/pubmed/28971850 DT18YD9 TI DT18YD9 DT18YD9 TN Glucose transporter type 14 DT18YD9 DI DMKYQO4 DT18YD9 DN Dehydroascorbic acid DT18YD9 MA Substrate DT18YD9 RA The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513. DT18YD9 RU http://www.ncbi.nlm.nih.gov/pubmed/28971850 DT195NK TI DT195NK DT195NK TN ATP-binding cassette sub-family A member 5 DT195NK DI DMR3J6S DT195NK DN Cholesterol DT195NK MA Substrate DT195NK RA Mutations in the cholesterol transporter gene ABCA5 are associated with excessive hair overgrowth. PLoS Genet. 2014 May 15;10(5):e1004333. DT195NK RU http://www.ncbi.nlm.nih.gov/pubmed/24831815 DT1BO38 TI DT1BO38 DT1BO38 TN Zinc transporter 1 DT1BO38 DI DMZ4R3Q DT1BO38 DN Zinc salts DT1BO38 MA Substrate DT1BO38 RA Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83. DT1BO38 RU http://www.ncbi.nlm.nih.gov/pubmed/18936201 DT1CP40 TI DT1CP40 DT1CP40 TN Sodium/glucose cotransporter 4 DT1CP40 DI DM43AN2 DT1CP40 DN Fructose DT1CP40 MA Substrate DT1CP40 RA SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50. DT1CP40 RU http://www.ncbi.nlm.nih.gov/pubmed/15607332 DT1CP40 TI DT1CP40 DT1CP40 TN Sodium/glucose cotransporter 4 DT1CP40 DI DMT6X03 DT1CP40 DN D-mannose DT1CP40 MA Substrate DT1CP40 RA SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50. DT1CP40 RU http://www.ncbi.nlm.nih.gov/pubmed/15607332 DT1CP40 TI DT1CP40 DT1CP40 TN Sodium/glucose cotransporter 4 DT1CP40 DI DMIAHVU DT1CP40 DN 2-Deoxyglucose DT1CP40 MA Substrate DT1CP40 RA SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50. DT1CP40 RU http://www.ncbi.nlm.nih.gov/pubmed/15607332 DT1MPHW TI DT1MPHW DT1MPHW TN Electroneutral potassium-chloride cotransporter 4 DT1MPHW DI DMLEJHF DT1MPHW DN Cation chloride DT1MPHW MA Substrate DT1MPHW RA A molecular analysis of the Na(+)-independent cation chloride cotransporters. Cell Physiol Biochem. 2013;32(7):14-31. DT1MPHW RU http://www.ncbi.nlm.nih.gov/pubmed/24429812 DT1UIT5 TI DT1UIT5 DT1UIT5 TN Zrt- and Irt-like protein 12 DT1UIT5 DI DMZ4R3Q DT1UIT5 DN Zinc salts DT1UIT5 MA Substrate DT1UIT5 RA The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature. 2015 Aug 20;524(7565):356-60. DT1UIT5 RU http://www.ncbi.nlm.nih.gov/pubmed/26258299 DT1UMXN TI DT1UMXN DT1UMXN TN Niemann-Pick C1-like protein 1 DT1UMXN DI DMR3J6S DT1UMXN DN Cholesterol DT1UMXN MA Substrate DT1UMXN RA Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4. DT1UMXN RU http://www.ncbi.nlm.nih.gov/pubmed/14976318 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DMQCTIH DT1V9AJ DN Digoxin DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DMQCTIH DT1V9AJ DN Digoxin DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DM3GO0J DT1V9AJ DN Sodium taurocholate DT1V9AJ MA Substrate DT1V9AJ RA OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/16317684 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DMTYOPD DT1V9AJ DN Dinoprostone DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DMTYOPD DT1V9AJ DN Dinoprostone DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DM2LZ8F DT1V9AJ DN Taurocholic acid DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DMVBIZL DT1V9AJ DN Estrone sulfate DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT1V9AJ TI DT1V9AJ DT1V9AJ TN Organic solute transporter subunit beta DT1V9AJ DI DMVBIZL DT1V9AJ DN Estrone sulfate DT1V9AJ MA Substrate DT1V9AJ RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DT1V9AJ RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DT206GF TI DT206GF DT206GF TN Copper-transporting ATPase 2 DT206GF DI DMRHGI9 DT206GF DN Cisplatin DT206GF MA Substrate DT206GF RA Effect of cisplatin on the transport activity of PII-type ATPases. Metallomics. 2017 Jul 19;9(7):960-968. DT206GF RU http://www.ncbi.nlm.nih.gov/pubmed/28636017 DT280XI TI DT280XI DT280XI TN Zinc transporter 4 DT280XI DI DMZ4R3Q DT280XI DN Zinc salts DT280XI MA Substrate DT280XI RA Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15. J Neural Transm (Vienna). 2003 Nov;110(11):1329-32. DT280XI RU http://www.ncbi.nlm.nih.gov/pubmed/14628196 DT2CAPQ TI DT2CAPQ DT2CAPQ TN Sodium/myo-inositol cotransporter 2 DT2CAPQ DI DMQKSGI DT2CAPQ DN MYO-inositol DT2CAPQ MA Substrate DT2CAPQ RA The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8. DT2CAPQ RU http://www.ncbi.nlm.nih.gov/pubmed/12748858 DT2CFQ5 TI DT2CFQ5 DT2CFQ5 TN Sodium- and chloride-dependent glycine transporter 1 DT2CFQ5 DI DMIOZ29 DT2CFQ5 DN Glycine DT2CFQ5 MA Substrate DT2CFQ5 RA Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum Genet. 2016 Nov;135(11):1263-1268. DT2CFQ5 RU http://www.ncbi.nlm.nih.gov/pubmed/27481395 DT2CFQ5 TI DT2CFQ5 DT2CFQ5 TN Sodium- and chloride-dependent glycine transporter 1 DT2CFQ5 DI DMIVGOR DT2CFQ5 DN Sarcosine DT2CFQ5 MA Substrate DT2CFQ5 RA Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32. DT2CFQ5 RU http://www.ncbi.nlm.nih.gov/pubmed/11259500 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DMSWYF5 DT2EG60 DN Quinine DT2EG60 MA Substrate DT2EG60 RA Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/10215651 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DM6SFYH DT2EG60 DN Tetraethylammonium DT2EG60 MA Substrate DT2EG60 RA Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics. 2007 Sep;17(9):773-82. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/17700366 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DMZD5QR DT2EG60 DN Cytarabine DT2EG60 MA Substrate DT2EG60 RA OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/28209616 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DMJBOCR DT2EG60 DN L-carnitine DT2EG60 MA Substrate DT2EG60 RA Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Mol Genet Metab. 2007 Dec;92(4):315-24. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/17884651 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DM6T924 DT2EG60 DN Gabapentin DT2EG60 MA Substrate DT2EG60 RA Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar;83(3):416-21. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/17609685 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DMA7PEW DT2EG60 DN Verapamil DT2EG60 MA Substrate DT2EG60 RA Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/10215651 DT2EG60 TI DT2EG60 DT2EG60 TN Organic cation/carnitine transporter 1 DT2EG60 DI DMFQ320 DT2EG60 DN Ipratropium DT2EG60 MA Substrate DT2EG60 RA Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. DT2EG60 RU http://www.ncbi.nlm.nih.gov/pubmed/20020740 DT2EGUN TI DT2EGUN DT2EGUN TN Putative sodium-coupled neutral amino acid transporter 7 DT2EGUN DI DM69G8X DT2EGUN DN L-glutamine DT2EGUN MA Substrate DT2EGUN RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DT2EGUN RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DT2EGUN TI DT2EGUN DT2EGUN TN Putative sodium-coupled neutral amino acid transporter 7 DT2EGUN DI DMNP60F DT2EGUN DN Anastrozole DT2EGUN MA Substrate DT2EGUN RA Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. Clin Pharmacol Ther. 2019 Jan 16. DT2EGUN RU http://www.ncbi.nlm.nih.gov/pubmed/30648747 DT2I79L TI DT2I79L DT2I79L TN Zinc transporter 9 DT2I79L DI DMZ4R3Q DT2I79L DN Zinc salts DT2I79L MA Substrate DT2I79L RA SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017 Apr 1;140(4):928-939. DT2I79L RU http://www.ncbi.nlm.nih.gov/pubmed/28334855 DT2I7BM TI DT2I7BM DT2I7BM TN Glucose transporter type 8 DT2I7BM DI DMIAHVU DT2I7BM DN 2-Deoxyglucose DT2I7BM MA Substrate DT2I7BM RA Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DT2I7BM RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DT2LGOY TI DT2LGOY DT2LGOY TN Putative sodium-coupled neutral amino acid transporter 10 DT2LGOY DI DM4PUDW DT2LGOY DN L-glutamic acid DT2LGOY MA Substrate DT2LGOY RA The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. FEBS Open Bio. 2017 Apr 26;7(6):730-746. DT2LGOY RU http://www.ncbi.nlm.nih.gov/pubmed/28593130 DT2LGOY TI DT2LGOY DT2LGOY TN Putative sodium-coupled neutral amino acid transporter 10 DT2LGOY DI DMK7EYA DT2LGOY DN Aspartic acid DT2LGOY MA Substrate DT2LGOY RA The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. FEBS Open Bio. 2017 Apr 26;7(6):730-746. DT2LGOY RU http://www.ncbi.nlm.nih.gov/pubmed/28593130 DT2T6VQ TI DT2T6VQ DT2T6VQ TN ATP-binding cassette sub-family A member 3 DT2T6VQ DI DMM39BF DT2T6VQ DN Mitoxantrone DT2T6VQ MA Substrate DT2T6VQ RA A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33. DT2T6VQ RU http://www.ncbi.nlm.nih.gov/pubmed/15381773 DT2UQYR TI DT2UQYR DT2UQYR TN Mitochondrial 2-oxodicarboxylate carrier DT2UQYR DI DM5LFYN DT2UQYR DN Alpha-ketoglutaric acid DT2UQYR MA Substrate DT2UQYR RA Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genet Med. 2018 Oct;20(10):1224-1235. DT2UQYR RU http://www.ncbi.nlm.nih.gov/pubmed/29517768 DT2UQYR TI DT2UQYR DT2UQYR TN Mitochondrial 2-oxodicarboxylate carrier DT2UQYR DI DM0KXN4 DT2UQYR DN Alpha-oxoadipic acid DT2UQYR MA Substrate DT2UQYR RA Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genet Med. 2018 Oct;20(10):1224-1235. DT2UQYR RU http://www.ncbi.nlm.nih.gov/pubmed/29517768 DT2WLAD TI DT2WLAD DT2WLAD TN Urate anion exchanger 1 DT2WLAD DI DMURH4X DT2WLAD DN Oxypurinol DT2WLAD MA Substrate DT2WLAD RA Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone. Drug Metab Dispos. 2005 Dec;33(12):1791-5. DT2WLAD RU http://www.ncbi.nlm.nih.gov/pubmed/16135657 DT2WLAD TI DT2WLAD DT2WLAD TN Urate anion exchanger 1 DT2WLAD DI DMMB29S DT2WLAD DN Orotate DT2WLAD MA Substrate DT2WLAD RA Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci. 2011 May;61(3):253-7. DT2WLAD RU http://www.ncbi.nlm.nih.gov/pubmed/21350910 DT2WLAD TI DT2WLAD DT2WLAD TN Urate anion exchanger 1 DT2WLAD DI DMA1MKT DT2WLAD DN Uric acid DT2WLAD MA Substrate DT2WLAD RA Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther. 2007 Jan;320(1):211-7. DT2WLAD RU http://www.ncbi.nlm.nih.gov/pubmed/17043154 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMQFBH6 DT342ZG DN Glycolic acid DT342ZG MA Substrate DT342ZG RA Cidofovir peptide conjugates as prodrugs. Journal of Organometallic Chemistry, 2005, 690(10):2673-2678. DT342ZG RU https://doi.org/10.1016/j.jorganchem.2005.03.004 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMF28YC DT342ZG DN Atorvastatin DT342ZG MA Substrate DT342ZG RA H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19. DT342ZG RU https://doi.org/10.1113/expphysiol.2005.029959 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMJY2TM DT342ZG DN Gabapentin enacarbil DT342ZG MA Substrate DT342ZG RA Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008 Jun;10(2):311-21. DT342ZG RU https://doi.org/10.1208/s12248-008-9035-6 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DM2F8XZ DT342ZG DN Salicylic acid DT342ZG MA Substrate DT342ZG RA H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19. DT342ZG RU https://doi.org/10.1113/expphysiol.2005.029959 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMVP5YE DT342ZG DN Doxorubicin DT342ZG MA Substrate DT342ZG RA Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):904-17. DT342ZG RU https://doi.org/10.1016/j.addr.2010.05.009 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMGBKVD DT342ZG DN Gamma-hydroxybutyric acid DT342ZG MA Substrate DT342ZG RA Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. Drug Metab Dispos. 2007 Feb;35(2):201-8. DT342ZG RU http://www.ncbi.nlm.nih.gov/pubmed/17108059 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DM7Q41G DT342ZG DN Pyruvic acid DT342ZG MA Substrate DT342ZG RA AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30. DT342ZG RU https://doi.org/10.1042/BJ20091515 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMKMCE1 DT342ZG DN Biotin DT342ZG MA Substrate DT342ZG RA Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46. DT342ZG RU http://www.ncbi.nlm.nih.gov/pubmed/19319844 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMTAJP7 DT342ZG DN Butyrate DT342ZG MA Substrate DT342ZG RA Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008 Jun;10(2):311-21. DT342ZG RU https://doi.org/10.1208/s12248-008-9035-6 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DMROZUA DT342ZG DN Pyroglutamic acid DT342ZG MA Substrate DT342ZG RA Interaction of atorvastatin with the human glial transporter SLC16A1. Eur J Pharmacol. 2016 Oct 5;788:248-254. DT342ZG RU http://www.ncbi.nlm.nih.gov/pubmed/27341998 DT342ZG TI DT342ZG DT342ZG TN Monocarboxylate transporter 1 DT342ZG DI DM462BT DT342ZG DN Milchsaure DT342ZG MA Substrate DT342ZG RA Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. DT342ZG RU http://www.ncbi.nlm.nih.gov/pubmed/16604139 DT38SZL TI DT38SZL DT38SZL TN Organic cation transporter-like 3 DT38SZL DI DM4PUDW DT38SZL DN L-glutamic acid DT38SZL MA Substrate DT38SZL RA SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct. Biochem J. 2014 Jan 15;457(2):243-51. DT38SZL RU http://www.ncbi.nlm.nih.gov/pubmed/24147638 DT38SZL TI DT38SZL DT38SZL TN Organic cation transporter-like 3 DT38SZL DI DMK7EYA DT38SZL DN Aspartic acid DT38SZL MA Substrate DT38SZL RA SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct. Biochem J. 2014 Jan 15;457(2):243-51. DT38SZL RU http://www.ncbi.nlm.nih.gov/pubmed/24147638 DT39AOM TI DT39AOM DT39AOM TN Monocarboxylate transporter 3 DT39AOM DI DMQ95GE DT39AOM DN Phenylacetic acid DT39AOM MA Substrate DT39AOM RA Immunohistochemical and functional characterization of peptide, organic cation, neutral and basic amino acid, and monocarboxylate drug transporters in human ocular tissues. Drug Metab Dispos. 2013 Feb;41(2):466-74. DT39AOM RU http://www.ncbi.nlm.nih.gov/pubmed/23169611 DT39CEA TI DT39CEA DT39CEA TN Thiamine transporter 2 DT39CEA DI DMZ1WXJ DT39CEA DN Vitamin B1 DT39CEA MA Substrate DT39CEA RA Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr-Jun;34(2-3):373-85. DT39CEA RU http://www.ncbi.nlm.nih.gov/pubmed/23506878 DT39CEA TI DT39CEA DT39CEA TN Thiamine transporter 2 DT39CEA DI DM89QE1 DT39CEA DN Metformin DT39CEA MA Substrate DT39CEA RA Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7;12(12):4301-10. DT39CEA RU http://www.ncbi.nlm.nih.gov/pubmed/26528626 DT3BA8L TI DT3BA8L DT3BA8L TN Sodium-dependent dopamine transporter DT3BA8L DI DM1FX74 DT3BA8L DN Bretylium DT3BA8L MA Substrate DT3BA8L RA Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species? J Biol Chem. 1999 Feb 19;274(8):4876-82. DT3BA8L RU http://www.ncbi.nlm.nih.gov/pubmed/9988729 DT3BA8L TI DT3BA8L DT3BA8L TN Sodium-dependent dopamine transporter DT3BA8L DI DMSZQAK DT3BA8L DN Amphetamine DT3BA8L MA Substrate DT3BA8L RA Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50. DT3BA8L RU http://www.ncbi.nlm.nih.gov/pubmed/25542076 DT3BA8L TI DT3BA8L DT3BA8L TN Sodium-dependent dopamine transporter DT3BA8L DI DMGZOVN DT3BA8L DN Benztropine DT3BA8L MA Substrate DT3BA8L RA Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J Pharmacol Exp Ther. 2014 Jan;348(1):106-15. DT3BA8L RU http://www.ncbi.nlm.nih.gov/pubmed/24194528 DT3BA8L TI DT3BA8L DT3BA8L TN Sodium-dependent dopamine transporter DT3BA8L DI DMHG57U DT3BA8L DN Brexpiprazole DT3BA8L MA Substrate DT3BA8L RA Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028. DT3BA8L RU http://www.ncbi.nlm.nih.gov/pubmed/28160035 DT3BA8L TI DT3BA8L DT3BA8L TN Sodium-dependent dopamine transporter DT3BA8L DI DMPGUCF DT3BA8L DN Dopamine DT3BA8L MA Substrate DT3BA8L RA Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension. DNA Cell Biol. 2017 Mar;36(3):227-236. DT3BA8L RU http://www.ncbi.nlm.nih.gov/pubmed/28055236 DT3BI6S TI DT3BI6S DT3BI6S TN Glucose transporter type 10 DT3BI6S DI DMIAHVU DT3BI6S DN 2-Deoxyglucose DT3BI6S MA Substrate DT3BI6S RA Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. DT3BI6S RU http://www.ncbi.nlm.nih.gov/pubmed/11592815 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMSKMET DT3D8F0 DN Gimatecan DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMS9503 DT3D8F0 DN Benzylpenicillin DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMNFUZR DT3D8F0 DN Enalapril DT3D8F0 MA Substrate DT3D8F0 RA The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/9794920 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM7HXWT DT3D8F0 DN Nilotinib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMLUA9D DT3D8F0 DN Simeprevir DT3D8F0 MA Substrate DT3D8F0 RA Drug-Drug Interactions with the NS3/4A Protease Inhibitor Simeprevir. Clin Pharmacokinet. 2016 Feb;55(2):197-208. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/26353895 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMGQIPT DT3D8F0 DN Caspofungin DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM4VAOG DT3D8F0 DN Gadobenate dimeglumine DT3D8F0 MA Substrate DT3D8F0 RA Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):657-667. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/27778300 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMF28YC DT3D8F0 DN Atorvastatin DT3D8F0 MA Substrate DT3D8F0 RA Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/19374892 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMGVH6N DT3D8F0 DN Axitinib DT3D8F0 MA Substrate DT3D8F0 RA Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Eur J Clin Pharmacol. 2012 May;68(5):645-55. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/22170007 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMCRGY4 DT3D8F0 DN Karenitecin DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM6A0X7 DT3D8F0 DN Pravastatin DT3D8F0 MA Substrate DT3D8F0 RA The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/18408565 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMWD39E DT3D8F0 DN TR-14035 DT3D8F0 MA Substrate DT3D8F0 RA Cellular entry of thyroid hormones by organic anion transporting polypeptides. Best Pract Res Clin Endocrinol Metab. 2007 Jun;21(2):209-21. DT3D8F0 RU https://doi.org/10.1016/j.beem.2007.03.004 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM3GO0J DT3D8F0 DN Sodium taurocholate DT3D8F0 MA Substrate DT3D8F0 RA Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMN3GCH DT3D8F0 DN Darunavir DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMXCM7H DT3D8F0 DN Cerivastatin DT3D8F0 MA Substrate DT3D8F0 RA FDA Drug Development and Drug Interactions DT3D8F0 RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMGW1ID DT3D8F0 DN Sirolimus DT3D8F0 MA Substrate DT3D8F0 RA Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010 Jun;87(6):663-7. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/20220747 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMZMSCT DT3D8F0 DN Cilostazol DT3D8F0 MA Substrate DT3D8F0 RA Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans. J Pharm Sci. 2017 Sep;106(9):2515-2523. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/28535976 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM4F29C DT3D8F0 DN Crizotinib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMU79X2 DT3D8F0 DN YM758 DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMPQAGE DT3D8F0 DN Mycophenolate mofetil DT3D8F0 MA Substrate DT3D8F0 RA Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/17906856 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMTYOPD DT3D8F0 DN Dinoprostone DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMLK2QH DT3D8F0 DN Nateglinide DT3D8F0 MA Substrate DT3D8F0 RA Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMHN027 DT3D8F0 DN Levothyroxine DT3D8F0 MA Substrate DT3D8F0 RA Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/10358072 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMQTFAO DT3D8F0 DN Fluorescein DT3D8F0 MA Substrate DT3D8F0 RA Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMREUQ6 DT3D8F0 DN Valsartan DT3D8F0 MA Substrate DT3D8F0 RA Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM9OZWQ DT3D8F0 DN Lovastatin DT3D8F0 MA Substrate DT3D8F0 RA A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/10601278 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMRM0OW DT3D8F0 DN [D-Ala2, D-Leu5]-enkephalin DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMOQVU9 DT3D8F0 DN Hydroxyurea DT3D8F0 MA Substrate DT3D8F0 RA Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMWBHRY DT3D8F0 DN Olmesartan medoxomil DT3D8F0 MA Substrate DT3D8F0 RA OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos. 2006 May;34(5):862-9. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/16501004 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM4MDJY DT3D8F0 DN Fluvastatin DT3D8F0 MA Substrate DT3D8F0 RA SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. Clin Pharmacol Ther. 2006 Oct;80(4):356-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/17015053 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM0SXNM DT3D8F0 DN Glycocholic acid DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMHSY1I DT3D8F0 DN Regorafenib DT3D8F0 MA Substrate DT3D8F0 RA Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2. Biol Pharm Bull. 2015;38(4):582-6. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/25739790 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMPDYFR DT3D8F0 DN Cefazolin DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM0MO8I DT3D8F0 DN BQ-123 DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM7A8TW DT3D8F0 DN Ezetimibe DT3D8F0 MA Substrate DT3D8F0 RA A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 2;830(1):143-50. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/16280261 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM2LZ8F DT3D8F0 DN Taurocholic acid DT3D8F0 MA Substrate DT3D8F0 RA Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/10358072 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM15F0X DT3D8F0 DN Gefitinib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMYZ0P1 DT3D8F0 DN Eluxadoline DT3D8F0 MA Substrate DT3D8F0 RA Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline. J Clin Pharmacol. 2015 May;55(5):534-42. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/25491493 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMN9RPO DT3D8F0 DN Nafcillin DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM7JT24 DT3D8F0 DN Ouabain DT3D8F0 MA Substrate DT3D8F0 RA Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM7RJXL DT3D8F0 DN Imatinib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMW50NF DT3D8F0 DN SN-38 DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMNH3PG DT3D8F0 DN Etoposide DT3D8F0 MA Substrate DT3D8F0 RA Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847. DT3D8F0 RU https://doi.org/10.1111/j.1476-5381.2011.01672.x DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMCPB0Q DT3D8F0 DN leukotriene E4 DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM53PV8 DT3D8F0 DN Cefoperazone DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMOL5IU DT3D8F0 DN Mesalazine DT3D8F0 MA Substrate DT3D8F0 RA Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. Drug Metab Dispos. 2011 Jun;39(6):1097-102. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21430235 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMSUVM1 DT3D8F0 DN Cefditoren DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMJV2EK DT3D8F0 DN Dasatinib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM6U9CQ DT3D8F0 DN Pazopanib hydrochloride DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM1UJO0 DT3D8F0 DN Pitavastatin calcium DT3D8F0 MA Substrate DT3D8F0 RA The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/18408565 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMA8J1G DT3D8F0 DN Rifampicin DT3D8F0 MA Substrate DT3D8F0 RA Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/12490595 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMCUT21 DT3D8F0 DN Chenodeoxycholic acid DT3D8F0 MA Substrate DT3D8F0 RA Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. J Lipid Res. 2006 Jun;47(6):1196-202. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/16534140 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMRICNP DT3D8F0 DN Vandetanib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM30SGU DT3D8F0 DN Simvastatin DT3D8F0 MA Substrate DT3D8F0 RA Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/19785645 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM3KJ45 DT3D8F0 DN Estradiol-17beta-glucuronide DT3D8F0 MA Substrate DT3D8F0 RA Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport. Pharmacol Res. 2009 Jul;60(1):50-6. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/19427586 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMN0J4W DT3D8F0 DN Sincalide DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMLBVKQ DT3D8F0 DN Entacapone DT3D8F0 MA Substrate DT3D8F0 RA Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMXKJ6C DT3D8F0 DN Torsemide DT3D8F0 MA Substrate DT3D8F0 RA Coleman J., Cox A. and Cowley N. (2011). Side Effects of Drugs Annual. Elsevier. DT3D8F0 RU http://www.doc88.com/p-7415211358030.html DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMMIQ7G DT3D8F0 DN Rosuvastatin DT3D8F0 MA Substrate DT3D8F0 RA Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMKSUOI DT3D8F0 DN Flavopiridol DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM5SXUV DT3D8F0 DN Repaglinide DT3D8F0 MA Substrate DT3D8F0 RA Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium. Clin Pharmacol Ther. 2018 Nov;104(5):900-915. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/29756222 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMDI269 DT3D8F0 DN Docetaxel DT3D8F0 MA Substrate DT3D8F0 RA FDA Drug Development and Drug Interactions DT3D8F0 RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMI0V4O DT3D8F0 DN Bilirubin DT3D8F0 MA Substrate DT3D8F0 RA Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin. Biochem J. 2003 May 1;371(Pt 3):897-905. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/12568656 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM7OKQV DT3D8F0 DN Cholic acid DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMCBJSR DT3D8F0 DN Sunitinib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM20MDU DT3D8F0 DN Danoprevir DT3D8F0 MA Substrate DT3D8F0 RA FDA Drug Development and Drug Interactions DT3D8F0 RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM6IR3P DT3D8F0 DN Liothyronine DT3D8F0 MA Substrate DT3D8F0 RA Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/10358072 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM2TEOL DT3D8F0 DN Methotrexate DT3D8F0 MA Substrate DT3D8F0 RA Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/26474710 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMKB79O DT3D8F0 DN Bromfenac DT3D8F0 MA Substrate DT3D8F0 RA Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMIOGBU DT3D8F0 DN Bosentan DT3D8F0 MA Substrate DT3D8F0 RA Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMITQS0 DT3D8F0 DN Lopinavir DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMS8IFC DT3D8F0 DN Sorafenib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM9W2ZV DT3D8F0 DN Bromsulphthalein DT3D8F0 MA Substrate DT3D8F0 RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMG814N DT3D8F0 DN Saquinavir DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMM74PK DT3D8F0 DN Atrasentan DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM62UG5 DT3D8F0 DN Vemurafenib DT3D8F0 MA Substrate DT3D8F0 RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMVBIZL DT3D8F0 DN Estrone sulfate DT3D8F0 MA Substrate DT3D8F0 RA Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Protein Sci. 2009 Nov;18(11):2298-306. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/19760661 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMLB81S DT3D8F0 DN Paclitaxel DT3D8F0 MA Substrate DT3D8F0 RA Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. Eur J Med Chem. 2015 Mar 6;92:723-31. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/25618019 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMLO9FU DT3D8F0 DN Fluo-3 DT3D8F0 MA Substrate DT3D8F0 RA Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMUEWM3 DT3D8F0 DN Technetium (99MTC) mebrofenin DT3D8F0 MA Substrate DT3D8F0 RA Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium. Clin Pharmacol Ther. 2018 Nov;104(5):900-915. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/29756222 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM4Q80H DT3D8F0 DN Dehydroepiandrosterone sulfate DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM1A79H DT3D8F0 DN Temocapril DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMJH792 DT3D8F0 DN Pitavastatin DT3D8F0 MA Substrate DT3D8F0 RA Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins. Eur J Pharm Sci. 2012 Aug 30;47(1):244-55. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/22538052 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DMALN2M DT3D8F0 DN Cholyl lysyl fluorescein DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3D8F0 TI DT3D8F0 DT3D8F0 TN Organic anion transporting polypeptide 1B1 DT3D8F0 DI DM37FKA DT3D8F0 DN Primovist DT3D8F0 MA Substrate DT3D8F0 RA Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DT3D8F0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DT3EAQP TI DT3EAQP DT3EAQP TN Equilibrative nucleoside transporter 4 DT3EAQP DI DM78IME DT3EAQP DN Ergotidine DT3EAQP MA Substrate DT3EAQP RA Histamine uptake mediated by plasma membrane monoamine transporter and organic cation transporters in rat mast cell lines. Eur J Pharmacol. 2019 Apr 15;849:75-83. DT3EAQP RU http://www.ncbi.nlm.nih.gov/pubmed/30707958 DT3EAQP TI DT3EAQP DT3EAQP TN Equilibrative nucleoside transporter 4 DT3EAQP DI DM89QE1 DT3EAQP DN Metformin DT3EAQP MA Substrate DT3EAQP RA Metformin: from mechanisms of action to therapies. Cell Metab. 2014 Dec 2;20(6):953-66. DT3EAQP RU http://www.ncbi.nlm.nih.gov/pubmed/25456737 DT3EAQP TI DT3EAQP DT3EAQP TN Equilibrative nucleoside transporter 4 DT3EAQP DI DMOFCRY DT3EAQP DN Serotonin DT3EAQP MA Substrate DT3EAQP RA Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Mol Autism. 2014 Aug 13;5:43. DT3EAQP RU http://www.ncbi.nlm.nih.gov/pubmed/25802735 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMSWYF5 DT3HUVD DN Quinine DT3HUVD MA Substrate DT3HUVD RA Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/10525100 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMSZQAK DT3HUVD DN Amphetamine DT3HUVD MA Substrate DT3HUVD RA Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther. 2005 Jan;312(1):192-8. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/15316089 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMB4SFH DT3HUVD DN Pyrilamide DT3HUVD MA Substrate DT3HUVD RA Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice. Biopharm Drug Dispos. 2009 Dec;30(9):495-507. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/19821448 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DM74HGJ DT3HUVD DN Acetyl-l-carnitine DT3HUVD MA Substrate DT3HUVD RA Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/10525100 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMMTAJC DT3HUVD DN Potassium chloride DT3HUVD MA Substrate DT3HUVD RA Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/20352446 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMJBOCR DT3HUVD DN L-carnitine DT3HUVD MA Substrate DT3HUVD RA Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5). Drug Metab Dispos. 2017 Dec;45(12):1240-1244. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/28986476 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DM7VTQO DT3HUVD DN Entecavir DT3HUVD MA Substrate DT3HUVD RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMFDC0Q DT3HUVD DN Tiotropium DT3HUVD MA Substrate DT3HUVD RA Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/20020740 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMA7PEW DT3HUVD DN Verapamil DT3HUVD MA Substrate DT3HUVD RA Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore. Drug Metab Pharmacokinet. 2010;25(1):112-9. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/20208395 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMFQ320 DT3HUVD DN Ipratropium DT3HUVD MA Substrate DT3HUVD RA Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/20020740 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DMHNAJ7 DT3HUVD DN D-carnitine DT3HUVD MA Substrate DT3HUVD RA Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol. 2000 Sep;279(3):F584-91. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/10966938 DT3HUVD TI DT3HUVD DT3HUVD TN Organic cation/carnitine transporter 2 DT3HUVD DI DM4UE3K DT3HUVD DN Acetylcarnitine DT3HUVD MA Substrate DT3HUVD RA Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Arch Biochem Biophys. 2006 Aug 1;452(1):29-37. DT3HUVD RU http://www.ncbi.nlm.nih.gov/pubmed/16839516 DT3I124 TI DT3I124 DT3I124 TN Monocarboxylate transporter 6 DT3I124 DI DMLK2QH DT3I124 DN Nateglinide DT3I124 MA Substrate DT3I124 RA Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936. DT3I124 RU http://www.ncbi.nlm.nih.gov/pubmed/28513167 DT3I124 TI DT3I124 DT3I124 TN Monocarboxylate transporter 6 DT3I124 DI DMMFWOJ DT3I124 DN Probenecid DT3I124 MA Substrate DT3I124 RA Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936. DT3I124 RU http://www.ncbi.nlm.nih.gov/pubmed/28513167 DT3I124 TI DT3I124 DT3I124 TN Monocarboxylate transporter 6 DT3I124 DI DMRV7H0 DT3I124 DN Bumetanide DT3I124 MA Substrate DT3I124 RA Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936. DT3I124 RU http://www.ncbi.nlm.nih.gov/pubmed/28513167 DT3I2SU TI DT3I2SU DT3I2SU TN Choline transporter-like protein 1 DT3I2SU DI DM5D9YK DT3I2SU DN Choline DT3I2SU MA Substrate DT3I2SU RA Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells. Pharm Res. 2008 Feb;25(2):417-27. DT3I2SU RU http://www.ncbi.nlm.nih.gov/pubmed/17624579 DT3JCE6 TI DT3JCE6 DT3JCE6 TN Sulfonylurea receptor 2 DT3JCE6 DI DM02AWV DT3JCE6 DN Tolbutamide DT3JCE6 MA Substrate DT3JCE6 RA ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. DT3JCE6 RU http://www.ncbi.nlm.nih.gov/pubmed/16897043 DT3KH2X TI DT3KH2X DT3KH2X TN Sodium-dependent vitamin C transporter 1 DT3KH2X DI DMXJ7O8 DT3KH2X DN Vitamin C DT3KH2X MA Substrate DT3KH2X RA A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5. DT3KH2X RU http://www.ncbi.nlm.nih.gov/pubmed/10331392 DT3LZWR TI DT3LZWR DT3LZWR TN GDP-fucose transporter 1 DT3LZWR DI DMZMULS DT3LZWR DN GDP-fucose DT3LZWR MA Substrate DT3LZWR RA Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. J Biol Chem. 2007 Apr 6;282(14):10762-72. DT3LZWR RU http://www.ncbi.nlm.nih.gov/pubmed/17276979 DT3Q1UO TI DT3Q1UO DT3Q1UO TN Protein spinster homolog 2 DT3Q1UO DI DMJCQKA DT3Q1UO DN Sphingosine-1-phosphate DT3Q1UO MA Substrate DT3Q1UO RA The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC63A2) DT3Q1UO RU http://slc.bioparadigms.org/protein?GeneName=SLC63A2 DT3T2K0 TI DT3T2K0 DT3T2K0 TN Vesicular acetylcholine transporter DT3T2K0 DI DMDF79Z DT3T2K0 DN Acetylcholine DT3T2K0 MA Substrate DT3T2K0 RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DT3T2K0 RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMH61ZB DT3TX4H DN Cimetidine DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMP6G8T DT3TX4H DN Topotecan DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DM1MBYQ DT3TX4H DN Ganciclovir DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DM93VBZ DT3TX4H DN Abemaciclib DT3TX4H MA Substrate DT3TX4H RA Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/30449032 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DM6SFYH DT3TX4H DN Tetraethylammonium DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMYLOVR DT3TX4H DN Acyclovir DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DM89QE1 DT3TX4H DN Metformin DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMPN1TW DT3TX4H DN Dofetilide DT3TX4H MA Substrate DT3TX4H RA FDA Drug Development and Drug Interactions DT3TX4H RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMNMXR8 DT3TX4H DN Procainamide DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMVBIZL DT3TX4H DN Estrone sulfate DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3TX4H TI DT3TX4H DT3TX4H TN Multidrug and toxin extrusion protein 2 DT3TX4H DI DMVUKEW DT3TX4H DN N-methylpyridinium DT3TX4H MA Substrate DT3TX4H RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DT3TX4H RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DT3VZJO TI DT3VZJO DT3VZJO TN Mitochondrial glutamate carrier 2 DT3VZJO DI DM4PUDW DT3VZJO DN L-glutamic acid DT3VZJO MA Substrate DT3VZJO RA The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC25A18) DT3VZJO RU http://slc.bioparadigms.org/protein?GeneName=SLC25A18 DT42EWA TI DT42EWA DT42EWA TN Sodium-dependent phosphate transport protein 2A DT42EWA DI DMGXCY9 DT42EWA DN Calcium phosphate DT42EWA MA Substrate DT42EWA RA Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DT42EWA RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DT4827A TI DT4827A DT4827A TN Glucose transporter type 4 DT4827A DI DMIAHVU DT4827A DN 2-Deoxyglucose DT4827A MA Substrate DT4827A RA Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice. Diabetes. 2002 Sep;51(9):2719-26. DT4827A RU http://www.ncbi.nlm.nih.gov/pubmed/12196464 DT48T0N TI DT48T0N DT48T0N TN L-type amino acid transporter 1 DT48T0N DI DMDVP3B DT48T0N DN Pregabalin DT48T0N MA Substrate DT48T0N RA Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246. DT48T0N RU http://www.ncbi.nlm.nih.gov/pubmed/30374619 DT48T0N TI DT48T0N DT48T0N TN L-type amino acid transporter 1 DT48T0N DI DM69G8X DT48T0N DN L-glutamine DT48T0N MA Substrate DT48T0N RA Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34. DT48T0N RU http://www.ncbi.nlm.nih.gov/pubmed/19203585 DT48T0N TI DT48T0N DT48T0N TN L-type amino acid transporter 1 DT48T0N DI DMN3E57 DT48T0N DN Levodopa DT48T0N MA Substrate DT48T0N RA Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. Sci Rep. 2017 Mar 8;7:43580. DT48T0N RU http://www.ncbi.nlm.nih.gov/pubmed/28272458 DT48T0N TI DT48T0N DT48T0N TN L-type amino acid transporter 1 DT48T0N DI DM6T924 DT48T0N DN Gabapentin DT48T0N MA Substrate DT48T0N RA Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol. 2013 Jun 1;85(11):1672-83. DT48T0N RU http://www.ncbi.nlm.nih.gov/pubmed/23567998 DT48T0N TI DT48T0N DT48T0N TN L-type amino acid transporter 1 DT48T0N DI DMQHN7I DT48T0N DN L-leucine DT48T0N MA Substrate DT48T0N RA Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34. DT48T0N RU http://www.ncbi.nlm.nih.gov/pubmed/19203585 DT48WEM TI DT48WEM DT48WEM TN Proton-coupled amino acid transporter 1 DT48WEM DI DMI53FU DT48WEM DN Gaboxadol DT48WEM MA Substrate DT48WEM RA Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan. Br J Pharmacol. 2009 Aug;157(8):1380-9. DT48WEM RU http://www.ncbi.nlm.nih.gov/pubmed/19594759 DT48WEM TI DT48WEM DT48WEM TN Proton-coupled amino acid transporter 1 DT48WEM DI DMT1I52 DT48WEM DN Cycloserine DT48WEM MA Substrate DT48WEM RA Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). J Cell Physiol. 2005 Aug;204(2):604-13. DT48WEM RU http://www.ncbi.nlm.nih.gov/pubmed/15754324 DT48WEM TI DT48WEM DT48WEM TN Proton-coupled amino acid transporter 1 DT48WEM DI DMKSTWR DT48WEM DN L-proline DT48WEM MA Substrate DT48WEM RA PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E65-74. DT48WEM RU http://www.ncbi.nlm.nih.gov/pubmed/24222668 DT48WEM TI DT48WEM DT48WEM TN Proton-coupled amino acid transporter 1 DT48WEM DI DMIOZ29 DT48WEM DN Glycine DT48WEM MA Substrate DT48WEM RA Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. Eur J Pharm Sci. 2008 Sep 2;35(1-2):86-95. DT48WEM RU http://www.ncbi.nlm.nih.gov/pubmed/18621125 DT48WEM TI DT48WEM DT48WEM TN Proton-coupled amino acid transporter 1 DT48WEM DI DMYT0OG DT48WEM DN Vigabatrin DT48WEM MA Substrate DT48WEM RA Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats. Pharm Res. 2012 Apr;29(4):1134-42. DT48WEM RU http://www.ncbi.nlm.nih.gov/pubmed/22234618 DT48WEM TI DT48WEM DT48WEM TN Proton-coupled amino acid transporter 1 DT48WEM DI DMS4BLQ DT48WEM DN Aminolevulinic acid DT48WEM MA Substrate DT48WEM RA Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). Br J Pharmacol. 2010 Mar;159(6):1339-53. DT48WEM RU http://www.ncbi.nlm.nih.gov/pubmed/20128809 DT4X2AH TI DT4X2AH DT4X2AH TN Anion exchange protein 3 DT4X2AH DI DMT5E36 DT4X2AH DN Bicarbonate DT4X2AH MA Substrate DT4X2AH RA The SLC4 family of bicarbonate (HCO??) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82. DT4X2AH RU http://www.ncbi.nlm.nih.gov/pubmed/23506864 DT4YL5R TI DT4YL5R DT4YL5R TN Concentrative Na(+)-nucleoside cotransporter 3 DT4YL5R DI DM7NKEV DT4YL5R DN Thioguanine DT4YL5R MA Substrate DT4YL5R RA Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15. DT4YL5R RU http://www.ncbi.nlm.nih.gov/pubmed/16530731 DT4YL5R TI DT4YL5R DT4YL5R TN Concentrative Na(+)-nucleoside cotransporter 3 DT4YL5R DI DMTM2IK DT4YL5R DN Mercaptopurine DT4YL5R MA Substrate DT4YL5R RA Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15. DT4YL5R RU http://www.ncbi.nlm.nih.gov/pubmed/16530731 DT4YL5R TI DT4YL5R DT4YL5R TN Concentrative Na(+)-nucleoside cotransporter 3 DT4YL5R DI DMEYLH9 DT4YL5R DN Ribavirin DT4YL5R MA Substrate DT4YL5R RA Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. Biophys Chem. 2010 Mar;147(1-2):59-65. DT4YL5R RU http://www.ncbi.nlm.nih.gov/pubmed/20096989 DT4YL5R TI DT4YL5R DT4YL5R TN Concentrative Na(+)-nucleoside cotransporter 3 DT4YL5R DI DM7VTQO DT4YL5R DN Entecavir DT4YL5R MA Substrate DT4YL5R RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DT4YL5R RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DT4YL5R TI DT4YL5R DT4YL5R TN Concentrative Na(+)-nucleoside cotransporter 3 DT4YL5R DI DMCVJ86 DT4YL5R DN Clofarabine DT4YL5R MA Substrate DT4YL5R RA Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62. DT4YL5R RU http://www.ncbi.nlm.nih.gov/pubmed/24692694 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DM3GO0J DT56EKP DN Sodium taurocholate DT56EKP MA Substrate DT56EKP RA Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. J Pharmacol Exp Ther. 2007 Jun;321(3):1170-8. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/17374746 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DMXCM7H DT56EKP DN Cerivastatin DT56EKP MA Substrate DT56EKP RA Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors. Xenobiotica. 2011 Jan;41(1):24-34. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/20946088 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DM2LZ8F DT56EKP DN Taurocholic acid DT56EKP MA Substrate DT56EKP RA Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J Pharmacol Exp Ther. 1999 Dec;291(3):1204-9. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/10565843 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DM1UJO0 DT56EKP DN Pitavastatin calcium DT56EKP MA Substrate DT56EKP RA Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/16259759 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DMMIQ7G DT56EKP DN Rosuvastatin DT56EKP MA Substrate DT56EKP RA Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/16697742 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DM6IR3P DT56EKP DN Liothyronine DT56EKP MA Substrate DT56EKP RA Identification of thyroid hormone transporters. Biochem Biophys Res Commun. 1999 Jan 19;254(2):497-501. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/9918867 DT56EKP TI DT56EKP DT56EKP TN Sodium/taurocholate cotransporting polypeptide DT56EKP DI DMVBIZL DT56EKP DN Estrone sulfate DT56EKP MA Substrate DT56EKP RA Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem. 2004 Feb 20;279(8):7213-22. DT56EKP RU http://www.ncbi.nlm.nih.gov/pubmed/14660639 DT582KR TI DT582KR DT582KR TN Multidrug resistance-associated protein 6 DT582KR DI DMQUSBT DT582KR DN Daunorubicin DT582KR MA Substrate DT582KR RA Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. DT582KR RU http://www.ncbi.nlm.nih.gov/pubmed/12414644 DT582KR TI DT582KR DT582KR TN Multidrug resistance-associated protein 6 DT582KR DI DMRHGI9 DT582KR DN Cisplatin DT582KR MA Substrate DT582KR RA Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. DT582KR RU http://www.ncbi.nlm.nih.gov/pubmed/12414644 DT582KR TI DT582KR DT582KR TN Multidrug resistance-associated protein 6 DT582KR DI DMC3YUA DT582KR DN Benzbromarone DT582KR MA Substrate DT582KR RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 3.A.1.208.10) DT582KR RU http://www.tcdb.org/search/result.php?tc=3.A.1.208.10 DT582KR TI DT582KR DT582KR TN Multidrug resistance-associated protein 6 DT582KR DI DMVNR20 DT582KR DN Epipodophyllotoxins DT582KR MA Substrate DT582KR RA Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. DT582KR RU http://www.ncbi.nlm.nih.gov/pubmed/12414644 DT5G94L TI DT5G94L DT5G94L TN Major facilitator superfamily domain-containing protein 2A DT5G94L DI DMOGFVH DT5G94L DN Lysophosphatidylcholine DT5G94L MA Substrate DT5G94L RA Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014 May 22;509(7501):503-6. DT5G94L RU http://www.ncbi.nlm.nih.gov/pubmed/24828044 DT5G94L TI DT5G94L DT5G94L TN Major facilitator superfamily domain-containing protein 2A DT5G94L DI DMMUCG4 DT5G94L DN Docosahexaenoic acid DT5G94L MA Substrate DT5G94L RA Mfsd2a Is a Transporter for the Essential -3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14. DT5G94L RU http://www.ncbi.nlm.nih.gov/pubmed/27008858 DT5LHCR TI DT5LHCR DT5LHCR TN Vesicular glutamate transporter 2 DT5LHCR DI DM4PUDW DT5LHCR DN L-glutamic acid DT5LHCR MA Substrate DT5LHCR RA Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65. DT5LHCR RU http://www.ncbi.nlm.nih.gov/pubmed/15210307 DT5LHCR TI DT5LHCR DT5LHCR TN Vesicular glutamate transporter 2 DT5LHCR DI DMUXQG7 DT5LHCR DN Phosphate DT5LHCR MA Substrate DT5LHCR RA Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13. DT5LHCR RU http://www.ncbi.nlm.nih.gov/pubmed/20566650 DT61TWI TI DT61TWI DT61TWI TN ATP-binding cassette sub-family A member 1 DT61TWI DI DMR3J6S DT61TWI DN Cholesterol DT61TWI MA Substrate DT61TWI RA ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions. J Lipid Res. 2003 Jul;44(7):1373-80. DT61TWI RU http://www.ncbi.nlm.nih.gov/pubmed/12700343 DT61TWI TI DT61TWI DT61TWI TN ATP-binding cassette sub-family A member 1 DT61TWI DI DMGO2MC DT61TWI DN Fenofibric acid DT61TWI MA Substrate DT61TWI RA Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1193-7. DT61TWI RU http://www.ncbi.nlm.nih.gov/pubmed/15790930 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM67PWD DT6201N DN Etilefrine DT6201N MA Substrate DT6201N RA Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/16263091 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM6RZ9Q DT6201N DN Clonidine DT6201N MA Substrate DT6201N RA Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM79NTF DT6201N DN Propranolol DT6201N MA Substrate DT6201N RA Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM3KJBC DT6201N DN Epinephrine DT6201N MA Substrate DT6201N RA Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM78IME DT6201N DN Ergotidine DT6201N MA Substrate DT6201N RA Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DMM3950 DT6201N DN Sodium chloride DT6201N MA Substrate DT6201N RA Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci. 2004 Mar 17;24(11):2846-51. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/15028779 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DMSZQAK DT6201N DN Amphetamine DT6201N MA Substrate DT6201N RA Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem. 2010 Jul;114(1):142-9. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/20402963 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DMOUC09 DT6201N DN Norepinephrine DT6201N MA Substrate DT6201N RA Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM89QE1 DT6201N DN Metformin DT6201N MA Substrate DT6201N RA Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology. 2009 Oct;50(4):1227-40. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/19591196 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM7VTQO DT6201N DN Entecavir DT6201N MA Substrate DT6201N RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DMDF79Z DT6201N DN Acetylcholine DT6201N MA Substrate DT6201N RA Organic cation transporters: physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab. 2009 Jul;10(6):617-31. