Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE3OGM0)

DME Name N-acetylneuraminate lyase (nanA)
Synonyms Sialic acid aldolase; N-acetylneuraminate pyruvate-lyase; Sialic acid lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Neu5Ac lyase; NAL; FN1475; nanA
Gene Name nanA
UniProt ID
NANA_FUSNN
INTEDE ID
DME1161
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
992414
EC Number EC: 4.1.3.3
Lyases
Carbon-carbon lyase
Oxo-acid-lyase
EC: 4.1.3.3
Lineage Species: Fusobacterium nucleatum
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium nucleatum
Tissue Distribution Primarily distributed in human gut.
Sequence
MKGIYSALMVPYNEDGSINEKGLREIIRYNIDKMKVDGLYVGGSTGENFMISTEEKKRVF
EIAIDEAKDSVNLIAQVGSINLNEAVELGKYVTKLGYKCLSAVTPFYYKFDFSEIKDYYE
TIVRETGNYMIIYSIPFLTGVNMSLSQFGELFENEKIIGVKFTAGDFYLLERVRKAFPDK
LIFAGFDEMLLPATVLGVDGAIGSTYNINGIRAKQIFELAKNSKIDEALKIQHTTNDLIE
GILSNGLYQTIKEILKLEGVDAGYCRKPMKKISQKQIEFAKELHKKFLKN
Function
This enzyme catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. It also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
KEGG Pathway
Amino sugar and nucleotide sugar metabolism (fnu00520 )
Metabolic pathways (fnu01100 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sialic acid DMAEY9X N. A. N. A. Investigative [1]

References

1 Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum. Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):725-732.