Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE3N1MH)

• DME Name: Alpha-galactosidase (melA)
• Synonyms: Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; NCTC13386_00641; rafA_1
• Gene Name: rafA_1
• UniProt ID: A0A378HFS0_LACBR
• INTEDE ID: DME2082
• EC Number:
  EC: 3.2.1.22
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.22
• Lineage:
  Species: Lactobacillus brevis
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus brevis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MSIHVNEANLTFHLQTDHTSYIFQIMKNGEAGQIYYGPRIHVQPTYQNLMSQEWRDATPS
  LNEENPNFQPATIKAEYASLGKGDFRQPAFQVTQTNGSRITELTYDHYQLLTGKQRLANL
  PSTFDDTDDDAQTLVVSFNDRITGLALDLNYSLFPHQDVIVKSAKFINPSSEKLVLNRAL
  SSQLDLPDANYDLIQFSGTWARERHLYRHPLRPGMQSISSLRMASSHQQNPFMMLARPQT
  TDEQGAVFGFNLVYSGNFLDAVEVDQYSTSRILTGINPDEFGWNLAPQATFQTPEAILSY
  TSAGMNQLSQQMASFYQQHLVNPRFAHEERPVLINNWEATYFDFNEAKLMTIVNQAKRLG
  IEMFVLDDGWFGHRDDDTTSLGDWFVDQKKFPDGIEHFSQAVHQQGMKFGLWFEPEMISV
  DSGLYQQHPDWLIHAPKSTPTPGRHQFVLDMARPEVVDYLFKLMSQMIESANLDYIKWDM
  NRYATEMFSSRLTSDQQLELPHRYILGVYQLYARLTQAYPNVLFESCASGGGRFDLGMMY
  YAPQAWTSDDTDAAERLLIQFGTSYGYPQAMMGAHVSAVPNDQMGRITSLKTRGAVAFFG
  DLGYELDITKMAPTELDQVKKQVAFYKRYRQLFQFGKFYRIDSPFVGDGNVTSWQVVSDD
  QKQAIAARYQLLNHPNAPYTRFYFKGLRPNQRYQINDDPSTYYGDELMNAGYFVPTILAD
  GQESKDFYTQLFVVTAI
• Function: This enzyme hydrolyzes alpha-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[1]

References

• [1] Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.