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/19702534 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DMVUKEW DT6201N DN N-methylpyridinium DT6201N MA Substrate DT6201N RA Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/10966924 DT6201N TI DT6201N DT6201N TN Organic cation transporter 3 DT6201N DI DM4GO8H DT6201N DN Guanidine DT6201N MA Substrate DT6201N RA Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. DT6201N RU http://www.ncbi.nlm.nih.gov/pubmed/10966924 DT68UV2 TI DT68UV2 DT68UV2 TN TAP-like protein DT68UV2 DI DMDI269 DT68UV2 DN Docetaxel DT68UV2 MA Substrate DT68UV2 RA RNA-sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel. Mol Biosyst. 2017 Sep 26;13(10):2125-2134. DT68UV2 RU http://www.ncbi.nlm.nih.gov/pubmed/28825433 DT68UV2 TI DT68UV2 DT68UV2 TN TAP-like protein DT68UV2 DI DMLB81S DT68UV2 DN Paclitaxel DT68UV2 MA Substrate DT68UV2 RA Overexpression of microRNA-24 increases the sensitivity to paclitaxel in drug-resistant breast carcinoma cell lines via targeting ABCB9. Oncol Lett. 2016 Nov;12(5):3905-3911. DT68UV2 RU http://www.ncbi.nlm.nih.gov/pubmed/27895747 DT6MDC9 TI DT6MDC9 DT6MDC9 TN Thiazide-sensitive sodium-chloride cotransporter DT6MDC9 DI DMB39LO DT6MDC9 DN Metolazone DT6MDC9 MA Substrate DT6MDC9 RA Inhibition of binding of [3H]metolazone to rat kidney membrane by stilbene disulfonates. Biochem Pharmacol. 1991 Jun 1;41(11):1745-50. DT6MDC9 RU http://www.ncbi.nlm.nih.gov/pubmed/2043163 DT6MDC9 TI DT6MDC9 DT6MDC9 TN Thiazide-sensitive sodium-chloride cotransporter DT6MDC9 DI DMRV7H0 DT6MDC9 DN Bumetanide DT6MDC9 MA Substrate DT6MDC9 RA Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9. DT6MDC9 RU http://www.ncbi.nlm.nih.gov/pubmed/17460608 DT7A9GF TI DT7A9GF DT7A9GF TN Synaptic vesicle glycoprotein 2C DT7A9GF DI DMPGUCF DT7A9GF DN Dopamine DT7A9GF MA Substrate DT7A9GF RA Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2253-E2262. DT7A9GF RU http://www.ncbi.nlm.nih.gov/pubmed/28246328 DT7JELC TI DT7JELC DT7JELC TN Apical sodium-dependent bile acid transporter DT7JELC DI DM1XEJV DT7JELC DN Glycodeoxycholic acid DT7JELC MA Substrate DT7JELC RA Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1):G157-69. DT7JELC RU http://ajpgi.physiology.org/content/274/1/G157.long DT7JELC TI DT7JELC DT7JELC TN Apical sodium-dependent bile acid transporter DT7JELC DI DM3GO0J DT7JELC DN Sodium taurocholate DT7JELC MA Substrate DT7JELC RA Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry. 2002 Dec 17;41(50):14916-24. DT7JELC RU http://www.ncbi.nlm.nih.gov/pubmed/12475240 DT7JELC TI DT7JELC DT7JELC TN Apical sodium-dependent bile acid transporter DT7JELC DI DM2LZ8F DT7JELC DN Taurocholic acid DT7JELC MA Substrate DT7JELC RA Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry. 2002 Dec 17;41(50):14916-24. DT7JELC RU http://www.ncbi.nlm.nih.gov/pubmed/12475240 DT7JELC TI DT7JELC DT7JELC TN Apical sodium-dependent bile acid transporter DT7JELC DI DM7OKQV DT7JELC DN Cholic acid DT7JELC MA Substrate DT7JELC RA Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1):G157-69. DT7JELC RU http://ajpgi.physiology.org/content/274/1/G157.long DT7JELC TI DT7JELC DT7JELC TN Apical sodium-dependent bile acid transporter DT7JELC DI DM3GYAL DT7JELC DN Deoxycholic acid DT7JELC MA Substrate DT7JELC RA Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018 Jan;151:13-23. DT7JELC RU http://www.ncbi.nlm.nih.gov/pubmed/29055774 DT7LDG0 TI DT7LDG0 DT7LDG0 TN ATP-binding cassette sub-family A member 12 DT7LDG0 DI DMR3J6S DT7LDG0 DN Cholesterol DT7LDG0 MA Substrate DT7LDG0 RA ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 2013 Aug 6;18(2):225-38. DT7LDG0 RU http://www.ncbi.nlm.nih.gov/pubmed/23931754 DT7NOKR TI DT7NOKR DT7NOKR TN Riboflavin transporter 1 DT7NOKR DI DM8YMWE DT7NOKR DN Riboflavin DT7NOKR MA Substrate DT7NOKR RA An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188. DT7NOKR RU http://www.ncbi.nlm.nih.gov/pubmed/29122468 DT7NVLY TI DT7NVLY DT7NVLY TN Zinc transporter 8 DT7NVLY DI DMZ4R3Q DT7NVLY DN Zinc salts DT7NVLY MA Substrate DT7NVLY RA Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24. DT7NVLY RU http://www.ncbi.nlm.nih.gov/pubmed/24751356 DT7RYVF TI DT7RYVF DT7RYVF TN Sodium-driven chloride bicarbonate exchanger DT7RYVF DI DMMU6BJ DT7RYVF DN Sodium bicarbonate DT7RYVF MA Substrate DT7RYVF RA Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. DT7RYVF RU http://www.ncbi.nlm.nih.gov/pubmed/15014910 DT82KPY TI DT82KPY DT82KPY TN Concentrative nucleoside transporter 2 DT82KPY DI DMI2QPE DT82KPY DN Didanosine DT82KPY MA Substrate DT82KPY RA Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals. DT82KPY RU https://books.google.co.jp/books?id=cYBGAAAAQBAJ&pg=PA59&lpg=PA59&dq=SLC15A1%09Didanosine&source=bl&ots=CeeUnMnW6Z&sig=ACfU3U10UhN6m18-AuKuLOfFeDKtUo5VYw&hl=zh-CN&sa=X&ved=2ahUKEwjh_IyK9KHiAhVIzbwKHZKiDoMQ6AEwAXoECAgQAQ#v=onepage&q=SLC15A1%09Didanosine&f=false DT82KPY TI DT82KPY DT82KPY TN Concentrative nucleoside transporter 2 DT82KPY DI DMTM2IK DT82KPY DN Mercaptopurine DT82KPY MA Substrate DT82KPY RA PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DT82KPY RU https://www.pharmgkb.org/pathway/PA2040 DT82KPY TI DT82KPY DT82KPY TN Concentrative nucleoside transporter 2 DT82KPY DI DMEYLH9 DT82KPY DN Ribavirin DT82KPY MA Substrate DT82KPY RA Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6. DT82KPY RU http://www.ncbi.nlm.nih.gov/pubmed/17700367 DT82KPY TI DT82KPY DT82KPY TN Concentrative nucleoside transporter 2 DT82KPY DI DM7VTQO DT82KPY DN Entecavir DT82KPY MA Substrate DT82KPY RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DT82KPY RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DT82KPY TI DT82KPY DT82KPY TN Concentrative nucleoside transporter 2 DT82KPY DI DMQTREB DT82KPY DN Uridine DT82KPY MA Substrate DT82KPY RA Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 May;163:60-70. DT82KPY RU http://www.ncbi.nlm.nih.gov/pubmed/30716294 DT85HYR TI DT85HYR DT85HYR TN Calcium-binding mitochondrial carrier protein Aralar1 DT85HYR DI DM4PUDW DT85HYR DN L-glutamic acid DT85HYR MA Substrate DT85HYR RA Mitochondrial Aspartate/Glutamate Carrier SLC25A12 and Autism Spectrum Disorder: a Meta-Analysis. Mol Neurobiol. 2016 Apr;53(3):1579-1588. DT85HYR RU http://www.ncbi.nlm.nih.gov/pubmed/25663199 DT8ACN1 TI DT8ACN1 DT8ACN1 TN Sodium/myo-inositol cotransporter DT8ACN1 DI DMQKSGI DT8ACN1 DN MYO-inositol DT8ACN1 MA Substrate DT8ACN1 RA Identification of a novel Na+/myo-inositol cotransporter. J Biol Chem. 2002 Sep 20;277(38):35219-24. DT8ACN1 RU http://www.ncbi.nlm.nih.gov/pubmed/12133831 DT8ARWJ TI DT8ARWJ DT8ARWJ TN Sodium-dependent phosphate transport protein 1 DT8ARWJ DI DMUXQG7 DT8ARWJ DN Phosphate DT8ARWJ MA Substrate DT8ARWJ RA Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13. DT8ARWJ RU http://www.ncbi.nlm.nih.gov/pubmed/20566650 DT8ARWJ TI DT8ARWJ DT8ARWJ TN Sodium-dependent phosphate transport protein 1 DT8ARWJ DI DM672AH DT8ARWJ DN Aspirin DT8ARWJ MA Substrate DT8ARWJ RA Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13. DT8ARWJ RU http://www.ncbi.nlm.nih.gov/pubmed/20566650 DT8H2IC TI DT8H2IC DT8H2IC TN Organic anion transporting polypeptide 4A1 DT8H2IC DI DMS9503 DT8H2IC DN Benzylpenicillin DT8H2IC MA Substrate DT8H2IC RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DT8H2IC RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DT8H2IC TI DT8H2IC DT8H2IC TN Organic anion transporting polypeptide 4A1 DT8H2IC DI DMTYOPD DT8H2IC DN Dinoprostone DT8H2IC MA Substrate DT8H2IC RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DT8H2IC RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DT8H2IC TI DT8H2IC DT8H2IC TN Organic anion transporting polypeptide 4A1 DT8H2IC DI DM2LZ8F DT8H2IC DN Taurocholic acid DT8H2IC MA Substrate DT8H2IC RA Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. DT8H2IC RU http://www.ncbi.nlm.nih.gov/pubmed/11316767 DT8H2IC TI DT8H2IC DT8H2IC TN Organic anion transporting polypeptide 4A1 DT8H2IC DI DM6IR3P DT8H2IC DN Liothyronine DT8H2IC MA Substrate DT8H2IC RA Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DT8H2IC RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DT8H2IC TI DT8H2IC DT8H2IC TN Organic anion transporting polypeptide 4A1 DT8H2IC DI DMVBIZL DT8H2IC DN Estrone sulfate DT8H2IC MA Substrate DT8H2IC RA Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. J Pharmacol Exp Ther. 2004 Dec;311(3):1032-7. DT8H2IC RU http://www.ncbi.nlm.nih.gov/pubmed/15328376 DT8KXR9 TI DT8KXR9 DT8KXR9 TN Choline transporter-like protein 4 DT8KXR9 DI DMZ1WXJ DT8KXR9 DN Vitamin B1 DT8KXR9 MA Substrate DT8KXR9 RA Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2017 Oct 6;292(40):16526. DT8KXR9 RU http://www.ncbi.nlm.nih.gov/pubmed/28986434 DT8KXR9 TI DT8KXR9 DT8KXR9 TN Choline transporter-like protein 4 DT8KXR9 DI DM5D9YK DT8KXR9 DN Choline DT8KXR9 MA Substrate DT8KXR9 RA SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet. 2017 Jan 15;26(2):383-394. DT8KXR9 RU http://www.ncbi.nlm.nih.gov/pubmed/28013291 DT8KXR9 TI DT8KXR9 DT8KXR9 TN Choline transporter-like protein 4 DT8KXR9 DI DMDF79Z DT8KXR9 DN Acetylcholine DT8KXR9 MA Substrate DT8KXR9 RA Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem. 2013 Aug;126(4):451-61. DT8KXR9 RU http://www.ncbi.nlm.nih.gov/pubmed/23651124 DT8Q56F TI DT8Q56F DT8Q56F TN Probable low affinity copper uptake protein 2 DT8Q56F DI DMRHGI9 DT8Q56F DN Cisplatin DT8Q56F MA Substrate DT8Q56F RA Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo. Mol Pharmacol. 2011 Jan;79(1):157-66. DT8Q56F RU http://www.ncbi.nlm.nih.gov/pubmed/20930109 DT8QC7K TI DT8QC7K DT8QC7K TN Urea transporter 2 DT8QC7K DI DMAEQB6 DT8QC7K DN Methylurea DT8QC7K MA Substrate DT8QC7K RA Urea transporter physiology studied in knockout mice. Front Physiol. 2012 Jun 26;3:217. DT8QC7K RU http://www.ncbi.nlm.nih.gov/pubmed/22745630 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM26E4B DT8QKNP DN Moexipril DT8QKNP MA Substrate DT8QKNP RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMHSJB4 DT8QKNP DN Cyclacillin DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMNFUZR DT8QKNP DN Enalapril DT8QKNP MA Substrate DT8QKNP RA Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May;32(5):777-84. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18336632 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM2R68E DT8QKNP DN Ramipril DT8QKNP MA Substrate DT8QKNP RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMOPZDT DT8QKNP DN Perindopril DT8QKNP MA Substrate DT8QKNP RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMHKS94 DT8QKNP DN Valacyclovir DT8QKNP MA Substrate DT8QKNP RA Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/9610386 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMWV2AG DT8QKNP DN Ceftibuten DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM5XLTY DT8QKNP DN Spirapril DT8QKNP MA Substrate DT8QKNP RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMUNSWV DT8QKNP DN Cephradine DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMY60I8 DT8QKNP DN Cefixime DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMY60I8 DT8QKNP DN Cefamandole DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMUYNEI DT8QKNP DN Amoxicillin DT8QKNP MA Substrate DT8QKNP RA Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16434549 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM7VTQO DT8QKNP DN Entecavir DT8QKNP MA Substrate DT8QKNP RA The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur J Pharm Sci. 2014 Feb 14;52:41-7. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/24184752 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM4L6EU DT8QKNP DN Trandolapril DT8QKNP MA Substrate DT8QKNP RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMANL0D DT8QKNP DN Moxalactam DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMJXDGC DT8QKNP DN Cefaclor DT8QKNP MA Substrate DT8QKNP RA Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16434549 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM8EU0Z DT8QKNP DN Dicloxacillin DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM8L9D4 DT8QKNP DN Bestatin DT8QKNP MA Substrate DT8QKNP RA Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1422-32. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18367661 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMH1M9B DT8QKNP DN Benazepril DT8QKNP MA Substrate DT8QKNP RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DM9NJ52 DT8QKNP DN Fosinopril DT8QKNP MA Substrate DT8QKNP RA Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos. 2001 Oct;29(10):1307-15. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/11560874 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMMC345 DT8QKNP DN Cefadroxil DT8QKNP MA Substrate DT8QKNP RA Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/27836942 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMS4BLQ DT8QKNP DN Aminolevulinic acid DT8QKNP MA Substrate DT8QKNP RA PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 2006 Nov 29;1122(1):18-23. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/17034769 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMHWE7P DT8QKNP DN Ampicillin DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMHWE7P DT8QKNP DN Cefamandole DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMD5JU8 DT8QKNP DN Cephalexin DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8QKNP TI DT8QKNP DT8QKNP TN Peptide transporter 2 DT8QKNP DI DMQW5MH DT8QKNP DN Metampicillin DT8QKNP MA Substrate DT8QKNP RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT8QKNP RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT8SQBG TI DT8SQBG DT8SQBG TN Glucose transporter type 7 DT8SQBG DI DM43AN2 DT8SQBG DN Fructose DT8SQBG MA Substrate DT8SQBG RA Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DT8SQBG RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DT8SQBG TI DT8SQBG DT8SQBG TN Glucose transporter type 7 DT8SQBG DI DMIAHVU DT8SQBG DN 2-Deoxyglucose DT8SQBG MA Substrate DT8SQBG RA Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DT8SQBG RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DT8Z563 TI DT8Z563 DT8Z563 TN Sodium- and chloride-dependent GABA transporter 1 DT8Z563 DI DMTW79H DT8Z563 DN Gamma-aminobutyric acid DT8Z563 MA Substrate DT8Z563 RA Mutations in the GABA Transporter SLC6A1 Cause Epilepsy with Myoclonic-Atonic Seizures. Am J Hum Genet. 2015 May 7;96(5):808-15. DT8Z563 RU http://www.ncbi.nlm.nih.gov/pubmed/25865495 DT8ZFIO TI DT8ZFIO DT8ZFIO TN Monocarboxylate transporter 7 DT8ZFIO DI DMNWCPB DT8ZFIO DN Monocarboxylic acids DT8ZFIO MA Substrate DT8ZFIO RA The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans. Front Physiol. 2019 Jan 14;9:1936. DT8ZFIO RU http://www.ncbi.nlm.nih.gov/pubmed/30692937 DT96BT4 TI DT96BT4 DT96BT4 TN Mitochondrial ornithine transporter 3 DT96BT4 DI DMOD5CK DT96BT4 DN Lysine DT96BT4 MA Substrate DT96BT4 RA The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. DT96BT4 RU http://www.ncbi.nlm.nih.gov/pubmed/24652292 DT96BT4 TI DT96BT4 DT96BT4 TN Mitochondrial ornithine transporter 3 DT96BT4 DI DMRE4FC DT96BT4 DN Arginine DT96BT4 MA Substrate DT96BT4 RA The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. DT96BT4 RU http://www.ncbi.nlm.nih.gov/pubmed/24652292 DT96BT4 TI DT96BT4 DT96BT4 TN Mitochondrial ornithine transporter 3 DT96BT4 DI DML83XP DT96BT4 DN L-homoarginine DT96BT4 MA Substrate DT96BT4 RA The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. DT96BT4 RU http://www.ncbi.nlm.nih.gov/pubmed/24652292 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM2NQUY DT9C1TS DN Indocyanine green DT9C1TS MA Substrate DT9C1TS RA Primovist, Eovist: what to expect? J Hepatol. 2012 Aug;57(2):421-9. DT9C1TS RU https://doi.org/10.1016/j.jhep.2012.01.031 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMS9503 DT9C1TS DN Benzylpenicillin DT9C1TS MA Substrate DT9C1TS RA Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci. 2006 May;91(1):140-9. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16495352 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMNFUZR DT9C1TS DN Enalapril DT9C1TS MA Substrate DT9C1TS RA Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther. 2006 Jul;318(1):395-402. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16627748 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM7HXWT DT9C1TS DN Nilotinib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM17ONX DT9C1TS DN Fexofenadine DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005 Oct;33(10):1477-81. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16014768 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM4VAOG DT9C1TS DN Gadobenate dimeglumine DT9C1TS MA Substrate DT9C1TS RA Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):657-667. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/27778300 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMF28YC DT9C1TS DN Atorvastatin DT9C1TS MA Substrate DT9C1TS RA FDA Drug Development and Drug Interactions DT9C1TS RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMAHMT9 DT9C1TS DN Glutathione DT9C1TS MA Substrate DT9C1TS RA Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMQCTIH DT9C1TS DN Digoxin DT9C1TS MA Substrate DT9C1TS RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM6A0X7 DT9C1TS DN Pravastatin DT9C1TS MA Substrate DT9C1TS RA Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/20100277 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM4K7GQ DT9C1TS DN Erythromycin DT9C1TS MA Substrate DT9C1TS RA Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/19785645 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM3GO0J DT9C1TS DN Sodium taurocholate DT9C1TS MA Substrate DT9C1TS RA LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMXCM7H DT9C1TS DN Cerivastatin DT9C1TS MA Substrate DT9C1TS RA FDA Drug Development and Drug Interactions DT9C1TS RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMZMSCT DT9C1TS DN Cilostazol DT9C1TS MA Substrate DT9C1TS RA Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans. J Pharm Sci. 2017 Sep;106(9):2515-2523. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/28535976 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM4F29C DT9C1TS DN Crizotinib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMPQAGE DT9C1TS DN Mycophenolate mofetil DT9C1TS MA Substrate DT9C1TS RA Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/17906856 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM42W1B DT9C1TS DN Cefmetazole DT9C1TS MA Substrate DT9C1TS RA Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34(3):389-95. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21372390 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMLK2QH DT9C1TS DN Nateglinide DT9C1TS MA Substrate DT9C1TS RA FDA Drug Development and Drug Interactions DT9C1TS RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMQTFAO DT9C1TS DN Fluorescein DT9C1TS MA Substrate DT9C1TS RA Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics. 2010 Mar 1;4:1-8. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/20448812 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMREUQ6 DT9C1TS DN Valsartan DT9C1TS MA Substrate DT9C1TS RA Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos. 2006 Jul;34(7):1247-54. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16624871 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM7HUNW DT9C1TS DN Testosterone DT9C1TS MA Substrate DT9C1TS RA Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin Cancer Res. 2008 Jun 1;14(11):3312-8. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18519758 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMCEW64 DT9C1TS DN Ceftriaxone DT9C1TS MA Substrate DT9C1TS RA Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34(3):389-95. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21372390 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMOQVU9 DT9C1TS DN Hydroxyurea DT9C1TS MA Substrate DT9C1TS RA Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMWBHRY DT9C1TS DN Olmesartan medoxomil DT9C1TS MA Substrate DT9C1TS RA Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM4MDJY DT9C1TS DN Fluvastatin DT9C1TS MA Substrate DT9C1TS RA Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos. 2007 Aug;35(8):1308-14. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/17470528 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM0SXNM DT9C1TS DN Glycocholic acid DT9C1TS MA Substrate DT9C1TS RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM0MO8I DT9C1TS DN BQ-123 DT9C1TS MA Substrate DT9C1TS RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM2LZ8F DT9C1TS DN Taurocholic acid DT9C1TS MA Substrate DT9C1TS RA Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM15F0X DT9C1TS DN Gefitinib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM7JT24 DT9C1TS DN Ouabain DT9C1TS MA Substrate DT9C1TS RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM7RJXL DT9C1TS DN Imatinib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMW50NF DT9C1TS DN SN-38 DT9C1TS MA Substrate DT9C1TS RA Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett. 2008 Feb 18;260(1-2):163-9. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18082941 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMNH3PG DT9C1TS DN Etoposide DT9C1TS MA Substrate DT9C1TS RA Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM53PV8 DT9C1TS DN Cefoperazone DT9C1TS MA Substrate DT9C1TS RA Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34(3):389-95. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21372390 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMOL5IU DT9C1TS DN Mesalazine DT9C1TS MA Substrate DT9C1TS RA Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. Drug Metab Dispos. 2011 Jun;39(6):1097-102. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21430235 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMJYCVW DT9C1TS DN Warfarin DT9C1TS MA Substrate DT9C1TS RA Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMJV2EK DT9C1TS DN Dasatinib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM1UJO0 DT9C1TS DN Pitavastatin calcium DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/15159445 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMA8J1G DT9C1TS DN Rifampicin DT9C1TS MA Substrate DT9C1TS RA Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/12085361 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMRICNP DT9C1TS DN Vandetanib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM3KJ45 DT9C1TS DN Estradiol-17beta-glucuronide DT9C1TS MA Substrate DT9C1TS RA Interactions of green tea catechins with organic anion-transporting polypeptides. Drug Metab Dispos. 2011 May;39(5):920-6. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21278283 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMN0J4W DT9C1TS DN Sincalide DT9C1TS MA Substrate DT9C1TS RA Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/22541068 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMMIQ7G DT9C1TS DN Rosuvastatin DT9C1TS MA Substrate DT9C1TS RA Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMT5GNL DT9C1TS DN Romidepsin DT9C1TS MA Substrate DT9C1TS RA Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/19228751 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM59IT4 DT9C1TS DN Amanitin DT9C1TS MA Substrate DT9C1TS RA Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci. 2006 May;91(1):140-9. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16495352 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMS3GX2 DT9C1TS DN Telmisartan DT9C1TS MA Substrate DT9C1TS RA Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos. 2006 Jul;34(7):1109-15. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16611857 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMDI269 DT9C1TS DN Docetaxel DT9C1TS MA Substrate DT9C1TS RA Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett. 2008 Feb 18;260(1-2):163-9. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18082941 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMI0V4O DT9C1TS DN Bilirubin DT9C1TS MA Substrate DT9C1TS RA Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin. Biochem J. 2003 May 1;371(Pt 3):897-905. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/12568656 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMCBJSR DT9C1TS DN Sunitinib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM20MDU DT9C1TS DN Danoprevir DT9C1TS MA Substrate DT9C1TS RA FDA Drug Development and Drug Interactions DT9C1TS RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM6IR3P DT9C1TS DN Liothyronine DT9C1TS MA Substrate DT9C1TS RA LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM2TEOL DT9C1TS DN Methotrexate DT9C1TS MA Substrate DT9C1TS RA LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMPIHLS DT9C1TS DN Diclofenac DT9C1TS MA Substrate DT9C1TS RA Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21389119 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMIOGBU DT9C1TS DN Bosentan DT9C1TS MA Substrate DT9C1TS RA Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMS8IFC DT9C1TS DN Sorafenib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM9W2ZV DT9C1TS DN Bromsulphthalein DT9C1TS MA Substrate DT9C1TS RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMM74PK DT9C1TS DN Atrasentan DT9C1TS MA Substrate DT9C1TS RA Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther. 2006 Mar;79(3):186-96. DT9C1TS RU https://doi.org/10.1016/j.clpt.2005.11.003 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM62UG5 DT9C1TS DN Vemurafenib DT9C1TS MA Substrate DT9C1TS RA Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMVBIZL DT9C1TS DN Estrone sulfate DT9C1TS MA Substrate DT9C1TS RA Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMLB81S DT9C1TS DN Paclitaxel DT9C1TS MA Substrate DT9C1TS RA Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther. 2005 Aug;4(8):815-8. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/16210916 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMLO9FU DT9C1TS DN Fluo-3 DT9C1TS MA Substrate DT9C1TS RA Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMUEWM3 DT9C1TS DN Technetium (99MTC) mebrofenin DT9C1TS MA Substrate DT9C1TS RA Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol. 2011 Apr;54(4):738-45. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/21163547 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM4Q80H DT9C1TS DN Dehydroepiandrosterone sulfate DT9C1TS MA Substrate DT9C1TS RA LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DMJH792 DT9C1TS DN Pitavastatin DT9C1TS MA Substrate DT9C1TS RA Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/19785645 DT9C1TS TI DT9C1TS DT9C1TS TN Organic anion transporting polypeptide 1B3 DT9C1TS DI DM37FKA DT9C1TS DN Primovist DT9C1TS MA Substrate DT9C1TS RA Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 2010 Jul;38(7):1024-8. DT9C1TS RU http://www.ncbi.nlm.nih.gov/pubmed/20406852 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM6W8V5 DT9G7XN DN Lisdexamfetamine DT9G7XN MA Substrate DT9G7XN RA Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr Dis Treat. 2010 Jun 24;6:317-27. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/20628632 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM26E4B DT9G7XN DN Moexipril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMHSJB4 DT9G7XN DN Cyclacillin DT9G7XN MA Substrate DT9G7XN RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMTP1DC DT9G7XN DN Irbesartan DT9G7XN MA Substrate DT9G7XN RA High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMS9503 DT9G7XN DN Benzylpenicillin DT9G7XN MA Substrate DT9G7XN RA Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics. Adv Drug Deliv Rev. 2006 Nov 15;58(11):1136-63. DT9G7XN RU https://doi.org/10.1016/j.addr.2006.07.024 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMNFUZR DT9G7XN DN Enalapril DT9G7XN MA Substrate DT9G7XN RA The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60. DT9G7XN RU https://doi.org/10.1016/S0928-0987(03)00142-8 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM2R68E DT9G7XN DN Ramipril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMFGOW0 DT9G7XN DN N-acetylaspartylglutamate DT9G7XN MA Substrate DT9G7XN RA Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. DT9G7XN RU https://doi.org/10.1113/jphysiol.2006.107904 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMYTXVR DT9G7XN DN Cefoxitin DT9G7XN MA Substrate DT9G7XN RA Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DME2PY5 DT9G7XN DN Midodrine DT9G7XN MA Substrate DT9G7XN RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMICA9H DT9G7XN DN Sulfasalazine DT9G7XN MA Substrate DT9G7XN RA Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DT9G7XN RU https://doi.org/10.1007/BF02980227 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMOPZDT DT9G7XN DN Perindopril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMF54ZG DT9G7XN DN Sulpiride DT9G7XN MA Substrate DT9G7XN RA Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2. Biol Pharm Bull. 2002 Oct;25(10):1345-50. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/12392092 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMHKS94 DT9G7XN DN Valacyclovir DT9G7XN MA Substrate DT9G7XN RA Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/9610386 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMTBKF3 DT9G7XN DN Piperacillin DT9G7XN MA Substrate DT9G7XN RA Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMWV2AG DT9G7XN DN Ceftibuten DT9G7XN MA Substrate DT9G7XN RA Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats. Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G664-70. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/15528259 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM5XLTY DT9G7XN DN Spirapril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMFBNI6 DT9G7XN DN Ceronapril DT9G7XN MA Substrate DT9G7XN RA Pharmaceutical and pharmacological importance of peptide transporters. J Pharm Pharmacol. 2008 May;60(5):543-85. DT9G7XN RU https://doi.org/10.1211/jpp.60.5.0002 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM42W1B DT9G7XN DN Cefmetazole DT9G7XN MA Substrate DT9G7XN RA Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DT9G7XN RU https://doi.org/10.1023/A:1018814627484 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMS2IUH DT9G7XN DN Valganciclovir DT9G7XN MA Substrate DT9G7XN RA Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/10824137 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMUNSWV DT9G7XN DN Cephradine DT9G7XN MA Substrate DT9G7XN RA Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/9374833 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMY60I8 DT9G7XN DN Cefixime DT9G7XN MA Substrate DT9G7XN RA Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells. J Pharmacol Exp Ther. 2001 Oct;299(1):351-7. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/11561098 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMREUQ6 DT9G7XN DN Valsartan DT9G7XN MA Substrate DT9G7XN RA High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMNEXZF DT9G7XN DN Cefamandole DT9G7XN MA Substrate DT9G7XN RA Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DT9G7XN RU https://doi.org/10.1023/A:1018814627484 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMCEW64 DT9G7XN DN Ceftriaxone DT9G7XN MA Substrate DT9G7XN RA Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DT9G7XN RU https://doi.org/10.1023/A:1018814627484 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMUOK4C DT9G7XN DN Lisinopril DT9G7XN MA Substrate DT9G7XN RA Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DT9G7XN RU https://doi.org/10.1007/BF02980227 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMYZITL DT9G7XN DN Cephaloglycin DT9G7XN MA Substrate DT9G7XN RA Pharmaceutical and pharmacological importance of peptide transporters. J Pharm Pharmacol. 2008 May;60(5):543-85. DT9G7XN RU https://doi.org/10.1211/jpp.60.5.0002 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMPDYFR DT9G7XN DN Cefazolin DT9G7XN MA Substrate DT9G7XN RA Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM72JXH DT9G7XN DN Losartan DT9G7XN MA Substrate DT9G7XN RA High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMUYNEI DT9G7XN DN Amoxicillin DT9G7XN MA Substrate DT9G7XN RA Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/16434549 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM4Y95F DT9G7XN DN Cephaloridine DT9G7XN MA Substrate DT9G7XN RA Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DT9G7XN RU https://doi.org/10.1023/A:1018814627484 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMEYLH9 DT9G7XN DN Ribavirin DT9G7XN MA Substrate DT9G7XN RA Transport of levovirin prodrugs in the human intestinal Caco-2 cell line. J Pharm Sci. 2006 Jun;95(6):1318-25. DT9G7XN RU https://doi.org/10.1002/jps.20434 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM458UM DT9G7XN DN Captopril DT9G7XN MA Substrate DT9G7XN RA Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar;9(3):215-36. DT9G7XN RU https://doi.org/10.1038/nrd3028 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMOJ0V6 DT9G7XN DN Metoprolol DT9G7XN MA Substrate DT9G7XN RA Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DT9G7XN RU https://doi.org/10.1007/BF02980227 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMMWZET DT9G7XN DN Dexamethasone DT9G7XN MA Substrate DT9G7XN RA Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DT9G7XN RU https://doi.org/10.1007/BF02980227 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM4L6EU DT9G7XN DN Trandolapril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMFYCB4 DT9G7XN DN Carnosine DT9G7XN MA Substrate DT9G7XN RA Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs. Amino Acids. 2012 Jul;43(1):111-26. DT9G7XN RU https://doi.org/10.1007/s00726-012-1224-z DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMPRBQV DT9G7XN DN Enalaprilat DT9G7XN MA Substrate DT9G7XN RA Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. DT9G7XN RU https://doi.org/10.2133/dmpk.17.253 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMGO72P DT9G7XN DN Oseltamivir DT9G7XN MA Substrate DT9G7XN RA Oseltamivir (tamiflu) is a substrate of peptide transporter 1. Drug Metab Dispos. 2009 Aug;37(8):1676-81. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/19439487 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMMQ8ZG DT9G7XN DN Furosemide DT9G7XN MA Substrate DT9G7XN RA Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DT9G7XN RU https://doi.org/10.1007/BF02980227 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMJXDGC DT9G7XN DN Cefaclor DT9G7XN MA Substrate DT9G7XN RA Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G895-902. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/21311026 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMNUWST DT9G7XN DN Flucloxacillin DT9G7XN MA Substrate DT9G7XN RA Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM8EU0Z DT9G7XN DN Dicloxacillin DT9G7XN MA Substrate DT9G7XN RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM8L9D4 DT9G7XN DN Bestatin DT9G7XN MA Substrate DT9G7XN RA Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol. 1993 Aug;265(2 Pt 1):G289-94. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/8396335 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM07K2I DT9G7XN DN Eprosartan DT9G7XN MA Substrate DT9G7XN RA High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMH1M9B DT9G7XN DN Benazepril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMJUNY5 DT9G7XN DN Cefpodoxime DT9G7XN MA Substrate DT9G7XN RA Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMJ7A0H DT9G7XN DN Cefdinir DT9G7XN MA Substrate DT9G7XN RA Transporter-mediated drug delivery: recent progress and experimental approaches. Drug Discov Today. 2004 Aug 15;9(16):712-20. DT9G7XN RU https://doi.org/10.1016/S1359-6446(04)03198-8 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM9NJ52 DT9G7XN DN Fosinopril DT9G7XN MA Substrate DT9G7XN RA Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMMC345 DT9G7XN DN Cefadroxil DT9G7XN MA Substrate DT9G7XN RA High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMQXLF3 DT9G7XN DN Cefsulodin DT9G7XN MA Substrate DT9G7XN RA Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DT9G7XN RU https://doi.org/10.1023/A:1018814627484 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMS4BLQ DT9G7XN DN Aminolevulinic acid DT9G7XN MA Substrate DT9G7XN RA Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine. J Pharmacol Exp Ther. 2010 Jan;332(1):220-8. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/19789362 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMHWE7P DT9G7XN DN Ampicillin DT9G7XN MA Substrate DT9G7XN RA Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/28214542 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMD5JU8 DT9G7XN DN Cephalexin DT9G7XN MA Substrate DT9G7XN RA Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction. Biol Pharm Bull. 2009 Aug;32(8):1459-61. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/19652390 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMNX2QI DT9G7XN DN Temocaprilate DT9G7XN MA Substrate DT9G7XN RA Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. DT9G7XN RU https://doi.org/10.2133/dmpk.17.253 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMQW5MH DT9G7XN DN Metampicillin DT9G7XN MA Substrate DT9G7XN RA Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM4CHN0 DT9G7XN DN Cefuroxime axetil DT9G7XN MA Substrate DT9G7XN RA Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DT9G7XN RU https://doi.org/10.1023/A:1018814627484 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DM1A79H DT9G7XN DN Temocapril DT9G7XN MA Substrate DT9G7XN RA The role of transporters in drug interactions. Eur J Pharm Sci. 2006 Apr;27(5):501-17. DT9G7XN RU https://doi.org/10.1016/j.ejps.2005.11.002 DT9G7XN TI DT9G7XN DT9G7XN TN Peptide transporter 1 DT9G7XN DI DMASVOD DT9G7XN DN QSP DT9G7XN MA Substrate DT9G7XN RA Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13. DT9G7XN RU http://www.ncbi.nlm.nih.gov/pubmed/17686765 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM4XAU7 DT9IDPW DN Prostaglandin f2Alpha DT9IDPW MA Substrate DT9IDPW RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMD9WSC DT9IDPW DN Memantine DT9IDPW MA Substrate DT9IDPW RA Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/9687576 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMH61ZB DT9IDPW DN Cimetidine DT9IDPW MA Substrate DT9IDPW RA Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Drug Metab Pharmacokinet. 2010;25(4):328-34. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/20814153 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMS3YE9 DT9IDPW DN Amantadine DT9IDPW MA Substrate DT9IDPW RA Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/9687576 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMSWYF5 DT9IDPW DN Quinine DT9IDPW MA Substrate DT9IDPW RA Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/9260930 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM6RZ9Q DT9IDPW DN Clonidine DT9IDPW MA Substrate DT9IDPW RA Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM79NTF DT9IDPW DN Propranolol DT9IDPW MA Substrate DT9IDPW RA Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM78IME DT9IDPW DN Ergotidine DT9IDPW MA Substrate DT9IDPW RA The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua. Mol Reprod Dev. 2007 Oct;74(10):1303-11. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/17393420 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM93VBZ DT9IDPW DN Abemaciclib DT9IDPW MA Substrate DT9IDPW RA Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/30449032 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMTYOPD DT9IDPW DN Dinoprostone DT9IDPW MA Substrate DT9IDPW RA Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16211406 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM6SFYH DT9IDPW DN Tetraethylammonium DT9IDPW MA Substrate DT9IDPW RA Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/10082798 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM5Q1W4 DT9IDPW DN YM155 DT9IDPW MA Substrate DT9IDPW RA Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant. Drug Metab Dispos. 2010 Jan;38(1):1-4. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/19833842 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMOUC09 DT9IDPW DN Norepinephrine DT9IDPW MA Substrate DT9IDPW RA Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMI347A DT9IDPW DN Lamivudine DT9IDPW MA Substrate DT9IDPW RA Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Biopharm Drug Dispos. 2012 Apr;33(3):170-8. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/22415520 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM5D9YK DT9IDPW DN Choline DT9IDPW MA Substrate DT9IDPW RA Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/11553644 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM0GUSX DT9IDPW DN Ranitidine DT9IDPW MA Substrate DT9IDPW RA A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM89QE1 DT9IDPW DN Metformin DT9IDPW MA Substrate DT9IDPW RA Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16272756 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMOFCRY DT9IDPW DN Serotonin DT9IDPW MA Substrate DT9IDPW RA Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMNMW9R DT9IDPW DN Pramipexole DT9IDPW MA Substrate DT9IDPW RA Uptake of pramipexole by human organic cation transporters. Mol Pharm. 2010 Aug 2;7(4):1342-7. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/20496886 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMRTSGP DT9IDPW DN Amiloride DT9IDPW MA Substrate DT9IDPW RA Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1521-31. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16394027 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DM6T924 DT9IDPW DN Gabapentin DT9IDPW MA Substrate DT9IDPW RA Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/20573085 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMRL3AB DT9IDPW DN Famotidine DT9IDPW MA Substrate DT9IDPW RA A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMMUOLJ DT9IDPW DN Varenicline DT9IDPW MA Substrate DT9IDPW RA Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro-in vivo study. Clin Pharmacol Ther. 2008 Apr;83(4):567-76. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/17971819 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMPN1TW DT9IDPW DN Dofetilide DT9IDPW MA Substrate DT9IDPW RA FDA Drug Development and Drug Interactions DT9IDPW RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMPGUCF DT9IDPW DN Dopamine DT9IDPW MA Substrate DT9IDPW RA Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMRHGI9 DT9IDPW DN Cisplatin DT9IDPW MA Substrate DT9IDPW RA Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol. 2005 Dec;167(6):1477-84. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/16314463 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMQNWRD DT9IDPW DN Oxaliplatin DT9IDPW MA Substrate DT9IDPW RA Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells. Metallomics. 2018 Mar 1;10(3):414-425. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/29417972 DT9IDPW TI DT9IDPW DT9IDPW TN Organic cation transporter 2 DT9IDPW DI DMVUKEW DT9IDPW DN N-methylpyridinium DT9IDPW MA Substrate DT9IDPW RA Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. Drug Metab Dispos. 2009 Jun;37(6):1312-8. DT9IDPW RU http://www.ncbi.nlm.nih.gov/pubmed/19251820 DT9JBVI TI DT9JBVI DT9JBVI TN Sodium-dependent noradrenaline transporter DT9JBVI DI DMSZQAK DT9JBVI DN Amphetamine DT9JBVI MA Substrate DT9JBVI RA Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50. DT9JBVI RU http://www.ncbi.nlm.nih.gov/pubmed/25542076 DT9JBVI TI DT9JBVI DT9JBVI TN Sodium-dependent noradrenaline transporter DT9JBVI DI DMOUC09 DT9JBVI DN Norepinephrine DT9JBVI MA Substrate DT9JBVI RA Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J Neurochem. 2006 May;97(4):1044-51. DT9JBVI RU http://www.ncbi.nlm.nih.gov/pubmed/16573647 DT9NXMV TI DT9NXMV DT9NXMV TN ATP-binding cassette sub-family A member 8 DT9NXMV DI DM3GO0J DT9NXMV DN Sodium taurocholate DT9NXMV MA Substrate DT9NXMV RA Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DT9NXMV RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DT9NXMV TI DT9NXMV DT9NXMV TN ATP-binding cassette sub-family A member 8 DT9NXMV DI DMUN54G DT9NXMV DN Aminohippuric acid DT9NXMV MA Substrate DT9NXMV RA Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DT9NXMV RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DT9NXMV TI DT9NXMV DT9NXMV TN ATP-binding cassette sub-family A member 8 DT9NXMV DI DM2KEW6 DT9NXMV DN Ochratoxin A DT9NXMV MA Substrate DT9NXMV RA Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DT9NXMV RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DT9NXMV TI DT9NXMV DT9NXMV TN ATP-binding cassette sub-family A member 8 DT9NXMV DI DMVBIZL DT9NXMV DN Estrone sulfate DT9NXMV MA Substrate DT9NXMV RA Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DT9NXMV RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DT9SQ3L TI DT9SQ3L DT9SQ3L TN Glucose transporter type 3 DT9SQ3L DI DMIAHVU DT9SQ3L DN 2-Deoxyglucose DT9SQ3L MA Substrate DT9SQ3L RA Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism. J Cell Physiol. 2011 Dec;226(12):3286-94. DT9SQ3L RU http://www.ncbi.nlm.nih.gov/pubmed/21321936 DT9U216 TI DT9U216 DT9U216 TN Excitatory amino acid transporter 1 DT9U216 DI DM4PUDW DT9U216 DN L-glutamic acid DT9U216 MA Substrate DT9U216 RA The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. DT9U216 RU http://www.ncbi.nlm.nih.gov/pubmed/23506861 DT9V8W1 TI DT9V8W1 DT9V8W1 TN Solute carrier family 35 member E4 DT9V8W1 DI DM5WYJ6 DT9V8W1 DN Thiamine pyrophosphate DT9V8W1 MA Substrate DT9V8W1 RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.7.9.11) DT9V8W1 RU http://www.tcdb.org/search/result.php?tc=2.A.7.9.11 DTA5QI0 TI DTA5QI0 DTA5QI0 TN Glucose transporter type 12 DTA5QI0 DI DMIAHVU DTA5QI0 DN 2-Deoxyglucose DTA5QI0 MA Substrate DTA5QI0 RA The human facilitative glucose transporter GLUT12: Expression and regulation in Caco-2 and 3T3-L1cells. DTA5QI0 RU https://2017.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170093096096098098424170 DTAGDH7 TI DTAGDH7 DTAGDH7 TN Vesicular glutamate transporter 3 DTAGDH7 DI DM4PUDW DTAGDH7 DN L-glutamic acid DTAGDH7 MA Substrate DTAGDH7 RA Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65. DTAGDH7 RU http://www.ncbi.nlm.nih.gov/pubmed/15210307 DTAKRNM TI DTAKRNM DTAKRNM TN Monocarboxylate transporter 4 DTAKRNM DI DM462BT DTAKRNM DN Milchsaure DTAKRNM MA Substrate DTAKRNM RA The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J. 2000 Aug 15;350 Pt 1:219-27. DTAKRNM RU http://www.ncbi.nlm.nih.gov/pubmed/10926847 DTAOPTV TI DTAOPTV DTAOPTV TN Proton-coupled amino acid transporter 2 DTAOPTV DI DMT1I52 DTAOPTV DN Cycloserine DTAOPTV MA Substrate DTAOPTV RA Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2). Br J Pharmacol. 2005 Jan;144(1):28-41. DTAOPTV RU http://www.ncbi.nlm.nih.gov/pubmed/15644866 DTAV4SY TI DTAV4SY DTAV4SY TN Sodium-dependent serotonin transporter DTAV4SY DI DMOFCRY DTAV4SY DN Serotonin DTAV4SY MA Substrate DTAV4SY RA Serotonin transporter gene, depressive symptoms, and interleukin-6. Circ Cardiovasc Genet. 