Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE4IY8S)

• DME Name: Peroxidase (katG)
• Synonyms: Catalase-peroxidase; Bacterial peroxidase/catalase; Bacterial katG; Dtox_0871
• Gene Name: katG
• UniProt ID: C8W2A6_DESAS
• INTEDE ID: DME1003
• EC Number:
  EC: 1.11.1.21
  Oxidoreductase
  Peroxidase
  Peroxidase
  EC: 1.11.1.21
• Lineage:
  Species: Desulfofarcimen acetoxidans
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Peptococcaceae
  Genus: Desulfofarcimen
  Species: Desulfofarcimen acetoxidans
  Subspecies: Desulfofarcimen acetoxidans DSM 771
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MYEKEKCPVTGRTNNAIAGAANSNRDWWPNQLNLKILHQNSNLSNPMALEFNYAEEFKKL
  DLDALKKDLYALMTDSQDWWPADYGHYGPFFIRMAWHSAGTYRTNDGRGGAGKGTQRFAP
  LNSWPDNVNLDKARRLLWPIKQKYGSKISWADLMILAGNCALESMGLKTFGFSGGREDVW
  EPQEDIYWGTESEWLGDNRYSGDRELENPLAAVQMGLIYVNPEGPNGNPDPVASGRDVRE
  TFARMAMNDEETVALVAGGHTFGKCHGMGDPTLVGPEPEAAGIEEQGLGWKSSFGSGKGG
  DTISSGIEGAWKPNPTKWDMGYLNMLFKYEWELVKSPAGAHQWLAKDVDEEDMVIDAHDP
  SKKHRPMMTTADLSLRYDPIYEPISRRYQQNPEEFTDAFARAWFKLTHRDMGPRSRYLGA
  EVPEEELIWQDPVPAIDHELVDEHDIEDLKSKILASGLSVSQLVSTAWASASTFRGSDKR
  GGANGARIRLAPQKDWEVNQPAQLNTVLNVLEKIIAEFNSAQTGPKKISLADLIVLGGCA
  GIEQAAKNAGCNVSVPFIPGRTDASQEQTDVQSFSVLEPIADGFRNYQKTKYSASAEELL
  VDRAQLLTLTAPEMTVLLGGMRVLNTNHGQSQHGVFTKRPEALTNDFFVNLLDMSTTWKA
  ISEDENVFEGRDRSTGEIKWTGTSVDLIFGSNSQLRAIAEVYACDDSQSKFINDFVSAWN
  KVMNADRFDLS
• Function: This enzyme is with both catalase and broad-spectrum peroxidase activity.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (dae01110)
  Metabolic pathways (dae01100)
  Phenylalanine metabolism (dae00360)
  Tryptophan metabolism (dae00380)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[1], [2]

References

• [1] Peroxidase activity in the sulfate-reducing bacterium Desulfotomaculum acetoxidans DSM 771. Pol J Microbiol. 2010;59(4):249-55.
• [2] The uptake and accumulation of iron by the intestinal bacterium Desulfotomaculum acetoxidans DSM 771. Folia Biol (Krakow). 2005;53(1-2):79-81.