Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE19C8A)

• DME Name: L,D-carboxypeptidase A (ldcA)
• Synonyms: Carboxypeptidase; LD-carboxypeptidase; Murein tetrapeptide carboxypeptidase; AC789_1c12840; ACN002_1829; ACU90_08670; AM270_04255; AMK83_26425; BANRA_01764; BB545_18240; BN17_10381; BON69_25620; BON71_20135; BON72_24745; BON76_11630; BON94_22610; BON95_19240; BVL39_22290; BvCms28BK_02847; BvCmsNSNP036_02737; BvCmsNSP006_02167; BvCmsOUP014_03493; BvCmsSIP019_04003; BvCmsSIP044_03891; C6669_23480; C7235_14540; C7B02_00395; C9114_05805; C9162_18910; C9Z28_09785; C9Z37_17470; COD46_20425; CR538_15200; CRD98_02440; CWS33_11925; D2184_25220; D6T60_03840; D9K48_17225; DEN89_04765; DEO04_08505; DL545_14375; DQF57_19545; DS732_10945; DXT69_15460; E0I42_05850; EHH55_11410; EJC75_04705; ERS085374_03985; ERS085379_03097; EXX24_08925; EXX78_01285; EYY78_23060; F0312_19185; F1E03_16650; F1E13_06740; F7F29_12315; FQ915_22760; FQR64_13480; HW43_09665; HmCmsJML079_01442; NCTC8009_03749; NCTC8179_03095; NCTC8622_05704; NCTC9055_04762; NCTC9111_02948; NCTC9703_02151; RG28_17325; RX35_02911; SAMEA3472043_03661; SAMEA3472055_01267; SAMEA3472070_03304; SAMEA3472114_00072; SAMEA3752553_01826; SAMEA3753064_00071; SAMEA3753290_01164; UN86_12510; b1192; ldcA
• Gene Name: b1192
• UniProt ID: J7R060_ECOLX
• INTEDE ID: DME1200
• EC Number:
  EC: 3.4.17.13
  Hydrolases
  Peptidase
  Metallocarboxypeptidase
  EC: 3.4.17.13
• Lineage:
  Species: Escherichia coli
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Enterobacteriaceae
  Genus: Escherichia
  Species: Escherichia coli
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MSLFHLIAPSGYCIKQHAALRGIHRLTDEGHQVNNVEVIARRCERFAGTETERLEDLNSL
  ARLTTPNTIVLAVRGGYGASRLLADIDWQALVARQQHDPLLICGHSDFTAIQCGLLAQGN
  VITFSGPMLVANFGADELNAFTEHHFWLALRNKTFTIEWQGEGPTCQTEGTLWGGNLAML
  ISLIGTPWMPKIENGILVLEDINEHPFRVERMLLQLYHAGILPRQKAIILGSFSGSTPND
  YDAGYNLESVYAFLRSRLSIPLITGLDFGHEQRTVTLPLGAHAILNNTREGTQLTISGHP
  VLKM
• Function: This enzyme hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side-chains.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dithiazoline	DMVJYKG	N. A.	N. A.	Investigative	[1]

References

• [1] Selective inhibition of Neisseria gonorrhoeae by a dithiazoline in mixed infections with Lactobacillus gasseri. Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00826-18.