Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE0KTEM)

DME Name	L,D-carboxypeptidase A (ldcA)
Synonyms	Carboxypeptidase; LD-carboxypeptidase; Murein tetrapeptide carboxypeptidase; VT05_01038; ldcA
Gene Name	ldcA
UniProt ID	A0A5K1KMI8_NEIGO
INTEDE ID	DME1199
EC Number	EC: 3.4.17.13 Hydrolases Peptidase Metallocarboxypeptidase EC: 3.4.17.13
Lineage	Species: Neisseria gonorrhoeae Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Neisseriales Family: Neisseriaceae Genus: Neisseria Species: Neisseria gonorrhoeae
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTEPTSRRRFLKTCTAAGAGLLQACGTSATSVPPLPSSHSVVKARTVPLQTPRRQSSDGN LLRVVASSGFAEDTNRVNTALTRLYNAGFTVTNQQAGSRRFQRFAGTDAQRAADFQEVAS GRVATPKVLMGLRGGYGAARILPHIDFASLGARMREHGTLFFGFSDVCAVQLALLAKGNM MSFAGPMAYSDFGKPAPGAFTMDAFIKGATQNRLTVDVPYIQRTDVETEGTLWGGNLSVL ASLAGTPYMPDIDGGILFLEDVGEQPYRIERMLNTLYLSGILGKQRAIVFGDFRMEKIRD LYDSSYDFSAVAKHISRTAKIPVLTGFPFGHIADKITFPLGAHTRIRMNGNGGYSVAFEG YPTLDASALTLDTLLPPPDLPIFPESGVADISE
Function	This enzyme hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side-chains.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dithiazoline	DMVJYKG	N. A.	N. A.	Investigative	[1]
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References

1	Selective inhibition of Neisseria gonorrhoeae by a dithiazoline in mixed infections with Lactobacillus gasseri. Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00826-18.