Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE4EX78)

DME Name	Beta-fructofuranosidase (BFRU)
Synonyms	Sucrose-6-phosphate hydrolase; Invertase; sacA; ERS852392_01502; ERS852444_00118
Gene Name	sacA
UniProt ID	A0A173R035_9FIRM
INTEDE ID	DME1939
EC Number	EC: 3.2.1.26 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.26
Lineage	Species: Roseburia inulinivorans Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Roseburia Species: Roseburia inulinivorans Subspecies: Roseburia inulinivorans DSM 16841
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSNMLEKARKYETEKIAATDPQTKPLFHVSAPTGWINDPNGFSFYDGQIHLFYQYHPYNR EWGPMHWGHSVTCDMIHWEQLPAALAPDEEYDKAGCFSGSAIEADGKHVLVYTGVTRIKQ PDGSEQDRQNQCIAFGDGKDYQKYDKNPVMTGEMLPEGCNRVDFRDPKIWKENDTYYMIV GNKNENQIGQVVLCSSKNLTDWKFETILASNESGKIGTMWECPDFFQLGSKRVLICSPQD MKAQKYEFHNGHNSVYFLGDYDEKTHTFVKELPHALDYGMDFYAPQTTELPDGRRIMIAW MKSWDACVIPNSQDWQGMMTLPRELELKDGKIWQTPVREIEKYHKNPCRYDHAEINQETT LCGIEGRTIDLTVLLEEDEFQTFSMKLAANKEYETSFTYHKAENMLEIDRTYCGVTKDVV CVRKLKISNPEGLKKMRFILDRQSIELFLNDGEQVATTAICTPLEAQEIHFYSDKKIHIN VEKYDIMSASEKNAFMHSANDEIIE
Function	This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Inulin	DM1Y2JH	Measure kidney function	MG02	Approved	[1]
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References

1	Substrate-driven gene expression in Roseburia inulinivorans: importance of inducible enzymes in the utilization of inulin and starch. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4672-9.