2009 Dec;2(6):614-20. DTAV4SY RU http://www.ncbi.nlm.nih.gov/pubmed/20031642 DTAV4SY TI DTAV4SY DTAV4SY TN Sodium-dependent serotonin transporter DTAV4SY DI DMYKG8R DTAV4SY DN Oxypertine DTAV4SY MA Substrate DTAV4SY RA Serotonin transporter gene and treatment of alcoholism. DTAV4SY RU https://patents.google.com/patent/CA2760675A1 DTAVOS6 TI DTAVOS6 DTAVOS6 TN Riboflavin transporter 3 DTAVOS6 DI DM8YMWE DTAVOS6 DN Riboflavin DTAVOS6 MA Substrate DTAVOS6 RA An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188. DTAVOS6 RU http://www.ncbi.nlm.nih.gov/pubmed/29122468 DTBGZ8H TI DTBGZ8H DTBGZ8H TN Excitatory amino acid transporter 5 DTBGZ8H DI DM4PUDW DTBGZ8H DN L-glutamic acid DTBGZ8H MA Substrate DTBGZ8H RA The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. DTBGZ8H RU http://www.ncbi.nlm.nih.gov/pubmed/23506861 DTBMSWG TI DTBMSWG DTBMSWG TN L-type amino acid transporter 3 DTBMSWG DI DM4B6H3 DTBMSWG DN L-isoleucine DTBMSWG MA Substrate DTBMSWG RA Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DTBMSWG RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DTBMSWG TI DTBMSWG DTBMSWG TN L-type amino acid transporter 3 DTBMSWG DI DM68RPD DTBMSWG DN L-valine DTBMSWG MA Substrate DTBMSWG RA Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DTBMSWG RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DTBMSWG TI DTBMSWG DTBMSWG TN L-type amino acid transporter 3 DTBMSWG DI DMQXI9F DTBMSWG DN L-phenylalanine DTBMSWG MA Substrate DTBMSWG RA Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DTBMSWG RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DTBMSWG TI DTBMSWG DTBMSWG TN L-type amino acid transporter 3 DTBMSWG DI DMQHN7I DTBMSWG DN L-leucine DTBMSWG MA Substrate DTBMSWG RA Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DTBMSWG RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DTBPTJF TI DTBPTJF DTBPTJF TN Na(+)/Cl(-) betaine/GABA transporter DTBPTJF DI DMSWYF5 DTBPTJF DN Quinine DTBPTJF MA Substrate DTBPTJF RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.22.3.1) DTBPTJF RU http://www.tcdb.org/search/result.php?tc=2.A.22.3.1 DTBPTJF TI DTBPTJF DTBPTJF TN Na(+)/Cl(-) betaine/GABA transporter DTBPTJF DI DM5D9YK DTBPTJF DN Choline DTBPTJF MA Substrate DTBPTJF RA Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692. DTBPTJF RU http://www.ncbi.nlm.nih.gov/pubmed/20195502 DTBPTJF TI DTBPTJF DTBPTJF TN Na(+)/Cl(-) betaine/GABA transporter DTBPTJF DI DMKSTWR DTBPTJF DN L-proline DTBPTJF MA Substrate DTBPTJF RA Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692. DTBPTJF RU http://www.ncbi.nlm.nih.gov/pubmed/20195502 DTBPTJF TI DTBPTJF DTBPTJF TN Na(+)/Cl(-) betaine/GABA transporter DTBPTJF DI DMIOZ29 DTBPTJF DN Glycine DTBPTJF MA Substrate DTBPTJF RA Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692. DTBPTJF RU http://www.ncbi.nlm.nih.gov/pubmed/20195502 DTBPTJF TI DTBPTJF DTBPTJF TN Na(+)/Cl(-) betaine/GABA transporter DTBPTJF DI DMGRZW2 DTBPTJF DN Betaine DTBPTJF MA Substrate DTBPTJF RA Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res. 2011 Jun;95(1-2):70-81. DTBPTJF RU http://www.ncbi.nlm.nih.gov/pubmed/21459558 DTBS49U TI DTBS49U DTBS49U TN Proton-coupled amino acid transporter 4 DTBS49U DI DMIBH7M DTBS49U DN L-tryptophan DTBS49U MA Substrate DTBS49U RA SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. J Biol Chem. 2011 Jan 28;286(4):2455-60. DTBS49U RU http://www.ncbi.nlm.nih.gov/pubmed/21097500 DTBS49U TI DTBS49U DTBS49U TN Proton-coupled amino acid transporter 4 DTBS49U DI DMKSTWR DTBS49U DN L-proline DTBS49U MA Substrate DTBS49U RA SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. J Biol Chem. 2011 Jan 28;286(4):2455-60. DTBS49U RU http://www.ncbi.nlm.nih.gov/pubmed/21097500 DTBVQIO TI DTBVQIO DTBVQIO TN Riboflavin transporter 2 DTBVQIO DI DM8YMWE DTBVQIO DN Riboflavin DTBVQIO MA Substrate DTBVQIO RA An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188. DTBVQIO RU http://www.ncbi.nlm.nih.gov/pubmed/29122468 DTC54PX TI DTC54PX DTC54PX TN Alanine/serine/cysteine/threonine transporter 1 DTC54PX DI DM3YH4I DTC54PX DN D-serine DTC54PX MA Substrate DTC54PX RA D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DTC54PX RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DTC54PX TI DTC54PX DTC54PX TN Alanine/serine/cysteine/threonine transporter 1 DTC54PX DI DMZDN4W DTC54PX DN L-alanine DTC54PX MA Substrate DTC54PX RA D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DTC54PX RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DTCL4P8 TI DTCL4P8 DTCL4P8 TN Electrogenic sodium bicarbonate cotransporter 4 DTCL4P8 DI DMMU6BJ DTCL4P8 DN Sodium bicarbonate DTCL4P8 MA Substrate DTCL4P8 RA The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. DTCL4P8 RU http://www.ncbi.nlm.nih.gov/pubmed/17071329 DTCRIWV TI DTCRIWV DTCRIWV TN Phosphate carrier protein DTCRIWV DI DMUXQG7 DTCRIWV DN Phosphate DTCRIWV MA Substrate DTCRIWV RA The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 2018 Feb 9;293(6):1887-1896. DTCRIWV RU http://www.ncbi.nlm.nih.gov/pubmed/29237729 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM4XAU7 DTCSGPB DN Prostaglandin f2Alpha DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM1XEJV DTCSGPB DN Glycodeoxycholic acid DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM4KI7O DTCSGPB DN Zidovudine DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMAHMT9 DTCSGPB DN Glutathione DTCSGPB MA Substrate DTCSGPB RA Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503. DTCSGPB RU https://doi.org/10.1042/0264-6021:3610497 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMP6G8T DTCSGPB DN Topotecan DTCSGPB MA Substrate DTCSGPB RA Topotecan is a substrate for multidrug resistance associated protein 4. Curr Drug Metab. 2006 Jan;7(1):105-18. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/16454695 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM7NKEV DTCSGPB DN Thioguanine DTCSGPB MA Substrate DTCSGPB RA Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/14643890 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMUN54G DTCSGPB DN Aminohippuric acid DTCSGPB MA Substrate DTCSGPB RA Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol. 2004 Nov;15(11):2828-35. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/15504935 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM1MBYQ DTCSGPB DN Ganciclovir DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM3JDRP DTCSGPB DN Cladribine DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMUM7HZ DTCSGPB DN Fluorouracil DTCSGPB MA Substrate DTCSGPB RA ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/19077464 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMTYOPD DTCSGPB DN Dinoprostone DTCSGPB MA Substrate DTCSGPB RA The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/12835412 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMP6SC2 DTCSGPB DN Irinotecan DTCSGPB MA Substrate DTCSGPB RA P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/20583968 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM9WLN4 DTCSGPB DN Hydroxycamptothecin DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMWBHRY DTCSGPB DN Olmesartan medoxomil DTCSGPB MA Substrate DTCSGPB RA Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM0SXNM DTCSGPB DN Glycocholic acid DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMPDYFR DTCSGPB DN Cefazolin DTCSGPB MA Substrate DTCSGPB RA Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM2LZ8F DTCSGPB DN Taurocholic acid DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMTM2IK DTCSGPB DN Mercaptopurine DTCSGPB MA Substrate DTCSGPB RA Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/19515727 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM6CHNJ DTCSGPB DN Camptothecin DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMMN36E DTCSGPB DN Abacavir DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMW50NF DTCSGPB DN SN-38 DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM4O2Z7 DTCSGPB DN Cyclophosphamide DTCSGPB MA Substrate DTCSGPB RA Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4). AAPS J. 2010 Sep;12(3):300-8. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/20405259 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM1IS6U DTCSGPB DN Tenofovir DTCSGPB MA Substrate DTCSGPB RA Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007 Feb;71(2):619-27. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/17110501 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM3KJ45 DTCSGPB DN Estradiol-17beta-glucuronide DTCSGPB MA Substrate DTCSGPB RA Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/16586096 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMWH7NQ DTCSGPB DN Alprostadil DTCSGPB MA Substrate DTCSGPB RA The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/12835412 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM67VKL DTCSGPB DN Prasterone DTCSGPB MA Substrate DTCSGPB RA Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/12523936 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM3NC4M DTCSGPB DN Quercetin DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM2NLS9 DTCSGPB DN Ciprofloxacin DTCSGPB MA Substrate DTCSGPB RA Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells. Antimicrob Agents Chemother. 2009 Jun;53(6):2410-6. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/19307362 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMGO72P DTCSGPB DN Oseltamivir DTCSGPB MA Substrate DTCSGPB RA Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug Metab Dispos. 2009 Feb;37(2):315-21. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/19029202 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM7OKQV DTCSGPB DN Cholic acid DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM2TEOL DTCSGPB DN Methotrexate DTCSGPB MA Substrate DTCSGPB RA Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/17005917 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM3RWXL DTCSGPB DN Resveratrol DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMZRQU7 DTCSGPB DN Cyclic adenosine monophosphate DTCSGPB MA Substrate DTCSGPB RA cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway. Pharmacogenet Genomics. 2014 Oct;24(10):522-6. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/25121519 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMMC345 DTCSGPB DN Cefadroxil DTCSGPB MA Substrate DTCSGPB RA Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMDWU1S DTCSGPB DN Rubitecan DTCSGPB MA Substrate DTCSGPB RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTCSGPB RU https://doi.org/10.1007/s11095-012-0935-x DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM3VOGS DTCSGPB DN Ceftizoxime DTCSGPB MA Substrate DTCSGPB RA Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMEMBJC DTCSGPB DN Folic acid DTCSGPB MA Substrate DTCSGPB RA Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/12036927 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM2QHZU DTCSGPB DN Sulindac DTCSGPB MA Substrate DTCSGPB RA Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/20649844 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMM278X DTCSGPB DN Adefovir DTCSGPB MA Substrate DTCSGPB RA Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007 Feb;71(2):619-27. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/17110501 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMUAZWG DTCSGPB DN Leucovorin DTCSGPB MA Substrate DTCSGPB RA Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/12036927 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DMWHDRI DTCSGPB DN 4-(2-Aminoethyl) benzenesulfonyl fluoride DTCSGPB MA Substrate DTCSGPB RA Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/20649844 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM4Q80H DTCSGPB DN Dehydroepiandrosterone sulfate DTCSGPB MA Substrate DTCSGPB RA Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. DTCSGPB RU http://www.ncbi.nlm.nih.gov/pubmed/12523936 DTCSGPB TI DTCSGPB DTCSGPB TN Multidrug resistance-associated protein 4 DTCSGPB DI DM3FLMR DTCSGPB DN Azidothymidine monophosphate DTCSGPB MA Substrate DTCSGPB RA MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med. 1999 Sep;5(9):1048-51. DTCSGPB RU https://doi.org/10.1038/12487 DTD3FHQ TI DTD3FHQ DTD3FHQ TN Iron-regulated transporter 1 DTD3FHQ DI DMZ4R3Q DTD3FHQ DN Zinc salts DTD3FHQ MA Substrate DTD3FHQ RA Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012 Sep;1823(9):1426-33. DTD3FHQ RU http://www.ncbi.nlm.nih.gov/pubmed/22440327 DTD5Y4G TI DTD5Y4G DTD5Y4G TN Sodium-dependent multivitamin transporter DTD5Y4G DI DMJY2TM DTD5Y4G DN Gabapentin enacarbil DTD5Y4G MA Substrate DTD5Y4G RA Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507. DTD5Y4G RU http://www.ncbi.nlm.nih.gov/pubmed/20573085 DTD62VB TI DTD62VB DTD62VB TN Electroneutral potassium-chloride cotransporter 2 DTD62VB DI DMMTAJC DTD62VB DN Potassium chloride DTD62VB MA Substrate DTD62VB RA Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci. 2010 Oct;45(2):173-9. DTD62VB RU http://www.ncbi.nlm.nih.gov/pubmed/20600929 DTD815L TI DTD815L DTD815L TN Sodium-coupled neutral amino acid transporter 1 DTD815L DI DM69G8X DTD815L DN L-glutamine DTD815L MA Substrate DTD815L RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTD815L RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTD815L TI DTD815L DTD815L TN Sodium-coupled neutral amino acid transporter 1 DTD815L DI DMZDN4W DTD815L DN L-alanine DTD815L MA Substrate DTD815L RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTD815L RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTDI5S3 TI DTDI5S3 DTDI5S3 TN Organic anion transporter 7 DTDI5S3 DI DM6A0X7 DTDI5S3 DN Pravastatin DTDI5S3 MA Substrate DTDI5S3 RA Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors. Pharmacogenomics J. 2016 Aug;16(4):341-51. DTDI5S3 RU http://www.ncbi.nlm.nih.gov/pubmed/26239079 DTDJEMI TI DTDJEMI DTDJEMI TN Proton-coupled folate transporter DTDJEMI DI DMAO80I DTDJEMI DN Pralatrexate DTDJEMI MA Substrate DTDJEMI RA Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210. DTDJEMI RU http://www.ncbi.nlm.nih.gov/pubmed/22921318 DTDJEMI TI DTDJEMI DTDJEMI TN Proton-coupled folate transporter DTDJEMI DI DM2TEOL DTDJEMI DN Methotrexate DTDJEMI MA Substrate DTDJEMI RA Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats. J Pharm Pharmacol. 2009 Jul;61(7):911-8. DTDJEMI RU http://www.ncbi.nlm.nih.gov/pubmed/19589233 DTDJEMI TI DTDJEMI DTDJEMI TN Proton-coupled folate transporter DTDJEMI DI DMMX2E6 DTDJEMI DN Pemetrexed DTDJEMI MA Substrate DTDJEMI RA The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62. DTDJEMI RU http://www.ncbi.nlm.nih.gov/pubmed/18524888 DTDJEMI TI DTDJEMI DTDJEMI TN Proton-coupled folate transporter DTDJEMI DI DMEMBJC DTDJEMI DN Folic acid DTDJEMI MA Substrate DTDJEMI RA Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells. Biofactors. 2010 May-Jun;36(3):201-9. DTDJEMI RU http://www.ncbi.nlm.nih.gov/pubmed/20232349 DTDPJ3F TI DTDPJ3F DTDPJ3F TN Mitochondrial ornithine transporter 2 DTDPJ3F DI DMRE4FC DTDPJ3F DN Arginine DTDPJ3F MA Substrate DTDPJ3F RA Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2. Amino Acids. 2016 Feb;48(2):427-36. DTDPJ3F RU http://www.ncbi.nlm.nih.gov/pubmed/26403849 DTDQSAM TI DTDQSAM DTDQSAM TN Zrt- Irt-like protein 7 DTDQSAM DI DMZ4R3Q DTDQSAM DN Zinc salts DTDQSAM MA Substrate DTDQSAM RA A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313. DTDQSAM RU http://www.ncbi.nlm.nih.gov/pubmed/28098160 DTDSYAQ TI DTDSYAQ DTDSYAQ TN Calcium-binding mitochondrial carrier protein Aralar2 DTDSYAQ DI DM4PUDW DTDSYAQ DN L-glutamic acid DTDSYAQ MA Substrate DTDSYAQ RA Epigenetic upregulation and functional role of the mitochondrial aspartate/glutamate carrier isoform 1 in hepatocellular carcinoma. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):38-47. DTDSYAQ RU http://www.ncbi.nlm.nih.gov/pubmed/30321589 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMD157S DTE2B1D DN Montelukast DTE2B1D MA Substrate DTE2B1D RA Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. J Clin Pharmacol. 2011 May;51(5):751-60. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/20974993 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMNFUZR DTE2B1D DN Enalapril DTE2B1D MA Substrate DTE2B1D RA Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/10859154 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM17ONX DTE2B1D DN Fexofenadine DTE2B1D MA Substrate DTE2B1D RA Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/20797388 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMF28YC DTE2B1D DN Atorvastatin DTE2B1D MA Substrate DTE2B1D RA Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/20797388 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMNKG1Z DTE2B1D DN Atenolol DTE2B1D MA Substrate DTE2B1D RA Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21039758 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMVRH9C DTE2B1D DN Lomefloxacin DTE2B1D MA Substrate DTE2B1D RA Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMS60RB DTE2B1D DN Levofloxacin DTE2B1D MA Substrate DTE2B1D RA Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMWD39E DTE2B1D DN TR-14035 DTE2B1D MA Substrate DTE2B1D RA Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Pharm Res. 2006 Nov;23(11):2646-56. DTE2B1D RU https://doi.org/10.1007/s11095-006-9102-6 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMUK75B DTE2B1D DN Urea DTE2B1D MA Substrate DTE2B1D RA Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM3GO0J DTE2B1D DN Sodium taurocholate DTE2B1D MA Substrate DTE2B1D RA Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/7557095 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMSL679 DTE2B1D DN Gatifloxacin DTE2B1D MA Substrate DTE2B1D RA Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMN3GCH DTE2B1D DN Darunavir DTE2B1D MA Substrate DTE2B1D RA P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines. Biol Pharm Bull. 2009 Sep;32(9):1588-93. DTE2B1D RU https://doi.org/10.1248/bpb.32.1588 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMFKRQE DTE2B1D DN Tauroursodeoxycholate DTE2B1D MA Substrate DTE2B1D RA Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/7557095 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMUN54G DTE2B1D DN Aminohippuric acid DTE2B1D MA Substrate DTE2B1D RA Characterization and identification of steroid sulfate transporters of human placenta. Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E390-8. DTE2B1D RU http://ajpendo.physiology.org/content/284/2/E390.full DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DML60TN DTE2B1D DN Sotalol DTE2B1D MA Substrate DTE2B1D RA Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMRTD16 DTE2B1D DN Talinolol DTE2B1D MA Substrate DTE2B1D RA Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). Pharm Res. 2009 Mar;26(3):560-7. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/19002566 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMW6GVL DTE2B1D DN Nadolol DTE2B1D MA Substrate DTE2B1D RA Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMTYOPD DTE2B1D DN Dinoprostone DTE2B1D MA Substrate DTE2B1D RA Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11713643 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMHN027 DTE2B1D DN Levothyroxine DTE2B1D MA Substrate DTE2B1D RA Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11316767 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMOQVU9 DTE2B1D DN Hydroxyurea DTE2B1D MA Substrate DTE2B1D RA Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM0SXNM DTE2B1D DN Glycocholic acid DTE2B1D MA Substrate DTE2B1D RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM0MO8I DTE2B1D DN BQ-123 DTE2B1D MA Substrate DTE2B1D RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM2LZ8F DTE2B1D DN Taurocholic acid DTE2B1D MA Substrate DTE2B1D RA Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2. Drug Metab Dispos. 2013 Mar;41(3):602-7. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/23255551 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMK8U72 DTE2B1D DN Labetalol DTE2B1D MA Substrate DTE2B1D RA Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM7JT24 DTE2B1D DN Ouabain DTE2B1D MA Substrate DTE2B1D RA Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/10600646 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMD5LBX DTE2B1D DN Celiprolol DTE2B1D MA Substrate DTE2B1D RA Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM7RJXL DTE2B1D DN Imatinib DTE2B1D MA Substrate DTE2B1D RA Environmental and genetic factors affecting transport of imatinib by OATP1A2. Clin Pharmacol Ther. 2011 Jun;89(6):816-20. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21508937 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMQAK6T DTE2B1D DN Rhodamine 123 DTE2B1D MA Substrate DTE2B1D RA Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays. PLoS One. 2012;7(3):e33253. DTE2B1D RU https://doi.org/10.1371/journal.pone.0033253 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM1UJO0 DTE2B1D DN Pitavastatin calcium DTE2B1D MA Substrate DTE2B1D RA Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/16259759 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM0TI4U DTE2B1D DN Acebutolol DTE2B1D MA Substrate DTE2B1D RA Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21039758 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM3KJ45 DTE2B1D DN Estradiol-17beta-glucuronide DTE2B1D MA Substrate DTE2B1D RA Regulation of renal oatp mRNA expression by testosterone. Am J Physiol. 1996 Feb;270(2 Pt 2):F332-7. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/8779895 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMMIQ7G DTE2B1D DN Rosuvastatin DTE2B1D MA Substrate DTE2B1D RA Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/16697742 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMGLX0T DTE2B1D DN Grepafloxacin DTE2B1D MA Substrate DTE2B1D RA Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMY9BMK DTE2B1D DN Rocuronium DTE2B1D MA Substrate DTE2B1D RA Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. DTE2B1D RU http://jpet.aspetjournals.org/content/291/1/147.long DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMMFWOJ DTE2B1D DN Probenecid DTE2B1D MA Substrate DTE2B1D RA Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11408557 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMS3GX2 DTE2B1D DN Telmisartan DTE2B1D MA Substrate DTE2B1D RA Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos. 2006 Jul;34(7):1109-15. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/16611857 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM2NLS9 DTE2B1D DN Ciprofloxacin DTE2B1D MA Substrate DTE2B1D RA Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21039758 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM7OKQV DTE2B1D DN Cholic acid DTE2B1D MA Substrate DTE2B1D RA Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/7557095 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMIZ6W2 DTE2B1D DN Norfloxacin DTE2B1D MA Substrate DTE2B1D RA Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM4WVC5 DTE2B1D DN Lifitegrast DTE2B1D MA Substrate DTE2B1D RA Clinical Pharmacology and Biopharmaceutics review(s) DTE2B1D RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208073Orig1s000ClinPharmR.pdf DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMYTE6L DTE2B1D DN Enoxacin DTE2B1D MA Substrate DTE2B1D RA Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM6IR3P DTE2B1D DN Liothyronine DTE2B1D MA Substrate DTE2B1D RA Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11316767 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM2TEOL DTE2B1D DN Methotrexate DTE2B1D MA Substrate DTE2B1D RA Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/16702441 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM32XZT DTE2B1D DN Trospium chloride DTE2B1D MA Substrate DTE2B1D RA Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/25466967 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMRKE63 DTE2B1D DN Chlorambucil DTE2B1D MA Substrate DTE2B1D RA Transporters and renal drug elimination. Annu Rev Pharmacol Toxicol. 2004;44:137-66. DTE2B1D RU https://doi.org/10.1146/annurev.pharmtox.44.101802.121856 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM9W2ZV DTE2B1D DN Bromsulphthalein DTE2B1D MA Substrate DTE2B1D RA Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMG814N DTE2B1D DN Saquinavir DTE2B1D MA Substrate DTE2B1D RA Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/15832500 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMM74PK DTE2B1D DN Atrasentan DTE2B1D MA Substrate DTE2B1D RA Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther. 2006 Mar;79(3):186-96. DTE2B1D RU https://doi.org/10.1016/j.clpt.2005.11.003 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM5GVHU DTE2B1D DN Quinolones DTE2B1D MA Substrate DTE2B1D RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.14) DTE2B1D RU http://www.tcdb.org/search/result.php?tc=2.A.60.1.14 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMVBIZL DTE2B1D DN Estrone sulfate DTE2B1D MA Substrate DTE2B1D RA Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes. Eur J Pharm Sci. 2011 Jul 17;43(4):297-307. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/21605667 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DM4Q80H DTE2B1D DN Dehydroepiandrosterone sulfate DTE2B1D MA Substrate DTE2B1D RA Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar;9(3):215-36. DTE2B1D RU https://doi.org/10.1038/nrd3028 DTE2B1D TI DTE2B1D DTE2B1D TN Organic anion transporting polypeptide 1A2 DTE2B1D DI DMJH792 DTE2B1D DN Pitavastatin DTE2B1D MA Substrate DTE2B1D RA Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. DTE2B1D RU http://www.ncbi.nlm.nih.gov/pubmed/16259759 DTE3TAW TI DTE3TAW DTE3TAW TN Sodium-coupled monocarboxylate transporter 1 DTE3TAW DI DMJY2TM DTE3TAW DN Gabapentin enacarbil DTE3TAW MA Substrate DTE3TAW RA Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507. DTE3TAW RU http://www.ncbi.nlm.nih.gov/pubmed/20573085 DTE3TAW TI DTE3TAW DTE3TAW TN Sodium-coupled monocarboxylate transporter 1 DTE3TAW DI DM0O8N6 DTE3TAW DN Propionate DTE3TAW MA Substrate DTE3TAW RA SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24. DTE3TAW RU http://www.ncbi.nlm.nih.gov/pubmed/27118869 DTE8R17 TI DTE8R17 DTE8R17 TN Sodium- and chloride-dependent glycine transporter 2 DTE8R17 DI DM7SJD6 DTE8R17 DN Methylphenidate DTE8R17 MA Substrate DTE8R17 RA SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr-Jun;34(2-3):197-219. DTE8R17 RU http://www.ncbi.nlm.nih.gov/pubmed/23506866 DTE8R17 TI DTE8R17 DTE8R17 TN Sodium- and chloride-dependent glycine transporter 2 DTE8R17 DI DMOUC09 DTE8R17 DN Norepinephrine DTE8R17 MA Substrate DTE8R17 RA SLC6A2 Gene (Protein Coding). DTE8R17 RU https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A2 DTE8R17 TI DTE8R17 DTE8R17 TN Sodium- and chloride-dependent glycine transporter 2 DTE8R17 DI DMIOZ29 DTE8R17 DN Glycine DTE8R17 MA Substrate DTE8R17 RA Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. J Biol Chem. 2012 Aug 17;287(34):28975-85. DTE8R17 RU http://www.ncbi.nlm.nih.gov/pubmed/22700964 DTEHSG0 TI DTEHSG0 DTEHSG0 TN Putative thiamine transporter SLC35F3 DTEHSG0 DI DMZ1WXJ DTEHSG0 DN Vitamin B1 DTEHSG0 MA Substrate DTEHSG0 RA Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22;63(15):1542-55. DTEHSG0 RU http://www.ncbi.nlm.nih.gov/pubmed/24509276 DTEOAND TI DTEOAND DTEOAND TN Zrt- and Irt-like protein 11 DTEOAND DI DMZ4R3Q DTEOAND DN Zinc salts DTEOAND MA Substrate DTEOAND RA Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8. DTEOAND RU http://www.ncbi.nlm.nih.gov/pubmed/24089422 DTEZCUM TI DTEZCUM DTEZCUM TN Zrt- and Irt-like protein 4 DTEZCUM DI DMZ4R3Q DTEZCUM DN Zinc salts DTEZCUM MA Substrate DTEZCUM RA Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 2014 Feb 20;10(2):e1004128. DTEZCUM RU http://www.ncbi.nlm.nih.gov/pubmed/24586184 DTF3LTV TI DTF3LTV DTF3LTV TN Ammonium transporter Rh type C DTF3LTV DI DMOEVK6 DTF3LTV DN Ammonia DTF3LTV MA Substrate DTF3LTV RA Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47. DTF3LTV RU http://www.ncbi.nlm.nih.gov/pubmed/19553567 DTF7GAL TI DTF7GAL DTF7GAL TN Anion exchange protein 2 DTF7GAL DI DMT5E36 DTF7GAL DN Bicarbonate DTF7GAL MA Substrate DTF7GAL RA HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9. DTF7GAL RU http://www.ncbi.nlm.nih.gov/pubmed/18971331 DTF7MYK TI DTF7MYK DTF7MYK TN Sodium-coupled neutral amino acid transporter 9 DTF7MYK DI DMRE4FC DTF7MYK DN Arginine DTF7MYK MA Substrate DTF7MYK RA Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. DTF7MYK RU http://www.ncbi.nlm.nih.gov/pubmed/25567906 DTF9Y2V TI DTF9Y2V DTF9Y2V TN ATP-binding cassette sub-family B member 6 DTF9Y2V DI DMIY6DB DTF9Y2V DN Verteporfin DTF9Y2V MA Substrate DTF9Y2V RA Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. J Biol Chem. 2013 Aug 2;288(31):22658-69. DTF9Y2V RU http://www.ncbi.nlm.nih.gov/pubmed/23792964 DTF9Y2V TI DTF9Y2V DTF9Y2V TN ATP-binding cassette sub-family B member 6 DTF9Y2V DI DMA3U15 DTF9Y2V DN Tomatine DTF9Y2V MA Substrate DTF9Y2V RA Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. J Biol Chem. 2013 Aug 2;288(31):22658-69. DTF9Y2V RU http://www.ncbi.nlm.nih.gov/pubmed/23792964 DTFD4VB TI DTFD4VB DTFD4VB TN Sodium-dependent phosphate transporter 2 DTFD4VB DI DMUXQG7 DTFD4VB DN Phosphate DTFD4VB MA Substrate DTFD4VB RA Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DTFD4VB RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMNFUZR DTFI42L DN Enalapril DTFI42L MA Substrate DTFI42L RA Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther. 2006 Jul;318(1):395-402. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16627748 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM7HXWT DTFI42L DN Nilotinib DTFI42L MA Substrate DTFI42L RA Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/19785662 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DME81IY DTFI42L DN Succimer DTFI42L MA Substrate DTFI42L RA MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):10-7. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/19063911 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMT9K8G DTFI42L DN Raltitrexed DTFI42L MA Substrate DTFI42L RA Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 1999 Jun 1;59(11):2532-5. DTFI42L RU http://cancerres.aacrjournals.org/content/59/11/2532 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM4VAOG DTFI42L DN Gadobenate dimeglumine DTFI42L MA Substrate DTFI42L RA Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):657-667. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/27778300 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMAHMT9 DTFI42L DN Glutathione DTFI42L MA Substrate DTFI42L RA Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology. 2007 Nov;46(5):1597-610. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17668877 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM6A0X7 DTFI42L DN Pravastatin DTFI42L MA Substrate DTFI42L RA Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release. 2002 Jan 17;78(1-3):43-54. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/11772448 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMHIDCJ DTFI42L DN Octreotide DTFI42L MA Substrate DTFI42L RA P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. Br J Pharmacol. 2000 Jan;129(2):251-6. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/10694230 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM4K7GQ DTFI42L DN Erythromycin DTFI42L MA Substrate DTFI42L RA Effect of ABCC2 (MRP2) transport function on erythromycin metabolism. Clin Pharmacol Ther. 2011 May;89(5):693-701. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/21451505 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMICA9H DTFI42L DN Sulfasalazine DTFI42L MA Substrate DTFI42L RA Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/19541926 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM3GO0J DTFI42L DN Sodium taurocholate DTFI42L MA Substrate DTFI42L RA Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMSL679 DTFI42L DN Gatifloxacin DTFI42L MA Substrate DTFI42L RA Uptake and intracellular release kinetics of liposome formulations in glioma cells. Int J Pharm. 2010 Aug 16;395(1-2):251-9. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/20573571 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMEV954 DTFI42L DN Sulfinpyrazone DTFI42L MA Substrate DTFI42L RA Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/10917554 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM5SICT DTFI42L DN Phenolphthalein DTFI42L MA Substrate DTFI42L RA Biliary excretion of phenolphthalein sulfate in rats. Pharmacology. 2003 Aug;68(4):177-82. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/12837971 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMXCM7H DTFI42L DN Cerivastatin DTFI42L MA Substrate DTFI42L RA Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. DTFI42L RU https://doi.org/10.1124/jpet.105.085589 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMFKRQE DTFI42L DN Tauroursodeoxycholate DTFI42L MA Substrate DTFI42L RA Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. J Pharmacol Exp Ther. 2007 Feb;320(2):893-9. DTFI42L RU https://doi.org/10.1124/jpet.106.106922 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMA13GD DTFI42L DN Cidofovir DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMUN54G DTFI42L DN Aminohippuric acid DTFI42L MA Substrate DTFI42L RA ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000 Apr;57(4):1636-42. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/10760098 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMPQAGE DTFI42L DN Mycophenolate mofetil DTFI42L MA Substrate DTFI42L RA Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17906856 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMZOLBI DTFI42L DN Carbamazepine DTFI42L MA Substrate DTFI42L RA A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. Pharmacogenet Genomics. 2010 Apr;20(4):249-56. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/20216337 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMRTD16 DTFI42L DN Talinolol DTFI42L MA Substrate DTFI42L RA FDA Drug Development and Drug Interactions DTFI42L RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMUM7HZ DTFI42L DN Fluorouracil DTFI42L MA Substrate DTFI42L RA Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/27602148 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMN0EMP DTFI42L DN (-)-epicatechin DTFI42L MA Substrate DTFI42L RA Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2. Pharm Res. 2001 Oct;18(10):1420-5. DTFI42L RU https://doi.org/10.1023/A:1012200805593 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM7G8T0 DTFI42L DN Azithromycin DTFI42L MA Substrate DTFI42L RA Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin. Antimicrob Agents Chemother. 2004 Mar;48(3):809-14. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/14982769 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMTYOPD DTFI42L DN Dinoprostone DTFI42L MA Substrate DTFI42L RA Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8. DTFI42L RU https://doi.org/10.1111/j.1478-3231.2005.01234.x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQTFAO DTFI42L DN Fluorescein DTFI42L MA Substrate DTFI42L RA Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C. Hepatology. 2010 Oct;52(4):1465-76. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/20815017 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMREUQ6 DTFI42L DN Valsartan DTFI42L MA Substrate DTFI42L RA Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos. 2006 Jul;34(7):1247-54. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16624871 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMNARGO DTFI42L DN Phlorizin DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMCEW64 DTFI42L DN Ceftriaxone DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMOMN31 DTFI42L DN Phenethyl isothiocyanate DTFI42L MA Substrate DTFI42L RA Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein. Biochem Pharmacol. 2005 Aug 15;70(4):640-7. DTFI42L RU https://doi.org/10.1016/j.bcp.2005.05.025 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMP6SC2 DTFI42L DN Irinotecan DTFI42L MA Substrate DTFI42L RA Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/12065434 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMWBHRY DTFI42L DN Olmesartan medoxomil DTFI42L MA Substrate DTFI42L RA Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM61TA4 DTFI42L DN Arsenic trioxide DTFI42L MA Substrate DTFI42L RA MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci. 2007 May;97(1):103-10. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17324950 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMVP5YE DTFI42L DN Doxorubicin DTFI42L MA Substrate DTFI42L RA Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16377671 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM0SXNM DTFI42L DN Glycocholic acid DTFI42L MA Substrate DTFI42L RA Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J Biol Chem. 2003 Jun 27;278(26):23529-37. DTFI42L RU https://doi.org/10.1074/jbc.M303515200 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMHSY1I DTFI42L DN Regorafenib DTFI42L MA Substrate DTFI42L RA Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2. Biol Pharm Bull. 2015;38(4):582-6. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/25739790 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMZ4P3A DTFI42L DN Telithromycin DTFI42L MA Substrate DTFI42L RA Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16377671 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM0MO8I DTFI42L DN BQ-123 DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM7A8TW DTFI42L DN Ezetimibe DTFI42L MA Substrate DTFI42L RA Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. Clin Pharmacol Ther. 2006 Mar;79(3):206-17. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16513445 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMINOX3 DTFI42L DN Vincristine DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM6CHNJ DTFI42L DN Camptothecin DTFI42L MA Substrate DTFI42L RA Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DTFI42L RU https://doi.org/10.1007/s12033-009-9220-6 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMYLOVR DTFI42L DN Acyclovir DTFI42L MA Substrate DTFI42L RA Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. J Pharmacol Exp Ther. 2003 Aug;306(2):778-86. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/12750437 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMW50NF DTFI42L DN SN-38 DTFI42L MA Substrate DTFI42L RA Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. Cancer Res. 1998 Nov 15;58(22):5137-43. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/9823324 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMNH3PG DTFI42L DN Etoposide DTFI42L MA Substrate DTFI42L RA Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/11901101 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMOL5IU DTFI42L DN Mesalazine DTFI42L MA Substrate DTFI42L RA Transport studies with 5-aminosalicylate. Eur J Clin Pharmacol. 2006 Oct;62(10):871-5. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16944117 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMPDW6T DTFI42L DN Epirubicin DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMNOKBV DTFI42L DN Phenytoin DTFI42L MA Substrate DTFI42L RA Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. Epilepsia. 2007 Apr;48(4):631-45. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17437408 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQAK6T DTFI42L DN Rhodamine 123 DTFI42L MA Substrate DTFI42L RA Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells. Eur J Pharm Sci. 2011 Aug 17;43(5):359-69. DTFI42L RU https://doi.org/10.1016/j.ejps.2011.05.003 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM1UJO0 DTFI42L DN Pitavastatin calcium DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMA8J1G DTFI42L DN Rifampicin DTFI42L MA Substrate DTFI42L RA Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs. Mol Cell Biochem. 2010 Apr;337(1-2):133-43. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/19844775 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM3KJ45 DTFI42L DN Estradiol-17beta-glucuronide DTFI42L MA Substrate DTFI42L RA Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol. 1999 May;55(5):929-37. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/10220572 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMN0J4W DTFI42L DN Sincalide DTFI42L MA Substrate DTFI42L RA Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16046661 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMMIQ7G DTFI42L DN Rosuvastatin DTFI42L MA Substrate DTFI42L RA Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMGLX0T DTFI42L DN Grepafloxacin DTFI42L MA Substrate DTFI42L RA Fluoroquinolone efflux mediated by ABC transporters. J Pharm Sci. 2008 Sep;97(9):3483-93. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/18200507 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DML97WV DTFI42L DN Pemirolast DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMIO4V5 DTFI42L DN Nelfinavir DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMMFWOJ DTFI42L DN Probenecid DTFI42L MA Substrate DTFI42L RA MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. DTFI42L RU https://doi.org/10.1002/ijc.21013 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQ2FPC DTFI42L DN Vasopressin DTFI42L MA Substrate DTFI42L RA Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol. 2000 Mar;57(3):634-41. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/10692506 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMT2KRV DTFI42L DN Cyclosporine DTFI42L MA Substrate DTFI42L RA Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2? Eur J Clin Pharmacol. 2010 Feb;66(2):153-8. DTFI42L RU https://doi.org/10.1007/s00228-009-0740-6 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMDI269 DTFI42L DN Docetaxel DTFI42L MA Substrate DTFI42L RA Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/18845662 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMI0V4O DTFI42L DN Bilirubin DTFI42L MA Substrate DTFI42L RA Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology. 1999 Aug;30(2):485-90. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/10421658 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM7OKQV DTFI42L DN Cholic acid DTFI42L MA Substrate DTFI42L RA Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol. 2002 Mar;135(5):1263-75. DTFI42L RU https://doi.org/10.1038/sj.bjp.0704560 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMM39BF DTFI42L DN Mitoxantrone DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DML0R9M DTFI42L DN 5-methyltetrahydrofolate DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM2TEOL DTFI42L DN Methotrexate DTFI42L MA Substrate DTFI42L RA Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/21841039 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM8M2N3 DTFI42L DN Glycyrrhizin DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMCP1G9 DTFI42L DN Chelerythrine DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMITQS0 DTFI42L DN Lopinavir DTFI42L MA Substrate DTFI42L RA Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir. Br J Pharmacol. 2010 Jul;160(5):1224-33. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/20590614 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMRHGI9 DTFI42L DN Cisplatin DTFI42L MA Substrate DTFI42L RA Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/18834541 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMUIE76 DTFI42L DN Acetaminophen DTFI42L MA Substrate DTFI42L RA Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/15276087 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMW9F1G DTFI42L DN Belotecan DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM0T3YH DTFI42L DN Indinavir DTFI42L MA Substrate DTFI42L RA Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes. Biopharm Drug Dispos. 2010 Mar;31(2-3):178-88. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/20238377 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMHT34O DTFI42L DN Gemifloxacin DTFI42L MA Substrate DTFI42L RA Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin. Int J Pharm. 2011 Nov 25;420(1):26-33. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/21864659 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMS8IFC DTFI42L DN Sorafenib DTFI42L MA Substrate DTFI42L RA Multidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib. Biol Pharm Bull. 2011;34(3):433-5. DTFI42L RU https://doi.org/10.1248/bpb.34.433 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM5TVS3 DTFI42L DN Vinblastine DTFI42L MA Substrate DTFI42L RA Severe hypokalemia due to a possible drug-drug interaction between vinblastine and antiretrovirals in a HIV-infected patient with Hodgkin's lymphoma. Int J STD AIDS. 2017 Oct;28(12):1259-1262. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/28403692 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMG814N DTFI42L DN Saquinavir DTFI42L MA Substrate DTFI42L RA Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003 Jun 27;278(26):23538-44. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/12702717 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMMC345 DTFI42L DN Cefadroxil DTFI42L MA Substrate DTFI42L RA Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMCFE9I DTFI42L DN Valproic Acid DTFI42L MA Substrate DTFI42L RA Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DTFI42L RU https://doi.org/10.1007/s12033-009-9220-6 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQNWRD DTFI42L DN Oxaliplatin DTFI42L MA Substrate DTFI42L RA Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26131551 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMMX2E6 DTFI42L DN Pemetrexed DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMXZOCG DTFI42L DN Phenobarbital DTFI42L MA Substrate DTFI42L RA Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/11706036 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMHWE7P DTFI42L DN Ampicillin DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMEMBJC DTFI42L DN Folic acid DTFI42L MA Substrate DTFI42L RA Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207. DTFI42L RU https://doi.org/10.1042/bse0500179 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMU764S DTFI42L DN Ritonavir DTFI42L MA Substrate DTFI42L RA Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes. Biopharm Drug Dispos. 2010 Mar;31(2-3):178-88. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/20238377 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMM278X DTFI42L DN Adefovir DTFI42L MA Substrate DTFI42L RA Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DTFI42L RU https://doi.org/10.1007/s12033-009-9220-6 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMVBIZL DTFI42L DN Estrone sulfate DTFI42L MA Substrate DTFI42L RA Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/16046661 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMUAZWG DTFI42L DN Leucovorin DTFI42L MA Substrate DTFI42L RA Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/12874005 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMLB81S DTFI42L DN Paclitaxel DTFI42L MA Substrate DTFI42L RA Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6125-32. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17062689 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMYTN18 DTFI42L DN Mycophenolic acid DTFI42L MA Substrate DTFI42L RA C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation. Pharmacogenomics. 2007 Sep;8(9):1127-41. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/17924828 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMUEWM3 DTFI42L DN Technetium (99MTC) mebrofenin DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMORSGU DTFI42L DN Cefodizime DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMMLNTW DTFI42L DN Genistein-7-glucoside DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMNX2QI DTFI42L DN Temocaprilate DTFI42L MA Substrate DTFI42L RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMNX2QI DTFI42L DN Temocaprilate DTFI42L MA Substrate DTFI42L RA Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DTFI42L RU https://doi.org/10.1007/s12033-009-9220-6 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DM4Q80H DTFI42L DN Dehydroepiandrosterone sulfate DTFI42L MA Substrate DTFI42L RA Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2. Biochem Pharmacol. 