Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2ARDZ)

DME Name	PenA beta-lactamase (penA1)
Synonyms	Beta-lactamase penA; Penicillinase penA; Cephalosporinase penA; penA
Gene Name	penA
UniProt ID	O08350_BURCE
INTEDE ID	DME1559
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Burkholderia cepacia Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Burkholderiaceae Genus: Burkholderia Species: Burkholderia cepacia Subspecies: Burkholderia cepacia 249
Tissue Distribution	Primarily distributed in human lung.
Sequence	MTHSSQRRILLLAAATAPLALSLGACAARDATVSDAASPVGAAPASFAALERAAGGRLGV CAIDTATGRRALHRADERFPFCSTFKAMLGAAVLAQSVAHPGLLQQRVTYGRSDLVNYSP VTERHVDTGMTVAELCAATIQYSDNTAANELMKRIGGPAAVTAYARSIGDDTFRLDRWET ELNTALPGDLRDTTTPAAMAANLRVLVLGDALPPAQRAQLIEWLRGNKVGDKRIRAGVPT GWRVGDKTGTGDYGTTNDVGVLWPPSRAPIVLAVYYTQTRADAKAKDDVIAAATRIASAT LA
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[1]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[1]
Oxacillin	DMTAFY4	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.