Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1OW2F)

DME Name	Cytochrome P450 RauA (rauA)
Synonyms	Cytochrome rauA; Quinoline N-hydroxylating cytochrome P450 RauA; P450 rauA; RauA
Gene Name	rauA
UniProt ID	S6BVH1_RHOER
INTEDE ID	DME1777
EC Number	EC: 1.14.14.1 Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.1
Lineage	Species: Rhodococcus erythropolis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Corynebacteriales Family: Nocardiaceae Genus: Rhodococcus Species: Rhodococcus erythropolis Subspecies: Rhodococcus erythropolis JCM 6824
Tissue Distribution	Primarily distributed in human eye.
Sequence	MTHTVDDTGDLALAVNPFDPTFKADPYPVYARLRTELPIHRSALGAWIVADYTSCDKVLR SRLFGKDFANSTFFDHLTSMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFT RSTTTSMDDIVLSAASSAVRHLEHCTDAVSEVAEPFPVEVLSSILGIPDKDRGRFSEWSN LVAGVLDINFAIPKEVADRRSAAIEESIDYFRTLATSGNAPEGLVRRLSEVSHGGDQLSV DEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRANPQFIENAVAEVLRFEPPA HEAGRIALEDCEVSGANITKGDAVMVLLASGNREAVERGDTFSVTRPDVSSLSYGRGIHH CLGSALANSMLQHFLRELSQRYRSIEVAEPINYKPGMGLRGPETLSVAVSR
Function	This enzyme catalyzes the hydroxylation of a nitrogen atom in the quinolone ring of aurachin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aurachin	DMZNUDT	N. A.	N. A.	Investigative	[1], [2]
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References

1	Structure of the quinoline N-hydroxylating cytochrome P450 RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids. FEBS Lett. 2014 Jan 3;588(1):105-10.
2	Rhodococcus erythropolis encephalitis in patient receiving rituximab. Emerg Infect Dis. 2012 Aug;18(8):1377-9.