2005 Feb 1;69(3):415-23. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/15652233 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMJH792 DTFI42L DN Pitavastatin DTFI42L MA Substrate DTFI42L RA Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. Mol Pharmacol. 2005 Sep;68(3):800-7. DTFI42L RU http://www.ncbi.nlm.nih.gov/pubmed/15955871 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQMAWK DTFI42L DN alpha-Zearalenol DTFI42L MA Substrate DTFI42L RA ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites. Toxicol Lett. 2009 Oct 28;190(2):215-23. DTFI42L RU https://doi.org/10.1016/j.toxlet.2009.07.021 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQJSF9 DTFI42L DN Taxifolin DTFI42L MA Substrate DTFI42L RA Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp. Int J Pharm. 2009 Aug 13;378(1-2):1-8. DTFI42L RU https://doi.org/10.1016/j.ijpharm.2009.05.022 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMJT1E5 DTFI42L DN Scutellarin DTFI42L MA Substrate DTFI42L RA Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DTFI42L RU https://doi.org/10.1124/dmd.112.047183 DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMJ85FS DTFI42L DN Glutathione-S-S-glutathione DTFI42L MA Substrate DTFI42L RA Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. Eur J Biochem. 1999 Oct 1;265(1):281-9. DTFI42L RU https://doi.org/10.1046/j.1432-1327.1999.00735.x DTFI42L TI DTFI42L DTFI42L TN Multidrug resistance-associated protein 2 DTFI42L DI DMQ4PKA DTFI42L DN Olamufloxacin DTFI42L MA Substrate DTFI42L RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTFI42L RU https://doi.org/10.1007/s11095-012-0935-x DTFOJL7 TI DTFOJL7 DTFOJL7 TN Sodium-dependent phosphate transport protein 4 DTFOJL7 DI DMUN54G DTFOJL7 DN Aminohippuric acid DTFOJL7 MA Substrate DTFOJL7 RA Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32. DTFOJL7 RU http://www.ncbi.nlm.nih.gov/pubmed/20810651 DTFOJL7 TI DTFOJL7 DTFOJL7 TN Sodium-dependent phosphate transport protein 4 DTFOJL7 DI DMUXQG7 DTFOJL7 DN Phosphate DTFOJL7 MA Substrate DTFOJL7 RA Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32. DTFOJL7 RU http://www.ncbi.nlm.nih.gov/pubmed/20810651 DTFPWJ9 TI DTFPWJ9 DTFPWJ9 TN Sodium-coupled citrate transporter DTFPWJ9 DI DM5LFYN DTFPWJ9 DN Alpha-ketoglutaric acid DTFPWJ9 MA Substrate DTFPWJ9 RA SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. DTFPWJ9 RU http://www.ncbi.nlm.nih.gov/pubmed/23506872 DTFPWJ9 TI DTFPWJ9 DTFPWJ9 TN Sodium-coupled citrate transporter DTFPWJ9 DI DMPY09A DTFPWJ9 DN Succinate DTFPWJ9 MA Substrate DTFPWJ9 RA SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. DTFPWJ9 RU http://www.ncbi.nlm.nih.gov/pubmed/23506872 DTFPWJ9 TI DTFPWJ9 DTFPWJ9 TN Sodium-coupled citrate transporter DTFPWJ9 DI DM37NYK DTFPWJ9 DN Citrate DTFPWJ9 MA Substrate DTFPWJ9 RA SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. DTFPWJ9 RU http://www.ncbi.nlm.nih.gov/pubmed/23506872 DTFSLX5 TI DTFSLX5 DTFSLX5 TN Sulfate transporter DTFSLX5 DI DMW0ZBF DTFSLX5 DN Sulfate DTFSLX5 MA Substrate DTFSLX5 RA Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun;298(6):C1363-75. DTFSLX5 RU http://www.ncbi.nlm.nih.gov/pubmed/20219950 DTG1RJO TI DTG1RJO DTG1RJO TN Sodium/bile acid cotransporter 7 DTG1RJO DI DMAP8MV DTG1RJO DN Iron monocation DTG1RJO MA Substrate DTG1RJO RA Modulation of macrophage iron transport by Nramp1 (Slc11a1). Immunobiology. 2007;212(9-10):751-7. DTG1RJO RU http://www.ncbi.nlm.nih.gov/pubmed/18086376 DTG3T6X TI DTG3T6X DTG3T6X TN Glucose transporter type 1 DTG3T6X DI DMMG2TO DTG3T6X DN D-glucose DTG3T6X MA Substrate DTG3T6X RA The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38. DTG3T6X RU http://www.ncbi.nlm.nih.gov/pubmed/23506862 DTG3T6X TI DTG3T6X DTG3T6X TN Glucose transporter type 1 DTG3T6X DI DMIAHVU DTG3T6X DN 2-Deoxyglucose DTG3T6X MA Substrate DTG3T6X RA Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding. J Biol Chem. 1994 Aug 12;269(32):20533-8. DTG3T6X RU http://www.jbc.org/content/269/32/20533.long DTG3T6X TI DTG3T6X DTG3T6X TN Glucose transporter type 1 DTG3T6X DI DM3NC4M DTG3T6X DN Quercetin DTG3T6X MA Substrate DTG3T6X RA Oral Bioavailability and Disposition of Phytochemicals DTG3T6X RU http://cdn.intechweb.org/pdfs/25496.pdf DTG3T6X TI DTG3T6X DTG3T6X TN Glucose transporter type 1 DTG3T6X DI DMKYQO4 DTG3T6X DN Dehydroascorbic acid DTG3T6X MA Substrate DTG3T6X RA Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9. DTG3T6X RU http://www.ncbi.nlm.nih.gov/pubmed/9228080 DTG3T6X TI DTG3T6X DTG3T6X TN Glucose transporter type 1 DTG3T6X DI DMBCO4Q DTG3T6X DN Arsenite DTG3T6X MA Substrate DTG3T6X RA Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30. DTG3T6X RU http://www.ncbi.nlm.nih.gov/pubmed/17064664 DTGBPR5 TI DTGBPR5 DTGBPR5 TN Equilibrative nucleobase transporter 1 DTGBPR5 DI DMTM2IK DTGBPR5 DN Mercaptopurine DTGBPR5 MA Substrate DTGBPR5 RA Characterization of 6-Mercaptopurine Transport by the SLC43A3-Encoded Nucleobase Transporter. Mol Pharmacol. 2019 Jun;95(6):584-596. DTGBPR5 RU http://www.ncbi.nlm.nih.gov/pubmed/30910793 DTGEFXH TI DTGEFXH DTGEFXH TN Solute carrier family 45 member 3 DTGEFXH DI DMVWUCF DTGEFXH DN Sucrose DTGEFXH MA Substrate DTGEFXH RA Putative role of the H(+)/sucrose symporter SLC45A3 as an osmolyte transporter in the kidney. Pflugers Arch. 2016 Aug;468(8):1353-62. DTGEFXH RU http://www.ncbi.nlm.nih.gov/pubmed/27228996 DTH08M7 TI DTH08M7 DTH08M7 TN Zrt- and Irt-like protein 3 DTH08M7 DI DMZ4R3Q DTH08M7 DN Zinc salts DTH08M7 MA Substrate DTH08M7 RA The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):612-9. DTH08M7 RU http://www.ncbi.nlm.nih.gov/pubmed/23506894 DTH1GEL TI DTH1GEL DTH1GEL TN Sodium-dependent proline transporter DTH1GEL DI DMKSTWR DTH1GEL DN L-proline DTH1GEL MA Substrate DTH1GEL RA A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma. J Hum Genet. 2010 Jun;55(6):358-65. DTH1GEL RU http://www.ncbi.nlm.nih.gov/pubmed/20431603 DTH6X7Q TI DTH6X7Q DTH6X7Q TN Feline leukemia virus subgroup C receptor-related protein 1 DTH6X7Q DI DM3NC4M DTH6X7Q DN Quercetin DTH6X7Q MA Substrate DTH6X7Q RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.1.28.1) DTH6X7Q RU http://www.tcdb.org/search/result.php?tc=2.A.1.28.1 DTH6X7Q TI DTH6X7Q DTH6X7Q TN Feline leukemia virus subgroup C receptor-related protein 1 DTH6X7Q DI DMBCO4Q DTH6X7Q DN Arsenite DTH6X7Q MA Substrate DTH6X7Q RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.1.28.1) DTH6X7Q RU http://www.tcdb.org/search/result.php?tc=2.A.1.28.1 DTH9SQJ TI DTH9SQJ DTH9SQJ TN Glycerol-3-phosphate permease DTH9SQJ DI DMKY1L4 DTH9SQJ DN Glucose-6-phosphate DTH9SQJ MA Substrate DTH9SQJ RA SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157. DTH9SQJ RU http://www.ncbi.nlm.nih.gov/pubmed/21949678 DTH9SQJ TI DTH9SQJ DTH9SQJ TN Glycerol-3-phosphate permease DTH9SQJ DI DMUXQG7 DTH9SQJ DN Phosphate DTH9SQJ MA Substrate DTH9SQJ RA SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157. DTH9SQJ RU http://www.ncbi.nlm.nih.gov/pubmed/21949678 DTHE530 TI DTHE530 DTHE530 TN Probable small intestine urate exporter DTHE530 DI DM6A0X7 DTHE530 DN Pravastatin DTHE530 MA Substrate DTHE530 RA A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DTHE530 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DTHE530 TI DTHE530 DTHE530 TN Probable small intestine urate exporter DTHE530 DI DM2F8XZ DTHE530 DN Salicylic acid DTHE530 MA Substrate DTHE530 RA A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DTHE530 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DTHE530 TI DTHE530 DTHE530 TN Probable small intestine urate exporter DTHE530 DI DMUXQG7 DTHE530 DN Phosphate DTHE530 MA Substrate DTHE530 RA A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DTHE530 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DTHE530 TI DTHE530 DTHE530 TN Probable small intestine urate exporter DTHE530 DI DM672AH DTHE530 DN Aspirin DTHE530 MA Substrate DTHE530 RA A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DTHE530 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DTHE530 TI DTHE530 DTHE530 TN Probable small intestine urate exporter DTHE530 DI DM8VCBE DTHE530 DN Ibuprofen DTHE530 MA Substrate DTHE530 RA A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DTHE530 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DTHKL3Q TI DTHKL3Q DTHKL3Q TN Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 DTHKL3Q DI DMM3950 DTHKL3Q DN Sodium chloride DTHKL3Q MA Substrate DTHKL3Q RA Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency. Mol Vis. 2010 May 4;16:800-12. DTHKL3Q RU http://www.ncbi.nlm.nih.gov/pubmed/20458365 DTHKL3Q TI DTHKL3Q DTHKL3Q TN Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 DTHKL3Q DI DMMTAJC DTHKL3Q DN Potassium chloride DTHKL3Q MA Substrate DTHKL3Q RA Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency. Mol Vis. 2010 May 4;16:800-12. DTHKL3Q RU http://www.ncbi.nlm.nih.gov/pubmed/20458365 DTHWCVA TI DTHWCVA DTHWCVA TN Sodium- and chloride-dependent taurine transporter DTHWCVA DI DMVW7N3 DTHWCVA DN Taurine DTHWCVA MA Substrate DTHWCVA RA Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DTHWCVA RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DTHWCVA TI DTHWCVA DTHWCVA TN Sodium- and chloride-dependent taurine transporter DTHWCVA DI DMC64EI DTHWCVA DN Beta-alanine DTHWCVA MA Substrate DTHWCVA RA Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DTHWCVA RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DTI58LU TI DTI58LU DTI58LU TN Sulfonylurea receptor 1 DTI58LU DI DM02AWV DTI58LU DN Tolbutamide DTI58LU MA Substrate DTI58LU RA ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. DTI58LU RU http://www.ncbi.nlm.nih.gov/pubmed/16897043 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMSKMET DTI7UX6 DN Gimatecan DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMOGFIX DTI7UX6 DN Eltrombopag DTI7UX6 MA Substrate DTI7UX6 RA Assessment of the pharmacokinetic interaction between eltrombopag and lopinavir-ritonavir in healthy adult subjects. Antimicrob Agents Chemother. 2012 Jun;56(6):2846-51. DTI7UX6 RU https://doi.org/10.1128/AAC.05214-11 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7HXWT DTI7UX6 DN Nilotinib DTI7UX6 MA Substrate DTI7UX6 RA Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/19785662 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMD7L94 DTI7UX6 DN Palbociclib DTI7UX6 MA Substrate DTI7UX6 RA Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model. J Pharmacol Exp Ther. 2015 Nov;355(2):264-71. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26354993 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM20ATW DTI7UX6 DN BN-80915 DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMLW57T DTI7UX6 DN Teniposide DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCA7FN DTI7UX6 DN Exatecan mesylate DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMT9K8G DTI7UX6 DN Raltitrexed DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7V2LG DTI7UX6 DN Chrysin DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMM0XGL DTI7UX6 DN Idarubicin DTI7UX6 MA Substrate DTI7UX6 RA Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5. DTI7UX6 RU https://doi.org/10.1038/leu.2008.87 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQUSBT DTI7UX6 DN Daunorubicin DTI7UX6 MA Substrate DTI7UX6 RA Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/11437380 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM4KI7O DTI7UX6 DN Zidovudine DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCRGY4 DTI7UX6 DN Karenitecin DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMR3J6S DTI7UX6 DN Cholesterol DTI7UX6 MA Substrate DTI7UX6 RA Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/12668685 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM40TBU DTI7UX6 DN Coumestrol DTI7UX6 MA Substrate DTI7UX6 RA Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens. Mol Pharmacol. 2007 Oct;72(4):967-75. DTI7UX6 RU https://doi.org/10.1124/mol.107.034751 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMH61ZB DTI7UX6 DN Cimetidine DTI7UX6 MA Substrate DTI7UX6 RA Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression. Mol Pharmacol. 2008 Mar;73(3):613-5. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18086804 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMAHMT9 DTI7UX6 DN Glutathione DTI7UX6 MA Substrate DTI7UX6 RA Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem. 2010 May 28;285(22):16582-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20332504 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMP6G8T DTI7UX6 DN Topotecan DTI7UX6 MA Substrate DTI7UX6 RA Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol. 2010 Oct 10;644(1-3):41-8. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20655304 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM6A0X7 DTI7UX6 DN Pravastatin DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM4K7GQ DTI7UX6 DN Erythromycin DTI7UX6 MA Substrate DTI7UX6 RA ABCG2: a perspective. Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. DTI7UX6 RU https://doi.org/10.1016/j.addr.2008.11.003 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMICA9H DTI7UX6 DN Sulfasalazine DTI7UX6 MA Substrate DTI7UX6 RA Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18841445 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7NKEV DTI7UX6 DN Thioguanine DTI7UX6 MA Substrate DTI7UX6 RA ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. DTI7UX6 RU https://doi.org/10.1016/j.bcp.2011.12.042 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMSJDTY DTI7UX6 DN Menadione DTI7UX6 MA Substrate DTI7UX6 RA The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3279-86. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18065489 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMXCM7H DTI7UX6 DN Cerivastatin DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM0VQN3 DTI7UX6 DN Ofloxacin DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMPQAGE DTI7UX6 DN Mycophenolate mofetil DTI7UX6 MA Substrate DTI7UX6 RA Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18695635 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMHTYBS DTI7UX6 DN JNJ 7706621 DTI7UX6 MA Substrate DTI7UX6 RA Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor. Mol Cancer Ther. 2006 Oct;5(10):2459-67. DTI7UX6 RU https://doi.org/10.1158/1535-7163.MCT-06-0339 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM8YMWE DTI7UX6 DN Riboflavin DTI7UX6 MA Substrate DTI7UX6 RA Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. Mol Cell Biol. 2007 Feb;27(4):1247-53. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17145775 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMXBLMP DTI7UX6 DN Riociguat DTI7UX6 MA Substrate DTI7UX6 RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DTI7UX6 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM1MBYQ DTI7UX6 DN Ganciclovir DTI7UX6 MA Substrate DTI7UX6 RA Side populations of glioblastoma cells are less sensitive to HSV-TK/GCV suicide gene therapy system than the non-side population. In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):497-501. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20135358 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3JDRP DTI7UX6 DN Cladribine DTI7UX6 MA Substrate DTI7UX6 RA Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther. 2008 Sep;7(9):3092-102. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18765824 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMUM7HZ DTI7UX6 DN Fluorouracil DTI7UX6 MA Substrate DTI7UX6 RA Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18820913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM8JXPZ DTI7UX6 DN Glibenclamide DTI7UX6 MA Substrate DTI7UX6 RA Glyburide transport across the human placenta. Obstet Gynecol. 2015 Mar;125(3):583-8. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/25730219 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMX6OE3 DTI7UX6 DN Dabrafenib DTI7UX6 MA Substrate DTI7UX6 RA Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/23249624 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMTKD7Q DTI7UX6 DN Afatinib DTI7UX6 MA Substrate DTI7UX6 RA Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation. Pharmacol Res. 2017 Jun;120:43-50. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/28288939 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMZIV6D DTI7UX6 DN Befloxatone DTI7UX6 MA Substrate DTI7UX6 RA Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening. J Nucl Med. 2011 Mar;52(3):415-23. DTI7UX6 RU https://doi.org/10.2967/jnumed.110.079608 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMRF9YK DTI7UX6 DN Empagliflozin DTI7UX6 MA Substrate DTI7UX6 RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DTI7UX6 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMOF0CA DTI7UX6 DN AG 337 DTI7UX6 MA Substrate DTI7UX6 RA Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DTI7UX6 RU https://doi.org/10.1007/s00280-006-0230-9 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7HUNW DTI7UX6 DN Testosterone DTI7UX6 MA Substrate DTI7UX6 RA Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival. BJU Int. 2008 Dec;102(11):1694-9. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18710444 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM0D9YJ DTI7UX6 DN Dirithromycin DTI7UX6 MA Substrate DTI7UX6 RA Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DTI7UX6 RU https://doi.org/10.1042/BJ20040791 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMOMN31 DTI7UX6 DN Phenethyl isothiocyanate DTI7UX6 MA Substrate DTI7UX6 RA A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DTI7UX6 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMUY35B DTI7UX6 DN Progesterone DTI7UX6 MA Substrate DTI7UX6 RA Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/12668685 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMP6SC2 DTI7UX6 DN Irinotecan DTI7UX6 MA Substrate DTI7UX6 RA Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol. 2006 Sep;58(3):374-83. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/16404634 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMPJQZG DTI7UX6 DN C-1311 DTI7UX6 MA Substrate DTI7UX6 RA C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells. Biochem Pharmacol. 2007 Jun 30;74(1):41-53. DTI7UX6 RU https://doi.org/10.1016/j.bcp.2007.03.028 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMLB0EZ DTI7UX6 DN Tamoxifen DTI7UX6 MA Substrate DTI7UX6 RA The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/27033456 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMKER83 DTI7UX6 DN Hesperetin DTI7UX6 MA Substrate DTI7UX6 RA Interaction of the breast cancer resistance protein with plant polyphenols. Biochem Biophys Res Commun. 2004 Apr 23;317(1):269-75. DTI7UX6 RU https://doi.org/10.1016/j.bbrc.2004.03.040 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCMBHA DTI7UX6 DN Erlotinib DTI7UX6 MA Substrate DTI7UX6 RA Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. Adv Drug Deliv Rev. 2009 Jan 31;61(1):26-33. DTI7UX6 RU https://doi.org/10.1016/j.addr.2008.07.003 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQ2FKJ DTI7UX6 DN Teriflunomide DTI7UX6 MA Substrate DTI7UX6 RA MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):779-87. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/23711386 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMI347A DTI7UX6 DN Lamivudine DTI7UX6 MA Substrate DTI7UX6 RA The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine. Br J Clin Pharmacol. 2007 Nov;64(5):645-54. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17509035 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMWBHRY DTI7UX6 DN Olmesartan medoxomil DTI7UX6 MA Substrate DTI7UX6 RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DTI7UX6 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMJCQKA DTI7UX6 DN Sphingosine-1-phosphate DTI7UX6 MA Substrate DTI7UX6 RA Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem. 2010 Apr 2;285(14):10477-86. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20110355 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQXYRG DTI7UX6 DN 9-Aminocamptothecin DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMVP5YE DTI7UX6 DN Doxorubicin DTI7UX6 MA Substrate DTI7UX6 RA Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17273774 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3BH1Y DTI7UX6 DN Lapatinib DTI7UX6 MA Substrate DTI7UX6 RA The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions. Drug Metab Dispos. 2008 Apr;36(4):695-701. DTI7UX6 RU https://doi.org/10.1124/dmd.107.018374 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMFRM1I DTI7UX6 DN Canagliflozin DTI7UX6 MA Substrate DTI7UX6 RA In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/27862160 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM4MDJY DTI7UX6 DN Fluvastatin DTI7UX6 MA Substrate DTI7UX6 RA Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates. Pharm Res. 2015 May;32(5):1634-47. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/25380981 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMZA017 DTI7UX6 DN Tetracycline DTI7UX6 MA Substrate DTI7UX6 RA Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DTI7UX6 RU https://doi.org/10.1042/BJ20040791 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7W94S DTI7UX6 DN Brigatinib DTI7UX6 MA Substrate DTI7UX6 RA NDA/BLA Multidisciplinary Review and Evaluation of ALUNBRIG (brigatinib) From FDA. DTI7UX6 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208772Orig1s000MultidisciplineR.pdf DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMUNTE3 DTI7UX6 DN Estradiol DTI7UX6 MA Substrate DTI7UX6 RA Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/12668685 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMR8ONJ DTI7UX6 DN Leflunomide DTI7UX6 MA Substrate DTI7UX6 RA Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance. Ann Rheum Dis. 2009 Jul;68(7):1201-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18397960 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM0SXNM DTI7UX6 DN Glycocholic acid DTI7UX6 MA Substrate DTI7UX6 RA Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83. DTI7UX6 RU https://doi.org/10.1124/mol.111.075143 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM276N1 DTI7UX6 DN Piritrexim DTI7UX6 MA Substrate DTI7UX6 RA Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DTI7UX6 RU https://doi.org/10.1007/s00280-006-0230-9 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMHSY1I DTI7UX6 DN Regorafenib DTI7UX6 MA Substrate DTI7UX6 RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DTI7UX6 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7A8TW DTI7UX6 DN Ezetimibe DTI7UX6 MA Substrate DTI7UX6 RA Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/19443695 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMZVMKF DTI7UX6 DN Alfuzosin DTI7UX6 MA Substrate DTI7UX6 RA In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2). Handb Exp Pharmacol. 2011;(201):325-71. DTI7UX6 RU https://doi.org/10.1007/978-3-642-14541-4_9 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM2LZ8F DTI7UX6 DN Taurocholic acid DTI7UX6 MA Substrate DTI7UX6 RA Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83. DTI7UX6 RU https://doi.org/10.1124/mol.111.075143 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMINOX3 DTI7UX6 DN Vincristine DTI7UX6 MA Substrate DTI7UX6 RA Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DTI7UX6 RU https://doi.org/10.1007/s00280-006-0230-9 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMTM2IK DTI7UX6 DN Mercaptopurine DTI7UX6 MA Substrate DTI7UX6 RA ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. DTI7UX6 RU https://doi.org/10.1016/j.bcp.2011.12.042 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM15F0X DTI7UX6 DN Gefitinib DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM6CHNJ DTI7UX6 DN Camptothecin DTI7UX6 MA Substrate DTI7UX6 RA The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. 2010 Jan;24(1):146-9. DTI7UX6 RU https://doi.org/10.1002/ptr.2860 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMMN36E DTI7UX6 DN Abacavir DTI7UX6 MA Substrate DTI7UX6 RA QSAR analysis and molecular modeling of ABCG2-specific inhibitors. Adv Drug Deliv Rev. 2009 Jan 31;61(1):34-46. DTI7UX6 RU https://doi.org/10.1016/j.addr.2008.10.004 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMWYE7A DTI7UX6 DN Protoporphyrin DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMA9MP5 DTI7UX6 DN SJG-136 DTI7UX6 MA Substrate DTI7UX6 RA Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters. AAPS J. 2010 Dec;12(4):617-27. DTI7UX6 RU https://doi.org/10.1208/s12248-010-9225-x DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7RJXL DTI7UX6 DN Imatinib DTI7UX6 MA Substrate DTI7UX6 RA Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/15251980 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMYLOVR DTI7UX6 DN Acyclovir DTI7UX6 MA Substrate DTI7UX6 RA Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity. Can J Physiol Pharmacol. 2011 Sep;89(9):675-80. DTI7UX6 RU https://doi.org/10.1139/y11-045 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMW50NF DTI7UX6 DN SN-38 DTI7UX6 MA Substrate DTI7UX6 RA Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells. Biochem Biophys Res Commun. 2001 Nov 9;288(4):827-32. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/11688982 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMNH3PG DTI7UX6 DN Etoposide DTI7UX6 MA Substrate DTI7UX6 RA Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Biochim Biophys Acta. 2014 Nov;1838(11):2929-38. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/25128152 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM5X7VY DTI7UX6 DN Pyrimethamine DTI7UX6 MA Substrate DTI7UX6 RA Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DTI7UX6 RU https://doi.org/10.1007/s00280-006-0230-9 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM1P6FR DTI7UX6 DN Binimetinib DTI7UX6 MA Substrate DTI7UX6 RA The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors. Int J Cancer. 2018 Jan 15;142(2):381-391. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/28921565 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMPDW6T DTI7UX6 DN Epirubicin DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMUJ0W7 DTI7UX6 DN CP-724714 DTI7UX6 MA Substrate DTI7UX6 RA Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors. ChemMedChem. 2009 Feb;4(2):188-95. DTI7UX6 RU https://doi.org/10.1002/cmdc.200800329 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMA1MKT DTI7UX6 DN Uric acid DTI7UX6 MA Substrate DTI7UX6 RA Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS One. 2012;7(2):e30456. DTI7UX6 RU https://doi.org/10.1371/journal.pone.0030456 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM89QE1 DTI7UX6 DN Metformin DTI7UX6 MA Substrate DTI7UX6 RA Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. Am J Obstet Gynecol. 2010 Apr;202(4):383.e1-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20350646 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM1IS6U DTI7UX6 DN Tenofovir DTI7UX6 MA Substrate DTI7UX6 RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DTI7UX6 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM51Z9E DTI7UX6 DN Cephalothin DTI7UX6 MA Substrate DTI7UX6 RA Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DTI7UX6 RU https://doi.org/10.1042/BJ20040791 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMJV2EK DTI7UX6 DN Dasatinib DTI7UX6 MA Substrate DTI7UX6 RA Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/19785662 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM6U9CQ DTI7UX6 DN Pazopanib hydrochloride DTI7UX6 MA Substrate DTI7UX6 RA Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/23548165 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMXY30O DTI7UX6 DN Dipyridamole DTI7UX6 MA Substrate DTI7UX6 RA ABCG2: a perspective. Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. DTI7UX6 RU https://doi.org/10.1016/j.addr.2008.11.003 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMSQLZJ DTI7UX6 DN Nifurtimox DTI7UX6 MA Substrate DTI7UX6 RA The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Brain Res. 2012 Feb 3;1436:111-21. DTI7UX6 RU https://doi.org/10.1016/j.brainres.2011.11.053 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQAK6T DTI7UX6 DN Rhodamine 123 DTI7UX6 MA Substrate DTI7UX6 RA Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo. Exp Mol Med. 2017 Mar 17;49(3):e303. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/28303028 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM1UJO0 DTI7UX6 DN Pitavastatin calcium DTI7UX6 MA Substrate DTI7UX6 RA Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. Mol Pharmacol. 2005 Sep;68(3):800-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/15955871 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMA8J1G DTI7UX6 DN Rifampicin DTI7UX6 MA Substrate DTI7UX6 RA Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DTI7UX6 RU https://doi.org/10.1042/BJ20040791 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMRICNP DTI7UX6 DN Vandetanib DTI7UX6 MA Substrate DTI7UX6 RA Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences. Cancer Chemother Pharmacol. 2010 Jan;65(2):335-46. DTI7UX6 RU https://doi.org/10.1007/s00280-009-1039-0 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3NF5G DTI7UX6 DN Delavirdine DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMYGJQO DTI7UX6 DN Ponatinib DTI7UX6 MA Substrate DTI7UX6 RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08901) DTI7UX6 RU https://www.drugbank.ca/drugs/DB08901 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMECBWN DTI7UX6 DN Riluzole DTI7UX6 MA Substrate DTI7UX6 RA Interactions between riluzole and ABCG2/BCRP transporter. Neurosci Lett. 2009 Mar 6;452(1):12-6. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/19146924 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM30SGU DTI7UX6 DN Simvastatin DTI7UX6 MA Substrate DTI7UX6 RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTI7UX6 RU https://doi.org/10.1007/s11095-012-0935-x DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMGVYXB DTI7UX6 DN NB-506 DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3ZL7D DTI7UX6 DN J-107088 DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3KJ45 DTI7UX6 DN Estradiol-17beta-glucuronide DTI7UX6 MA Substrate DTI7UX6 RA Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites. Drug Metab Dispos. 2014 Apr;42(4):575-85. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/24384916 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMIY6DB DTI7UX6 DN Verteporfin DTI7UX6 MA Substrate DTI7UX6 RA The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2. Clin Cancer Res. 2007 Apr 15;13(8):2463-70. DTI7UX6 RU https://doi.org/10.1158/1078-0432.CCR-06-1599 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM89JLN DTI7UX6 DN Apixaban DTI7UX6 MA Substrate DTI7UX6 RA Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug Metab Dispos. 2013 Apr;41(4):827-35. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/23382458 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMLBVKQ DTI7UX6 DN Entacapone DTI7UX6 MA Substrate DTI7UX6 RA Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors. Drug Metab Dispos. 2017 Dec;45(12):1282-1291. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/28916530 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM6VM38 DTI7UX6 DN Reserpine DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM602WT DTI7UX6 DN Idelalisib DTI7UX6 MA Substrate DTI7UX6 RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB09054) DTI7UX6 RU https://www.drugbank.ca/drugs/DB09054 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMMIQ7G DTI7UX6 DN Rosuvastatin DTI7UX6 MA Substrate DTI7UX6 RA Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMGLX0T DTI7UX6 DN Grepafloxacin DTI7UX6 MA Substrate DTI7UX6 RA Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones. Drug Metab Dispos. 2007 Oct;35(10):1873-9. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17639028 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM35KZG DTI7UX6 DN E3040 DTI7UX6 MA Substrate DTI7UX6 RA Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J. 2005 May 11;7(1):E118-33. DTI7UX6 RU https://doi.org/10.1208/aapsj070112 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM67VKL DTI7UX6 DN Prasterone DTI7UX6 MA Substrate DTI7UX6 RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTI7UX6 RU https://doi.org/10.1007/s11095-012-0935-x DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM76TSG DTI7UX6 DN Phosphatidylserine DTI7UX6 MA Substrate DTI7UX6 RA ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci. 2010 Apr 24;86(17-18):631-7. DTI7UX6 RU https://doi.org/10.1016/j.lfs.2010.02.012 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3NC4M DTI7UX6 DN Quercetin DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQMBZ1 DTI7UX6 DN Rivaroxaban DTI7UX6 MA Substrate DTI7UX6 RA Absence of both MDR1 (ABCB1) and breast cancer resistance protein (ABCG2) transporters significantly alters rivaroxaban disposition and central nervous system entry. Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):164-70. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/22958812 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMMZXIW DTI7UX6 DN Rabeprazole DTI7UX6 MA Substrate DTI7UX6 RA Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009 Jan;67(1):44-9. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/19076159 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7VTQO DTI7UX6 DN Entecavir DTI7UX6 MA Substrate DTI7UX6 RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMIO4V5 DTI7UX6 DN Nelfinavir DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM0JETC DTI7UX6 DN Genistein DTI7UX6 MA Substrate DTI7UX6 RA Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2. J Pharm Sci. 2012 May;101(5):1888-97. DTI7UX6 RU https://doi.org/10.1002/jps.23069 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMKSUOI DTI7UX6 DN Flavopiridol DTI7UX6 MA Substrate DTI7UX6 RA The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2. Mol Cancer Ther. 2012 Sep;11(9):2033-44. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/22778153 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMXU4ON DTI7UX6 DN Hypericin DTI7UX6 MA Substrate DTI7UX6 RA Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. Photochem Photobiol Sci. 2009 Dec;8(12):1716-23. DTI7UX6 RU https://doi.org/10.1039/b9pp00086k DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMLHESP DTI7UX6 DN Chlorothiazide DTI7UX6 MA Substrate DTI7UX6 RA ABCG2 modulates chlorothiazide permeability--in vitro-characterization of its interactions. Drug Metab Pharmacokinet. 2012;27(3):349-53. DTI7UX6 RU https://doi.org/10.2133/dmpk.DMPK-11-NT-068 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMRQV8I DTI7UX6 DN Becatecarin DTI7UX6 MA Substrate DTI7UX6 RA Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009 Aug;64(3):575-83. DTI7UX6 RU https://doi.org/10.1007/s00280-008-0908-2 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM2NLS9 DTI7UX6 DN Ciprofloxacin DTI7UX6 MA Substrate DTI7UX6 RA Fluoroquinolone efflux mediated by ABC transporters. J Pharm Sci. 2008 Sep;97(9):3483-93. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18200507 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMU8L7C DTI7UX6 DN Quinacrine DTI7UX6 MA Substrate DTI7UX6 RA Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DTI7UX6 RU https://doi.org/10.1042/BJ20040791 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMT2KRV DTI7UX6 DN Cyclosporine DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMDI269 DTI7UX6 DN Docetaxel DTI7UX6 MA Substrate DTI7UX6 RA Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMSIVND DTI7UX6 DN Hydroxychloroquine DTI7UX6 MA Substrate DTI7UX6 RA MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):779-87. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/23711386 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7OKQV DTI7UX6 DN Cholic acid DTI7UX6 MA Substrate DTI7UX6 RA Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83. DTI7UX6 RU https://doi.org/10.1124/mol.111.075143 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM2YGNW DTI7UX6 DN Dactinomycin DTI7UX6 MA Substrate DTI7UX6 RA Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. DTI7UX6 RU https://doi.org/10.1124/mol.63.1.65 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMIZ6W2 DTI7UX6 DN Norfloxacin DTI7UX6 MA Substrate DTI7UX6 RA Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab Dispos. 2006 Apr;34(4):690-5. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/16434544 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMF1RTW DTI7UX6 DN Lurtotecan DTI7UX6 MA Substrate DTI7UX6 RA A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DTI7UX6 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM7PQIK DTI7UX6 DN Nitrofurantoin DTI7UX6 MA Substrate DTI7UX6 RA The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol. 2005 May;67(5):1758-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/15709111 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCBJSR DTI7UX6 DN Sunitinib DTI7UX6 MA Substrate DTI7UX6 RA Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier. Mol Pharm. 2011 Apr 4;8(2):571-82. DTI7UX6 RU https://doi.org/10.1021/mp1003898 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMM39BF DTI7UX6 DN Mitoxantrone DTI7UX6 MA Substrate DTI7UX6 RA Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/11437380 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCVJ86 DTI7UX6 DN Clofarabine DTI7UX6 MA Substrate DTI7UX6 RA Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther. 2008 Sep;7(9):3092-102. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18765824 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM2TEOL DTI7UX6 DN Methotrexate DTI7UX6 MA Substrate DTI7UX6 RA Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/14500392 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMRFTJX DTI7UX6 DN Daidzein DTI7UX6 MA Substrate DTI7UX6 RA Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens. Mol Pharmacol. 2007 Oct;72(4):967-75. DTI7UX6 RU https://doi.org/10.1124/mol.107.034751 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMMP3Y2 DTI7UX6 DN Apatinib DTI7UX6 MA Substrate DTI7UX6 RA Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 2010 Oct 15;70(20):7981-91. DTI7UX6 RU https://doi.org/10.1158/0008-5472.CAN-10-0111 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCDYW7 DTI7UX6 DN Nicardipine DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMTAJP7 DTI7UX6 DN Butyrate DTI7UX6 MA Substrate DTI7UX6 RA The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein. Am J Physiol Cell Physiol. 2011 Nov;301(5):C984-94. DTI7UX6 RU https://doi.org/10.1152/ajpcell.00146.2011 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMSVOCZ DTI7UX6 DN Pantoprazole DTI7UX6 MA Substrate DTI7UX6 RA Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 2004 Aug 15;64(16):5804-11. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/15313923 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMGTW1I DTI7UX6 DN Pirarubicin DTI7UX6 MA Substrate DTI7UX6 RA Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18820913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMPIHLS DTI7UX6 DN Diclofenac DTI7UX6 MA Substrate DTI7UX6 RA Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18845662 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3RWXL DTI7UX6 DN Resveratrol DTI7UX6 MA Substrate DTI7UX6 RA The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17032904 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMITQS0 DTI7UX6 DN Lopinavir DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMRHGI9 DTI7UX6 DN Cisplatin DTI7UX6 MA Substrate DTI7UX6 RA Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93. DTI7UX6 RU https://doi.org/10.1016/j.bcp.2008.11.007 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMW9F1G DTI7UX6 DN Belotecan DTI7UX6 MA Substrate DTI7UX6 RA Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18654741 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMZMSPF DTI7UX6 DN Bicalutamide DTI7UX6 MA Substrate DTI7UX6 RA Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans. Clin Chim Acta. 2015 Jan 1;438:7-11. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/25124867 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMS8IFC DTI7UX6 DN Sorafenib DTI7UX6 MA Substrate DTI7UX6 RA Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier. Mol Pharm. 2011 Apr 4;8(2):571-82. DTI7UX6 RU https://doi.org/10.1021/mp1003898 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM5TVS3 DTI7UX6 DN Vinblastine DTI7UX6 MA Substrate DTI7UX6 RA Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMG814N DTI7UX6 DN Saquinavir DTI7UX6 MA Substrate DTI7UX6 RA Nicotine and cotinine increases the brain penetration of saquinavir in rat. J Neurochem. 2010 Dec;115(6):1495-507. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20950334 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMCD9YG DTI7UX6 DN Prazosin DTI7UX6 MA Substrate DTI7UX6 RA P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats. Brain Res. 2011 Jan 25;1370:238-45. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/21075088 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM5PCS7 DTI7UX6 DN Bupropion DTI7UX6 MA Substrate DTI7UX6 RA Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion. Biochem Pharmacol. 2010 Oct 1;80(7):1080-6. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/20599802 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQNWRD DTI7UX6 DN Oxaliplatin DTI7UX6 MA Substrate DTI7UX6 RA Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro. 2008 Dec;22(8):1846-52. DTI7UX6 RU https://doi.org/10.1016/j.tiv.2008.09.001 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMMX2E6 DTI7UX6 DN Pemetrexed DTI7UX6 MA Substrate DTI7UX6 RA pH-Dependent transport of pemetrexed by breast cancer resistance protein. Drug Metab Dispos. 2011 Sep;39(9):1478-85. DTI7UX6 RU https://doi.org/10.1124/dmd.111.039370 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM4ONW5 DTI7UX6 DN Baricitinib DTI7UX6 MA Substrate DTI7UX6 RA Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran. Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01201-17. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/28848011 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMDEA85 DTI7UX6 DN Trimetrexate DTI7UX6 MA Substrate DTI7UX6 RA Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DTI7UX6 RU https://doi.org/10.1007/s00280-006-0230-9 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM1EK5D DTI7UX6 DN Ortataxel DTI7UX6 MA Substrate DTI7UX6 RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMEMBJC DTI7UX6 DN Folic acid DTI7UX6 MA Substrate DTI7UX6 RA The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17032904 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMUNJZB DTI7UX6 DN UCN-01 DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM87ZIH DTI7UX6 DN AG1478 DTI7UX6 MA Substrate DTI7UX6 RA Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93. DTI7UX6 RU https://doi.org/10.1016/j.bcp.2008.11.007 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMM278X DTI7UX6 DN Adefovir DTI7UX6 MA Substrate DTI7UX6 RA ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. DTI7UX6 RU https://doi.org/10.1016/j.bcp.2011.12.042 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMVBIZL DTI7UX6 DN Estrone sulfate DTI7UX6 MA Substrate DTI7UX6 RA ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/12682043 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMVBIZL DTI7UX6 DN Estrone sulfate DTI7UX6 MA Substrate DTI7UX6 RA Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2. J Pharm Sci. 2012 May;101(5):1888-97. DTI7UX6 RU https://doi.org/10.1002/jps.23069 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMVK36Q DTI7UX6 DN Hematoporphyrin DTI7UX6 MA Substrate DTI7UX6 RA Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. Pharm Res. 2009 Feb;26(2):449-58. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18841444 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMLB81S DTI7UX6 DN Paclitaxel DTI7UX6 MA Substrate DTI7UX6 RA Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM2M3OC DTI7UX6 DN Talazoparib DTI7UX6 MA Substrate DTI7UX6 RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB11760) DTI7UX6 RU https://www.drugbank.ca/drugs/DB11760 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMQI86A DTI7UX6 DN Sofosbuvir DTI7UX6 MA Substrate DTI7UX6 RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DTI7UX6 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMILWZR DTI7UX6 DN Rosiglitazone DTI7UX6 MA Substrate DTI7UX6 RA ATP-binding cassette transporters in human heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):231-43. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18392808 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3GYAL DTI7UX6 DN Deoxycholic acid DTI7UX6 MA Substrate DTI7UX6 RA Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DTI7UX6 RU https://doi.org/10.1042/BJ20040791 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMW76V0 DTI7UX6 DN Bisantrene DTI7UX6 MA Substrate DTI7UX6 RA Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DTI7UX6 RU https://doi.org/10.2217/14622416.9.8.1005 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMHOV7D DTI7UX6 DN Tenofovir alafenamide DTI7UX6 MA Substrate DTI7UX6 RA Pharmacokinetics of Tenofovir Alafenamide When Coadministered With Other HIV Antiretrovirals. J Acquir Immune Defic Syndr. 2018 Aug 1;78(4):465-472. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/29649076 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM4Q80H DTI7UX6 DN Dehydroepiandrosterone sulfate DTI7UX6 MA Substrate DTI7UX6 RA A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DTI7UX6 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMDKLB5 DTI7UX6 DN Puromycin DTI7UX6 MA Substrate DTI7UX6 RA A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DTI7UX6 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMJH792 DTI7UX6 DN Pitavastatin DTI7UX6 MA Substrate DTI7UX6 RA ABCG2: a perspective. Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. DTI7UX6 RU https://doi.org/10.1016/j.addr.2008.11.003 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMSNL51 DTI7UX6 DN Oxfendazole DTI7UX6 MA Substrate DTI7UX6 RA Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2). Drug Metab Dispos. 2005 May;33(5):614-8. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/15703302 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMK6WIO DTI7UX6 DN Enrofloxacin DTI7UX6 MA Substrate DTI7UX6 RA Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep. J Vet Pharmacol Ther. 2006 Aug;29(4):279-87. DTI7UX6 RU https://doi.org/10.1111/j.1365-2885.2006.00744.x DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMBQDA3 DTI7UX6 DN Homocamptothecin DTI7UX6 MA Substrate DTI7UX6 RA ABCG2: determining its relevance in clinical drug resistance. Cancer Metastasis Rev. 2007 Mar;26(1):39-57. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/17323127 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM25PQB DTI7UX6 DN HPPH DTI7UX6 MA Substrate DTI7UX6 RA Substrate affinity of photosensitizers derived from chlorophyll-a: the ABCG2 transporter affects the phototoxic response of side population stem cell-like cancer cells to photodynamic therapy. Mol Pharm. 