Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE69WKO)

DME Name	Phloroglucinol reductase (PHGR)
Synonyms	Phloro-glucinol reductase; Dihydrophloroglucinol:NADP+ oxidoreductase; PGR; PGRcl; PGRde; PGReu
Gene Name	PHGR
UniProt ID	PHGR_EUBOX
INTEDE ID	DME1165
EC Number	EC: 1.3.1.57 Oxidoreductase CH-CH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.3.1.57
Lineage	Species: Eubacterium oxidoreducens Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Eubacteriaceae Genus: Eubacterium Species: Eubacterium oxidoreducens Subspecies: Eubacterium oxidoreducens G41
Tissue Distribution	Primarily distributed in human gut.
Sequence	MVNVKKEFVDNMFSVKGKVALVTGATGALGCVLSKAYGYAGAKVFMTGRNEKKLQALEAE FKAEGIDCAYGVADPADEAQVDAMITACVAQYGEVNILAVTHGFNKPQNILEQSVADWQY IMDADCKSVYVVCKYVAQQMVDQGKGGKIVVVTSQRSKRGMAGYTGYCTSKGGADLMVSS MACDLSAKYGINVNSICPTVFRSDLTEWMFDPESAVYQNFLKREPIGRLAEPEDFVGYAL FLSSDASNYITGANCDCSGGYLTC
Function	This enzyme is involved in the gallate anaerobic degradation pathway in bacteria.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phloroglucinol	DMUKMC8	Urinary tract disease	GC2Z	Approved	[1]
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References

1	Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41. J Biol Chem. 1989 Mar 15;264(8):4423-7.