Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE3U2Y6)

DME Name	Nitroreductase (NTR)
Synonyms	FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; NCTC12362_00253
Gene Name	nfrA2
UniProt ID	A0A377KR04_ENTCA
INTEDE ID	DME1327
EC Number	EC: 1.5.1.39 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.39
Lineage	Species: Enterococcus casseliflavus Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus casseliflavus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MNETIELLHNHRTYRQFDPDYRLSQEQVTAILTAARQAPSWMNGQAYSILVIDDPQIRQQ MVEWNPGNPHIAACSLFLLFLADLNRTKKVADEKQTPYPIDEGYQPLLIATTDASIALQS GAIAAESLGLGTVISGSVRKDSAKIAELLHLPEYVYPVAGLSIGKPIVEMKVKPRLPEEA VIHYNHYQDYSYEAIEAYDQTMTAFGEARETKPWSEKFAGFYSNRPDQGFDAFLKKQNLI K
Function	This enzyme contains FMN and can utilize NADH and NADPH with similar reaction rates. It also reduces riboflavin and FAD, but more slowly.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metronidazole	DMTIVEN	Abscess		Approved	[1]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1]
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[1]
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References

1	Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200.