Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE68SAL)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; DW869_09665; ERS852509_02025; ERS852556_03307; uidA
• Gene Name: uidA
• UniProt ID: A0A174N6T8_BACVU
• INTEDE ID: DME1846
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Bacteroides vulgatus
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Bacteroidaceae
  Genus: Bacteroides
  Species: Bacteroides vulgatus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKKTLLTICLVWMCFSLSAQKIIDLSGKWSFSIDRQDNGEKEKWFSHTLNDFINLPGSMP
  EKLKGDEVTAKTQWTGSLYDSSYYYNPYMEKYRKEGNIKFPFFLTPDKHYVGAAWYQKEV
  NIPADWKGERILLFLERPHIETTVWVNGQKTGMQNSLCVPHQYDITRYVRPGKCTITIRV
  DNRIKEINVGPDSHSITDQTQGNWNGIVGRICLQTTPKTYFDDIQIYPEPEQKLARVKVV
  IKGTGTAKVKLSAESFNTDKKHIVPAIQQEIKLNKGVTETEMVLPMGNDMLLWDEFHPAL
  YKLKAEVTNGKKTEIKEIQFGIRRFEIKGKWFYVNGRKTQLRGTVENCDFPLTGYAPMDV
  ESWERVFRICRSYGLNHMRFHSFCPPEAAFMAADRVGFYLQPEGPSWPNHGPKLGLGQPI
  DKYLMDETIALTKEYGNYASYCMLACGNEPSGRWVEWVTKFVEYWEKKDPRHVYTGASVG
  NGWQWQPRNQYHVKAGARGLTWSKKQPSTQDDYRFQNHLDTVRQPYVSHETGQWCAFPNF
  NEIRKYTGVNKAKNFEIFKDILADNHMSDQAHLFMMASGKLQALCYKYEIEKTLRTPDYA
  GFQLLALNDYSGQGTALVGVLDVFFEEKGYINSAEWRRFCSPTVPLMRTDKFVYNNKEIL
  KADIEIAHFGAEALKQAEIVYTLKDEYGKVYAQGTLATQDIPVGNLNRTGSLEFPLTDIQ
  EAKKLNLEIRIMGTEAVNDWNFWVYPAQVTIAEGKVYTTDTLDSKALEILQNGGNVLITA
  AGKVSYGKEVVQQFTPVFWNTSWFKMRPPHTTGILVNPKHPLFRQFPTEYHSNLQWWELL
  NRAQVMQFTHFPPAFQPTVQSIDTWFISRKIGMLFEANVLNGKVLMTSMDITSQPEKRIV
  ARQMHKAILDYMNSDQFRPQFTVTPQQISELFTKTAGDIKSYTNDSPDELKPKIN
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin glucuronide	DMSBENK	N. A.	N. A.	Investigative	[1]

References

• [1] Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.