Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE6CQ0I)

DME Name	Cytochrome P450 130A1 (cyp130)
Synonyms	Cytochrome P450 family 130 subfamily A member 1; P450 130A1; MTCY50.26; P450 130A1; Rv1256c; cyp130A1
Gene Name	cyp130
UniProt ID	CP130_MYCTU
INTEDE ID	DME1442
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 1.14.15.29 Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.29
Lineage	Species: Mycobacterium tuberculosis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Corynebacteriales Family: Mycobacteriaceae Genus: Mycobacterium Species: Mycobacterium tuberculosis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAAR DHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTV RKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWTQAIVAANAVD GATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTM VTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRD VTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILTFSHGAHHCLGAAAA RMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS
Function	This enzyme catalyzes the N-demethylation of dextromethorphan yielding 3-methoxymorphinan.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[1]
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References

1	Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.