2010 Oct 4;7(5):1789-804. DTI7UX6 RU https://doi.org/10.1021/mp100154j DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM5O4X9 DTI7UX6 DN Mycophenolic acid glucuronide DTI7UX6 MA Substrate DTI7UX6 RA Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. DTI7UX6 RU http://www.ncbi.nlm.nih.gov/pubmed/18695635 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3YUGA DTI7UX6 DN Pancratistatin DTI7UX6 MA Substrate DTI7UX6 RA Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharmacol. 2009 Nov;76(5):946-56. DTI7UX6 RU https://doi.org/10.1124/mol.109.056192 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMN7J43 DTI7UX6 DN Benzo(a)pyrene DTI7UX6 MA Substrate DTI7UX6 RA A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DTI7UX6 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMDJH2L DTI7UX6 DN BMS 536924 DTI7UX6 MA Substrate DTI7UX6 RA Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924. Mol Cancer Ther. 2011 Jan;10(1):117-25. DTI7UX6 RU https://doi.org/10.1158/1535-7163.MCT-10-0438 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM5ATJ0 DTI7UX6 DN N-desethyl sunitinib DTI7UX6 MA Substrate DTI7UX6 RA P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther. 2012 Apr;341(1):164-73. DTI7UX6 RU https://doi.org/10.1124/jpet.111.186908 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMJT1E5 DTI7UX6 DN Scutellarin DTI7UX6 MA Substrate DTI7UX6 RA Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DTI7UX6 RU https://doi.org/10.1124/dmd.112.047183 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMMW4HV DTI7UX6 DN Benzoylphenylurea DTI7UX6 MA Substrate DTI7UX6 RA American Association for Cancer Research. DTI7UX6 RU http://www.aacrmeetingabstracts.org/cgi/content/abstract/2004/1/119-b DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DM3FLMR DTI7UX6 DN Azidothymidine monophosphate DTI7UX6 MA Substrate DTI7UX6 RA Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J. 2005 May 11;7(1):E118-33. DTI7UX6 RU https://doi.org/10.1208/aapsj070112 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMTJZIL DTI7UX6 DN Barasertib-hQPA DTI7UX6 MA Substrate DTI7UX6 RA P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the aurora-B kinase inhibitor barasertib-hQPA. BMC Cancer. 2011 Jun 16;11:254. DTI7UX6 RU https://doi.org/10.1186/1471-2407-11-254 DTI7UX6 TI DTI7UX6 DTI7UX6 TN Breast cancer resistance protein DTI7UX6 DI DMDKXYC DTI7UX6 DN Parabis DTI7UX6 MA Substrate DTI7UX6 RA Human and rat ABC transporter efflux of bisphenol a and bisphenol a glucuronide: interspecies comparison and implications for pharmacokinetic assessment. Toxicol Sci. 2012 Aug;128(2):317-25. DTI7UX6 RU https://doi.org/10.1093/toxsci/kfs167 DTIAF6C TI DTIAF6C DTIAF6C TN Zinc transporter 2 DTIAF6C DI DMZ4R3Q DTIAF6C DN Zinc salts DTIAF6C MA Substrate DTIAF6C RA Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. PLoS One. 2013 May 31;8(5):e64045. DTIAF6C RU http://www.ncbi.nlm.nih.gov/pubmed/23741301 DTIZEMV TI DTIZEMV DTIZEMV TN Sodium/sulfate cotransporter 1 DTIZEMV DI DMW0ZBF DTIZEMV DN Sulfate DTIZEMV MA Substrate DTIZEMV RA Na+-sulfate cotransporter SLC13A1. Pflugers Arch. 2014 Jan;466(1):131-7. DTIZEMV RU http://www.ncbi.nlm.nih.gov/pubmed/24193406 DTJ0EW4 TI DTJ0EW4 DTJ0EW4 TN Bile salt export pump DTJ0EW4 DI DM6A0X7 DTJ0EW4 DN Pravastatin DTJ0EW4 MA Substrate DTJ0EW4 RA Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. DTJ0EW4 RU http://www.ncbi.nlm.nih.gov/pubmed/15901796 DTJ0EW4 TI DTJ0EW4 DTJ0EW4 TN Bile salt export pump DTJ0EW4 DI DM3GO0J DTJ0EW4 DN Sodium taurocholate DTJ0EW4 MA Substrate DTJ0EW4 RA Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. DTJ0EW4 RU http://www.ncbi.nlm.nih.gov/pubmed/15901796 DTJ0EW4 TI DTJ0EW4 DTJ0EW4 TN Bile salt export pump DTJ0EW4 DI DM7A8TW DTJ0EW4 DN Ezetimibe DTJ0EW4 MA Substrate DTJ0EW4 RA Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. DTJ0EW4 RU http://www.ncbi.nlm.nih.gov/pubmed/24014644 DTJ0EW4 TI DTJ0EW4 DTJ0EW4 TN Bile salt export pump DTJ0EW4 DI DM2LZ8F DTJ0EW4 DN Taurocholic acid DTJ0EW4 MA Substrate DTJ0EW4 RA Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. DTJ0EW4 RU http://www.ncbi.nlm.nih.gov/pubmed/12106615 DTJ0EW4 TI DTJ0EW4 DTJ0EW4 TN Bile salt export pump DTJ0EW4 DI DM5FSJA DTJ0EW4 DN Glimepiride DTJ0EW4 MA Substrate DTJ0EW4 RA Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. DTJ0EW4 RU http://www.ncbi.nlm.nih.gov/pubmed/24014644 DTJ0EW4 TI DTJ0EW4 DTJ0EW4 TN Bile salt export pump DTJ0EW4 DI DMZA5PQ DTJ0EW4 DN Glipizide DTJ0EW4 MA Substrate DTJ0EW4 RA Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. DTJ0EW4 RU http://www.ncbi.nlm.nih.gov/pubmed/24014644 DTJ4NEG TI DTJ4NEG DTJ4NEG TN ATP-binding cassette sub-family A member 2 DTJ4NEG DI DMR3J6S DTJ4NEG DN Cholesterol DTJ4NEG MA Substrate DTJ4NEG RA The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Biochim Biophys Acta. 2011 Dec;1811(12):1152-64. DTJ4NEG RU http://www.ncbi.nlm.nih.gov/pubmed/21810484 DTJ785O TI DTJ785O DTJ785O TN Sulfate anion transporter 1 DTJ785O DI DM40SEU DTJ785O DN Oxalate DTJ785O MA Substrate DTJ785O RA Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234. DTJ785O RU http://www.ncbi.nlm.nih.gov/pubmed/27210743 DTJ785O TI DTJ785O DTJ785O TN Sulfate anion transporter 1 DTJ785O DI DMW0ZBF DTJ785O DN Sulfate DTJ785O MA Substrate DTJ785O RA Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234. DTJ785O RU http://www.ncbi.nlm.nih.gov/pubmed/27210743 DTJ785O TI DTJ785O DTJ785O TN Sulfate anion transporter 1 DTJ785O DI DMT5E36 DTJ785O DN Bicarbonate DTJ785O MA Substrate DTJ785O RA SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703. DTJ785O RU http://www.ncbi.nlm.nih.gov/pubmed/26671068 DTJCWP8 TI DTJCWP8 DTJCWP8 TN Mitochondrial glutamate carrier 1 DTJCWP8 DI DM4PUDW DTJCWP8 DN L-glutamic acid DTJCWP8 MA Substrate DTJCWP8 RA Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy. Am J Hum Genet. 2005 Feb;76(2):334-9. DTJCWP8 RU http://www.ncbi.nlm.nih.gov/pubmed/15592994 DTJF3DX TI DTJF3DX DTJF3DX TN L-type amino acid transporter 2 DTJF3DX DI DM9O8DT DTJF3DX DN L-tyrosine DTJF3DX MA Substrate DTJF3DX RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DTJF3DX RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DTJF3DX TI DTJF3DX DTJF3DX TN L-type amino acid transporter 2 DTJF3DX DI DMIBH7M DTJF3DX DN L-tryptophan DTJF3DX MA Substrate DTJF3DX RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DTJF3DX RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DTJF3DX TI DTJF3DX DTJF3DX TN L-type amino acid transporter 2 DTJF3DX DI DMZDN4W DTJF3DX DN L-alanine DTJF3DX MA Substrate DTJF3DX RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DTJF3DX RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DTJF3DX TI DTJF3DX DTJF3DX TN L-type amino acid transporter 2 DTJF3DX DI DMKSTWR DTJF3DX DN L-proline DTJF3DX MA Substrate DTJF3DX RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DTJF3DX RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DTJF3DX TI DTJF3DX DTJF3DX TN L-type amino acid transporter 2 DTJF3DX DI DMIOZ29 DTJF3DX DN Glycine DTJF3DX MA Substrate DTJF3DX RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DTJF3DX RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DTJF3DX TI DTJF3DX DTJF3DX TN L-type amino acid transporter 2 DTJF3DX DI DMQXI9F DTJF3DX DN L-phenylalanine DTJF3DX MA Substrate DTJF3DX RA Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628. DTJF3DX RU http://www.ncbi.nlm.nih.gov/pubmed/28091567 DTJH79E TI DTJH79E DTJH79E TN Zrt- and Irt-like protein 9 DTJH79E DI DMZ4R3Q DTJH79E DN Zinc salts DTJH79E MA Substrate DTJH79E RA A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313. DTJH79E RU http://www.ncbi.nlm.nih.gov/pubmed/28098160 DTJIRMD TI DTJIRMD DTJIRMD TN Excitatory amino acid transporter 3 DTJIRMD DI DM4PUDW DTJIRMD DN L-glutamic acid DTJIRMD MA Substrate DTJIRMD RA Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest. 2011 Jan;121(1):446-53. DTJIRMD RU http://www.ncbi.nlm.nih.gov/pubmed/21123949 DTJYKDQ TI DTJYKDQ DTJYKDQ TN Mitochondrial dicarboxylate carrier DTJYKDQ DI DMW0ZBF DTJYKDQ DN Sulfate DTJYKDQ MA Substrate DTJYKDQ RA SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504. DTJYKDQ RU http://www.ncbi.nlm.nih.gov/pubmed/29211846 DTJYKDQ TI DTJYKDQ DTJYKDQ TN Mitochondrial dicarboxylate carrier DTJYKDQ DI DMUXQG7 DTJYKDQ DN Phosphate DTJYKDQ MA Substrate DTJYKDQ RA SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504. DTJYKDQ RU http://www.ncbi.nlm.nih.gov/pubmed/29211846 DTJZ7W2 TI DTJZ7W2 DTJZ7W2 TN Na(+)/sulfate cotransporter SUT-1 DTJZ7W2 DI DMW0ZBF DTJZ7W2 DN Sulfate DTJZ7W2 MA Substrate DTJZ7W2 RA Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6. DTJZ7W2 RU http://www.ncbi.nlm.nih.gov/pubmed/26292834 DTK02I1 TI DTK02I1 DTK02I1 TN L-type amino acid transporter 4 DTK02I1 DI DM4B6H3 DTK02I1 DN L-isoleucine DTK02I1 MA Substrate DTK02I1 RA Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DTK02I1 RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DTK02I1 TI DTK02I1 DTK02I1 TN L-type amino acid transporter 4 DTK02I1 DI DM68RPD DTK02I1 DN L-valine DTK02I1 MA Substrate DTK02I1 RA Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DTK02I1 RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DTK02I1 TI DTK02I1 DTK02I1 TN L-type amino acid transporter 4 DTK02I1 DI DMQXI9F DTK02I1 DN L-phenylalanine DTK02I1 MA Substrate DTK02I1 RA Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DTK02I1 RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DTK02I1 TI DTK02I1 DTK02I1 TN L-type amino acid transporter 4 DTK02I1 DI DMQHN7I DTK02I1 DN L-leucine DTK02I1 MA Substrate DTK02I1 RA Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DTK02I1 RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DTK02RZ TI DTK02RZ DTK02RZ TN Zrt- and Irt-like protein 10 DTK02RZ DI DMZ4R3Q DTK02RZ DN Zinc salts DTK02RZ MA Substrate DTK02RZ RA Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5. DTK02RZ RU http://www.ncbi.nlm.nih.gov/pubmed/25074913 DTKDTML TI DTKDTML DTKDTML TN Fatty acid transport protein 1 DTKDTML DI DM54O1Z DTKDTML DN Oleic acid DTKDTML MA Substrate DTKDTML RA The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport. J Neurochem. 2017 May;141(3):400-412. DTKDTML RU http://www.ncbi.nlm.nih.gov/pubmed/28035674 DTKLMH6 TI DTKLMH6 DTKLMH6 TN Cystine/glutamate transporter DTKLMH6 DI DM4PUDW DTKLMH6 DN L-glutamic acid DTKLMH6 MA Substrate DTKLMH6 RA The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem. 2017 Aug 25;292(34):14240-14249. DTKLMH6 RU http://www.ncbi.nlm.nih.gov/pubmed/28630042 DTKMECW TI DTKMECW DTKMECW TN Zinc transporter 3 DTKMECW DI DMZ4R3Q DTKMECW DN Zinc salts DTKMECW MA Substrate DTKMECW RA Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec 9;5:17816. DTKMECW RU http://www.ncbi.nlm.nih.gov/pubmed/26647834 DTKNH2D TI DTKNH2D DTKNH2D TN Sodium/glucose cotransporter 2 DTKNH2D DI DMMG2TO DTKNH2D DN D-glucose DTKNH2D MA Substrate DTKNH2D RA The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. DTKNH2D RU http://www.ncbi.nlm.nih.gov/pubmed/24587162 DTKPHZ6 TI DTKPHZ6 DTKPHZ6 TN Solute carrier family 45 member 4 DTKPHZ6 DI DMVWUCF DTKPHZ6 DN Sucrose DTKPHZ6 MA Substrate DTKPHZ6 RA The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):655-60. DTKPHZ6 RU http://www.ncbi.nlm.nih.gov/pubmed/23506898 DTKPRIL TI DTKPRIL DTKPRIL TN Zinc transporter 6 DTKPRIL DI DMZ4R3Q DTKPRIL DN Zinc salts DTKPRIL MA Substrate DTKPRIL RA Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes Nutr. 2015 Sep;10(5):487. DTKPRIL RU http://www.ncbi.nlm.nih.gov/pubmed/26319140 DTKS517 TI DTKS517 DTKS517 TN Sodium-dependent phosphate transport protein 2C DTKS517 DI DMJ3CFY DTKS517 DN Calcium phosphate dihydrate DTKS517 MA Substrate DTKS517 RA Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DTKS517 RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DTKVEXO TI DTKVEXO DTKVEXO TN ATP-binding cassette sub-family B member 5 DTKVEXO DI DMVP5YE DTKVEXO DN Doxorubicin DTKVEXO MA Substrate DTKVEXO RA ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005 May 15;65(10):4320-33. DTKVEXO RU http://www.ncbi.nlm.nih.gov/pubmed/15899824 DTKVEXO TI DTKVEXO DTKVEXO TN ATP-binding cassette sub-family B member 5 DTKVEXO DI DM7W94S DTKVEXO DN Brigatinib DTKVEXO MA Substrate DTKVEXO RA NDA/BLA Multidisciplinary Review and Evaluation of ALUNBRIG (brigatinib) From FDA. DTKVEXO RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208772Orig1s000MultidisciplineR.pdf DTKVEXO TI DTKVEXO DTKVEXO TN ATP-binding cassette sub-family B member 5 DTKVEXO DI DM6AUHV DTKVEXO DN Fostamatinib DTKVEXO MA Substrate DTKVEXO RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB12010) DTKVEXO RU https://www.drugbank.ca/drugs/DB12010 DTKWJH3 TI DTKWJH3 DTKWJH3 TN Sodium-coupled neutral amino acid transporter 3 DTKWJH3 DI DM69G8X DTKWJH3 DN L-glutamine DTKWJH3 MA Substrate DTKWJH3 RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTKWJH3 RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTKWJH3 TI DTKWJH3 DTKWJH3 TN Sodium-coupled neutral amino acid transporter 3 DTKWJH3 DI DMENSL5 DTKWJH3 DN Aminosalicylic acid DTKWJH3 MA Substrate DTKWJH3 RA Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66. DTKWJH3 RU http://www.ncbi.nlm.nih.gov/pubmed/10794727 DTKWJH3 TI DTKWJH3 DTKWJH3 TN Sodium-coupled neutral amino acid transporter 3 DTKWJH3 DI DMZDN4W DTKWJH3 DN L-alanine DTKWJH3 MA Substrate DTKWJH3 RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTKWJH3 RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTKWJH3 TI DTKWJH3 DTKWJH3 TN Sodium-coupled neutral amino acid transporter 3 DTKWJH3 DI DMEMBJC DTKWJH3 DN Folic acid DTKWJH3 MA Substrate DTKWJH3 RA Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol. 1995 Jun 16;49(12):1759-67. DTKWJH3 RU http://www.ncbi.nlm.nih.gov/pubmed/7598738 DTKXTPW TI DTKXTPW DTKXTPW TN Sodium/dicarboxylate cotransporter 3 DTKXTPW DI DM5LFYN DTKXTPW DN Alpha-ketoglutaric acid DTKXTPW MA Substrate DTKXTPW RA SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395. DTKXTPW RU http://www.ncbi.nlm.nih.gov/pubmed/30635937 DTKXTPW TI DTKXTPW DTKXTPW TN Sodium/dicarboxylate cotransporter 3 DTKXTPW DI DML3HEM DTKXTPW DN Dicarboxylate DTKXTPW MA Substrate DTKXTPW RA SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395. DTKXTPW RU http://www.ncbi.nlm.nih.gov/pubmed/30635937 DTKXTPW TI DTKXTPW DTKXTPW TN Sodium/dicarboxylate cotransporter 3 DTKXTPW DI DMPY09A DTKXTPW DN Succinate DTKXTPW MA Substrate DTKXTPW RA SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395. DTKXTPW RU http://www.ncbi.nlm.nih.gov/pubmed/30635937 DTL8VXO TI DTL8VXO DTL8VXO TN Zrt- and Irt-like protein 2 DTL8VXO DI DMZ4R3Q DTL8VXO DN Zinc salts DTL8VXO MA Substrate DTL8VXO RA Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. Biochemistry. 2018 Jul 3;57(26):3976-3986. DTL8VXO RU http://www.ncbi.nlm.nih.gov/pubmed/29791142 DTLA4Q2 TI DTLA4Q2 DTLA4Q2 TN Thiamine transporter 1 DTLA4Q2 DI DM89QE1 DTLA4Q2 DN Metformin DTLA4Q2 MA Substrate DTLA4Q2 RA Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7;12(12):4301-10. DTLA4Q2 RU http://www.ncbi.nlm.nih.gov/pubmed/26528626 DTLHZFU TI DTLHZFU DTLHZFU TN Glucose-6-phosphate translocase DTLHZFU DI DMKY1L4 DTLHZFU DN Glucose-6-phosphate DTLHZFU MA Substrate DTLHZFU RA A novel mutation (A148V) in the glucose 6-phosphate translocase (SLC37A4) gene in a Korean patient with glycogen storage disease type 1b. J Korean Med Sci. 2005 Jun;20(3):499-501. DTLHZFU RU http://www.ncbi.nlm.nih.gov/pubmed/15953877 DTLMGFJ TI DTLMGFJ DTLMGFJ TN Adenine nucleotide translocator 3 DTLMGFJ DI DMZLHKJ DTLMGFJ DN Adenine DTLMGFJ MA Substrate DTLMGFJ RA Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Mol Biol Cell. 2007 Nov;18(11):4681-9. DTLMGFJ RU http://www.ncbi.nlm.nih.gov/pubmed/17855512 DTLPQGT TI DTLPQGT DTLPQGT TN Zrt- and Irt-like protein 8 DTLPQGT DI DMZ4R3Q DTLPQGT DN Zinc salts DTLPQGT MA Substrate DTLPQGT RA Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83. DTLPQGT RU http://www.ncbi.nlm.nih.gov/pubmed/18936201 DTLQ0EZ TI DTLQ0EZ DTLQ0EZ TN Calcium-binding mitochondrial carrier protein SCaMC-3 DTLQ0EZ DI DMUXQG7 DTLQ0EZ DN Phosphate DTLQ0EZ MA Substrate DTLQ0EZ RA Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene. 2005 Jan 31;345(2):173-82. DTLQ0EZ RU http://www.ncbi.nlm.nih.gov/pubmed/15716113 DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DMF28YC DTLT3UG DN Atorvastatin DTLT3UG MA Substrate DTLT3UG RA Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DTLT3UG RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DM2F8XZ DTLT3UG DN Salicylic acid DTLT3UG MA Substrate DTLT3UG RA Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy. Clin Transl Sci. 2018 Jul;11(4):352-364. DTLT3UG RU http://www.ncbi.nlm.nih.gov/pubmed/29660777 DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DM3NC4M DTLT3UG DN Quercetin DTLT3UG MA Substrate DTLT3UG RA Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DTLT3UG RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DM8VCBE DTLT3UG DN Ibuprofen DTLT3UG MA Substrate DTLT3UG RA Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DTLT3UG RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DMWDHUZ DTLT3UG DN Propicillin DTLT3UG MA Substrate DTLT3UG RA Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DTLT3UG RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DMCFE9I DTLT3UG DN Valproic Acid DTLT3UG MA Substrate DTLT3UG RA Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DTLT3UG RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DTLT3UG TI DTLT3UG DTLT3UG TN Monocarboxylate transporter 2 DTLT3UG DI DM462BT DTLT3UG DN Milchsaure DTLT3UG MA Substrate DTLT3UG RA Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. DTLT3UG RU http://www.ncbi.nlm.nih.gov/pubmed/10417314 DTLWPXS TI DTLWPXS DTLWPXS TN Zrt- and Irt-like protein 1 DTLWPXS DI DMZ4R3Q DTLWPXS DN Zinc salts DTLWPXS MA Substrate DTLWPXS RA SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24. DTLWPXS RU http://www.ncbi.nlm.nih.gov/pubmed/27118869 DTLX28N TI DTLX28N DTLX28N TN Sodium-coupled neutral amino acid transporter 5 DTLX28N DI DM69G8X DTLX28N DN L-glutamine DTLX28N MA Substrate DTLX28N RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTLX28N RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTLX28N TI DTLX28N DTLX28N TN Sodium-coupled neutral amino acid transporter 5 DTLX28N DI DMZDN4W DTLX28N DN L-alanine DTLX28N MA Substrate DTLX28N RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTLX28N RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTLYEPH TI DTLYEPH DTLYEPH TN ATP-binding cassette sub-family G member 1 DTLYEPH DI DMR3J6S DTLYEPH DN Cholesterol DTLYEPH MA Substrate DTLYEPH RA Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):139-43. DTLYEPH RU http://www.ncbi.nlm.nih.gov/pubmed/19797709 DTM301H TI DTM301H DTM301H TN Sodium-coupled monocarboxylate transporter 2 DTM301H DI DM2F8XZ DTM301H DN Salicylic acid DTM301H MA Substrate DTM301H RA Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. DTM301H RU http://www.ncbi.nlm.nih.gov/pubmed/18446519 DTM301H TI DTM301H DTM301H TN Sodium-coupled monocarboxylate transporter 2 DTM301H DI DMGBKVD DTM301H DN Gamma-hydroxybutyric acid DTM301H MA Substrate DTM301H RA Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. DTM301H RU http://www.ncbi.nlm.nih.gov/pubmed/18446519 DTM301H TI DTM301H DTM301H TN Sodium-coupled monocarboxylate transporter 2 DTM301H DI DMKB9FI DTM301H DN Benzoic acid DTM301H MA Substrate DTM301H RA Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. DTM301H RU http://www.ncbi.nlm.nih.gov/pubmed/18446519 DTM4YG0 TI DTM4YG0 DTM4YG0 TN ATP-binding cassette sub-family A member 4 DTM4YG0 DI DMOPYWF DTM4YG0 DN Phosphatidylethanolamine DTM4YG0 MA Substrate DTM4YG0 RA The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010;703:105-25. DTM4YG0 RU http://www.ncbi.nlm.nih.gov/pubmed/20711710 DTM8E7H TI DTM8E7H DTM8E7H TN Mitochondrial folate transporter/carrier DTM8E7H DI DMEMBJC DTM8E7H DN Folic acid DTM8E7H MA Substrate DTM8E7H RA Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women. Geriatr Gerontol Int. 2014 Oct;14(4):942-6. DTM8E7H RU http://www.ncbi.nlm.nih.gov/pubmed/24354357 DTM953D TI DTM953D DTM953D TN Vesicular amine transporter 1 DTM953D DI DM78IME DTM953D DN Ergotidine DTM953D MA Substrate DTM953D RA Gastrin-producing endocrine cells: a novel source of histamine in the rat stomach. Endocrinology. 1998 Oct;139(10):4404-15. DTM953D RU http://www.ncbi.nlm.nih.gov/pubmed/9751525 DTM953D TI DTM953D DTM953D TN Vesicular amine transporter 1 DTM953D DI DMOUC09 DTM953D DN Norepinephrine DTM953D MA Substrate DTM953D RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DTM953D RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DTM953D TI DTM953D DTM953D TN Vesicular amine transporter 1 DTM953D DI DMOFCRY DTM953D DN Serotonin DTM953D MA Substrate DTM953D RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DTM953D RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DTM953D TI DTM953D DTM953D TN Vesicular amine transporter 1 DTM953D DI DMPGUCF DTM953D DN Dopamine DTM953D MA Substrate DTM953D RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DTM953D RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DTMA4FJ TI DTMA4FJ DTMA4FJ TN Electroneutral potassium-chloride cotransporter 3 DTMA4FJ DI DMMTAJC DTMA4FJ DN Potassium chloride DTMA4FJ MA Substrate DTMA4FJ RA Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site. Neuropsychopharmacology. 2009 Jan;34(2):458-67. DTMA4FJ RU http://www.ncbi.nlm.nih.gov/pubmed/18536702 DTMALXP TI DTMALXP DTMALXP TN UDP-xylose and UDP-N-acetylglucosamine transporter DTMALXP DI DMVE7MZ DTMALXP DN Udp-xylose DTMALXP MA Substrate DTMALXP RA The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. J Biol Chem. 2005 Jul 22;280(29):27230-5. DTMALXP RU http://www.ncbi.nlm.nih.gov/pubmed/15911612 DTMEQ32 TI DTMEQ32 DTMEQ32 TN Organic solute transporter subunit alpha DTMEQ32 DI DMQCTIH DTMEQ32 DN Digoxin DTMEQ32 MA Substrate DTMEQ32 RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DTMEQ32 RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DTMEQ32 TI DTMEQ32 DTMEQ32 TN Organic solute transporter subunit alpha DTMEQ32 DI DMTYOPD DTMEQ32 DN Dinoprostone DTMEQ32 MA Substrate DTMEQ32 RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DTMEQ32 RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DTMEQ32 TI DTMEQ32 DTMEQ32 TN Organic solute transporter subunit alpha DTMEQ32 DI DMTYOPD DTMEQ32 DN Dinoprostone DTMEQ32 MA Substrate DTMEQ32 RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DTMEQ32 RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DTMEQ32 TI DTMEQ32 DTMEQ32 TN Organic solute transporter subunit alpha DTMEQ32 DI DM2LZ8F DTMEQ32 DN Taurocholic acid DTMEQ32 MA Substrate DTMEQ32 RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DTMEQ32 RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DTMEQ32 TI DTMEQ32 DTMEQ32 TN Organic solute transporter subunit alpha DTMEQ32 DI DMVBIZL DTMEQ32 DN Estrone sulfate DTMEQ32 MA Substrate DTMEQ32 RA Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DTMEQ32 RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DTMF8LB TI DTMF8LB DTMF8LB TN Urea transporter 1 DTMF8LB DI DMAEQB6 DTMF8LB DN Methylurea DTMF8LB MA Substrate DTMF8LB RA Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim Biophys Acta. 2007 Jul;1768(7):1815-21. DTMF8LB RU http://www.ncbi.nlm.nih.gov/pubmed/17506977 DTMF8LB TI DTMF8LB DTMF8LB TN Urea transporter 1 DTMF8LB DI DMUELHN DTMF8LB DN Thiourea DTMF8LB MA Substrate DTMF8LB RA Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol. 1996 Dec;271(6 Pt 2):F1264-8. DTMF8LB RU http://www.ncbi.nlm.nih.gov/pubmed/8997401 DTMJK12 TI DTMJK12 DTMJK12 TN Solute carrier family 22 member 23 DTMJK12 DI DM1N62C DTMJK12 DN Quetiapine DTMJK12 MA Substrate DTMJK12 RA Genome-wide association study of antipsychotic-induced QTc interval prolongation. Pharmacogenomics J. 2012 Apr;12(2):165-72. DTMJK12 RU http://www.ncbi.nlm.nih.gov/pubmed/20921969 DTMSNOU TI DTMSNOU DTMSNOU TN Proton-associated sugar transporter A DTMSNOU DI DMIAHVU DTMSNOU DN 2-Deoxyglucose DTMSNOU MA Substrate DTMSNOU RA Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Am J Hum Genet. 2017 May 4;100(5):824-830. DTMSNOU RU http://www.ncbi.nlm.nih.gov/pubmed/28434495 DTMULXV TI DTMULXV DTMULXV TN Sodium-dependent phosphate transporter 1 DTMULXV DI DMUXQG7 DTMULXV DN Phosphate DTMULXV MA Substrate DTMULXV RA Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DTMULXV RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DTMWE5P TI DTMWE5P DTMWE5P TN Sodium-independent aspartate/glutamate transporter 1 DTMWE5P DI DM4PUDW DTMWE5P DN L-glutamic acid DTMWE5P MA Substrate DTMWE5P RA Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):775-80. DTMWE5P RU http://www.ncbi.nlm.nih.gov/pubmed/26739563 DTN7X5J TI DTN7X5J DTN7X5J TN Calcium-binding mitochondrial carrier protein SCaMC-2 DTN7X5J DI DMUXQG7 DTN7X5J DN Phosphate DTN7X5J MA Substrate DTN7X5J RA Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Sci Rep. 2017 Jun 6;7(1):2885. DTN7X5J RU http://www.ncbi.nlm.nih.gov/pubmed/28588221 DTN9ACR TI DTN9ACR DTN9ACR TN Zrt- and Irt-like protein 5 DTN9ACR DI DMZ4R3Q DTN9ACR DN Zinc salts DTN9ACR MA Substrate DTN9ACR RA The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem. 2004 Dec 3;279(49):51433-41. DTN9ACR RU http://www.ncbi.nlm.nih.gov/pubmed/15322118 DTNCJAT TI DTNCJAT DTNCJAT TN Membrane-associated transporter protein DTNCJAT DI DMVWUCF DTNCJAT DN Sucrose DTNCJAT MA Substrate DTNCJAT RA Identification of amino acids important for substrate specificity in sucrose transporters using gene shuffling. J Biol Chem. 2012 Aug 31;287(36):30296-304. DTNCJAT RU http://www.ncbi.nlm.nih.gov/pubmed/22807445 DTNK0FR TI DTNK0FR DTNK0FR TN Vesicular glutamate transporter 1 DTNK0FR DI DM4PUDW DTNK0FR DN L-glutamic acid DTNK0FR MA Substrate DTNK0FR RA Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65. DTNK0FR RU http://www.ncbi.nlm.nih.gov/pubmed/15210307 DTNK0FR TI DTNK0FR DTNK0FR TN Vesicular glutamate transporter 1 DTNK0FR DI DMUXQG7 DTNK0FR DN Phosphate DTNK0FR MA Substrate DTNK0FR RA SLC17: a functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):350-9. DTNK0FR RU http://www.ncbi.nlm.nih.gov/pubmed/23506876 DTNU9EW TI DTNU9EW DTNU9EW TN Graves disease carrier protein DTNU9EW DI DM1I8LU DTNU9EW DN Coenzyme A DTNU9EW MA Substrate DTNU9EW RA Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):137-146. DTNU9EW RU http://www.ncbi.nlm.nih.gov/pubmed/27836698 DTO1UQY TI DTO1UQY DTO1UQY TN Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 DTO1UQY DI DMM3950 DTO1UQY DN Sodium chloride DTO1UQY MA Substrate DTO1UQY RA Upregulation of renal sodium transporters in D5 dopamine receptor-deficient mice. Hypertension. 2010 Jun;55(6):1431-7. DTO1UQY RU http://www.ncbi.nlm.nih.gov/pubmed/20404220 DTO1UQY TI DTO1UQY DTO1UQY TN Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 DTO1UQY DI DMMTAJC DTO1UQY DN Potassium chloride DTO1UQY MA Substrate DTO1UQY RA Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8. DTO1UQY RU http://www.ncbi.nlm.nih.gov/pubmed/24253496 DTO4FLB TI DTO4FLB DTO4FLB TN Sodium/glucose cotransporter 3 DTO4FLB DI DMIAHVU DTO4FLB DN 2-Deoxyglucose DTO4FLB MA Substrate DTO4FLB RA The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8. DTO4FLB RU http://www.ncbi.nlm.nih.gov/pubmed/12748858 DTOFXP5 TI DTOFXP5 DTOFXP5 TN MFS-type transporter SLC18B1 DTOFXP5 DI DMVJNFI DTOFXP5 DN Spermidine DTOFXP5 MA Substrate DTOFXP5 RA Identification of a mammalian vesicular polyamine transporter. Sci Rep. 2014 Oct 30;4:6836. DTOFXP5 RU http://www.ncbi.nlm.nih.gov/pubmed/25355561 DTOFXP5 TI DTOFXP5 DTOFXP5 TN MFS-type transporter SLC18B1 DTOFXP5 DI DMD4BFY DTOFXP5 DN Spermine DTOFXP5 MA Substrate DTOFXP5 RA Identification of a mammalian vesicular polyamine transporter. Sci Rep. 2014 Oct 30;4:6836. DTOFXP5 RU http://www.ncbi.nlm.nih.gov/pubmed/25355561 DTOKC04 TI DTOKC04 DTOKC04 TN Sodium/glucose cotransporter 1 DTOKC04 DI DMAHMSV DTOKC04 DN Fucose DTOKC04 MA Substrate DTOKC04 RA The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. DTOKC04 RU http://www.ncbi.nlm.nih.gov/pubmed/24587162 DTOKC04 TI DTOKC04 DTOKC04 TN Sodium/glucose cotransporter 1 DTOKC04 DI DMIAHVU DTOKC04 DN 2-Deoxyglucose DTOKC04 MA Substrate DTOKC04 RA The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. DTOKC04 RU http://www.ncbi.nlm.nih.gov/pubmed/24587162 DTOR02F TI DTOR02F DTOR02F TN Glucose transporter type 5 DTOR02F DI DM43AN2 DTOR02F DN Fructose DTOR02F MA Substrate DTOR02F RA Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function. Endocrinology. 2008 Jan;149(1):409-23. DTOR02F RU http://www.ncbi.nlm.nih.gov/pubmed/17947353 DTOSN46 TI DTOSN46 DTOSN46 TN Folate transporter 1 DTOSN46 DI DMAO80I DTOSN46 DN Pralatrexate DTOSN46 MA Substrate DTOSN46 RA Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210. DTOSN46 RU http://www.ncbi.nlm.nih.gov/pubmed/22921318 DTOSN46 TI DTOSN46 DTOSN46 TN Folate transporter 1 DTOSN46 DI DM2TEOL DTOSN46 DN Methotrexate DTOSN46 MA Substrate DTOSN46 RA Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204. DTOSN46 RU http://www.ncbi.nlm.nih.gov/pubmed/24745983 DTOSN46 TI DTOSN46 DTOSN46 TN Folate transporter 1 DTOSN46 DI DMMX2E6 DTOSN46 DN Pemetrexed DTOSN46 MA Substrate DTOSN46 RA Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204. DTOSN46 RU http://www.ncbi.nlm.nih.gov/pubmed/24745983 DTOSN46 TI DTOSN46 DTOSN46 TN Folate transporter 1 DTOSN46 DI DMEMBJC DTOSN46 DN Folic acid DTOSN46 MA Substrate DTOSN46 RA Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204. DTOSN46 RU http://www.ncbi.nlm.nih.gov/pubmed/24745983 DTOTKBS TI DTOTKBS DTOTKBS TN Zrt- and Irt-like protein 13 DTOTKBS DI DMZ4R3Q DTOTKBS DN Zinc salts DTOTKBS MA Substrate DTOTKBS RA Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3530-8. DTOTKBS RU http://www.ncbi.nlm.nih.gov/pubmed/23213233 DTOTME4 TI DTOTME4 DTOTME4 TN Anion exchange transporter DTOTME4 DI DMVFB93 DTOTME4 DN Nitrate DTOTME4 MA Substrate DTOTME4 RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6) DTOTME4 RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.6 DTOTME4 TI DTOTME4 DTOTME4 TN Anion exchange transporter DTOTME4 DI DM40SEU DTOTME4 DN Oxalate DTOTME4 MA Substrate DTOTME4 RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6) DTOTME4 RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.6 DTOTME4 TI DTOTME4 DTOTME4 TN Anion exchange transporter DTOTME4 DI DMW0ZBF DTOTME4 DN Sulfate DTOTME4 MA Substrate DTOTME4 RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6) DTOTME4 RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.6 DTOTME4 TI DTOTME4 DTOTME4 TN Anion exchange transporter DTOTME4 DI DMT5E36 DTOTME4 DN Bicarbonate DTOTME4 MA Substrate DTOTME4 RA Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201. DTOTME4 RU http://www.ncbi.nlm.nih.gov/pubmed/16352747 DTOUNZE TI DTOUNZE DTOUNZE TN UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter DTOUNZE DI DMLT4JA DTOUNZE DN UDP-glucose DTOUNZE MA Substrate DTOUNZE RA Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Genomics. 2005 Jan;85(1):106-16. DTOUNZE RU http://www.ncbi.nlm.nih.gov/pubmed/15607426 DTP7AEQ TI DTP7AEQ DTP7AEQ TN Glycoprotein-associated amino acid transporter b0, +AT1 DTP7AEQ DI DMT4K0Z DTP7AEQ DN L-citrulline DTP7AEQ MA Substrate DTP7AEQ RA Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. Biopharm Drug Dispos. 2009 Apr;30(3):126-37. DTP7AEQ RU http://www.ncbi.nlm.nih.gov/pubmed/19322909 DTP8L4F TI DTP8L4F DTP8L4F TN High affinity copper uptake protein 1 DTP8L4F DI DMP0NFQ DTP8L4F DN Cupric sulfate DTP8L4F MA Substrate DTP8L4F RA Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci. 2010 Jul 14;30(28):9500-9. DTP8L4F RU http://www.ncbi.nlm.nih.gov/pubmed/20631178 DTP8L4F TI DTP8L4F DTP8L4F TN High affinity copper uptake protein 1 DTP8L4F DI DMRHGI9 DTP8L4F DN Cisplatin DTP8L4F MA Substrate DTP8L4F RA Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61. DTP8L4F RU http://www.ncbi.nlm.nih.gov/pubmed/24122978 DTP8L4F TI DTP8L4F DTP8L4F TN High affinity copper uptake protein 1 DTP8L4F DI DMG281S DTP8L4F DN Carboplatin DTP8L4F MA Substrate DTP8L4F RA Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61. DTP8L4F RU http://www.ncbi.nlm.nih.gov/pubmed/24122978 DTP8L4F TI DTP8L4F DTP8L4F TN High affinity copper uptake protein 1 DTP8L4F DI DMQNWRD DTP8L4F DN Oxaliplatin DTP8L4F MA Substrate DTP8L4F RA Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs. Crit Rev Oncol Hematol. 2005 Jan;53(1):13-23. DTP8L4F RU http://www.ncbi.nlm.nih.gov/pubmed/15607932 DTPAQJO TI DTPAQJO DTPAQJO TN Monocarboxylate transporter 10 DTPAQJO DI DMIBH7M DTPAQJO DN L-tryptophan DTPAQJO MA Substrate DTPAQJO RA Phosphatidylserine synthesis required for the maximal tryptophan transport activity in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2000 Jan;64(1):167-72. DTPAQJO RU http://www.ncbi.nlm.nih.gov/pubmed/10705462 DTPATLS TI DTPATLS DTPATLS TN Fly-like putative transporter 2 DTPATLS DI DMVP5YE DTPATLS DN Doxorubicin DTPATLS MA Substrate DTPATLS RA Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer. 2010 Mar 16;102(6):1003-9. DTPATLS RU http://www.ncbi.nlm.nih.gov/pubmed/20179710 DTPATLS TI DTPATLS DTPATLS TN Fly-like putative transporter 2 DTPATLS DI DMJBOCR DTPATLS DN L-carnitine DTPATLS MA Substrate DTPATLS RA The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem. 2010 Feb 26;285(9):6275-84. DTPATLS RU http://www.ncbi.nlm.nih.gov/pubmed/20037140 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM4PUDW DTPFTEQ DN L-glutamic acid DTPFTEQ MA Substrate DTPFTEQ RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.20) DTPFTEQ RU http://www.tcdb.org/search/result.php?tc=2.A.60.1.20 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMOGFIX DTPFTEQ DN Eltrombopag DTPFTEQ MA Substrate DTPFTEQ RA Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug Metab Dispos. 2011 Jun;39(6):1088-96. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/21422191 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMS9503 DTPFTEQ DN Benzylpenicillin DTPFTEQ MA Substrate DTPFTEQ RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMD157S DTPFTEQ DN Montelukast DTPFTEQ MA Substrate DTPFTEQ RA Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans. J Clin Pharmacol. 2013 Nov;53(11):1186-93. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/23970434 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM17ONX DTPFTEQ DN Fexofenadine DTPFTEQ MA Substrate DTPFTEQ RA The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. Pharmacogenet Genomics. 2011 Feb;21(2):84-93. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/21280267 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMF28YC DTPFTEQ DN Atorvastatin DTPFTEQ MA Substrate DTPFTEQ RA Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009 May;37(5):1129-37. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/19237515 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMQCTIH DTPFTEQ DN Digoxin DTPFTEQ MA Substrate DTPFTEQ RA Drug Interactions in Infectious Diseases. DTPFTEQ RU http://www.springer.com/medicine/internal/book/978-1-61779-212-0 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM6A0X7 DTPFTEQ DN Pravastatin DTPFTEQ MA Substrate DTPFTEQ RA Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/14610227 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMICA9H DTPFTEQ DN Sulfasalazine DTPFTEQ MA Substrate DTPFTEQ RA Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP. J Pharm Sci. 2017 Sep;106(9):2688-2694. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/28322941 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM3GO0J DTPFTEQ DN Sodium taurocholate DTPFTEQ MA Substrate DTPFTEQ RA Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/14610227 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMXCM7H DTPFTEQ DN Cerivastatin DTPFTEQ MA Substrate DTPFTEQ RA pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1. Mol Pharm. 2011 Aug 1;8(4):1303-13. DTPFTEQ RU https://doi.org/10.1021/mp200103h DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM1BV7W DTPFTEQ DN Aliskiren fumarate DTPFTEQ MA Substrate DTPFTEQ RA Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol. 2011 May;71(5):718-26. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/21204914 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMRTD16 DTPFTEQ DN Talinolol DTPFTEQ MA Substrate DTPFTEQ RA Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther. 2010 Jan;332(1):181-9. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/19779132 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM2EXC5 DTPFTEQ DN Latanoprostene bunod DTPFTEQ MA Substrate DTPFTEQ RA The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/20019365 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM8JXPZ DTPFTEQ DN Glibenclamide DTPFTEQ MA Substrate DTPFTEQ RA Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/15640378 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM9R2SD DTPFTEQ DN M17055 DTPFTEQ MA Substrate DTPFTEQ RA Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B. Pharm Res. 2007 Jan;24(1):90-8. DTPFTEQ RU https://doi.org/10.1007/s11095-006-9127-x DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMANBZI DTPFTEQ DN Abiraterone Acetate DTPFTEQ MA Substrate DTPFTEQ RA The impact of statin use on the efficacy of abiraterone acetate in patients with castration-resistant prostate cancer. Prostate. 2017 May;77(13):1303-1311. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/28762529 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMTYOPD DTPFTEQ DN Dinoprostone DTPFTEQ MA Substrate DTPFTEQ RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM4MDJY DTPFTEQ DN Fluvastatin DTPFTEQ MA Substrate DTPFTEQ RA Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos. 2007 Aug;35(8):1308-14. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/17470528 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM2LZ8F DTPFTEQ DN Taurocholic acid DTPFTEQ MA Substrate DTPFTEQ RA Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/14610227 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMNH3PG DTPFTEQ DN Etoposide DTPFTEQ MA Substrate DTPFTEQ RA Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847. DTPFTEQ RU https://doi.org/10.1111/j.1476-5381.2011.01672.x DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMOL5IU DTPFTEQ DN Mesalazine DTPFTEQ MA Substrate DTPFTEQ RA Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. Drug Metab Dispos. 2011 Jun;39(6):1097-102. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/21430235 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMI5OXG DTPFTEQ DN Latanoprost DTPFTEQ MA Substrate DTPFTEQ RA The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/20019365 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM1UJO0 DTPFTEQ DN Pitavastatin calcium DTPFTEQ MA Substrate DTPFTEQ RA Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab Dispos. 2006 Jul;34(7):1229-36. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/16595711 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMMIQ7G DTPFTEQ DN Rosuvastatin DTPFTEQ MA Substrate DTPFTEQ RA Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMY9BMK DTPFTEQ DN Rocuronium DTPFTEQ MA Substrate DTPFTEQ RA Drug Interactions in Infectious Diseases. DTPFTEQ RU http://www.springer.com/medicine/internal/book/978-1-61779-212-0 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMS3GX2 DTPFTEQ DN Telmisartan DTPFTEQ MA Substrate DTPFTEQ RA Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide. Drug Metab Dispos. 2008 Apr;36(4):796-805. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/18180273 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM4WVC5 DTPFTEQ DN Lifitegrast DTPFTEQ MA Substrate DTPFTEQ RA Clinical Pharmacology and Biopharmaceutics review(s) DTPFTEQ RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208073Orig1s000ClinPharmR.pdf DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMIOGBU DTPFTEQ DN Bosentan DTPFTEQ MA Substrate DTPFTEQ RA Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM9W2ZV DTPFTEQ DN Bromsulphthalein DTPFTEQ MA Substrate DTPFTEQ RA Organic anion-transporting polypeptide (OATP) 2B1 contributes to the cellular uptake of theaflavin. Drug Metab Pharmacokinet. 2017 Apr;32(2):145-150. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/28190756 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMMX2E6 DTPFTEQ DN Pemetrexed DTPFTEQ MA Substrate DTPFTEQ RA Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1). Mol Pharmacol. 2012 Feb;81(2):134-42. DTPFTEQ RU https://doi.org/10.1124/mol.111.074823 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMU764S DTPFTEQ DN Ritonavir DTPFTEQ MA Substrate DTPFTEQ RA pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions. J Pharmacol Exp Ther. 2010 Sep 1;334(3):1009-22. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/20507927 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMVBIZL DTPFTEQ DN Estrone sulfate DTPFTEQ MA Substrate DTPFTEQ RA Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos. 2007 Aug;35(8):1308-14. DTPFTEQ RU http://www.ncbi.nlm.nih.gov/pubmed/17470528 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DM4Q80H DTPFTEQ DN Dehydroepiandrosterone sulfate DTPFTEQ MA Substrate DTPFTEQ RA Expression of OATP family members in hormone-related cancers: potential markers of progression. PLoS One. 2011;6(5):e20372. DTPFTEQ RU https://doi.org/10.1371/journal.pone.0020372 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMJH792 DTPFTEQ DN Pitavastatin DTPFTEQ MA Substrate DTPFTEQ RA Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. Drug Metab Pharmacokinet. 2011;26(2):171-9. DTPFTEQ RU https://doi.org/10.2133/dmpk.DMPK-10-RG-073 DTPFTEQ TI DTPFTEQ DTPFTEQ TN Organic anion transporting polypeptide 2B1 DTPFTEQ DI DMJT1E5 DTPFTEQ DN Scutellarin DTPFTEQ MA Substrate DTPFTEQ RA Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DTPFTEQ RU https://doi.org/10.1124/dmd.112.047183 DTPJBD5 TI DTPJBD5 DTPJBD5 TN Sodium-coupled neutral amino acid transporter 4 DTPJBD5 DI DM69G8X DTPJBD5 DN L-glutamine DTPJBD5 MA Substrate DTPJBD5 RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTPJBD5 RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTPJBD5 TI DTPJBD5 DTPJBD5 TN Sodium-coupled neutral amino acid transporter 4 DTPJBD5 DI DMZDN4W DTPJBD5 DN L-alanine DTPJBD5 MA Substrate DTPJBD5 RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTPJBD5 RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTPKTHL TI DTPKTHL DTPKTHL TN Creatine transporter 1 DTPKTHL DI DMKD2BQ DTPKTHL DN Creatine ALS-08 DTPKTHL MA Substrate DTPKTHL RA Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DTPKTHL RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DTPS120 TI DTPS120 DTPS120 TN Multidrug resistance-associated protein 7 DTPS120 DI DMLB0EZ DTPS120 DN Tamoxifen DTPS120 MA Substrate DTPS120 RA Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67. DTPS120 RU http://www.ncbi.nlm.nih.gov/pubmed/23087055 DTPS120 TI DTPS120 DTPS120 TN Multidrug resistance-associated protein 7 DTPS120 DI DM1IS6U DTPS120 DN Tenofovir DTPS120 MA Substrate DTPS120 RA Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. J Infect Dis. 2011 Jul 1;204(1):145-53. DTPS120 RU http://www.ncbi.nlm.nih.gov/pubmed/21628669 DTPS120 TI DTPS120 DTPS120 TN Multidrug resistance-associated protein 7 DTPS120 DI DMDI269 DTPS120 DN Docetaxel DTPS120 MA Substrate DTPS120 RA Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67. DTPS120 RU http://www.ncbi.nlm.nih.gov/pubmed/23087055 DTPS120 TI DTPS120 DTPS120 TN Multidrug resistance-associated protein 7 DTPS120 DI DMLB81S DTPS120 DN Paclitaxel DTPS120 MA Substrate DTPS120 RA Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67. DTPS120 RU http://www.ncbi.nlm.nih.gov/pubmed/23087055 DTPYCQ4 TI DTPYCQ4 DTPYCQ4 TN Organic anion transporting polypeptide 1C1 DTPYCQ4 DI DMTYOPD DTPYCQ4 DN Dinoprostone DTPYCQ4 MA Substrate DTPYCQ4 RA Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. DTPYCQ4 RU http://www.ncbi.nlm.nih.gov/pubmed/12351693 DTPYCQ4 TI DTPYCQ4 DTPYCQ4 TN Organic anion transporting polypeptide 1C1 DTPYCQ4 DI DMHN027 DTPYCQ4 DN Levothyroxine DTPYCQ4 MA Substrate DTPYCQ4 RA Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. DTPYCQ4 RU http://www.ncbi.nlm.nih.gov/pubmed/12351693 DTPYCQ4 TI DTPYCQ4 DTPYCQ4 TN Organic anion transporting polypeptide 1C1 DTPYCQ4 DI DM3KJ45 DTPYCQ4 DN Estradiol-17beta-glucuronide DTPYCQ4 MA Substrate DTPYCQ4 RA The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. Endocrinology. 2009 Nov;150(11):5153-62. DTPYCQ4 RU http://www.ncbi.nlm.nih.gov/pubmed/19819953 DTPYCQ4 TI DTPYCQ4 DTPYCQ4 TN Organic anion transporting polypeptide 1C1 DTPYCQ4 DI DM6IR3P DTPYCQ4 DN Liothyronine DTPYCQ4 MA Substrate DTPYCQ4 RA Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91. DTPYCQ4 RU http://www.ncbi.nlm.nih.gov/pubmed/15166123 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM4XAU7 DTQ23VB DN Prostaglandin f2Alpha DTQ23VB MA Substrate DTQ23VB RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM4KI7O DTQ23VB DN Zidovudine DTQ23VB MA Substrate DTQ23VB RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMA13GD DTQ23VB DN Cidofovir DTQ23VB MA Substrate DTQ23VB RA Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/17372702 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMUN54G DTQ23VB DN Aminohippuric acid DTQ23VB MA Substrate DTQ23VB RA Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology. Leg Med (Tokyo). 2011 Jul;13(4):180-5. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/21561794 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMPUFDS DTQ23VB DN Glutarate DTQ23VB MA Substrate DTQ23VB RA Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/10929807 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM1MBYQ DTQ23VB DN Ganciclovir DTQ23VB MA Substrate DTQ23VB RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMU4T9Y DTQ23VB DN Dimesna DTQ23VB MA Substrate DTQ23VB RA In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52(4):530-42. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/21505084 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMG2YBD DTQ23VB DN Trifluridine DTQ23VB MA Substrate DTQ23VB RA Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/10945832 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM8ZHP1 DTQ23VB DN Edaravone DTQ23VB MA Substrate DTQ23VB RA Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/17502342 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMTYOPD DTQ23VB DN Dinoprostone DTQ23VB MA Substrate DTQ23VB RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMQTFAO DTQ23VB DN Fluorescein DTQ23VB MA Substrate DTQ23VB RA Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem. 2004;14(3):177-86. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/15107594 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMWBHRY DTQ23VB DN Olmesartan medoxomil DTQ23VB MA Substrate DTQ23VB RA Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMPDYFR DTQ23VB DN Cefazolin DTQ23VB MA Substrate DTQ23VB RA Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/14984259 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMYLOVR DTQ23VB DN Acyclovir DTQ23VB MA Substrate DTQ23VB RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMA1MKT DTQ23VB DN Uric acid DTQ23VB MA Substrate DTQ23VB RA Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/17674156 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM1IS6U DTQ23VB DN Tenofovir DTQ23VB MA Substrate DTQ23VB RA Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):641-8. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11563082 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMUYNEI DTQ23VB DN Amoxicillin DTQ23VB MA Substrate DTQ23VB RA The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11744606 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMWH7NQ DTQ23VB DN Alprostadil DTQ23VB MA Substrate DTQ23VB RA Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3. Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/26692285 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMRL3AB DTQ23VB DN Famotidine DTQ23VB MA Substrate DTQ23VB RA Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/15496291 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM2KEW6 DTQ23VB DN Ochratoxin A DTQ23VB MA Substrate DTQ23VB RA Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/11669456 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM62UHC DTQ23VB DN Meropenem DTQ23VB MA Substrate DTQ23VB RA Characterization of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem as substrates of human renal transporters. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):41-7. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/17329910 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMGO72P DTQ23VB DN Oseltamivir DTQ23VB MA Substrate DTQ23VB RA FDA Drug Development and Drug Interactions DTQ23VB RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMMQ8ZG DTQ23VB DN Furosemide DTQ23VB MA Substrate DTQ23VB RA Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMJXDGC DTQ23VB DN Cefaclor DTQ23VB MA Substrate DTQ23VB RA FDA Drug Development and Drug Interactions DTQ23VB RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM2TEOL DTQ23VB DN Methotrexate DTQ23VB MA Substrate DTQ23VB RA Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/20460822 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DM3VOGS DTQ23VB DN Ceftizoxime DTQ23VB MA Substrate DTQ23VB RA FDA Drug Development and Drug Interactions DTQ23VB RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMH7MUV DTQ23VB DN Zalcitabine DTQ23VB MA Substrate DTQ23VB RA Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/16724555 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMM278X DTQ23VB DN Adefovir DTQ23VB MA Substrate DTQ23VB RA Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol. 2000 Mar;11(3):383-93. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/10703662 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMWTMDH DTQ23VB DN 6-Carboxyfluorescein DTQ23VB MA Substrate DTQ23VB RA Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/10929807 DTQ23VB TI DTQ23VB DTQ23VB TN Organic anion transporter 1 DTQ23VB DI DMYTN18 DTQ23VB DN Mycophenolic acid DTQ23VB MA Substrate DTQ23VB RA Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3. Biochem Pharmacol. 2007 Jun 30;74(1):161-8. DTQ23VB RU http://www.ncbi.nlm.nih.gov/pubmed/17462604 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMLW57T DTQ3ZHF DN Teniposide DTQ3ZHF MA Substrate DTQ3ZHF RA Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/11581266 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM17ONX DTQ3ZHF DN Fexofenadine DTQ3ZHF MA Substrate DTQ3ZHF RA Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/18245269 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM3GO0J DTQ3ZHF DN Sodium taurocholate DTQ3ZHF MA Substrate DTQ3ZHF RA Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/12924948 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMUM7HZ DTQ3ZHF DN Fluorouracil DTQ3ZHF MA Substrate DTQ3ZHF RA ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/19077464 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM8JXPZ DTQ3ZHF DN Glibenclamide DTQ3ZHF MA Substrate DTQ3ZHF RA Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/16460798 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMC0GSJ DTQ3ZHF DN Efavirenz DTQ3ZHF MA Substrate DTQ3ZHF RA Induction of multiple drug transporters by efavirenz. J Pharmacol Sci. 2009 Feb;109(2):242-50. DTQ3ZHF RU https://doi.org/10.1254/jphs.08209FP DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM0SXNM DTQ3ZHF DN Glycocholic acid DTQ3ZHF MA Substrate DTQ3ZHF RA Measurement of transport activities of bile acids in human multidrug resistance-associated protein 3 using liquid chromatography-tandem mass spectrometry. Anal Sci. 2010;26(3):317-23. DTQ3ZHF RU https://doi.org/10.2116/analsci.26.317 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM7A8TW DTQ3ZHF DN Ezetimibe DTQ3ZHF MA Substrate DTQ3ZHF RA Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/19443695 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM2LZ8F DTQ3ZHF DN Taurocholic acid DTQ3ZHF MA Substrate DTQ3ZHF RA Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/12924948 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMNH3PG DTQ3ZHF DN Etoposide DTQ3ZHF MA Substrate DTQ3ZHF RA Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/19334674 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMGV8QU DTQ3ZHF DN Etravirine DTQ3ZHF MA Substrate DTQ3ZHF RA Interaction potential of etravirine with drug transporters assessed in vitro. Antimicrob Agents Chemother. 2011 Mar;55(3):1282-4. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/21189339 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM3KJ45 DTQ3ZHF DN Estradiol-17beta-glucuronide DTQ3ZHF MA Substrate DTQ3ZHF RA Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/12924948 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM2TEOL DTQ3ZHF DN Methotrexate DTQ3ZHF MA Substrate DTQ3ZHF RA Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/12731885 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM8M2N3 DTQ3ZHF DN Glycyrrhizin DTQ3ZHF MA Substrate DTQ3ZHF RA The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins. Int J Oncol. 2007 Dec;31(6):1465-72. DTQ3ZHF RU http://www.spandidos-publications.com/ijo/31/6/1465 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMRMS0L DTQ3ZHF DN Morphine DTQ3ZHF MA Substrate DTQ3ZHF RA Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/16586096 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMMC345 DTQ3ZHF DN Cefadroxil DTQ3ZHF MA Substrate DTQ3ZHF RA Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMEMBJC DTQ3ZHF DN Folic acid DTQ3ZHF MA Substrate DTQ3ZHF RA Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/11585759 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMUAZWG DTQ3ZHF DN Leucovorin DTQ3ZHF MA Substrate DTQ3ZHF RA Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/11585759 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMLB81S DTQ3ZHF DN Paclitaxel DTQ3ZHF MA Substrate DTQ3ZHF RA Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res. 2008 Jul 1;68(13):5380-9. DTQ3ZHF RU https://doi.org/10.1158/0008-5472.CAN-08-0234 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMVNR20 DTQ3ZHF DN Epipodophyllotoxins DTQ3ZHF MA Substrate DTQ3ZHF RA Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/11581266 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMUEWM3 DTQ3ZHF DN Technetium (99MTC) mebrofenin DTQ3ZHF MA Substrate DTQ3ZHF RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTQ3ZHF RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DM4Q80H DTQ3ZHF DN Dehydroepiandrosterone sulfate DTQ3ZHF MA Substrate DTQ3ZHF RA Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci. 2006 Apr;27(5):447-86. DTQ3ZHF RU https://doi.org/10.1016/j.ejps.2005.12.007 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMALN2M DTQ3ZHF DN Cholyl lysyl fluorescein DTQ3ZHF MA Substrate DTQ3ZHF RA The emerging role of transport systems in liver function tests. Eur J Pharmacol. 2012 Jan 30;675(1-3):1-5. DTQ3ZHF RU https://doi.org/10.1016/j.ejphar.2011.11.048 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMJT1E5 DTQ3ZHF DN Scutellarin DTQ3ZHF MA Substrate DTQ3ZHF RA Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DTQ3ZHF RU https://doi.org/10.1124/dmd.112.047183 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMJ85FS DTQ3ZHF DN Glutathione-S-S-glutathione DTQ3ZHF MA Substrate DTQ3ZHF RA MRP2 and 3 in health and disease. Cancer Lett. 2006 Mar 8;234(1):51-61. DTQ3ZHF RU https://doi.org/10.1016/j.canlet.2005.05.051 DTQ3ZHF TI DTQ3ZHF DTQ3ZHF TN Multidrug resistance-associated protein 3 DTQ3ZHF DI DMG2UJS DTQ3ZHF DN Monomethyl-auristatin-E DTQ3ZHF MA Substrate DTQ3ZHF RA Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res. 2008 Jul 1;68(13):5380-9. DTQ3ZHF RU https://doi.org/10.1158/0008-5472.CAN-08-0234 DTQK38X TI DTQK38X DTQK38X TN Zinc transporter 7 DTQK38X DI DMZ4R3Q DTQK38X DN Zinc salts DTQK38X MA Substrate DTQK38X RA Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J Biol Chem. 2007 Dec 21;282(51):37053-63. DTQK38X RU http://www.ncbi.nlm.nih.gov/pubmed/17954933 DTQK5O9 TI DTQK5O9 DTQK5O9 TN Monocarboxylate transporter 9 DTQK5O9 DI DMA1MKT DTQK5O9 DN Uric acid DTQK5O9 MA Substrate DTQK5O9 RA Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013 Dec;26(4):133-6. DTQK5O9 RU http://www.ncbi.nlm.nih.gov/pubmed/23990105 DTQK5O9 TI DTQK5O9 DTQK5O9 TN Monocarboxylate transporter 9 DTQK5O9 DI DMJBOCR DTQK5O9 DN L-carnitine DTQK5O9 MA Substrate DTQK5O9 RA Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. BMC Neurosci. 2016 Jul 1;17(1):43. DTQK5O9 RU http://www.ncbi.nlm.nih.gov/pubmed/27364523 DTQNIG7 TI DTQNIG7 DTQNIG7 TN Sodium/glucose cotransporter 5 DTQNIG7 DI DMIAHVU DTQNIG7 DN 2-Deoxyglucose DTQNIG7 MA Substrate DTQNIG7 RA The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8. DTQNIG7 RU http://www.ncbi.nlm.nih.gov/pubmed/12748858 DTQOUM4 TI DTQOUM4 DTQOUM4 TN Carnitine/acylcarnitine translocase DTQOUM4 DI DMJBOCR DTQOUM4 DN L-carnitine DTQOUM4 MA Substrate DTQOUM4 RA Molecular and functional analysis of SLC25A20 mutations causing carnitine-acylcarnitine translocase deficiency. Hum Mutat. 2004 Oct;24(4):312-20. DTQOUM4 RU http://www.ncbi.nlm.nih.gov/pubmed/15365988 DTRF4L3 TI DTRF4L3 DTRF4L3 TN Sodium-dependent phosphate transport protein 3 DTRF4L3 DI DMUN54G DTRF4L3 DN Aminohippuric acid DTRF4L3 MA Substrate DTRF4L3 RA Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter. Am J Physiol Cell Physiol. 2015 Jul 15;309(2):C71-80. DTRF4L3 RU http://www.ncbi.nlm.nih.gov/pubmed/25972451 DTS4MKQ TI DTS4MKQ DTS4MKQ TN Glucose transporter type 6 DTS4MKQ DI DMIAHVU DTS4MKQ DN 2-Deoxyglucose DTS4MKQ MA Substrate DTS4MKQ RA Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DTS4MKQ RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DTSF91X TI DTSF91X DTSF91X TN Choline transporter-like protein 2 DTSF91X DI DM5D9YK DTSF91X DN Choline DTSF91X MA Substrate DTSF91X RA The choline transporter-like family SLC44: properties and roles in human diseases. Mol Aspects Med. 2013 Apr-Jun;34(2-3):646-54. DTSF91X RU http://www.ncbi.nlm.nih.gov/pubmed/23506897 DTSQY0W TI DTSQY0W DTSQY0W TN Anion exchange protein 4 DTSQY0W DI DMMU6BJ DTSQY0W DN Sodium bicarbonate DTSQY0W MA Substrate DTSQY0W RA A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011. DTSQY0W RU http://www.ncbi.nlm.nih.gov/pubmed/11305939 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMM0XGL DTSYQGK DN Idarubicin DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMQUSBT DTSYQGK DN Daunorubicin DTSYQGK MA Substrate DTSYQGK RA Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/10917554 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMAHMT9 DTSYQGK DN Glutathione DTSYQGK MA Substrate DTSYQGK RA Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/18775981 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMP6G8T DTSYQGK DN Topotecan DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMUN54G DTSYQGK DN Aminohippuric acid DTSYQGK MA Substrate DTSYQGK RA ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000 Apr;57(4):1636-42. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/10760098 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMQTFAO DTSYQGK DN Fluorescein DTSYQGK MA Substrate DTSYQGK RA Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice. Biochem Biophys Res Commun. 2001 Jun 22;284(4):863-9. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/11409873 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM60QMR DTSYQGK DN Ethacrynic acid DTSYQGK MA Substrate DTSYQGK RA Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs. Mol Pharmacol. 2002 Nov;62(5):1160-6. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/12391280 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMOMN31 DTSYQGK DN Phenethyl isothiocyanate DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMP6SC2 DTSYQGK DN Irinotecan DTSYQGK MA Substrate DTSYQGK RA ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8. DTSYQGK RU http://molpharm.aspetjournals.org/content/55/5/921 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMVP5YE DTSYQGK DN Doxorubicin DTSYQGK MA Substrate DTSYQGK RA The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br J Cancer. 2005 Jul 11;93(1):89-97. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/15942634 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMVZO01 DTSYQGK DN 99mTc-sestamibi DTSYQGK MA Substrate DTSYQGK RA 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77(3):353-8. DTSYQGK RU https://doi.org/10.1038/bjc.1998.57 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM2POTE DTSYQGK DN Colchicine DTSYQGK MA Substrate DTSYQGK RA Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. DTSYQGK RU http://molpharm.aspetjournals.org/content/52/3/344 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMINOX3 DTSYQGK DN Vincristine DTSYQGK MA Substrate DTSYQGK RA Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol. 2008 Sep 4;591(1-3):128-31. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/18619955 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMDBX5F DTSYQGK DN Ivermectin DTSYQGK MA Substrate DTSYQGK RA Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). Chem Biol Interact. 2006 Feb 25;159(3):169-79. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/16384552 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMW50NF DTSYQGK DN SN-38 DTSYQGK MA Substrate DTSYQGK RA ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8. DTSYQGK RU http://molpharm.aspetjournals.org/content/55/5/921 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMNH3PG DTSYQGK DN Etoposide DTSYQGK MA Substrate DTSYQGK RA Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/11504821 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM5URA2 DTSYQGK DN Chlorpheniramine DTSYQGK MA Substrate DTSYQGK RA Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/15666293 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMCPB0Q DTSYQGK DN leukotriene E4 DTSYQGK MA Substrate DTSYQGK RA Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 1996 Mar 1;56(5):988-94. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/8640791 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMPDW6T DTSYQGK DN Epirubicin DTSYQGK MA Substrate DTSYQGK RA Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion. J Biomed Res. 2016 Mar;30(2):120-133. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/28276667 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMNOKBV DTSYQGK DN Phenytoin DTSYQGK MA Substrate DTSYQGK RA Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010 Jun;58(7):1019-32. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/20080116 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM3KJ45 DTSYQGK DN Estradiol-17beta-glucuronide DTSYQGK MA Substrate DTSYQGK RA Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol. 1999 May;55(5):929-37. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/10220572 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMGLX0T DTSYQGK DN Grepafloxacin DTSYQGK MA Substrate DTSYQGK RA Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. J Pharmacol Exp Ther. 2000 Oct;295(1):146-52. DTSYQGK RU http://jpet.aspetjournals.org/content/295/1/146.long DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM3NC4M DTSYQGK DN Quercetin DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMGXENV DTSYQGK DN Saxagliptin DTSYQGK MA Substrate DTSYQGK RA Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet. 2010 Sep;49(9):573-88. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/20690781 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMDI269 DTSYQGK DN Docetaxel DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM2YGNW DTSYQGK DN Dactinomycin DTSYQGK MA Substrate DTSYQGK RA Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 1995 Nov 15;55(22):5342-7. DTSYQGK RU http://cancerres.aacrjournals.org/content/55/22/5342 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMA7PEW DTSYQGK DN Verapamil DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMM39BF DTSYQGK DN Mitoxantrone DTSYQGK MA Substrate DTSYQGK RA Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr;69(4):1499-505. DTSYQGK RU https://doi.org/10.1124/mol.105.017988 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM2TEOL DTSYQGK DN Methotrexate DTSYQGK MA Substrate DTSYQGK RA Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/11585759 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM3RWXL DTSYQGK DN Resveratrol DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMITQS0 DTSYQGK DN Lopinavir DTSYQGK MA Substrate DTSYQGK RA Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes. J Antimicrob Chemother. 2007 Nov;60(5):987-93. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/17890284 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMRHGI9 DTSYQGK DN Cisplatin DTSYQGK MA Substrate DTSYQGK RA Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 2001 Oct;8(10):803-14. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/11687904 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM0T3YH DTSYQGK DN Indinavir DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMIXC7G DTSYQGK DN zoledronic acid DTSYQGK MA Substrate DTSYQGK RA Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: an in vitro study. Cell Biol Int. 2006 Mar;30(3):278-82. DTSYQGK RU https://doi.org/10.1016/j.cellbi.2005.11.008 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM5TVS3 DTSYQGK DN Vinblastine DTSYQGK MA Substrate DTSYQGK RA Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). AAPS PharmSci. 2004 Mar 9;6(1):E8. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/15198509 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMG814N DTSYQGK DN Saquinavir DTSYQGK MA Substrate DTSYQGK RA Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother. 2002 Nov;46(11):3456-62. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/12384350 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMBCO4Q DTSYQGK DN Arsenite DTSYQGK MA Substrate DTSYQGK RA Comparative Molecular Docking Studies with ABCC1 and Aquaporin 9 in the Arsenite Complex Efflux. Bioinformation. 2014 Aug 30;10(8):474-9. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/25258480 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMMC345 DTSYQGK DN Cefadroxil DTSYQGK MA Substrate DTSYQGK RA Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMK0O7U DTSYQGK DN Flutamide DTSYQGK MA Substrate DTSYQGK RA The multidrug resistance-associated protein 1 transports methoxychlor and protects the seminiferous epithelium from injury. Toxicol Lett. 2003 Apr 30;142(1-2):61-70. DTSYQGK RU https://doi.org/10.1016/S0378-4274(02)00485-X DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM2G9AE DTSYQGK DN Citalopram DTSYQGK MA Substrate DTSYQGK RA MRP1 polymorphisms associated with citalopram response in patients with major depression. J Clin Psychopharmacol. 2010 Apr;30(2):116-25. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/20520284 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMEMBJC DTSYQGK DN Folic acid DTSYQGK MA Substrate DTSYQGK RA Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/15041471 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMM278X DTSYQGK DN Adefovir DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMVBIZL DTSYQGK DN Estrone sulfate DTSYQGK MA Substrate DTSYQGK RA Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab Dispos. 2003 Aug;31(8):1016-26. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/12867490 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMLB81S DTSYQGK DN Paclitaxel DTSYQGK MA Substrate DTSYQGK RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTSYQGK RU https://doi.org/10.1007/s11095-012-0935-x DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMLO9FU DTSYQGK DN Fluo-3 DTSYQGK MA Substrate DTSYQGK RA Export pumps for anionic conjugates encoded by MRP genes. Adv Enzyme Regul. 1999;39:237-46. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/10470375 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM3L52Q DTSYQGK DN Chlorcyclizine DTSYQGK MA Substrate DTSYQGK RA Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/15666293 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DM4Q80H DTSYQGK DN Dehydroepiandrosterone sulfate DTSYQGK MA Substrate DTSYQGK RA Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/12523936 DTSYQGK TI DTSYQGK DTSYQGK TN Multidrug resistance-associated protein 1 DTSYQGK DI DMJ85FS DTSYQGK DN Glutathione-S-S-glutathione DTSYQGK MA Substrate DTSYQGK RA Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. DTSYQGK RU http://www.ncbi.nlm.nih.gov/pubmed/9188796 DTT1S93 TI DTT1S93 DTT1S93 TN Zrt- and Irt-like protein 6 DTT1S93 DI DMZ4R3Q DTT1S93 DN Zinc salts DTT1S93 MA Substrate DTT1S93 RA A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313. DTT1S93 RU http://www.ncbi.nlm.nih.gov/pubmed/28098160 DTT3IKQ TI DTT3IKQ DTT3IKQ TN Organic anion transporter 6 DTT3IKQ DI DMVBIZL DTT3IKQ DN Estrone sulfate DTT3IKQ MA Substrate DTT3IKQ RA Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol. 2006 Aug;291(2):F314-21. DTT3IKQ RU http://www.ncbi.nlm.nih.gov/pubmed/16478971 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM4XAU7 DTT79CX DN Prostaglandin f2Alpha DTT79CX MA Substrate DTT79CX RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM2HU9I DTT79CX DN Triamterene DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM17ONX DTT79CX DN Fexofenadine DTT79CX MA Substrate DTT79CX RA Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther. 2007 Mar;81(3):362-70. DTT79CX RU https://doi.org/10.1038/sj.clpt.6100056 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMT2FDC DTT79CX DN Desipramine DTT79CX MA Substrate DTT79CX RA Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DTT79CX RU https://doi.org/10.1016/j.canlet.2005.06.051 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMNKG1Z DTT79CX DN Atenolol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM4KI7O DTT79CX DN Zidovudine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM57SVW DTT79CX DN Benzamil DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMH61ZB DTT79CX DN Cimetidine DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMA4MRX DTT79CX DN Perphenazine DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMSWYF5 DTT79CX DN Quinine DTT79CX MA Substrate DTT79CX RA Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/11408531 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMJX6ZG DTT79CX DN Codeine DTT79CX MA Substrate DTT79CX RA Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes. 2015 May;64(5):1786-93. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/25510240 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMQJHR7 DTT79CX DN Indacaterol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM8SXYG DTT79CX DN Lamotrigine DTT79CX MA Substrate DTT79CX RA Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochem Pharmacol. 2012 Mar 15;83(6):805-14. DTT79CX RU https://doi.org/10.1016/j.bcp.2011.12.032 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM6RZ9Q DTT79CX DN Clonidine DTT79CX MA Substrate DTT79CX RA Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM79NTF DTT79CX DN Propranolol DTT79CX MA Substrate DTT79CX RA Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMSOURV DTT79CX DN Formoterol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM3KJBC DTT79CX DN Epinephrine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMIP3ZV DTT79CX DN Fenoterol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM1MBYQ DTT79CX DN Ganciclovir DTT79CX MA Substrate DTT79CX RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMHZJCG DTT79CX DN Pentamidine DTT79CX MA Substrate DTT79CX RA Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metab Dispos. 2009 Feb;37(2):424-30. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/18971316 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM3JDRP DTT79CX DN Cladribine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMBZIVP DTT79CX DN Tubocurarine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMTYOPD DTT79CX DN Dinoprostone DTT79CX MA Substrate DTT79CX RA Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/16211406 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM6SFYH DTT79CX DN Tetraethylammonium DTT79CX MA Substrate DTT79CX RA Involvement of human organic cation transporter 1 in the hepatic uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel, small molecule survivin suppressant. Drug Metab Dispos. 2009 Sep;37(9):1856-63. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/19520775 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM5Q1W4 DTT79CX DN YM155 DTT79CX MA Substrate DTT79CX RA Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant. Drug Metab Dispos. 2010 Jan;38(1):1-4. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/19833842 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMOUC09 DTT79CX DN Norepinephrine DTT79CX MA Substrate DTT79CX RA Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53. DTT79CX RU https://doi.org/10.2133/dmpk.23.243 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMI347A DTT79CX DN Lamivudine DTT79CX MA Substrate DTT79CX RA Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection. Drug Metab Dispos. 2008 Aug;36(8):1616-23. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/18490433 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMQ52JG DTT79CX DN Phenformin DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMZD5QR DTT79CX DN Cytarabine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMVJNFI DTT79CX DN Spermidine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM5D9YK DTT79CX DN Choline DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMFA5MY DTT79CX DN Metoclopramide DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMM7CHK DTT79CX DN Trimethoprim DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM7RJXL DTT79CX DN Imatinib DTT79CX MA Substrate DTT79CX RA Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/18398725 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMYLOVR DTT79CX DN Acyclovir DTT79CX MA Substrate DTT79CX RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM0GUSX DTT79CX DN Ranitidine DTT79CX MA Substrate DTT79CX RA Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther. 2005 Dec;315(3):1288-97. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/16141367 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM4UXT1 DTT79CX DN Tyramine DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMMQHOZ DTT79CX DN Oxyphenonium DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM89QE1 DTT79CX DN Metformin DTT79CX MA Substrate DTT79CX RA Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/16272756 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMNMW9R DTT79CX DN Pramipexole DTT79CX MA Substrate DTT79CX RA OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users. Neurogenetics. 2011 Feb;12(1):79-82. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/20680652 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM0TI4U DTT79CX DN Acebutolol DTT79CX MA Substrate DTT79CX RA Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DTT79CX RU https://doi.org/10.1016/j.canlet.2005.06.051 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMRTSGP DTT79CX DN Amiloride DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMN9CWF DTT79CX DN Salbutamol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMWE2N4 DTT79CX DN Auranofin DTT79CX MA Substrate DTT79CX RA Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017 Oct 9;8(56):96062-96078. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/29221187 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMMUOLJ DTT79CX DN Varenicline DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM2M3ZA DTT79CX DN Glycopyrrolate DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM5SYZP DTT79CX DN Disopyramide DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMD4381 DTT79CX DN Terbutaline DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMC50ME DTT79CX DN Debrisoquine DTT79CX MA Substrate DTT79CX RA The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1. Biochem Pharmacol. 2012 May 15;83(10):1427-34. DTT79CX RU https://doi.org/10.1016/j.bcp.2012.01.032 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM1IB4Q DTT79CX DN Zolmitriptan DTT79CX MA Substrate DTT79CX RA OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/26659468 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMFDC0Q DTT79CX DN Tiotropium DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM16PWF DTT79CX DN N1-methylnicotinamide DTT79CX MA Substrate DTT79CX RA Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/9260930 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMUMQZ0 DTT79CX DN Clidinium DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMQBEYX DTT79CX DN Phencyclidine DTT79CX MA Substrate DTT79CX RA Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resist Updat. 2011 Feb;14(1):22-34. DTT79CX RU https://doi.org/10.1016/j.drup.2010.12.002 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMGFV3Z DTT79CX DN Nizatidine DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMDF79Z DTT79CX DN Acetylcholine DTT79CX MA Substrate DTT79CX RA Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res. 2006 Apr 12;7:65. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/16608531 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMA7PEW DTT79CX DN Verapamil DTT79CX MA Substrate DTT79CX RA Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DTT79CX RU https://doi.org/10.1016/j.canlet.2005.06.051 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMEN6X7 DTT79CX DN Atropine DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMFQ320 DTT79CX DN Ipratropium DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMDJMA3 DTT79CX DN Rizatriptan DTT79CX MA Substrate DTT79CX RA OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/26659468 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMO50U2 DTT79CX DN Naratriptan DTT79CX MA Substrate DTT79CX RA OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/26659468 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMPGUCF DTT79CX DN Dopamine DTT79CX MA Substrate DTT79CX RA Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53. DTT79CX RU https://doi.org/10.2133/dmpk.23.243 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMLEPYN DTT79CX DN Tetramethylammonium DTT79CX MA Substrate DTT79CX RA Scintillation proximity assay for measuring uptake by the human drug transporters hOCT1, hOAT3, and hOATP1B1. Anal Biochem. 2007 Jul 15;366(2):117-25. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/17555702 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMGDKXN DTT79CX DN Sitagliptin DTT79CX MA Substrate DTT79CX RA 265 effect of dietary cholesterol on gallbladder bile lithogenicity and gene expression in the enterohepatic axis of non-obese gallstone and control women. Journal of Hepatology, 2009, 50(09):S105-S106. DTT79CX RU https://doi.org/10.1016/S0168-8278(09)60267-1 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMRHGI9 DTT79CX DN Cisplatin DTT79CX MA Substrate DTT79CX RA Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/16914559 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMNMXR8 DTT79CX DN Procainamide DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM32XZT DTT79CX DN Trospium chloride DTT79CX MA Substrate DTT79CX RA Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/25466967 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMS8IFC DTT79CX DN Sorafenib DTT79CX MA Substrate DTT79CX RA nan DTT79CX RU nan DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMC5Q8X DTT79CX DN Berberine DTT79CX MA Substrate DTT79CX RA Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol. 2008 Feb;376(6):449-61. DTT79CX RU https://doi.org/10.1007/s00210-007-0219-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMCD9YG DTT79CX DN Prazosin DTT79CX MA Substrate DTT79CX RA Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DTT79CX RU https://doi.org/10.1016/j.canlet.2005.06.051 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM8KSQH DTT79CX DN Phenoxybenzamine DTT79CX MA Substrate DTT79CX RA Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DTT79CX RU https://doi.org/10.1016/j.canlet.2005.06.051 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMQNWRD DTT79CX DN Oxaliplatin DTT79CX MA Substrate DTT79CX RA Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/16951202 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM2G9AE DTT79CX DN Citalopram DTT79CX MA Substrate DTT79CX RA Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53. DTT79CX RU https://doi.org/10.2133/dmpk.23.243 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMQ7UL8 DTT79CX DN Camostat DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM1M0Q4 DTT79CX DN Procaterol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMVYXR8 DTT79CX DN Sumatriptan DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMVUKEW DTT79CX DN N-methylpyridinium DTT79CX MA Substrate DTT79CX RA Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1. Diabetes. 2008 Jun;57(6):1463-9. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/18314419 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMX82DO DTT79CX DN Buformin DTT79CX MA Substrate DTT79CX RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTT79CX RU https://doi.org/10.1007/s11095-012-0935-x DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DMXWD08 DTT79CX DN (R)-Xamoterol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT79CX TI DTT79CX DTT79CX TN Organic cation transporter 1 DTT79CX DI DM1ZQ5G DTT79CX DN (S)-Xamoterol DTT79CX MA Substrate DTT79CX RA Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DTT79CX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DTT7VPB TI DTT7VPB DTT7VPB TN Vesicular amine transporter 2 DTT7VPB DI DM78IME DTT7VPB DN Ergotidine DTT7VPB MA Substrate DTT7VPB RA The vesicular monoamine transporter 2: an underexplored pharmacological target. Neurochem Int. 2014 Jul;73:89-97. DTT7VPB RU http://www.ncbi.nlm.nih.gov/pubmed/24398404 DTT7VPB TI DTT7VPB DTT7VPB TN Vesicular amine transporter 2 DTT7VPB DI DMOUC09 DTT7VPB DN Norepinephrine DTT7VPB MA Substrate DTT7VPB RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DTT7VPB RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DTT7VPB TI DTT7VPB DTT7VPB TN Vesicular amine transporter 2 DTT7VPB DI DMOFCRY DTT7VPB DN Serotonin DTT7VPB MA Substrate DTT7VPB RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DTT7VPB RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DTT7VPB TI DTT7VPB DTT7VPB TN Vesicular amine transporter 2 DTT7VPB DI DMPM4SK DTT7VPB DN Methamphetamine DTT7VPB MA Substrate DTT7VPB RA Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem. 2018 Oct 25;61(20):9121-9131. DTT7VPB RU http://www.ncbi.nlm.nih.gov/pubmed/30240563 DTT7VPB TI DTT7VPB DTT7VPB TN Vesicular amine transporter 2 DTT7VPB DI DMPGUCF DTT7VPB DN Dopamine DTT7VPB MA Substrate DTT7VPB RA SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DTT7VPB RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DTT82QK TI DTT82QK DTT82QK TN Mitochondrial thiamine pyrophosphate carrier DTT82QK DI DM5WYJ6 DTT82QK DN Thiamine pyrophosphate DTT82QK MA Substrate DTT82QK RA Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15927-32. DTT82QK RU http://www.ncbi.nlm.nih.gov/pubmed/17035501 DTTQ8WI TI DTTQ8WI DTTQ8WI TN Probable phospholipid-transporting ATPase VA DTTQ8WI DI DMOPYWF DTTQ8WI DN Phosphatidylethanolamine DTTQ8WI MA Substrate DTTQ8WI RA Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine). FASEB J. 2019 Mar;33(3):3087-3096. DTTQ8WI RU http://www.ncbi.nlm.nih.gov/pubmed/30509129 DTTWL58 TI DTTWL58 DTTWL58 TN Sodium-coupled neutral amino acid transporter 2 DTTWL58 DI DM69G8X DTTWL58 DN L-glutamine DTTWL58 MA Substrate DTTWL58 RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTTWL58 RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTTWL58 TI DTTWL58 DTTWL58 TN Sodium-coupled neutral amino acid transporter 2 DTTWL58 DI DMZDN4W DTTWL58 DN L-alanine DTTWL58 MA Substrate DTTWL58 RA Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DTTWL58 RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DTU4HKJ TI DTU4HKJ DTU4HKJ TN Mitochondrial coenzyme A transporter SLC25A42 DTU4HKJ DI DM1I8LU DTU4HKJ DN Coenzyme A DTU4HKJ MA Substrate DTU4HKJ RA A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem. 2009 Jul 3;284(27):18152-9. DTU4HKJ RU http://www.ncbi.nlm.nih.gov/pubmed/19429682 DTU6IF7 TI DTU6IF7 DTU6IF7 TN Ammonium transporter Rh type B DTU6IF7 DI DMOEVK6 DTU6IF7 DN Ammonia DTU6IF7 MA Substrate DTU6IF7 RA Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47. DTU6IF7 RU http://www.ncbi.nlm.nih.gov/pubmed/19553567 DTU8NCX TI DTU8NCX DTU8NCX TN Choline transporter-like protein 5 DTU8NCX DI DM5D9YK DTU8NCX DN Choline DTU8NCX MA Substrate DTU8NCX RA The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins. PLoS One. 2012;7(7):e41267. DTU8NCX RU http://www.ncbi.nlm.nih.gov/pubmed/22815983 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM13495 DTUGYRD DN Fesoterodine fumarate DTUGYRD MA Substrate DTUGYRD RA Blood-brain barrier permeation and efflux exclusion of anticholinergics used in the treatment of overactive bladder. Drugs Aging. 2012 Apr 1;29(4):259-73. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/22390261 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMR8O3X DTUGYRD DN Paraquat DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXBR27 DTUGYRD DN Gallopamil DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOLNHF DTUGYRD DN Melphalan DTUGYRD MA Substrate DTUGYRD RA Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br J Cancer. 1998;77(2):201-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/9460989 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0FROP DTUGYRD DN Nafoxidine DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW83TP DTUGYRD DN Pimozide DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMYZ57N DTUGYRD DN Albendazole DTUGYRD MA Substrate DTUGYRD RA The anthelminthic agent albendazole does not interact with p-glycoprotein. Drug Metab Dispos. 2002 Apr;30(4):365-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11901088 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMNHTZI DTUGYRD DN Protriptyline DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7HXWT DTUGYRD DN Nilotinib DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDPM7R DTUGYRD DN Azasetron DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMLUA9D DTUGYRD DN Simeprevir DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM48K0X DTUGYRD DN Carfilzomib DTUGYRD MA Substrate DTUGYRD RA Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol. 2013 Apr;88(4):265-72. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/23475625 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMX4GND DTUGYRD DN Meperidine DTUGYRD MA Substrate DTUGYRD RA Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3638-40. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18499452 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMD7L94 DTUGYRD DN Palbociclib DTUGYRD MA Substrate DTUGYRD RA Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model. J Pharmacol Exp Ther. 2015 Nov;355(2):264-71. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26354993 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCZGRE DTUGYRD DN Dolutegravir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5T6US DTUGYRD DN Estrone DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15290871 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMN6DXL DTUGYRD DN Risperidone DTUGYRD MA Substrate DTUGYRD RA Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. Clin Pharmacol Ther. 2005 Jul;78(1):43-51. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/16003291 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMLW57T DTUGYRD DN Teniposide DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM56YN7 DTUGYRD DN Desloratadine DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12584158 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVXFYE DTUGYRD DN Vinorelbine DTUGYRD MA Substrate DTUGYRD RA Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11602674 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM17ONX DTUGYRD DN Fexofenadine DTUGYRD MA Substrate DTUGYRD RA Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005 Aug;78(2):191-201. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/16084853 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOSQGU DTUGYRD DN Nalbuphine DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4W8RE DTUGYRD DN Melagatran DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMF28YC DTUGYRD DN Atorvastatin DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM47CO1 DTUGYRD DN Okadaic acid DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKR3C5 DTUGYRD DN Ergotamine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMT2FDC DTUGYRD DN Desipramine DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMNKG1Z DTUGYRD DN Atenolol DTUGYRD MA Substrate DTUGYRD RA Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11895100 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPVW6H DTUGYRD DN Morphine-6-glucuronide DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMYJ8Z3 DTUGYRD DN Alprenolol DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDKF3M DTUGYRD DN Raloxifene DTUGYRD MA Substrate DTUGYRD RA Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment. Transl Res. 2012 Oct;160(4):298-308. DTUGYRD RU https://doi.org/10.1016/j.trsl.2012.03.002 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMM0XGL DTUGYRD DN Idarubicin DTUGYRD MA Substrate DTUGYRD RA Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5. DTUGYRD RU https://doi.org/10.1038/leu.2008.87 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM471KJ DTUGYRD DN Omeprazole DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQUSBT DTUGYRD DN Daunorubicin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4KI7O DTUGYRD DN Zidovudine DTUGYRD MA Substrate DTUGYRD RA The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109. DTUGYRD RU https://doi.org/10.1016/j.antiviral.2008.12.013 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMBGZI3 DTUGYRD DN Chlorpromazine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGVH6N DTUGYRD DN Axitinib DTUGYRD MA Substrate DTUGYRD RA Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Eur J Clin Pharmacol. 2012 May;68(5):645-55. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/22170007 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMHAZLM DTUGYRD DN Naringenin DTUGYRD MA Substrate DTUGYRD RA Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004 Mar 1;36(5):592-604. DTUGYRD RU https://doi.org/10.1016/j.freeradbiomed.2003.11.023 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM49DUI DTUGYRD DN Tretinoin DTUGYRD MA Substrate DTUGYRD RA Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DTUGYRD RU https://doi.org/10.1016/j.phymed.2012.05.010 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMR3J6S DTUGYRD DN Cholesterol DTUGYRD MA Substrate DTUGYRD RA Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. Biochem Biophys Res Commun. 2000 Oct 5;276(3):909-16. DTUGYRD RU https://doi.org/10.1006/bbrc.2000.3554 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW649X DTUGYRD DN Eletriptan DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMH61ZB DTUGYRD DN Cimetidine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTAJQE DTUGYRD DN Amphotericin B DTUGYRD MA Substrate DTUGYRD RA Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DTUGYRD RU https://doi.org/10.1016/j.phymed.2012.05.010 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWFJTR DTUGYRD DN Linagliptin DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDJW5K DTUGYRD DN Ajmaline DTUGYRD MA Substrate DTUGYRD RA ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P-glycoprotein. FEBS Lett. 1994 Apr 25;343(2):168-72. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7909523 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMA4MRX DTUGYRD DN Perphenazine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMAHMT9 DTUGYRD DN Glutathione DTUGYRD MA Substrate DTUGYRD RA Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells. BMC Pharmacol Toxicol. 2015 Dec 15;16:37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26666373 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQCTIH DTUGYRD DN Digoxin DTUGYRD MA Substrate DTUGYRD RA MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Biochem Biophys Res Commun. 2010 Jul 16;398(1):7-12. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20510202 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMP6G8T DTUGYRD DN Topotecan DTUGYRD MA Substrate DTUGYRD RA Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18654741 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6A0X7 DTUGYRD DN Pravastatin DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMS60RB DTUGYRD DN Levofloxacin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOIP7R DTUGYRD DN Flesinoxan DTUGYRD MA Substrate DTUGYRD RA Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. Eur J Pharm Sci. 2001 Aug;14(1):81-6. DTUGYRD RU https://doi.org/10.1016/S0928-0987(01)00150-6 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMV26S8 DTUGYRD DN Levomilnacipran DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier inivo. Neuropharmacology. 2016 Apr;103:104-11. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26700248 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4K7GQ DTUGYRD DN Erythromycin DTUGYRD MA Substrate DTUGYRD RA Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids. Pharm Res. 2009 May;26(5):1270-82. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18958406 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSL679 DTUGYRD DN Gatifloxacin DTUGYRD MA Substrate DTUGYRD RA Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. Int J Pharm. 2010 Aug 16;395(1-2):114-21. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20573570 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSWYF5 DTUGYRD DN Quinine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQJHR7 DTUGYRD DN Indacaterol DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSJVAM DTUGYRD DN Amisulpride DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM8SXYG DTUGYRD DN Lamotrigine DTUGYRD MA Substrate DTUGYRD RA Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18824002 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQTJSX DTUGYRD DN Fluvoxamine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0C9IL DTUGYRD DN Ranolazine DTUGYRD MA Substrate DTUGYRD RA Ranolazine-tacrolimus interaction. Ann Pharmacother. 2010 Nov;44(11):1844-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20876828 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMN3GCH DTUGYRD DN Darunavir DTUGYRD MA Substrate DTUGYRD RA Impact of drug transporters on cellular resistance towards saquinavir and darunavir. J Antimicrob Chemother. 2010 Nov;65(11):2319-28. DTUGYRD RU https://doi.org/10.1093/jac/dkq324 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6LQGO DTUGYRD DN Pafenolol DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMMS2J5 DTUGYRD DN Isoxicam DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXCM7H DTUGYRD DN Cerivastatin DTUGYRD MA Substrate DTUGYRD RA Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. DTUGYRD RU https://doi.org/10.1124/jpet.105.085589 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMIWFRL DTUGYRD DN Tolvaptan DTUGYRD MA Substrate DTUGYRD RA In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects. J Clin Pharmacol. 