Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE0QGHP)

DME Name	Insulin-degrading enzyme (ide)
Synonyms	Insulin-degrading protein; Bacterial insulin protease; Bacterial insulinase; Bacterial insulysin
Gene Name	ide
UniProt ID	A0A0C1JXV9_9BACT
INTEDE ID	DME2014
EC Number	EC: 3.4.24.56 Hydrolases Peptidase Metallopeptidase EC: 3.4.24.56
Lineage	Species: Vibrio vulnificus Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Vibrionales Family: Vibrionaceae Genus: Vibrio Species: Vibrio vulnificus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSDPLYSIFFKPSTIKAMKINYLIITLGCIGSLLGFPLLPALENKGYTLIEDKALLKVKT PTFSQTQVLKIKLNNGLQAVLISDPQTDQSSATLVVGAGSWQDPDPYPGLAHFVEHMLFL GTKKYPNESEFQRFITEHGGFSNAFTANDHTAYMFSIDNEAFPQALDRFASFFKEPLFNV SGIVRELNAIDQEYAKNYENDDVREVMVMKHIQNPRHPNYRFNIGNSTTLKAASQEILKA WYNEHYSSNIMRLLLVSNLPLEEMTRLTVDEFGDVADKHKVCYVPPMDLNNPDMEAKLFY ITPIQNIRKLTLVWDLPQEFAEMKDTYPDRLICQVLGHEGKESLLAQLKREKLAENLGCS TFNLGEKNLVLFVQMELTDKGVQSIDRIILRCFQTLALMKEKPFPRYIYDEVRQINLLNY EYQQREEVFTAAMKNADLLVRENIATYPEQTKVIQKFSQADVQNLLDYLTPSNCRFLIQA PSSLTGVEPTHQEEWLQVAYAMKAIEPFKMQEWASATPIAEITLPLPNPFLPKSLDLLHA LPSKETHLSRLPHPHLIEDSEHGTIYYAKDQHFLIPQLYLNFNIRTPAIDIGDANKIVMG DIYIKAVEENLSKFSYAATVAGLNFSVARTEYGLAFKITGYNDHAFLLFEEILKQLKDLK LSEQAFKIIKQSLLRRYQNFNKRAPLKRAKELFQQTIYKKYAAEHQKISAIRKLSFAKFQ EDVQSLFRQSFVEGLIYGNVTENQAKEYADNLIKTLDSAPYPKQMHKHAEIINLSSAEGP LLLEMKIPVQGSATLLAIENSSFTLKERAAQQILMKAMKEPFFAELRTRQQTGYLISSAA EEIERKLFLAFVVQSNTHDPRDLLARFELFIESFLQGIEKNYLTLKNFEIIKNSLLEELE KPPHNMESLGALLHSLAFKYEGRFDWIDKRIQALRALTHGELLSFTHACIGKDNKRRLGL LIKGHMDKAKGLYYTLINTPEQLKQKSTFSSSWGNEEKERKLE
Function	This enzyme catalyzes the hydrolysis of insulin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Insulin	DMB7CE0	Diabetic complication	5A2Y	Approved	[1], [2]
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References

1	Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
2	Complete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad. Gut Pathog. 2016 Jun 20;8:22.