Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE12T80)

DME Name Beta-mannosidase (manB)
Synonyms Mannan endo-1,4-beta-mannosidase; Beta-mannoside mannohydrolase; BetaMANNOS1; HMPREF1071_04441
Gene Name manB
UniProt ID
I8XYI3_9BACE
INTEDE ID
DME1195
EC Number EC: 3.2.1.78
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.78
Lineage Species: Bacteroides salyersiae
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides salyersiae

Subspecies: Bacteroides salyersiae CL02T12C01
Tissue Distribution Primarily distributed in human gut.
Sequence
MKNSFLIGIIIISFFSCKTPMKNKMPTDPQATHETVALYNRLFNLAEKGIMLGHQDDPLY
GHGWYGEQDRSDVKGMIGDYPAIFGFELGHIELDSEYSLDSVYFSQIKKHVKEHHARGGI
SSFSWHADNIATGNSTWDCAQDTVVRSILPGGSLHKEYLVWLERLANFFLDLKDENGAYI
PVIFRMYHEHTGDWFWWSSQQSTPEEYKQLWIMTCDYLQKTKQVHHLLYAYSSSNVQSEE
HYLERYPGDQYVDILGFDHYLKGREQKNVEQYKIDFERNIKIVTKCAEQSGKLPVIGETG
EESIWDPTYFTNVVYPIINKYKLGWILFWRNAWEPDKPNHYYLPYPGHSSESDFKQFVDQ
PLILTNKDVYQQ
Function This enzyme catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Preclinical Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
W-201259 DM68HNR N. A. N. A. Preclinical [1]
2 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Man-b-4MU DMNUA6S N. A. N. A. Investigative [1]
Mannotetraose DMSO8EU N. A. N. A. Investigative [1]

References

1 Structure and function of Bs164 beta-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. J Biol Chem. 2020 Mar 27;295(13):4316-4326.