2011 May;51(5):761-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20679500 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGW1ID DTUGYRD DN Sirolimus DTUGYRD MA Substrate DTUGYRD RA Pharmacogenetics of tacrolimus and sirolimus in renal transplant patients: from retrospective analyses to prospective studies. Transplant Proc. 2007 Sep;39(7):2142-4. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17889118 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKTJBU DTUGYRD DN Geneticin DTUGYRD MA Substrate DTUGYRD RA ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50. DTUGYRD RU https://doi.org/10.1016/j.ab.2009.12.014 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM50TCG DTUGYRD DN Nogalamycin DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6RZ9Q DTUGYRD DN Clonidine DTUGYRD MA Substrate DTUGYRD RA Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1BV7W DTUGYRD DN Aliskiren fumarate DTUGYRD MA Substrate DTUGYRD RA Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys. Biopharm Drug Dispos. 2015 Jan;36(1):15-33. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25264342 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTPQ84 DTUGYRD DN Corticosterone DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSE3I7 DTUGYRD DN Gemcitabine DTUGYRD MA Substrate DTUGYRD RA Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. Br J Cancer. 2003 Jun 16;88(12):1963-70. DTUGYRD RU https://doi.org/10.1038/sj.bjc.6601011 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDRKH2 DTUGYRD DN Thiamphenicol DTUGYRD MA Substrate DTUGYRD RA Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr;107(4):1178-1184. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29221992 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4F29C DTUGYRD DN Crizotinib DTUGYRD MA Substrate DTUGYRD RA Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Int J Cancer. 2014 Mar 15;134(6):1484-94. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/24037730 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5L6HI DTUGYRD DN Atomoxetine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3S8XC DTUGYRD DN Dihydrotestosterone DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate. 2004 Apr 1;59(1):77-90. DTUGYRD RU https://doi.org/10.1002/pros.10354 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQ4HIN DTUGYRD DN Cabergoline DTUGYRD MA Substrate DTUGYRD RA Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas. Eur J Endocrinol. 2012 Sep;167(3):327-35. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/22672924 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPQAGE DTUGYRD DN Mycophenolate mofetil DTUGYRD MA Substrate DTUGYRD RA Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18695635 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW1TV2 DTUGYRD DN Rifaximin DTUGYRD MA Substrate DTUGYRD RA Advantageous Solubility-Permeability Interplay When Using Amorphous Solid Dispersion (ASD) Formulation for the BCS Class IV P-gp Substrate Rifaximin: Simultaneous Increase of Both the Solubility and the Permeability. AAPS J. 2017 May;19(3):806-813. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28204967 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM79NTF DTUGYRD DN Propranolol DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7TOWX DTUGYRD DN Dasabuvir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMB920Z DTUGYRD DN Ceritinib DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer. EBioMedicine. 2015 Dec 12;3:54-66. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26870817 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQI43G DTUGYRD DN Asunaprevir DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSVOZT DTUGYRD DN Nifedipine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMM4U9G DTUGYRD DN Prucalopride DTUGYRD MA Substrate DTUGYRD RA Resolor, INN-prucalopride DTUGYRD RU https://www.ema.europa.eu/documents/product-information/resolor-epar-product-information_en.pdf DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVR628 DTUGYRD DN Vindesine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXBLMP DTUGYRD DN Riociguat DTUGYRD MA Substrate DTUGYRD RA Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, initro. Pulm Pharmacol Ther. 2014 Aug;28(2):130-7. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/24657506 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQYUWG DTUGYRD DN Toremifene DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSH108 DTUGYRD DN Roscovitine DTUGYRD MA Substrate DTUGYRD RA ATP-binding cassette B1 transports seliciclib (R-roscovitine), a cyclin-dependent kinase inhibitor. Drug Metab Dispos. 2010 Nov;38(11):2000-6. DTUGYRD RU https://doi.org/10.1124/dmd.110.032805 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMIBH7M DTUGYRD DN L-tryptophan DTUGYRD MA Substrate DTUGYRD RA Pharmacogenetics of antidepressants. Front Pharmacol. 2011 Feb 16;2:6. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/21687501 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWHEV8 DTUGYRD DN Spiperone DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRQD04 DTUGYRD DN Tramadol DTUGYRD MA Substrate DTUGYRD RA Tramadol hydrochloride: pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomed Pharmacother. 2015 Mar;70:234-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25776506 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKMWQG DTUGYRD DN Olopatadine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSPWMF DTUGYRD DN Niguldipine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRTD16 DTUGYRD DN Talinolol DTUGYRD MA Substrate DTUGYRD RA Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. J Pharm Sci. 2007 Oct;96(10):2808-17. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17542018 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMUM7HZ DTUGYRD DN Fluorouracil DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMJZHT1 DTUGYRD DN Tadalafil DTUGYRD MA Substrate DTUGYRD RA In Vitro P-Glycoprotein-Mediated Transport of Tadalafil: A Comparison with Sildenafil. Biol Pharm Bull. 2017;40(8):1314-1319. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28769012 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKFQJP DTUGYRD DN Triflupromazine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMX6OE3 DTUGYRD DN Dabrafenib DTUGYRD MA Substrate DTUGYRD RA Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/23249624 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZNAEQ DTUGYRD DN Cinchonidine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW6GVL DTUGYRD DN Nadolol DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTKD7Q DTUGYRD DN Afatinib DTUGYRD MA Substrate DTUGYRD RA Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation. Pharmacol Res. 2017 Jun;120:43-50. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28288939 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3NXRU DTUGYRD DN Timolol DTUGYRD MA Substrate DTUGYRD RA Relationship between urinary sodium excretion and pioglitazone-induced edema. J Diabetes Investig. 2010 Oct 19;1(5):208-11. DTUGYRD RU https://doi.org/10.1111/j.2042-7158.1996.tb05904.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMEROU4 DTUGYRD DN Tolafentrine DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMF3AN7 DTUGYRD DN Loratadine DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12584158 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRF9YK DTUGYRD DN Empagliflozin DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMNE56X DTUGYRD DN ABT-263 DTUGYRD MA Substrate DTUGYRD RA The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. DTUGYRD RU https://doi.org/10.1016/j.bbrc.2011.04.043 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7G8T0 DTUGYRD DN Azithromycin DTUGYRD MA Substrate DTUGYRD RA Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29209109 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5PVQE DTUGYRD DN Paroxetine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSL3DX DTUGYRD DN Ledipasvir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMODJ40 DTUGYRD DN Ethinyl estradiol DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15290871 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZ7XNQ DTUGYRD DN Tacrolimus DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM9OZWQ DTUGYRD DN Lovastatin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7HUNW DTUGYRD DN Testosterone DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVE3TK DTUGYRD DN Bromocriptine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1DBV5 DTUGYRD DN Lansoprazole DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2NUH3 DTUGYRD DN Imipramine DTUGYRD MA Substrate DTUGYRD RA Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGDA3C DTUGYRD DN Cycloheximide DTUGYRD MA Substrate DTUGYRD RA Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DTUGYRD RU https://doi.org/10.1016/j.phymed.2012.05.010 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMUL5EW DTUGYRD DN Posaconazole DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCEW64 DTUGYRD DN Ceftriaxone DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMUY35B DTUGYRD DN Progesterone DTUGYRD MA Substrate DTUGYRD RA Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11785684 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOQVU9 DTUGYRD DN Hydroxyurea DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCT2YF DTUGYRD DN Emetine DTUGYRD MA Substrate DTUGYRD RA Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35. DTUGYRD RU https://doi.org/10.1111/j.0013-9580.2005.31904.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZPHIK DTUGYRD DN Beclomethasone DTUGYRD MA Substrate DTUGYRD RA Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DTUGYRD RU https://doi.org/10.1016/j.taap.2012.03.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTWS9E DTUGYRD DN Apremilast DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMP6SC2 DTUGYRD DN Irinotecan DTUGYRD MA Substrate DTUGYRD RA Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12065434 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMC0GSJ DTUGYRD DN Efavirenz DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM08E9O DTUGYRD DN Diazepam DTUGYRD MA Substrate DTUGYRD RA Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11785684 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2AOTZ DTUGYRD DN Perazine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMLB0EZ DTUGYRD DN Tamoxifen DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DML0B41 DTUGYRD DN Naloxegol DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWC4X8 DTUGYRD DN Prostaglandin A2 DTUGYRD MA Substrate DTUGYRD RA Unveiling the role of multidrug resistance proteins in hypertension. Hypertension. 2009 Aug;54(2):210-6. DTUGYRD RU https://doi.org/10.1161/HYPERTENSIONAHA.109.129742 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMI6E0R DTUGYRD DN Midostaurin DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCMBHA DTUGYRD DN Erlotinib DTUGYRD MA Substrate DTUGYRD RA Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice. Mol Cancer Ther. 2008 Aug;7(8):2280-7. DTUGYRD RU https://doi.org/10.1158/1535-7163.MCT-07-2250 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMMZSXQ DTUGYRD DN Azathioprine DTUGYRD MA Substrate DTUGYRD RA Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQPH29 DTUGYRD DN Curcuminoids DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMND3AB DTUGYRD DN Asimadoline DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWBHRY DTUGYRD DN Olmesartan medoxomil DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMJCQKA DTUGYRD DN Sphingosine-1-phosphate DTUGYRD MA Substrate DTUGYRD RA Lipid dependence of ABC transporter localization and function. Chem Phys Lipids. 2009 Oct;161(2):57-64. DTUGYRD RU https://doi.org/10.1016/j.chemphyslip.2009.07.004 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM82Z30 DTUGYRD DN Topiramate DTUGYRD MA Substrate DTUGYRD RA The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins. Pharm Res. 2009 Nov;26(11):2464-70. DTUGYRD RU https://doi.org/10.1007/s11095-009-9961-8 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM61TA4 DTUGYRD DN Arsenic trioxide DTUGYRD MA Substrate DTUGYRD RA Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells. Cancer Chemother Pharmacol. 2003 Feb;51(2):119-26. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12647012 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVP5YE DTUGYRD DN Doxorubicin DTUGYRD MA Substrate DTUGYRD RA MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19123050 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVP5YE DTUGYRD DN Doxorubicin DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZD5QR DTUGYRD DN Cytarabine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3BH1Y DTUGYRD DN Lapatinib DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMFRM1I DTUGYRD DN Canagliflozin DTUGYRD MA Substrate DTUGYRD RA In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/27862160 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4MDJY DTUGYRD DN Fluvastatin DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMN3E57 DTUGYRD DN Levodopa DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMU075F DTUGYRD DN Leupeptin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZA017 DTUGYRD DN Tetracycline DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4BDON DTUGYRD DN Methylprednisolone DTUGYRD MA Substrate DTUGYRD RA Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells. Biol Pharm Bull. 2002 Mar;25(3):393-6. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11913542 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMUNTE3 DTUGYRD DN Estradiol DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4KLPT DTUGYRD DN Terfenadine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6T2J3 DTUGYRD DN Neostigmine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2POTE DTUGYRD DN Colchicine DTUGYRD MA Substrate DTUGYRD RA Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19427995 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSI5CB DTUGYRD DN Chloroquine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMHSY1I DTUGYRD DN Regorafenib DTUGYRD MA Substrate DTUGYRD RA Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1). Pharm Res. 2015 Jul;32(7):2205-16. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25563977 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZ4P3A DTUGYRD DN Telithromycin DTUGYRD MA Substrate DTUGYRD RA Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010 Sep 11;41(1):86-95. DTUGYRD RU https://doi.org/10.1016/j.ejps.2010.05.016 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSTA36 DTUGYRD DN Nintedanib DTUGYRD MA Substrate DTUGYRD RA Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):533-541. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29500603 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMAFBCY DTUGYRD DN Mequitazine DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMHZCPO DTUGYRD DN Ibrutinib DTUGYRD MA Substrate DTUGYRD RA P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability. Mol Pharm. 2018 Nov 5;15(11):5124-5134. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/30247919 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7A8TW DTUGYRD DN Ezetimibe DTUGYRD MA Substrate DTUGYRD RA Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010 Jun;87(6):663-7. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20220747 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMIKFEL DTUGYRD DN Levomepromazine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5SQ1G DTUGYRD DN Dihydroergocristine DTUGYRD MA Substrate DTUGYRD RA Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. DTUGYRD RU https://doi.org/10.1124/jpet.102.037549 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMFORDT DTUGYRD DN 4-Hydroxytamoxifen DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTW6IU DTUGYRD DN Methadone DTUGYRD MA Substrate DTUGYRD RA In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites. Pharmacology. 2007;80(4):304-11. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17690563 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMINOX3 DTUGYRD DN Vincristine DTUGYRD MA Substrate DTUGYRD RA L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19944135 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSFK9V DTUGYRD DN Daclatasvir DTUGYRD MA Substrate DTUGYRD RA Influence of ABCB11 and HNF4 genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29091211 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXRU9M DTUGYRD DN Valspodar DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMV0RNS DTUGYRD DN Deflazacort DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM15F0X DTUGYRD DN Gefitinib DTUGYRD MA Substrate DTUGYRD RA Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers. Br J Clin Pharmacol. 2009 Aug;68(2):226-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19694743 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDBX5F DTUGYRD DN Ivermectin DTUGYRD MA Substrate DTUGYRD RA MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur J Pharmacol. 2003 Jan 24;460(2-3):85-91. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12559367 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMLMXE0 DTUGYRD DN Amprenavir DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM21C09 DTUGYRD DN Nitrendipine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTGBAX DTUGYRD DN Pomalidomide DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08910) DTUGYRD RU https://www.drugbank.ca/drugs/DB08910 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMMN36E DTUGYRD DN Abacavir DTUGYRD MA Substrate DTUGYRD RA The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109. DTUGYRD RU https://doi.org/10.1016/j.antiviral.2008.12.013 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMARQE0 DTUGYRD DN Hydroxybupropion DTUGYRD MA Substrate DTUGYRD RA Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein. Biol Pharm Bull. 2008 Feb;31(2):231-4. DTUGYRD RU https://doi.org/10.1248/bpb.31.231 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMK8U72 DTUGYRD DN Labetalol DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMM7CHK DTUGYRD DN Trimethoprim DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM07TX3 DTUGYRD DN Cefotetan DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMBDPY0 DTUGYRD DN Domperidone DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMD5LBX DTUGYRD DN Celiprolol DTUGYRD MA Substrate DTUGYRD RA Relationship between urinary sodium excretion and pioglitazone-induced edema. J Diabetes Investig. 2010 Oct 19;1(5):208-11. DTUGYRD RU https://doi.org/10.1111/j.2042-7158.1996.tb05904.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7RJXL DTUGYRD DN Imatinib DTUGYRD MA Substrate DTUGYRD RA Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/21311410 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMLZIT2 DTUGYRD DN Dexniguldipine DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7NPJS DTUGYRD DN Paliperidone DTUGYRD MA Substrate DTUGYRD RA Invega (paliperidone) extended release tablets FDA Label DTUGYRD RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021999s018lbl.pdf DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPZI3Q DTUGYRD DN Ketoconazole DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMS7EHF DTUGYRD DN Silvestrol DTUGYRD MA Substrate DTUGYRD RA Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells. AAPS J. 2011 Sep;13(3):357-64. DTUGYRD RU https://doi.org/10.1208/s12248-011-9276-7 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMNH3PG DTUGYRD DN Etoposide DTUGYRD MA Substrate DTUGYRD RA Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12948018 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0GUSX DTUGYRD DN Ranitidine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM53PV8 DTUGYRD DN Cefoperazone DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCIJBH DTUGYRD DN Edoxaban DTUGYRD MA Substrate DTUGYRD RA Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. Br J Clin Pharmacol. 2016 Dec;82(6):1591-1600. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/27530188 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1P6FR DTUGYRD DN Binimetinib DTUGYRD MA Substrate DTUGYRD RA The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors. Int J Cancer. 2018 Jan 15;142(2):381-391. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28921565 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPDW6T DTUGYRD DN Epirubicin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3AVO1 DTUGYRD DN Apafant DTUGYRD MA Substrate DTUGYRD RA Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. Eur J Pharm Sci. 2002 Aug;16(3):119-28. DTUGYRD RU https://doi.org/10.1016/S0928-0987(02)00088-X DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMER3I9 DTUGYRD DN S9788 DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOJZQ9 DTUGYRD DN Loperamide DTUGYRD MA Substrate DTUGYRD RA In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metab Dispos. 2008 Feb;36(2):268-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17962372 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKI7RB DTUGYRD DN Clomifene DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMAHJEF DTUGYRD DN Betamethasone DTUGYRD MA Substrate DTUGYRD RA Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/14661924 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM96SE0 DTUGYRD DN Haloperidol DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQ8FR2 DTUGYRD DN Prednisolone DTUGYRD MA Substrate DTUGYRD RA The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone. J Endocrinol. 2002 Oct;175(1):251-60. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12379510 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMD0LCA DTUGYRD DN Azidopine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1IS6U DTUGYRD DN Tenofovir DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM72JXH DTUGYRD DN Losartan DTUGYRD MA Substrate DTUGYRD RA Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar;129(6):1235-43. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/10725273 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOMP9U DTUGYRD DN Cetirizine DTUGYRD MA Substrate DTUGYRD RA Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction. Chirality. 2010 Jul;22(7):684-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20014242 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMX0K3Q DTUGYRD DN Epinastine DTUGYRD MA Substrate DTUGYRD RA Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. Drug Metab Dispos. 2004 May;32(5):519-24. DTUGYRD RU https://doi.org/10.1124/dmd.32.5.519 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM8WAHT DTUGYRD DN Fentanyl DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTGDN8 DTUGYRD DN Levetiracetam DTUGYRD MA Substrate DTUGYRD RA Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17045309 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM58WKG DTUGYRD DN Panobinostat DTUGYRD MA Substrate DTUGYRD RA Panobinostat for the treatment of multiple myeloma: the evidence to date. J Blood Med. 2015 Oct 8;6:269-76. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26504410 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0E9BR DTUGYRD DN Staurosporine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMNOKBV DTUGYRD DN Phenytoin DTUGYRD MA Substrate DTUGYRD RA The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.003 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMJV2EK DTUGYRD DN Dasatinib DTUGYRD MA Substrate DTUGYRD RA Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20423956 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM51FY6 DTUGYRD DN Tacrine DTUGYRD MA Substrate DTUGYRD RA Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes. J Pharm Pharm Sci. 2014;17(3):427-38. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25224352 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7SWIA DTUGYRD DN Triprolidine DTUGYRD MA Substrate DTUGYRD RA Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures. Drug Metab Dispos. 2007 Aug;35(8):1341-9. DTUGYRD RU https://doi.org/10.1124/dmd.106.013953 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMK1CZJ DTUGYRD DN Ingenol-3-angelate DTUGYRD MA Substrate DTUGYRD RA The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res. 2010 Jun 1;70(11):4509-19. DTUGYRD RU https://doi.org/10.1158/0008-5472.CAN-09-4303 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMS104F DTUGYRD DN Temsirolimus DTUGYRD MA Substrate DTUGYRD RA Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer. Cancer Chemother Pharmacol. 2017 Sep;80(3):653-659. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28676933 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6U9CQ DTUGYRD DN Pazopanib hydrochloride DTUGYRD MA Substrate DTUGYRD RA Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/23548165 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMK7IWL DTUGYRD DN Relugolix DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4W9B3 DTUGYRD DN Fosamprenavir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMUYNEI DTUGYRD DN Amoxicillin DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXY30O DTUGYRD DN Dipyridamole DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQAK6T DTUGYRD DN Rhodamine 123 DTUGYRD MA Substrate DTUGYRD RA Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKRBL2 DTUGYRD DN Hoechst 33342 DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMA8J1G DTUGYRD DN Rifampicin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3NF5G DTUGYRD DN Delavirdine DTUGYRD MA Substrate DTUGYRD RA The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109. DTUGYRD RU https://doi.org/10.1016/j.antiviral.2008.12.013 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMP7LK1 DTUGYRD DN E-guggulsterone DTUGYRD MA Substrate DTUGYRD RA Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1. Biochem Biophys Res Commun. 2008 May 2;369(2):363-8. DTUGYRD RU https://doi.org/10.1016/j.bbrc.2008.02.026 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWT905 DTUGYRD DN Mefloquine DTUGYRD MA Substrate DTUGYRD RA Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33. DTUGYRD RU https://doi.org/10.1016/j.clpt.2003.09.012 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM053KT DTUGYRD DN Aprepitant DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM672AH DTUGYRD DN Aspirin DTUGYRD MA Substrate DTUGYRD RA Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMYGJQO DTUGYRD DN Ponatinib DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08901) DTUGYRD RU https://www.drugbank.ca/drugs/DB08901 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM30SGU DTUGYRD DN Simvastatin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1N62C DTUGYRD DN Quetiapine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0TI4U DTUGYRD DN Acebutolol DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM9S2JW DTUGYRD DN Aldosterone DTUGYRD MA Substrate DTUGYRD RA MDR1 genotype-dependent regulation of the aldosterone system in humans. Pharmacogenet Genomics. 2007 Feb;17(2):137-44. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17301693 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM89JLN DTUGYRD DN Apixaban DTUGYRD MA Substrate DTUGYRD RA Effect of Rifampin on the Pharmacokinetics of Apixaban, an Oral Direct Inhibitor of Factor Xa. Am J Cardiovasc Drugs. 2016 Apr;16(2):119-27. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26749408 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMS51VC DTUGYRD DN Clomiphene citrate DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVAZP9 DTUGYRD DN Tenoxicam DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2HG4X DTUGYRD DN Prednisone DTUGYRD MA Substrate DTUGYRD RA Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/14661924 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMMWZET DTUGYRD DN Dexamethasone DTUGYRD MA Substrate DTUGYRD RA Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMU5QZX DTUGYRD DN Cortisone DTUGYRD MA Substrate DTUGYRD RA Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/14661924 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2C4RF DTUGYRD DN Betrixaban DTUGYRD MA Substrate DTUGYRD RA Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015 Jun 26;11:343-51. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26170684 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPIBJK DTUGYRD DN Propafenone DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZCBMS DTUGYRD DN Pepstatin A DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6VM38 DTUGYRD DN Reserpine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPT74U DTUGYRD DN Gramicidin D DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSRZAO DTUGYRD DN Eliglustat tartrate DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQ6W4I DTUGYRD DN Substance P DTUGYRD MA Substrate DTUGYRD RA Transport of somatostatin and substance P by human P-glycoprotein. FEBS Lett. 2004 Sep 10;574(1-3):55-61. DTUGYRD RU https://doi.org/10.1016/j.febslet.2004.07.084 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM8QB1D DTUGYRD DN Olaparib DTUGYRD MA Substrate DTUGYRD RA Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. Transl Oncol. 2019 May 7;12(7):871-878. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/31075528 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMMIQ7G DTUGYRD DN Rosuvastatin DTUGYRD MA Substrate DTUGYRD RA Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGLX0T DTUGYRD DN Grepafloxacin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMABRJL DTUGYRD DN Ximelagatran DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0FB1J DTUGYRD DN Sertraline DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM8X2EH DTUGYRD DN Everolimus DTUGYRD MA Substrate DTUGYRD RA Closer to the Site of Action: Everolimus Concentrations in Peripheral Blood Mononuclear Cells Correlate Well With Whole Blood Concentrations. Ther Drug Monit. 2015 Oct;37(5):675-80. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25565673 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DML97WV DTUGYRD DN Pemirolast DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMB4HCT DTUGYRD DN Sparfloxacin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2NA4K DTUGYRD DN Ciclesonide DTUGYRD MA Substrate DTUGYRD RA Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DTUGYRD RU https://doi.org/10.1016/j.taap.2012.03.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOTQ1I DTUGYRD DN Ondansetron DTUGYRD MA Substrate DTUGYRD RA Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33. DTUGYRD RU https://doi.org/10.1016/j.clpt.2003.09.012 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3NC4M DTUGYRD DN Quercetin DTUGYRD MA Substrate DTUGYRD RA Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004 Mar 1;36(5):592-604. DTUGYRD RU https://doi.org/10.1016/j.freeradbiomed.2003.11.023 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGXENV DTUGYRD DN Saxagliptin DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQMBZ1 DTUGYRD DN Rivaroxaban DTUGYRD MA Substrate DTUGYRD RA Downregulation of ABCB1 gene in patients with total hip or knee arthroplasty influences pharmacokinetics of rivaroxaban: a population pharmacokinetic-pharmacodynamic study. Eur J Clin Pharmacol. 2019 Feb 6. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/30725221 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGEMB7 DTUGYRD DN Hydrocortisone DTUGYRD MA Substrate DTUGYRD RA Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DTUGYRD RU https://doi.org/10.1016/j.taap.2012.03.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMYN59P DTUGYRD DN vildagliptin DTUGYRD MA Substrate DTUGYRD RA Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010 Aug;12(8):648-58. DTUGYRD RU https://doi.org/10.1111/j.1463-1326.2010.01212.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMIO4V5 DTUGYRD DN Nelfinavir DTUGYRD MA Substrate DTUGYRD RA Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. J Infect Dis. 2005 Dec 1;192(11):1931-42. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/16267764 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5QWEL DTUGYRD DN Guanabenz DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMUTEX3 DTUGYRD DN Amiodarone DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMT5GNL DTUGYRD DN Romidepsin DTUGYRD MA Substrate DTUGYRD RA Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19228751 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DML0DBV DTUGYRD DN ABT-737 DTUGYRD MA Substrate DTUGYRD RA The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. DTUGYRD RU https://doi.org/10.1016/j.bbrc.2011.04.043 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWVIGP DTUGYRD DN Digitoxin DTUGYRD MA Substrate DTUGYRD RA The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patients. Eur J Clin Pharmacol. 2008 Apr;64(4):367-72. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18080812 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMELB5S DTUGYRD DN Trans-flupentixol DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRT28X DTUGYRD DN NSC325663 DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDI6R4 DTUGYRD DN Dabigatran DTUGYRD MA Substrate DTUGYRD RA Influence of ABCB11 and HNF4 genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29091211 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMI6GKT DTUGYRD DN beta-Acetyldigoxin DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43. DTUGYRD RU https://doi.org/10.1007/s002100000354 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMC50ME DTUGYRD DN Debrisoquine DTUGYRD MA Substrate DTUGYRD RA Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/10213372 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0RXBT DTUGYRD DN beta-Carotene DTUGYRD MA Substrate DTUGYRD RA Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DTUGYRD RU https://doi.org/10.1016/j.phymed.2012.05.010 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOL54H DTUGYRD DN Clopidogrel DTUGYRD MA Substrate DTUGYRD RA Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006 Nov;80(5):486-501. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17112805 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DML27AE DTUGYRD DN Norverapamil DTUGYRD MA Substrate DTUGYRD RA Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. DTUGYRD RU http://jpet.aspetjournals.org/content/293/2/376.long DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1IB4Q DTUGYRD DN Zolmitriptan DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTL94F DTUGYRD DN Maraviroc DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0659E DTUGYRD DN Cannabidiol DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6HX9B DTUGYRD DN Nevirapine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMT2KRV DTUGYRD DN Cyclosporine DTUGYRD MA Substrate DTUGYRD RA Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model. J Pharmacol Exp Ther. 2008 Nov;327(2):592-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/18725544 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTIGA0 DTUGYRD DN Acrivastine DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGO72P DTUGYRD DN Oseltamivir DTUGYRD MA Substrate DTUGYRD RA Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19721074 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDI269 DTUGYRD DN Docetaxel DTUGYRD MA Substrate DTUGYRD RA Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Br J Cancer. 2010 Aug 10;103(4):560-6. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20628376 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1EF73 DTUGYRD DN Methysergide DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTI8YE DTUGYRD DN Bosutinib DTUGYRD MA Substrate DTUGYRD RA In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib. J Hematol Oncol. 2015 Jul 7;8:81. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26149173 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMAI7ZV DTUGYRD DN Diltiazem DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMIT8LX DTUGYRD DN Fluphenazine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2YGNW DTUGYRD DN Dactinomycin DTUGYRD MA Substrate DTUGYRD RA Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35. DTUGYRD RU https://doi.org/10.1111/j.0013-9580.2005.31904.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKMCE1 DTUGYRD DN Biotin DTUGYRD MA Substrate DTUGYRD RA Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol Pharm. 2006 May-Jun;3(3):329-39. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/16749865 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMIZ6W2 DTUGYRD DN Norfloxacin DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM6Q7U4 DTUGYRD DN Lenalidomide DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00480) DTUGYRD RU https://www.drugbank.ca/drugs/DB00480 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGFV3Z DTUGYRD DN Nizatidine DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00585) DTUGYRD RU https://www.drugbank.ca/drugs/DB00585 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5PU6O DTUGYRD DN Oxcarbazepine DTUGYRD MA Substrate DTUGYRD RA The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.003 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDO279 DTUGYRD DN Phenprocoumon DTUGYRD MA Substrate DTUGYRD RA Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell model. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):259-65. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/23663291 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMA7PEW DTUGYRD DN Verapamil DTUGYRD MA Substrate DTUGYRD RA Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells. Protein Expr Purif. 2009 Jul;66(1):7-14. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19233288 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMB1IU4 DTUGYRD DN Lenvatinib DTUGYRD MA Substrate DTUGYRD RA Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/30931962 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCBJSR DTUGYRD DN Sunitinib DTUGYRD MA Substrate DTUGYRD RA Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19773380 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMM58JY DTUGYRD DN Ziprasidone DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSC4A7 DTUGYRD DN Indomethacin DTUGYRD MA Substrate DTUGYRD RA Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1. Br J Cancer. 2007 Oct 22;97(8):1077-83. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17940500 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM9JPUD DTUGYRD DN Droloxifene DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM8EU0Z DTUGYRD DN Dicloxacillin DTUGYRD MA Substrate DTUGYRD RA Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res. 2002 Apr;19(4):457-62. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12033380 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMM39BF DTUGYRD DN Mitoxantrone DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKBYWI DTUGYRD DN Trifluoperazine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMH7GN8 DTUGYRD DN Ramosetron DTUGYRD MA Substrate DTUGYRD RA Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier. J Pharm Pharmacol. 2002 Aug;54(8):1055-63. DTUGYRD RU https://doi.org/10.1211/002235702320266208 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7ICNU DTUGYRD DN Doxycycline DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM7ISKJ DTUGYRD DN Nisoldipine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMEBOFW DTUGYRD DN Clofazimine DTUGYRD MA Substrate DTUGYRD RA Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy. J Antimicrob Chemother. 2016 Jan;71(1):17-26. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26472768 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM9X2D0 DTUGYRD DN Calphostin C DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW1OQ0 DTUGYRD DN Clobazam DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMNO38U DTUGYRD DN Bortezomib DTUGYRD MA Substrate DTUGYRD RA CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy. Neurobiol Dis. 2016 Apr;88:118-24. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26792401 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2TEOL DTUGYRD DN Methotrexate DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCDYW7 DTUGYRD DN Nicardipine DTUGYRD MA Substrate DTUGYRD RA Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMP6M1N DTUGYRD DN Pirenzepine DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSWLM5 DTUGYRD DN CP-122721 DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11504828 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSVOCZ DTUGYRD DN Pantoprazole DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGTW1I DTUGYRD DN Pirarubicin DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM3PD2C DTUGYRD DN Fluoxetine DTUGYRD MA Substrate DTUGYRD RA Fluoxetine and reversal of multidrug resistance. Cancer Lett. 2006 Jun 18;237(2):180-7. DTUGYRD RU https://doi.org/10.1016/j.canlet.2005.06.003 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMJSBT6 DTUGYRD DN Silodosin DTUGYRD MA Substrate DTUGYRD RA The influence of UGT2B7, UGT1A8, MDR1, ALDH, ADH, CYP3A4 and CYP3A5 genetic polymorphisms on the pharmacokinetics of silodosin in healthy Chinese volunteers. Drug Metab Pharmacokinet. 2013;28(3):239-43. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/23257391 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM35M8J DTUGYRD DN Thioridazine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGDKXN DTUGYRD DN Sitagliptin DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMWSI0H DTUGYRD DN Tiapamil DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMITQS0 DTUGYRD DN Lopinavir DTUGYRD MA Substrate DTUGYRD RA Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir. Br J Pharmacol. 2010 Jul;160(5):1224-33. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20590614 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRHGI9 DTUGYRD DN Cisplatin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXOELT DTUGYRD DN Midazolam DTUGYRD MA Substrate DTUGYRD RA A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DTUGYRD RU https://doi.org/10.1007/s00210-008-0345-0 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW9F1G DTUGYRD DN Belotecan DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM32XZT DTUGYRD DN Trospium chloride DTUGYRD MA Substrate DTUGYRD RA Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25466967 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMBSHMF DTUGYRD DN Boceprevir DTUGYRD MA Substrate DTUGYRD RA Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage? Eur J Clin Pharmacol. 2014 Jul;70(7):775-89. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/24817413 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCR1MV DTUGYRD DN Itraconazole DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPFN6Y DTUGYRD DN Olanzapine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0T3YH DTUGYRD DN Indinavir DTUGYRD MA Substrate DTUGYRD RA HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry. 1998 Mar 17;37(11):3594-601. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/9530286 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRKE63 DTUGYRD DN Chlorambucil DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZMSPF DTUGYRD DN Bicalutamide DTUGYRD MA Substrate DTUGYRD RA Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans. Clin Chim Acta. 2015 Jan 1;438:7-11. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/25124867 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMJHLSD DTUGYRD DN Famciclovir DTUGYRD MA Substrate DTUGYRD RA Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2OZ3G DTUGYRD DN Ixabepilone DTUGYRD MA Substrate DTUGYRD RA Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMS8IFC DTUGYRD DN Sorafenib DTUGYRD MA Substrate DTUGYRD RA Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. Mol Cancer Ther. 2010 Feb;9(2):319-26. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20103600 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1XBHS DTUGYRD DN Pentazocine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMZC1HS DTUGYRD DN Ivacaftor DTUGYRD MA Substrate DTUGYRD RA Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1). Sci Rep. 2017 Dec 13;7(1):17481. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29235532 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMC5Q8X DTUGYRD DN Berberine DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers. J Pharm Sci. 2002 Dec;91(12):2614-21. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12434406 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMU9VDS DTUGYRD DN Mibefradil DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMHTEAO DTUGYRD DN Carvedilol DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5TVS3 DTUGYRD DN Vinblastine DTUGYRD MA Substrate DTUGYRD RA Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/19631272 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRMS0L DTUGYRD DN Morphine DTUGYRD MA Substrate DTUGYRD RA Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005 Aug;49(7):902-8. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/16045647 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMBR01X DTUGYRD DN Brilinta DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMG814N DTUGYRD DN Saquinavir DTUGYRD MA Substrate DTUGYRD RA Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15180340 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOSW35 DTUGYRD DN Felodipine DTUGYRD MA Substrate DTUGYRD RA The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers. J Clin Pharm Ther. 2017 Jun;42(3):345-349. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28244604 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCD9YG DTUGYRD DN Prazosin DTUGYRD MA Substrate DTUGYRD RA Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/9380680 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DML4ZOT DTUGYRD DN Lidocaine DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5PCS7 DTUGYRD DN Bupropion DTUGYRD MA Substrate DTUGYRD RA Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein. Biol Pharm Bull. 2008 Feb;31(2):231-4. DTUGYRD RU https://doi.org/10.1248/bpb.31.231 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMD1QXW DTUGYRD DN Ambrisentan DTUGYRD MA Substrate DTUGYRD RA Potential for pharmacokinetic interactions between ambrisentan and cyclosporine. Clin Pharmacol Ther. 2010 Oct;88(4):513-20. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20811346 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMFXEWT DTUGYRD DN Chloramphenicol DTUGYRD MA Substrate DTUGYRD RA Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr;107(4):1178-1184. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29221992 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMMRV29 DTUGYRD DN Telaprevir DTUGYRD MA Substrate DTUGYRD RA Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage? Eur J Clin Pharmacol. 2014 Jul;70(7):775-89. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/24817413 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQ0RKZ DTUGYRD DN Nimodipine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMH0ZJE DTUGYRD DN Mitomycin DTUGYRD MA Substrate DTUGYRD RA In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate. J Gene Med. 2010 Jul;12(7):596-603. