Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE30GZN)

DME Name	Carboxylic ester hydrolase (CEH)
Synonyms	Carboxylic ester hydrolase CEH; Acyl coenzyme A:cholesterol acyltransferase; CPT75_14810
Gene Name	CEH
UniProt ID	A0A317G4I6_BUTFI
INTEDE ID	DME1112
EC Number	EC: 3.1.1.1 Hydrolases Ester bond hydrolase Carboxylic ester hydrolase EC: 3.1.1.1
Lineage	Species: Butyrivibrio fibrisolvens Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Butyrivibrio Species: Butyrivibrio fibrisolvens
Tissue Distribution	Primarily distributed in human gut and stomach.
Sequence	MNTIIRDTDLGQIKGLELDDNTVQFRGIRYATARRFAYPEPVTSFDGIYDATRFGYACPQ FRTYDPEDQKDPAPFYYKEFREGAEFTYDEDCLFLNIYAPKDAKKVPVIIYIHGGAFLGG CGNENHMDGTAYARKGIIFVSINYRLGVLGFLCDRKLTKESGHSGNYGLYDQLEAIKWVH DHIENFGGDKSNITLFGQSAGAMSIQQHCFSPLTKPYIQKVYMASGAGIGKEFAGVSPVE DSYDYFERLTSLLGDDPEDWRQIPVKELIEKFQSVIDRDLMSHCCPHIDGLIIPKDPAQS LEDKDYADVPYLLSTNSEDMAPQFLHQMSKDFCNTVNRNGGRAYYFYFSRKLPGDDKGAF HSAELWYTIGSIRKCWRPMTQEDFDLSDKLVDMICEFANTGAISYSSFDTPMASFEIHP
Function	This enzyme can hydrolyse vitamin A esters anh has wide specificity.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[1], [2]
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References

1	Immunogenic inhibition of prominent ruminal bacteria as a means to reduce lipolysis and biohydrogenation activity in vitro. Food Chem. 2017 Mar 1;218:372-377.
2	Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290.