Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DE6QXYP)
| DME Name | Pyruvate oxidase (pyrO) | ||||
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| Synonyms | Pyruvate dehydrogenase; Pyruvic oxidase; POX; AAW28_13255; AUQ39_11915 | ||||
| Gene Name | pyrO | ||||
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| EC Number | EC: 1.2.3.3 | ||||
| Lineage | Species: Lactobacillus casei | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MATKAADQLVSVLMDWQVKHVFGLPGDSIDTTVDALRRHQDKIKFVQVRHEEVAALAASA
TAKLTGGLGVCLSIGGPGAIHLLNGLYDAKMDHAPVLALLGQVTTSNLNEGFFQEVNTPK LFDDVAVYNKTVMASDNLGQIVDTAIRTAFTEKGVAVLTIPDDLPDQKETTSYRDSAAAF ALNVPEVDPKQLDDVASLLQKSQKPLALIGRGAEHAGEQVQKFVEANHIPFIQTMPAKGT VADDHPNSLGNVGKLGTKPAYEAMKATDLLFMIGTNYPYTPYLPDEGQAKCVQIDTQPEN LGKRYSVDVAVDGDVETFLTELNAKGSLRDDDRFLKACQKNMESWDKWMAEKRLLTTNPA SPEAVFATIDQTAPKDAVYSVDVGTSTSWGARFLNVQPTQKYTISAWLGTMGCGLPGAIA GAEAFPKRQNISVAGDGAFAMVMQDFVTAVKYKLPIIMVVLNNQKLAFIEYEQQSAGQLN YEIDLADMDYAKIAEAAGGVGYTAHSNDEFKEALTKAYQETEKPVLINTYVQDDAPLPGK IVGEEAKGYMKYGSQYLENYWKIPSMPPLKDIMRQFF |
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| Function |
This enzyme is a flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin.
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Molecular Interaction Atlas (MIA) of This DME
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1 Clinical Trial Drug(s) Metabolized by This DME
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