Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE7BILX)

• DME Name: Alpha-L-rhamnosidase (lrA)
• Synonyms: Alpha-L-rhamnosidase T; Alpha-L-rhamnosidase N; Alpha-L-rhamnoside rhamnohydrolase; SAMN02910431_01901
• Gene Name: SAMN02910431_01901
• UniProt ID: A0A1H8EBM0_9BACE
• INTEDE ID: DME1481
• EC Number:
  EC: 3.2.1.40
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.40
• Lineage:
  Species: Bacteroides thetaiotaomicron
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Bacteroidaceae
  Genus: Bacteroides
  Species: Bacteroides thetaiotaomicron
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MNLKLKFILVYLSLCASAYTIQAQNIQYDPLLDPAVEIPDTPVRNGNGEYIWYPGQLSAH
  LQQKRLKESEKRCVNVGYPGKFYAPVYHASFCKEVNLPAETLMEWTSTGKVKVSVNGKEA
  GNSDKSSLTLPKGKSTLLFKVETDNDLPAIKVSFNGEVSTDHWKASMDGTEWNIAETSPV
  FGTAGRMPLDDPETEVTIHPVSILPIRNATVENQKIKIQKNGYILVDFFHIEVGKVSFTA
  KGEGKLTAFVGESPEEALNENTKLFEQYPIESYSLTEGEQQIILPERAVRYLKIFSDKEC
  EISDVKFKAKIWPVDFLMSFECNDERMNNIWNASVASLHTSTHGFYLDGIKRDYLPWSMD
  AVLSTFAGDYLFGDEQVSRNSLSVAMLPLNPQKTDLGIPDYPLHALIGFNHYYQRYGDFN
  TILSYRDRIEQLLKLYETLQDERGFISANVGVSWGFVPGWATRRGPDKKGTPTYAQIMLY
  YNYKIGADFSEKWGDKKSAKYYRMKSEDLKKSIIKHFWNEEQGLFINGYTKDGKLDTVIS
  HHAQYWAILADIFPKERYDHLFEVLPTIPYYHDYVSYEKGYEFLAYSKAGKVREMWNFLF
  TVFGDWLAQGHTRFPENFSYKKSKDEQLIFYKRPYGLSLCHGANGVPGVVAVLNGIAGFS
  QSPTQPNHYTIRPELMDLEWANIEFPVKEGKIKLKLSKEGKNQIEIPDGCKVDFINQNKV
  KKTFTKKGSYSM
• Function: This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[1]

References

• [1] Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.