Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2VSMT)

DME Name	Nitroreductase (NTR)
Synonyms	FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; TVAG_026310
Gene Name	NTR
UniProt ID	A2DZ34_TRIVA
INTEDE ID	DME1065
Gene ID	4772298
EC Number	EC: 1.5.1.39 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.39
Lineage	Species: Trichomonas vaginalis Kingdom: Metamonada Phylum: Parabasalia Class: Trichomonadida Order: Trichomonadida Family: Trichomonadidae Genus: Trichomonas Species: Trichomonas vaginalis
Tissue Distribution	Primarily distributed in human vagina.
Sequence	MTSVFECIERRRTIRHYDQNWVCPKEHLEAIVNAALKSPTACNRQSIDLLVITNKEVLDK IGEVGLNTLKKGTKEHMEERKHEGYKNVFTCDAPVLFLLVKNDRVNPLYTDVDAGIMCES IMLTAASYGYGTMCIGVLRATDLYEAVGIHKEDLAMAVCMGKIEDGYVPPEKPIKCKATY IE
Function	This enzyme can reduce other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metronidazole	DMTIVEN	Abscess		Approved	[1]
------------------------------------------------------------------------------------

References

1	Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64.