Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2S6QE)
| DME Name | Arylamine N-acetyltransferase (NAT) | ||||
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| Synonyms | N-hydroxyarylamine O-acetyltransferase; nhoA; nat; PWN146_00756 | ||||
| Gene Name | nat | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 2.3.1.5 | ||||
| Lineage | Species: Serratia marcescens | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MDTQRYLQHIGFIGAARPDLPTLQQLHHRHMLSVPFENLSIIYHQGIRLAPEALFSKVVE
RNRGGFCYELNTLFALLLREIGFKVSFISGEIRARDGHFGPPYDHLALRVDLEDQAWLVD VGFGDSFLTPLKIVVAEPQPQASGTFHLEQEGEYYLLERRNGDQRSHAKTLYRFTIQPRA LHEFDEMCRFHSTSPQSHFTQRLVCSRPTDHGRVTLSDMKLIVTEDHQRHETTLHSEEER RAALWQHFAIDLDR |
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| Function | This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA. | ||||
Molecular Interaction Atlas (MIA) of This DME
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1 Investigative Drug(s) Metabolized by This DME
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