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/20533531 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2HN6Q DTUGYRD DN Astemizole DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMN3UXQ DTUGYRD DN Diethylstilbestrol DTUGYRD MA Substrate DTUGYRD RA Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVMIK2 DTUGYRD DN Roxithromycin DTUGYRD MA Substrate DTUGYRD RA Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010 Sep 11;41(1):86-95. DTUGYRD RU https://doi.org/10.1016/j.ejps.2010.05.016 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0RKS4 DTUGYRD DN Bepridil DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2G9AE DTUGYRD DN Citalopram DTUGYRD MA Substrate DTUGYRD RA ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Int J Legal Med. 2013 May;127(3):579-86. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/23515680 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMK7F9S DTUGYRD DN Amitriptyline DTUGYRD MA Substrate DTUGYRD RA Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4ONW5 DTUGYRD DN Baricitinib DTUGYRD MA Substrate DTUGYRD RA Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib. Clin Transl Sci. 2017 Nov;10(6):509-519. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/28749581 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMXZOCG DTUGYRD DN Phenobarbital DTUGYRD MA Substrate DTUGYRD RA The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.003 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM62UG5 DTUGYRD DN Vemurafenib DTUGYRD MA Substrate DTUGYRD RA Differential effects of the oncogenic BRAF inhibitor PLX4032 (vemurafenib) and its progenitor PLX4720 on ABCB1 function. J Pharm Pharm Sci. 2014;17(1):154-68. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/24735766 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMEMBJC DTUGYRD DN Folic acid DTUGYRD MA Substrate DTUGYRD RA Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26105097 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMOEM2I DTUGYRD DN Estriol DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15290871 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMFC71L DTUGYRD DN Clozapine DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4M1SG DTUGYRD DN Clarithromycin DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVYXR8 DTUGYRD DN Sumatriptan DTUGYRD MA Substrate DTUGYRD RA HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer. J Pharm Sci. 2001 Oct;90(10):1608-19. Comparative Study DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11745719 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMP0UK2 DTUGYRD DN Vecuronium DTUGYRD MA Substrate DTUGYRD RA Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33. DTUGYRD RU https://doi.org/10.1016/j.clpt.2003.09.012 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM87ZIH DTUGYRD DN AG1478 DTUGYRD MA Substrate DTUGYRD RA Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93. DTUGYRD RU https://doi.org/10.1016/j.bcp.2008.11.007 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMINRKW DTUGYRD DN Clomipramine DTUGYRD MA Substrate DTUGYRD RA Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DTUGYRD RU https://doi.org/10.1016/j.addr.2011.12.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMU764S DTUGYRD DN Ritonavir DTUGYRD MA Substrate DTUGYRD RA MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS. 2005 Oct 14;19(15):1617-25. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/16184031 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM8I94Y DTUGYRD DN Venetoclax DTUGYRD MA Substrate DTUGYRD RA Venclexta FDA label DTUGYRD RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/002/127/original/Venclexta_FDA_label.pdf?1543869212 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMVBIZL DTUGYRD DN Estrone sulfate DTUGYRD MA Substrate DTUGYRD RA Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. DTUGYRD RU https://doi.org/10.1124/jpet.105.085589 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW4TYV DTUGYRD DN Valinomycin DTUGYRD MA Substrate DTUGYRD RA Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMLB81S DTUGYRD DN Paclitaxel DTUGYRD MA Substrate DTUGYRD RA Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J Pharmacol Exp Ther. 2001 Sep;298(3):1236-42. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/11504826 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDPV82 DTUGYRD DN Metildigoxin DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCWNZG DTUGYRD DN Vibegron DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTI0ZO DTUGYRD DN Gilteritinib DTUGYRD MA Substrate DTUGYRD RA KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DTUGYRD RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMU5G01 DTUGYRD DN Omadacycline DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB12455) DTUGYRD RU https://www.drugbank.ca/drugs/DB12455 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRVITQ DTUGYRD DN Ivosidenib DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB14568) DTUGYRD RU https://www.drugbank.ca/drugs/DB14568 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRJ9EN DTUGYRD DN Baloxavir marboxil DTUGYRD MA Substrate DTUGYRD RA Baloxavir Marboxil FDA label DTUGYRD RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/002/078/original/Baloxavir_Marboxil_FDA_label.pdf?1543255968 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2M3OC DTUGYRD DN Talazoparib DTUGYRD MA Substrate DTUGYRD RA DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB11760) DTUGYRD RU https://www.drugbank.ca/drugs/DB11760 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQI86A DTUGYRD DN Sofosbuvir DTUGYRD MA Substrate DTUGYRD RA Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine. Clin Pharmacol Ther. 2018 Dec;104(6):1191-1198. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29569712 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM27BL1 DTUGYRD DN Pibrentasvir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0DJ9O DTUGYRD DN Flupentixol DTUGYRD MA Substrate DTUGYRD RA Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMN8E5D DTUGYRD DN Sunitinib malate DTUGYRD MA Substrate DTUGYRD RA JNK-AKT-NF-kB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. Biochem Pharmacol. 2018 Oct;156:120-134. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/30121250 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPG1LJ DTUGYRD DN Bcecf-Am DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMW76V0 DTUGYRD DN Bisantrene DTUGYRD MA Substrate DTUGYRD RA Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMSVBND DTUGYRD DN Glecaprevir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMQIMTK DTUGYRD DN Ombitasvir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM4N7BT DTUGYRD DN Paritaprevir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM9OEK1 DTUGYRD DN Velpatasvir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM215XO DTUGYRD DN Voxilaprevir DTUGYRD MA Substrate DTUGYRD RA Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DTUGYRD RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMHOV7D DTUGYRD DN Tenofovir alafenamide DTUGYRD MA Substrate DTUGYRD RA Pharmacokinetics of Tenofovir Alafenamide When Coadministered With Other HIV Antiretrovirals. J Acquir Immune Defic Syndr. 2018 Aug 1;78(4):465-472. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/29649076 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM9Y5JB DTUGYRD DN Cepharanthine DTUGYRD MA Substrate DTUGYRD RA Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein. J Pharmacol Exp Ther. 1995 Oct;275(1):73-8. DTUGYRD RU http://jpet.aspetjournals.org/content/275/1/73.long DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM0QDC9 DTUGYRD DN Dolastatin 10 DTUGYRD MA Substrate DTUGYRD RA Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. DTUGYRD RU http://www.ncbi.nlm.nih.gov/pubmed/8621716 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMT4532 DTUGYRD DN Bunitrolol DTUGYRD MA Substrate DTUGYRD RA Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier. Biopharm Drug Dispos. 1999 Mar;20(2):85-90. DTUGYRD RU https://doi.org/10.1002/(SICI)1099-081X(199903)20:2<85::AID-BDD159>3.0.CO;2-3 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDKLB5 DTUGYRD DN Puromycin DTUGYRD MA Substrate DTUGYRD RA ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50. DTUGYRD RU https://doi.org/10.1016/j.ab.2009.12.014 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMG3BE1 DTUGYRD DN Coelenterazine DTUGYRD MA Substrate DTUGYRD RA Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1702-7. DTUGYRD RU https://doi.org/10.1073/pnas.0304326101 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM18QHT DTUGYRD DN Simvastatin acid DTUGYRD MA Substrate DTUGYRD RA Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. DTUGYRD RU https://doi.org/10.1023/B:PHAM.0000041466.84653.8c DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMP3G0W DTUGYRD DN Pazufloxacin DTUGYRD MA Substrate DTUGYRD RA Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats. Eur J Pharmacol. 2004 Oct 6;501(1-3):151-9. DTUGYRD RU https://doi.org/10.1016/j.ejphar.2004.08.013 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKF2H0 DTUGYRD DN Nonactin DTUGYRD MA Substrate DTUGYRD RA Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35. DTUGYRD RU https://doi.org/10.1111/j.0013-9580.2005.31904.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRSATG DTUGYRD DN Abamectin B1A DTUGYRD MA Substrate DTUGYRD RA Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 2007 Jan;30(1):84-94. DTUGYRD RU https://doi.org/10.1016/j.ejps.2006.10.004 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5LU3N DTUGYRD DN Selamectin DTUGYRD MA Substrate DTUGYRD RA Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 2007 Jan;30(1):84-94. DTUGYRD RU https://doi.org/10.1016/j.ejps.2006.10.004 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2I76R DTUGYRD DN Desmethylsertraline DTUGYRD MA Substrate DTUGYRD RA Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein. Biol Pharm Bull. 2008 Feb;31(2):231-4. DTUGYRD RU https://doi.org/10.1248/bpb.31.231 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMKA2YS DTUGYRD DN MG-132 DTUGYRD MA Substrate DTUGYRD RA Increased ABCB1 expression in TP-110-resistant RPMI-8226 cells. Biosci Biotechnol Biochem. 2010;74(9):1913-9. DTUGYRD RU https://doi.org/10.1271/bbb.100325 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM2ILSJ DTUGYRD DN Norbuprenorphine DTUGYRD MA Substrate DTUGYRD RA Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. DTUGYRD RU https://doi.org/10.1017/S1461145709990848 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMREUZV DTUGYRD DN Eslicarbazepine acetate DTUGYRD MA Substrate DTUGYRD RA In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct;52(10):1894-904. DTUGYRD RU https://doi.org/10.1111/j.1528-1167.2011.03140.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTGN0U DTUGYRD DN Genz 644282 DTUGYRD MA Substrate DTUGYRD RA Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9. DTUGYRD RU https://doi.org/10.1158/1535-7163.MCT-10-1043 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGDOS2 DTUGYRD DN (Z)-endoxifen DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration. J Pharmacol Exp Ther. 2011 Jun;337(3):710-7. DTUGYRD RU https://doi.org/10.1124/jpet.110.178301 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPN5IH DTUGYRD DN Guanfacine DTUGYRD MA Substrate DTUGYRD RA An in vitro evaluation of guanfacine as a substrate for P-glycoprotein. Neuropsychiatr Dis Treat. 2011;7:501-5. DTUGYRD RU https://doi.org/10.2147/NDT.S24153 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5ATJ0 DTUGYRD DN N-desethyl sunitinib DTUGYRD MA Substrate DTUGYRD RA P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther. 2012 Apr;341(1):164-73. DTUGYRD RU https://doi.org/10.1124/jpet.111.186908 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMRWLB2 DTUGYRD DN Fluticasone propionate DTUGYRD MA Substrate DTUGYRD RA Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DTUGYRD RU https://doi.org/10.1016/j.taap.2012.03.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5O3HC DTUGYRD DN Bouvardin DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM1ZFCS DTUGYRD DN Cephaeline DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDU8KC DTUGYRD DN Metkephamid DTUGYRD MA Substrate DTUGYRD RA Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DTUGYRD RU https://doi.org/10.1016/j.bmc.2012.03.045 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMPQFTA DTUGYRD DN Fucoxanthin DTUGYRD MA Substrate DTUGYRD RA Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DTUGYRD RU https://doi.org/10.1016/j.phymed.2012.05.010 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5F24X DTUGYRD DN Crocin DTUGYRD MA Substrate DTUGYRD RA Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DTUGYRD RU https://doi.org/10.1016/j.phymed.2012.05.010 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5NW1E DTUGYRD DN Beclomethasone dipropionate DTUGYRD MA Substrate DTUGYRD RA Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DTUGYRD RU https://doi.org/10.1016/j.taap.2012.03.008 DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMX2FZS DTUGYRD DN Epothilone A DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMGCQ4E DTUGYRD DN Lovastatin acid DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMTV5XC DTUGYRD DN Sitafloxacin DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMH21D9 DTUGYRD DN Ebastine DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMC40UY DTUGYRD DN Tenofovir disoproxil DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMDIZCS DTUGYRD DN S-licarbazepine DTUGYRD MA Substrate DTUGYRD RA In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct;52(10):1894-904. DTUGYRD RU https://doi.org/10.1111/j.1528-1167.2011.03140.x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DM5VP0F DTUGYRD DN Saphris DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMCWIBU DTUGYRD DN BMS-3870032 DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUGYRD TI DTUGYRD DTUGYRD TN P-glycoprotein 1 DTUGYRD DI DMO9WU8 DTUGYRD DN Gepirone DTUGYRD MA Substrate DTUGYRD RA Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DTUGYRD RU https://doi.org/10.1007/s11095-012-0935-x DTUJPOL TI DTUJPOL DTUJPOL TN Glucose transporter type 2 DTUJPOL DI DMIAHVU DTUJPOL DN 2-Deoxyglucose DTUJPOL MA Substrate DTUJPOL RA GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol Genet Metab. 2011 Dec;104(4):648-53. DTUJPOL RU http://www.ncbi.nlm.nih.gov/pubmed/21920790 DTUO05P TI DTUO05P DTUO05P TN Sodium/dicarboxylate cotransporter 1 DTUO05P DI DML3HEM DTUO05P DN Dicarboxylate DTUO05P MA Substrate DTUO05P RA Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers. J Nephrol. 2017 Jun;30(3):411-418. DTUO05P RU http://www.ncbi.nlm.nih.gov/pubmed/27639591 DTV2AOB TI DTV2AOB DTV2AOB TN Excitatory amino acid transporter 4 DTV2AOB DI DM4PUDW DTV2AOB DN L-glutamic acid DTV2AOB MA Substrate DTV2AOB RA The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. DTV2AOB RU http://www.ncbi.nlm.nih.gov/pubmed/23506861 DTVAEDK TI DTVAEDK DTVAEDK TN Calcium-binding mitochondrial carrier protein SCaMC-1 DTVAEDK DI DMUXQG7 DTVAEDK DN Phosphate DTVAEDK MA Substrate DTVAEDK RA De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. Am J Hum Genet. 2017 Nov 2;101(5):844-855. DTVAEDK RU http://www.ncbi.nlm.nih.gov/pubmed/29100094 DTVGOLN TI DTVGOLN DTVGOLN TN Anion exchange transporter DTVGOLN DI DM40SEU DTVGOLN DN Oxalate DTVGOLN MA Substrate DTVGOLN RA Oxalate (urine, plasma) DTVGOLN RU http://www.acb.org.uk/Nat%20Lab%20Med%20Hbk/Oxalate.pdf DTVGOLN TI DTVGOLN DTVGOLN TN Anion exchange transporter DTVGOLN DI DMW0ZBF DTVGOLN DN Sulfate DTVGOLN MA Substrate DTVGOLN RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.7) DTVGOLN RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.7 DTVGOLN TI DTVGOLN DTVGOLN TN Anion exchange transporter DTVGOLN DI DMT5E36 DTVGOLN DN Bicarbonate DTVGOLN MA Substrate DTVGOLN RA Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005 Jul 20;24(14):2499-511. DTVGOLN RU http://www.ncbi.nlm.nih.gov/pubmed/15990874 DTVHQT2 TI DTVHQT2 DTVHQT2 TN Zinc transporter 5 DTVHQT2 DI DMZ4R3Q DTVHQT2 DN Zinc salts DTVHQT2 MA Substrate DTVHQT2 RA Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes Nutr. 2015 Sep;10(5):487. DTVHQT2 RU http://www.ncbi.nlm.nih.gov/pubmed/26319140 DTVKMHD TI DTVKMHD DTVKMHD TN Natural resistance-associated macrophage protein 2 DTVKMHD DI DMAP8MV DTVKMHD DN Iron monocation DTVKMHD MA Substrate DTVKMHD RA Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34. DTVKMHD RU http://www.ncbi.nlm.nih.gov/pubmed/19621945 DTVKMHD TI DTVKMHD DTVKMHD TN Natural resistance-associated macrophage protein 2 DTVKMHD DI DMKT129 DTVKMHD DN Manganese DTVKMHD MA Substrate DTVKMHD RA Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34. DTVKMHD RU http://www.ncbi.nlm.nih.gov/pubmed/19621945 DTVNRXW TI DTVNRXW DTVNRXW TN Organic anion transporting polypeptide 3A1 DTVNRXW DI DM4XAU7 DTVNRXW DN Prostaglandin f2Alpha DTVNRXW MA Substrate DTVNRXW RA Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DTVNRXW RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DTVNRXW TI DTVNRXW DTVNRXW TN Organic anion transporting polypeptide 3A1 DTVNRXW DI DMS9503 DTVNRXW DN Benzylpenicillin DTVNRXW MA Substrate DTVNRXW RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DTVNRXW RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DTVNRXW TI DTVNRXW DTVNRXW TN Organic anion transporting polypeptide 3A1 DTVNRXW DI DMVPZBE DTVNRXW DN Iloprost DTVNRXW MA Substrate DTVNRXW RA Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DTVNRXW RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DTVNRXW TI DTVNRXW DTVNRXW TN Organic anion transporting polypeptide 3A1 DTVNRXW DI DMTYOPD DTVNRXW DN Dinoprostone DTVNRXW MA Substrate DTVNRXW RA Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DTVNRXW RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DTVNRXW TI DTVNRXW DTVNRXW TN Organic anion transporting polypeptide 3A1 DTVNRXW DI DMWH7NQ DTVNRXW DN Alprostadil DTVNRXW MA Substrate DTVNRXW RA Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DTVNRXW RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DTVNRXW TI DTVNRXW DTVNRXW TN Organic anion transporting polypeptide 3A1 DTVNRXW DI DMVBIZL DTVNRXW DN Estrone sulfate DTVNRXW MA Substrate DTVNRXW RA Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DTVNRXW RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM4XAU7 DTVP67E DN Prostaglandin f2Alpha DTVP67E MA Substrate DTVP67E RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMS9503 DTVP67E DN Benzylpenicillin DTVP67E MA Substrate DTVP67E RA Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM4KI7O DTVP67E DN Zidovudine DTVP67E MA Substrate DTVP67E RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMH61ZB DTVP67E DN Cimetidine DTVP67E MA Substrate DTVP67E RA Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther. 2007 May;321(2):673-83. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17314201 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM6A0X7 DTVP67E DN Pravastatin DTVP67E MA Substrate DTVP67E RA Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMZMSCT DTVP67E DN Cilostazol DTVP67E MA Substrate DTVP67E RA Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos. 2014 Jun;42(6):996-1007. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/24692216 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMA13GD DTVP67E DN Cidofovir DTVP67E MA Substrate DTVP67E RA Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17372702 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMUN54G DTVP67E DN Aminohippuric acid DTVP67E MA Substrate DTVP67E RA Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11306713 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMLPAOB DTVP67E DN Allopurinol DTVP67E MA Substrate DTVP67E RA Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/15100168 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMHKS94 DTVP67E DN Valacyclovir DTVP67E MA Substrate DTVP67E RA Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM1MBYQ DTVP67E DN Ganciclovir DTVP67E MA Substrate DTVP67E RA FDA Drug Development and Drug Interactions DTVP67E RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMIBH7M DTVP67E DN L-tryptophan DTVP67E MA Substrate DTVP67E RA Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1075-84. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/15944205 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMU4T9Y DTVP67E DN Dimesna DTVP67E MA Substrate DTVP67E RA In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52(4):530-42. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/21505084 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM8ZHP1 DTVP67E DN Edaravone DTVP67E MA Substrate DTVP67E RA Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17502342 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMTYOPD DTVP67E DN Dinoprostone DTVP67E MA Substrate DTVP67E RA Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMREUQ6 DTVP67E DN Valsartan DTVP67E MA Substrate DTVP67E RA Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMWBHRY DTVP67E DN Olmesartan medoxomil DTVP67E MA Substrate DTVP67E RA Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMZA017 DTVP67E DN Tetracycline DTVP67E MA Substrate DTVP67E RA Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11855680 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMPDYFR DTVP67E DN Cefazolin DTVP67E MA Substrate DTVP67E RA Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/14984259 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMTM2IK DTVP67E DN Mercaptopurine DTVP67E MA Substrate DTVP67E RA Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J Neurochem. 2004 Aug;90(4):931-41. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/15287899 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMYLOVR DTVP67E DN Acyclovir DTVP67E MA Substrate DTVP67E RA Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. Drug Metab Dispos. 2012 Mar;40(3):617-24. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/22190696 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM0GUSX DTVP67E DN Ranitidine DTVP67E MA Substrate DTVP67E RA A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMA1MKT DTVP67E DN Uric acid DTVP67E MA Substrate DTVP67E RA Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17674156 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM1IS6U DTVP67E DN Tenofovir DTVP67E MA Substrate DTVP67E RA Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity. Antivir Ther. 2014;19(7):687-92. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/24699134 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM4Y95F DTVP67E DN Cephaloridine DTVP67E MA Substrate DTVP67E RA Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM1UJO0 DTVP67E DN Pitavastatin calcium DTVP67E MA Substrate DTVP67E RA Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16259759 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMMIQ7G DTVP67E DN Rosuvastatin DTVP67E MA Substrate DTVP67E RA The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther. 2007 Sep;322(3):1221-7. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17585018 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM67VKL DTVP67E DN Prasterone DTVP67E MA Substrate DTVP67E RA Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11306713 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMRL3AB DTVP67E DN Famotidine DTVP67E MA Substrate DTVP67E RA A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMF5HU6 DTVP67E DN Cefotiam DTVP67E MA Substrate DTVP67E RA Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. Am J Physiol Renal Physiol. 2008 Jul;295(1):F247-52. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/18480179 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMGXENV DTVP67E DN Saxagliptin DTVP67E MA Substrate DTVP67E RA Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/22686547 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM2KEW6 DTVP67E DN Ochratoxin A DTVP67E MA Substrate DTVP67E RA Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/11669456 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMLHESP DTVP67E DN Chlorothiazide DTVP67E MA Substrate DTVP67E RA Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr;294(4):F867-73. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/18216144 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM2NLS9 DTVP67E DN Ciprofloxacin DTVP67E MA Substrate DTVP67E RA Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Mol Pharmacol. 2008 Jul;74(1):122-31. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/18381565 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMGO72P DTVP67E DN Oseltamivir DTVP67E MA Substrate DTVP67E RA FDA Drug Development and Drug Interactions DTVP67E RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMMQ8ZG DTVP67E DN Furosemide DTVP67E MA Substrate DTVP67E RA Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMJXDGC DTVP67E DN Cefaclor DTVP67E MA Substrate DTVP67E RA Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMRV7H0 DTVP67E DN Bumetanide DTVP67E MA Substrate DTVP67E RA Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM2TEOL DTVP67E DN Methotrexate DTVP67E MA Substrate DTVP67E RA Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/15548848 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMGDKXN DTVP67E DN Sitagliptin DTVP67E MA Substrate DTVP67E RA Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther. 2007 May;321(2):673-83. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/17314201 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMJ7A0H DTVP67E DN Cefdinir DTVP67E MA Substrate DTVP67E RA Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMHAQCO DTVP67E DN Trichloromethiazide DTVP67E MA Substrate DTVP67E RA Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DM3VOGS DTVP67E DN Ceftizoxime DTVP67E MA Substrate DTVP67E RA Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMM278X DTVP67E DN Adefovir DTVP67E MA Substrate DTVP67E RA FDA Drug Development and Drug Interactions DTVP67E RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMVBIZL DTVP67E DN Estrone sulfate DTVP67E MA Substrate DTVP67E RA Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1057-64. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/15956776 DTVP67E TI DTVP67E DTVP67E TN Organic anion transporter 3 DTVP67E DI DMCTUAD DTVP67E DN Phenolsulfonphthalein DTVP67E MA Substrate DTVP67E RA Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7. DTVP67E RU http://www.ncbi.nlm.nih.gov/pubmed/14984259 DTVY9PJ TI DTVY9PJ DTVY9PJ TN Sodium-dependent vitamin C transporter 2 DTVY9PJ DI DMXJ7O8 DTVY9PJ DN Vitamin C DTVY9PJ MA Substrate DTVY9PJ RA Molecular characterization and transcriptional regulation of the sodium-dependent vitamin C transporter genes (slc23a1 and slc23a2) in a teleost fish, the Senegalese sole (Solea senegalensis). Comp Biochem Physiol B Biochem Mol Biol. 2012 Mar;161(3):208-18. DTVY9PJ RU http://www.ncbi.nlm.nih.gov/pubmed/22142801 DTVZIRG TI DTVZIRG DTVZIRG TN CMP-sialic acid transporter DTVZIRG DI DMH48YE DTVZIRG DN CMP-sialic acid DTVZIRG MA Substrate DTVZIRG RA Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal -dystroglycan O-mannosylation, independent from sialic acid. Hum Mol Genet. 2015 Apr 15;24(8):2241-6. DTVZIRG RU http://www.ncbi.nlm.nih.gov/pubmed/25552652 DTW40Z7 TI DTW40Z7 DTW40Z7 TN Electroneutral sodium bicarbonate exchanger 1 DTW40Z7 DI DMMU6BJ DTW40Z7 DN Sodium bicarbonate DTW40Z7 MA Substrate DTW40Z7 RA The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. DTW40Z7 RU http://www.ncbi.nlm.nih.gov/pubmed/17071329 DTW78DQ TI DTW78DQ DTW78DQ TN Equilibrative nucleoside transporter 2 DTW78DQ DI DMG2YBD DTW78DQ DN Trifluridine DTW78DQ MA Substrate DTW78DQ RA Lonsurf, INN-trifluridine/tipiracil. DTW78DQ RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/649/original/WC500206246.pdf?1531845997 DTW78DQ TI DTW78DQ DTW78DQ TN Equilibrative nucleoside transporter 2 DTW78DQ DI DMZD5QR DTW78DQ DN Cytarabine DTW78DQ MA Substrate DTW78DQ RA FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799. DTW78DQ RU http://www.ncbi.nlm.nih.gov/pubmed/27391351 DTW78DQ TI DTW78DQ DTW78DQ TN Equilibrative nucleoside transporter 2 DTW78DQ DI DMTM2IK DTW78DQ DN Mercaptopurine DTW78DQ MA Substrate DTW78DQ RA PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DTW78DQ RU https://www.pharmgkb.org/pathway/PA2040 DTW78DQ TI DTW78DQ DTW78DQ TN Equilibrative nucleoside transporter 2 DTW78DQ DI DM7VTQO DTW78DQ DN Entecavir DTW78DQ MA Substrate DTW78DQ RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DTW78DQ RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DTW78DQ TI DTW78DQ DTW78DQ TN Equilibrative nucleoside transporter 2 DTW78DQ DI DMCVJ86 DTW78DQ DN Clofarabine DTW78DQ MA Substrate DTW78DQ RA Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62. DTW78DQ RU http://www.ncbi.nlm.nih.gov/pubmed/24692694 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DM69G8X DTW7AE3 DN L-glutamine DTW7AE3 MA Substrate DTW7AE3 RA High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/16516348 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DM3YH4I DTW7AE3 DN D-serine DTW7AE3 MA Substrate DTW7AE3 RA D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DMHKS94 DTW7AE3 DN Valacyclovir DTW7AE3 MA Substrate DTW7AE3 RA Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/14617696 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DM1MBYQ DTW7AE3 DN Ganciclovir DTW7AE3 MA Substrate DTW7AE3 RA Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/16375689 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DMS2IUH DTW7AE3 DN Valganciclovir DTW7AE3 MA Substrate DTW7AE3 RA Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/15290873 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DM1RBYG DTW7AE3 DN Nitric oxide DTW7AE3 MA Substrate DTW7AE3 RA Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/15848195 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DMYLOVR DTW7AE3 DN Acyclovir DTW7AE3 MA Substrate DTW7AE3 RA Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/16375689 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DMJBOCR DTW7AE3 DN L-carnitine DTW7AE3 MA Substrate DTW7AE3 RA A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/18771654 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DMIOZ29 DTW7AE3 DN Glycine DTW7AE3 MA Substrate DTW7AE3 RA Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/17855766 DTW7AE3 TI DTW7AE3 DTW7AE3 TN Alanine/serine/cysteine/threonine transporter 2 DTW7AE3 DI DMFHTBX DTW7AE3 DN L-threonine DTW7AE3 MA Substrate DTW7AE3 RA D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DTW7AE3 RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DTWDEIL TI DTWDEIL DTWDEIL TN Electrogenic sodium bicarbonate cotransporter 1 DTWDEIL DI DMMU6BJ DTWDEIL DN Sodium bicarbonate DTWDEIL MA Substrate DTWDEIL RA The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8. DTWDEIL RU http://www.ncbi.nlm.nih.gov/pubmed/20529845 DTWFOPY TI DTWFOPY DTWFOPY TN Sodium-dependent phosphate transport protein 2B DTWFOPY DI DMKY27B DTWFOPY DN Sodium phosphate dibasic/Sodium phosphate monobasic DTWFOPY MA Substrate DTWFOPY RA Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DTWFOPY RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DTWI9TE TI DTWI9TE DTWI9TE TN High affinity choline transporter 1 DTWI9TE DI DMUPK6G DTWI9TE DN Triethylcholine DTWI9TE MA Substrate DTWI9TE RA The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. (familyId=172) DTWI9TE RU http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=172 DTWLACT TI DTWLACT DTWLACT TN Vesicular H(+)/Aspartate-glutamate cotransporter DTWLACT DI DMVFB93 DTWLACT DN Nitrate DTWLACT MA Substrate DTWLACT RA Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9. DTWLACT RU http://www.ncbi.nlm.nih.gov/pubmed/22778404 DTWLACT TI DTWLACT DTWLACT TN Vesicular H(+)/Aspartate-glutamate cotransporter DTWLACT DI DMFGOW0 DTWLACT DN N-acetylaspartylglutamate DTWLACT MA Substrate DTWLACT RA Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8. DTWLACT RU http://www.ncbi.nlm.nih.gov/pubmed/23889254 DTWN7FC TI DTWN7FC DTWN7FC TN Multidrug resistance-associated protein 8 DTWN7FC DI DM1IS6U DTWN7FC DN Tenofovir DTWN7FC MA Substrate DTWN7FC RA Tenofovir Disoproxil Fumarate Is a New Substrate of ATP-Binding Cassette Subfamily C Member 11. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e01725-16. DTWN7FC RU http://www.ncbi.nlm.nih.gov/pubmed/28167562 DTWN7FC TI DTWN7FC DTWN7FC TN Multidrug resistance-associated protein 8 DTWN7FC DI DM67VKL DTWN7FC DN Prasterone DTWN7FC MA Substrate DTWN7FC RA Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. Neuroscience. 2006;137(4):1247-57. DTWN7FC RU http://www.ncbi.nlm.nih.gov/pubmed/16359813 DTWN7FC TI DTWN7FC DTWN7FC TN Multidrug resistance-associated protein 8 DTWN7FC DI DM2TEOL DTWN7FC DN Methotrexate DTWN7FC MA Substrate DTWN7FC RA ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci. 2010 Nov;101(11):2404-10. DTWN7FC RU http://www.ncbi.nlm.nih.gov/pubmed/20718756 DTWN7FC TI DTWN7FC DTWN7FC TN Multidrug resistance-associated protein 8 DTWN7FC DI DMH7MUV DTWN7FC DN Zalcitabine DTWN7FC MA Substrate DTWN7FC RA MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem. 2003 Aug 8;278(32):29509-14. DTWN7FC RU http://www.ncbi.nlm.nih.gov/pubmed/12764137 DTWY9RT TI DTWY9RT DTWY9RT TN Cationic amino acid transporter 2 DTWY9RT DI DMHKGCM DTWY9RT DN L-ornithine DTWY9RT MA Substrate DTWY9RT RA Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population. Eur J Hum Genet. 2019 Apr;27(4):621-630. DTWY9RT RU http://www.ncbi.nlm.nih.gov/pubmed/30659259 DTX8KP0 TI DTX8KP0 DTX8KP0 TN Sodium- and chloride-dependent GABA transporter 2 DTX8KP0 DI DMC64EI DTX8KP0 DN Beta-alanine DTX8KP0 MA Substrate DTX8KP0 RA Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DTX8KP0 RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DTXBIQG TI DTXBIQG DTXBIQG TN Sodium- and chloride-dependent GABA transporter 3 DTXBIQG DI DMC64EI DTXBIQG DN Beta-alanine DTXBIQG MA Substrate DTXBIQG RA Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DTXBIQG RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DM9T6MS DTXD1TQ DN Tecadenoson DTXD1TQ MA Substrate DTXD1TQ RA Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/23388705 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMUM7HZ DTXD1TQ DN Fluorouracil DTXD1TQ MA Substrate DTXD1TQ RA Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/17695509 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMG2YBD DTXD1TQ DN Trifluridine DTXD1TQ MA Substrate DTXD1TQ RA Lonsurf, INN-trifluridine/tipiracil. DTXD1TQ RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/649/original/WC500206246.pdf?1531845997 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMM2NSK DTXD1TQ DN Adenosine DTXD1TQ MA Substrate DTXD1TQ RA Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol. 2006 Aug;208(2):451-60. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/16688763 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMZD5QR DTXD1TQ DN Cytarabine DTXD1TQ MA Substrate DTXD1TQ RA FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/27391351 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMTM2IK DTXD1TQ DN Mercaptopurine DTXD1TQ MA Substrate DTXD1TQ RA PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DTXD1TQ RU https://www.pharmgkb.org/pathway/PA2040 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMEYLH9 DTXD1TQ DN Ribavirin DTXD1TQ MA Substrate DTXD1TQ RA Effects of dipyridamole coadministration on the pharmacokinetics of ribavirin in healthy volunteers. Drug Metab Pharmacokinet. 2013;28(5):406-10. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/23459628 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DM7VTQO DTXD1TQ DN Entecavir DTXD1TQ MA Substrate DTXD1TQ RA Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DTXD1TQ TI DTXD1TQ DTXD1TQ TN Equilibrative nucleoside transporter 1 DTXD1TQ DI DMCVJ86 DTXD1TQ DN Clofarabine DTXD1TQ MA Substrate DTXD1TQ RA Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62. DTXD1TQ RU http://www.ncbi.nlm.nih.gov/pubmed/24692694 DTXQYLR TI DTXQYLR DTXQYLR TN Vesicular inhibitory amino acid transporter DTXQYLR DI DMTW79H DTXQYLR DN Gamma-aminobutyric acid DTXQYLR MA Substrate DTXQYLR RA Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jul 1;87(1):164-78. DTXQYLR RU http://www.ncbi.nlm.nih.gov/pubmed/26094607 DTY0QMU TI DTY0QMU DTY0QMU TN Organic anion transporting polypeptide 4C1 DTY0QMU DI DMQCTIH DTY0QMU DN Digoxin DTY0QMU MA Substrate DTY0QMU RA Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DTY0QMU RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DTY0QMU TI DTY0QMU DTY0QMU TN Organic anion transporting polypeptide 4C1 DTY0QMU DI DM7JT24 DTY0QMU DN Ouabain DTY0QMU MA Substrate DTY0QMU RA Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DTY0QMU RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DTY0QMU TI DTY0QMU DTY0QMU TN Organic anion transporting polypeptide 4C1 DTY0QMU DI DMGXENV DTY0QMU DN Saxagliptin DTY0QMU MA Substrate DTY0QMU RA Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. DTY0QMU RU http://www.ncbi.nlm.nih.gov/pubmed/22686547 DTY0QMU TI DTY0QMU DTY0QMU TN Organic anion transporting polypeptide 4C1 DTY0QMU DI DM6IR3P DTY0QMU DN Liothyronine DTY0QMU MA Substrate DTY0QMU RA Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DTY0QMU RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DTY0QMU TI DTY0QMU DTY0QMU TN Organic anion transporting polypeptide 4C1 DTY0QMU DI DMVBIZL DTY0QMU DN Estrone sulfate DTY0QMU MA Substrate DTY0QMU RA Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Drug Metab Pharmacokinet. 2010;25(3):314-7. DTY0QMU RU http://www.ncbi.nlm.nih.gov/pubmed/20610891 DTY25IU TI DTY25IU DTY25IU TN Electroneutral potassium-chloride cotransporter 1 DTY25IU DI DMMTAJC DTY25IU DN Potassium chloride DTY25IU MA Substrate DTY25IU RA Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. Blood. 2004 Jun 1;103(11):4302-9. DTY25IU RU http://www.ncbi.nlm.nih.gov/pubmed/14976052 DTYBI73 TI DTYBI73 DTYBI73 TN Zinc transporter 10 DTYBI73 DI DMZ4R3Q DTYBI73 DN Zinc salts DTYBI73 MA Substrate DTYBI73 RA Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet. 2012 Mar 9;90(3):467-77. DTYBI73 RU http://www.ncbi.nlm.nih.gov/pubmed/22341971 DTYEM9B TI DTYEM9B DTYEM9B TN RalBP1-associated Eps domain-containing protein 2 DTYEM9B DI DMCBJSR DTYEM9B DN Sunitinib DTYEM9B MA Substrate DTYEM9B RA Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38. DTYEM9B RU http://www.ncbi.nlm.nih.gov/pubmed/19626587 DTYEM9B TI DTYEM9B DTYEM9B TN RalBP1-associated Eps domain-containing protein 2 DTYEM9B DI DMS8IFC DTYEM9B DN Sorafenib DTYEM9B MA Substrate DTYEM9B RA Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38. DTYEM9B RU http://www.ncbi.nlm.nih.gov/pubmed/19626587 DTYR5U7 TI DTYR5U7 DTYR5U7 TN Peroxisomal membrane protein PMP34 DTYR5U7 DI DMNIJT0 DTYR5U7 DN Adenosine monophosphate DTYR5U7 MA Substrate DTYR5U7 RA The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochem J. 2012 Apr 1;443(1):241-7. DTYR5U7 RU http://www.ncbi.nlm.nih.gov/pubmed/22185573 DTYR5U7 TI DTYR5U7 DTYR5U7 TN Peroxisomal membrane protein PMP34 DTYR5U7 DI DM1I8LU DTYR5U7 DN Coenzyme A DTYR5U7 MA Substrate DTYR5U7 RA The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochem J. 2012 Apr 1;443(1):241-7. DTYR5U7 RU http://www.ncbi.nlm.nih.gov/pubmed/22185573 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMSE3I7 DTYVM24 DN Gemcitabine DTYVM24 MA Substrate DTYVM24 RA Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/20824050 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DM1MBYQ DTYVM24 DN Ganciclovir DTYVM24 MA Substrate DTYVM24 RA Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/15747503 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMUM7HZ DTYVM24 DN Fluorouracil DTYVM24 MA Substrate DTYVM24 RA ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/19077464 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMM2NSK DTYVM24 DN Adenosine DTYVM24 MA Substrate DTYVM24 RA Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/12423063 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMQTFAO DTYVM24 DN Fluorescein DTYVM24 MA Substrate DTYVM24 RA Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/17540771 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMP6SC2 DTYVM24 DN Irinotecan DTYVM24 MA Substrate DTYVM24 RA Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/18690847 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMTM2IK DTYVM24 DN Mercaptopurine DTYVM24 MA Substrate DTYVM24 RA Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/25674464 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DM2TEOL DTYVM24 DN Methotrexate DTYVM24 MA Substrate DTYVM24 RA The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/15899835 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMZRQU7 DTYVM24 DN Cyclic adenosine monophosphate DTYVM24 MA Substrate DTYVM24 RA The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/10893247 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMMX2E6 DTYVM24 DN Pemetrexed DTYVM24 MA Substrate DTYVM24 RA Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/16337112 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMEMBJC DTYVM24 DN Folic acid DTYVM24 MA Substrate DTYVM24 RA The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/15899835 DTYVM24 TI DTYVM24 DTYVM24 TN Multidrug resistance-associated protein 5 DTYVM24 DI DMTAYMR DTYVM24 DN Carboxydichlorofluorescein DTYVM24 MA Substrate DTYVM24 RA Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32. DTYVM24 RU http://www.ncbi.nlm.nih.gov/pubmed/16337112 DTYVQ5M TI DTYVQ5M DTYVQ5M TN Organic anion transporting polypeptide 5A1 DTYVQ5M DI DMTYOPD DTYVQ5M DN Dinoprostone DTYVQ5M MA Substrate DTYVQ5M RA Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs. Asian-Australas J Anim Sci. 2017 May;30(5):643-652. DTYVQ5M RU http://www.ncbi.nlm.nih.gov/pubmed/27764917 DTZ6IJW TI DTZ6IJW DTZ6IJW TN Zrt- and Irt-like protein 14 DTZ6IJW DI DMZ4R3Q DTZ6IJW DN Zinc salts DTZ6IJW MA Substrate DTZ6IJW RA SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1769-E1778. DTZ6IJW RU http://www.ncbi.nlm.nih.gov/pubmed/29437953 DTZAH46 TI DTZAH46 DTZAH46 TN Sodium/iodide cotransporter DTZAH46 DI DMVFB93 DTZAH46 DN Nitrate DTZAH46 MA Substrate DTZAH46 RA The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.21.5.1) DTZAH46 RU http://www.tcdb.org/search/result.php?tc=2.A.21.5.1 DTZAWTH TI DTZAWTH DTZAWTH TN Equilibrative nucleoside transporter 3 DTZAWTH DI DM3JDRP DTZAWTH DN Cladribine DTZAWTH MA Substrate DTZAWTH RA Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7. DTZAWTH RU http://www.ncbi.nlm.nih.gov/pubmed/15701636 DTZAWTH TI DTZAWTH DTZAWTH TN Equilibrative nucleoside transporter 3 DTZAWTH DI DMHICK8 DTZAWTH DN Tubercidin DTZAWTH MA Substrate DTZAWTH RA Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7. DTZAWTH RU http://www.ncbi.nlm.nih.gov/pubmed/15701636 DTZAWTH TI DTZAWTH DTZAWTH TN Equilibrative nucleoside transporter 3 DTZAWTH DI DM72Y01 DTZAWTH DN Cordycepin DTZAWTH MA Substrate DTZAWTH RA Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7. DTZAWTH RU http://www.ncbi.nlm.nih.gov/pubmed/15701636 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMR8O3X DTZGT0P DN Paraquat DTZGT0P MA Substrate DTZGT0P RA Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J. 2009 Apr;9(2):127-36. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/19172157 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMH61ZB DTZGT0P DN Cimetidine DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMP6G8T DTZGT0P DN Topotecan DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DM1MBYQ DTZGT0P DN Ganciclovir DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DM93VBZ DTZGT0P DN Abemaciclib DTZGT0P MA Substrate DTZGT0P RA Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/30449032 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DM6SFYH DTZGT0P DN Tetraethylammonium DTZGT0P MA Substrate DTZGT0P RA A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17923-8. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/16330770 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMSI5CB DTZGT0P DN Chloroquine DTZGT0P MA Substrate DTZGT0P RA Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/21518836 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMYLOVR DTZGT0P DN Acyclovir DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DM5X7VY DTZGT0P DN Pyrimethamine DTZGT0P MA Substrate DTZGT0P RA Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018 May;46(5):592-599. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/29514829 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DM89QE1 DTZGT0P DN Metformin DTZGT0P MA Substrate DTZGT0P RA Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/20053795 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMWE2N4 DTZGT0P DN Auranofin DTZGT0P MA Substrate DTZGT0P RA Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017 Oct 9;8(56):96062-96078. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/29221187 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMPN1TW DTZGT0P DN Dofetilide DTZGT0P MA Substrate DTZGT0P RA FDA Drug Development and Drug Interactions DTZGT0P RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMYTE6L DTZGT0P DN Enoxacin DTZGT0P MA Substrate DTZGT0P RA Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones. J Pharmacol Exp Ther. 2009 Feb;328(2):628-34. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/19004926 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMBMUWZ DTZGT0P DN Emtricitabine DTZGT0P MA Substrate DTZGT0P RA Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters. Xenobiotica. 2017 Jan;47(1):77-85. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/27052107 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMNMXR8 DTZGT0P DN Procainamide DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMD5JU8 DTZGT0P DN Cephalexin DTZGT0P MA Substrate DTZGT0P RA Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/20484555 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMVBIZL DTZGT0P DN Estrone sulfate DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMVUKEW DTZGT0P DN N-methylpyridinium DTZGT0P MA Substrate DTZGT0P RA Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DTZGT0P TI DTZGT0P DTZGT0P TN Multidrug and toxin extrusion protein 1 DTZGT0P DI DMX4IS3 DTZGT0P DN Mephenoxalone DTZGT0P MA Substrate DTZGT0P RA Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. DTZGT0P RU http://www.ncbi.nlm.nih.gov/pubmed/20519552 DTZOKFJ TI DTZOKFJ DTZOKFJ TN Monocarboxylate transporter 12 DTZOKFJ DI DMKD2BQ DTZOKFJ DN Creatine ALS-08 DTZOKFJ MA Substrate DTZOKFJ RA Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria. J Am Soc Nephrol. 2016 May;27(5):1426-36. DTZOKFJ RU http://www.ncbi.nlm.nih.gov/pubmed/26376857 DTZRMK5 TI DTZRMK5 DTZRMK5 TN Multidrug resistance protein 3 DTZRMK5 DI DMQCTIH DTZRMK5 DN Digoxin DTZRMK5 MA Substrate DTZRMK5 RA MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DTZRMK5 RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DTZRMK5 TI DTZRMK5 DTZRMK5 TN Multidrug resistance protein 3 DTZRMK5 DI DMA7PEW DTZRMK5 DN Verapamil DTZRMK5 MA Substrate DTZRMK5 RA MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DTZRMK5 RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DTZRMK5 TI DTZRMK5 DTZRMK5 TN Multidrug resistance protein 3 DTZRMK5 DI DMJSBT6 DTZRMK5 DN Silodosin DTZRMK5 MA Substrate DTZRMK5 RA Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. DTZRMK5 RU http://www.ncbi.nlm.nih.gov/pubmed/16518089 DTZRMK5 TI DTZRMK5 DTZRMK5 TN Multidrug resistance protein 3 DTZRMK5 DI DM5TVS3 DTZRMK5 DN Vinblastine DTZRMK5 MA Substrate DTZRMK5 RA MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DTZRMK5 RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DTZRMK5 TI DTZRMK5 DTZRMK5 TN Multidrug resistance protein 3 DTZRMK5 DI DMLB81S DTZRMK5 DN Paclitaxel DTZRMK5 MA Substrate DTZRMK5 RA MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DTZRMK5 RU http://www.ncbi.nlm.nih.gov/pubmed/10918072