Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1C8Q4)

DME Name	Endoglucanase A (EGA)
Synonyms	Endo-1,4-beta-glucanase A; SGNH_hydro domain-containing protein A; Cellulase A; EGA
Gene Name	EGA
UniProt ID	A0A660DUI5_9LACO
INTEDE ID	DME1182
EC Number	EC: 3.2.1.4 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.4
Lineage	Species: Lactobacillus gasseri Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus gasseri
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKWRIGLLTLIAGLALGSVGGQAASRPKSDWLHAKGNRIVDARGKTVRITGLNWFGYNTG TNTFDGLWTANLDKTVKSVANHGFNTIRVPFSVQLVKAWSQKKYPKANINLSTNAALKGK NSLQIWQRFLADCQKNGIKVIIDMHSAKSDPQGHNAPLWKSGKYTTKDYYAALTWLAKRY KKNDTIIGYDLKNEPHGLVTDASYAKWDGSKASNNWRYIAAQAGKKVLKANPHALIFVEG VQSTPKSWKTGYKKSAQYNYTLWGANLRGVAKYPVKVKKSQLVYSIHDYGPSVAPGSSWL QGNFTYNSLMKNYWRPNWYFIHAKKTAPLYIGEWGGYLTGSNLKWMKAERKLITTHKLNF TFWCLNNNSGDTGGLLNSDWTTWNSKLYKFVKPTLWQSKKGQFYSLDGQVKLGTKGLRKP
Function	This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkages.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[1]
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References

1	Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.