Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE28NZ9)

• DME Name: Cytochrome P450 124 (cyp124)
• Synonyms: Cytochrome P450 family 124 subfamily A member 1; Cholest-4-en-3-one C26-monooxygenase; Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]; Cholesterol C26-monooxygenase; Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming]; MTCY339.44c; Methyl-branched lipid omega-hydroxylase; Rv2266; Steroid C26-monooxygenase; Steroid C27-monooxygenase; cyp124
• Gene Name: cyp124
• UniProt ID: CP124_MYCTU
• INTEDE ID: DME1234
• Gene ID: 887763
• EC Number:
  EC: 1.14.15.14
  Oxidoreductase
  Oxygen paired donor oxidoreductase
  Iron-sulfur protein donor oxidoreductase
  EC: 1.14.15.14
• Lineage:
  Species: Mycobacterium tuberculosis
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Actinobacteria
  Order: Corynebacteriales
  Family: Mycobacteriaceae
  Genus: Mycobacterium
  Species: Mycobacterium tuberculosis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIEL
  PGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQR
  LRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMM
  GIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTS
  SLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGL
  APTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFD
  LARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGI
  KTLPVTWS
• Function: This enzyme is a P-450 heme-thiolate protein, and it primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. And it also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[1]

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Provitamin D3	DM43ABN	N. A.	N. A.	Investigative	[1]

References

• [1] Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209.