Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE0JX6R)

• DME Name: Beta-galactosidase (bgaB)
• Synonyms: Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; Lactase; lacZ
• Gene Name: lacZ
• UniProt ID: BGAL1_ENTCL
• INTEDE ID: DME1725
• EC Number:
  EC: 3.2.1.23
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.23
• Lineage:
  Species: Enterobacter cloacae
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Enterobacteriaceae
  Genus: Enterobacter
  Species: Enterobacter cloacae
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MSDTPSLTLSALLARRDWENPVVTQWNRLAAHAPLHSWRNEPSARDDAGSARRQTLNGLW
  RFSYFTAPEQVPQAWVTEDCADAVAMPVPSNWQMQGFDTPIYTNVTYPIPVNPPFVPQEN
  PTGCYSLTFEVDDAWLQSGQTRIIFDGVNSAFHLWCNGQWIGYSQDSRLPAEFDLSAALR
  PGQNRLAVMVLRWCDGSYLEDQDMWRMSGIFRDVTLLHKPETQIADYHVVTDLNAELDRA
  VLKVDVTLAGAGFADGEVVFTLWRKGEKCASVSRQPGSAIVDERGSWAERLTVTIPVETP
  ALWSAETPELYRLTMALLNPQGEVLEIEACDVGFRRVEISNGLLKLNGKPLLIRGVNRHE
  HHSENGQVMDEATMRRDIETMKQHSFNAVRCSHYPNHPLWYQLCDRYGLYVVDEANIETH
  GMVPMSRLADDPRWLPAMSERVTRMVQRDRNHPSIIIWSLGNESGHGANHDALYRWLKTT
  DPTRPVQYEGGGANTAATDIVCPMYARVDRDQPFPAVPKWSIKKWIGMPDETRPLILCEY
  AHAMGNSFGGFAKYWQAFRSHPRLQGGFVWDWVDQALTKRDEDGNTFWAYGGDFGDKPND
  RQFCLNGLVFPDRTPHPALYEAHGPQQFFTFTRVSTSPLVIEVQSGYLFRHTDNEVLNWT
  VARDGDVLVAGEVTLAMVPEGTQRLEIALPELNAGPGEVWLNVEVRQPRATPWSPAAIAA
  AGSSGRFRLRSLLLRQPRRRAAVLTQTDRILEIAHRQQRWQFDRASGNLTQWWRNGVETL
  LSPLTDNVSRAPLDNDIGVSEATKIDPNAWVERWKAAGMYDLTPRVLHCEAEQHAGEVVV
  TTQHVLEYRGKALFLSRKVWRIDEQGVLHGDIQVDMASDIPEPARIGLSVHLAETPENVR
  WLGLGPHENYPDRKLAAQQGRWTLPLEAMHTPYIFPTENGLRCDTRELVVGMHQLNGHFH
  FSVSRYSQQQLRETTHHHLLREEPGCWLNLDAFHMGVGGDDSWSPSVSPEFILQTRQLRY
  TFSWQQNP
• Function: This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-69767	DM8VBQJ	N. A.	N. A.	Phase 1	[1]

References

• [1] In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.