Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2IMU4)

DME Name	Beta-glucuronidase (uidA)
Synonyms	Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; JFP838_00890
Gene Name	uidA
UniProt ID	A0A127EEJ8_CLOPF
INTEDE ID	DME1208
EC Number	EC: 3.2.1.31 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.31
Lineage	Species: Clostridium perfringens Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae Genus: Clostridium Species: Clostridium perfringens
Tissue Distribution	Primarily distributed in human gut.
Sequence	MLYPIITESRQLIDLSGIWKFKLNEGNGLTEELSKAPLKDTIEMAVPSSYNDLVESQEVR DHVGWVWYERNFTIPKTLLNERIVLRFGSATHEAKVYLNGELLVEHKGGFTPFEAEINNL LVSGDNRLTVAVNNIIDETTLPVGLVKEVEVDGKKVIKNSVNFDFFNYAGIHRPVKIYTT PKSYVEDITIVTDFKENNGYVNYEVQAVGKCNIKVTIIDEENNIVAEGEGESGKLTINNV HLWEPMNAYLYKLKVELLDDEEIIDTYFEEFGVRTVEVKDGKFLINNKPFYFKGFGKHED SYVNGRGINEAINIKDFNLMKWIGANSFRTSHYPYSEEIMRLADREGIVVIDETPAVGLH LNFMATGFGGDATKRDTWKEIGTKEAHERILRELVSRDKNHPCVVMWSVANEPDSDSEGA KEYFEPLIKLTKELDPQKRPVTVVTYLMSTPDRCKVGDIVDVLCLNRYYGWYVAGGDLEE AKRMLEDELKGWEERCPNTPIMFTEYGADTVAGLHDTVPVMFTEEYQVEYYKANHEVMDK CKNFVGEQVWNFADFATSQGIIRVQGNKKGIFTRERKPKMIAHSLRERWTNIPEFGYKK
Function	This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SN-38G	DM2UVNB	N. A.	N. A.	Investigative	[1]
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References

1	Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49.