Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1GYMX)

DME Name	Dihydrofolate reductase (folA)
Synonyms	DHF reductase; 5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase; Bifunctional TS-DHFR; BmDHFR; Bacterial DFR-TS; Bacterial DHFR; TC_0902; folA
Gene Name	folA
UniProt ID	Q9PJC7_CHLMU
INTEDE ID	DME1051
Gene ID	1246271
EC Number	EC: 1.5.1.3 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.3
Lineage	Species: Chlamydia muridarum Kingdom: Bacteria Phylum: Chlamydiae Class: Chlamydiia Order: Chlamydiales Family: Chlamydiaceae Genus: Chlamydia Species: Chlamydia muridarum
Tissue Distribution	Primarily distributed in human gut and vagina.
Sequence	MIQATGIVAIDPRGVMGGAGKLPWNYPEDLRFFSETIQDHPIIMGRKTWESLPDRYKCGR TVIVFSRQHSCAQGIWISSLVEYEKLSLNSPFLIGGAELFDWFFQYNLLKSCFVTHIKRE YQGDTFFPVERLSGWKRESVLKTEDFNIYHYENYANQNP
Function	This enzyme can slowly reduces folate to 5,6,7,8-tetrahydrofolate in animals and some micro-organisms.
KEGG Pathway	Folate biosynthesis (cmu00790 ) Metabolic pathways (cmu01100 ) One carbon pool by folate (cmu00670 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1], [2]
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References

1	Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
2	The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.