Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE5DTYB)

DME Name L-Lactate dehydrogenase (ldh)
Synonyms L-lactate ferricytochrome C oxidoreductase; Cytochrome b2 mitochondrial; L-LCR; L-LDH; LBUL_0100
Gene Name ldh
UniProt ID
LDH_LACDB
INTEDE ID
DME1688
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 1.1.1.27
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.27
Lineage Species: Lactobacillus delbrueckii
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus delbrueckii

Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Tissue Distribution Primarily distributed in human gut.
Sequence
MSRKVLLVGDGAVGSNFANDLLQTTQVDELVICDLNKDRAAGDCLDLEDMTYFTGQTKLR
AGDYSDAADADVVVITAGVPRKPGESRLDLIKKNEAILRSIVDPVVASGFSGIFVVSANP
VDILTTLTQKLSGFPKKRVIGTGTSLDSARLRVELAKRLQVPIESVNAWVLGEHGDSSFE
NFSSAVVNGKPLLDYPGMTEAALDEIEAHVREKGSEIIVKKGATYYGVAMMLAKIVTAIL
ENNDLALPLSAPLHGEYGIKDEIYLGTLAIINGQGISHVLELPLNDSELAKMRASAATIK
ATLDSLG
Function This enzyme catalyzes the conversion of lactate to pyruvate, and it also oxidizes other (S)-2-hydroxymonocarboxylic acids.
KEGG Pathway
Biosynthesis of secondary metabolites (lbu01110 )
Cysteine and methionine metabolism (lbu00270 )
Glycolysis / Gluconeogenesis (lbu00010 )
Metabolic pathways (lbu01100 )
Microbial metabolism in diverse environments (lbu01120 )
Propanoate metabolism (lbu00640 )
Pyruvate metabolism (lbu00620 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
DB-053072 DM1K248 N. A. N. A. Phase 1 [1]

References

1 Positive selection on D-lactate dehydrogenases of Lactobacillus delbrueckii subspecies bulgaricus. IET Syst Biol. 2015 Aug;9(4):172-9.