Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE07EIQ)

DME Name	General stress protein 14 (ywrO)
Synonyms	Alkyl hydroperoxide reductase; Reductase alkyl hydroperoxide; GS protein 14; GSP14; BSU35990; ywrO
Gene Name	ywrO
UniProt ID	GS14_BACSU
INTEDE ID	DME1302
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	936853
EC Number	EC: 1.6.99.- Oxidoreductase NADH/NADPH oxidoreductase Other acceptor oxidoreductase EC: 1.6.99.-
Lineage	Species: Bacillus subtilis Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus subtilis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEAIDVAKEQQLCEEYDRI VFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELMLAVSTGSEAEKYQAGGAN HYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDISHSAKRLAEYIQQPFV
Function	This enzyme has electron transfer activity, FMN binding, and NAD(P)H dehydrogenase (quinone) activity.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Discontinued Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[1]
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References

1	Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. Microbiology. 2002 Jan;148(Pt 1):297-306.