Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE7NXHG)

DME Name Maltose phosphorylase (malP)
Synonyms Glycoside hydrolase 65 protein; Glycoside hydrolase family 65; Glycoside hydrolase family 65 protein; Kojibiose phosphorylase; LBA1870
Gene Name malP
UniProt ID
Q5FI04_LACAC
INTEDE ID
DME1137
Gene ID
3251782
EC Number EC: 2.4.1.8
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.8
Lineage Species: Lactobacillus acidophilus
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus acidophilus
Tissue Distribution Primarily distributed in human gut.
Sequence
MKRIFEIDPWKVITHKFDPKDKRLQESMTAIGNDYMGMRGNFEEGYSGDSLQGTYLAGVW
FPDKTVVGWWKNGYPKYFGKTPNAPSFIGIGINVNGEKVDLAKVKFSDFELSLDMHQGLL
SRSFIYEGKDVKVKLEFERFLHIVQKEAALIKVKATVLEGHAKIDFDSTLDGTVVNEDSN
YGDRFWIPLGEDKDEKTIQVKTKKNPYDVPQFTVLLKEALRNNGVAVNGEVTTEDAKLSE
RFSVELDEGQSYELEKDVIVVTSRDVEEKDQAAVANNLMSKLQTKSFEDNLADHTEAWKK
RWETSDVEISGDDAAQQGIRFNICQLFMTYYGEDKRLNVGPKGFTGEKYGGATYWDTEAF
IVPMYLAVTKPSVTRALLQYRHDQLPGAYHNAKEQGLPGALFPMVTFNGIECHNEWEITF
EEIHRNADIPHAIAMYTDYTGDDSYVKNEGMDVLVGTARFWAARVHWSKMRNKYVMHGVT
GPNEYENNVNNNWFTNTMARWLLKYTLERLPLATKEAQERVRVTDEEKAKWQDIVDNMYL
PEDEDLGIFLQQDDFLDKDIRPVTEIEDQRPINQHWSWDKILRSPFIKQADVLQGIYFFD
DQYTMDQKEKNFDFYEPLTVHESSLSPCIYSIMAAELGKKEKAVELYQRTARLDLDNYNN
DTVDGLHITSMSGSWLAIVQGFAGMRYDHDQLKFNPFVPDGWDHYSFKINYRGRLIEVYV
DHDECKITLLSGDDLEVMVHDNKLDLKEGKTKCLKA
Function This enzyme catalyzes the conversion of maltose to D-glucose and beta-D-glucose 1-phosphate.
KEGG Pathway
Metabolic pathways (lac01100 )
Starch and sucrose metabolism (lac00500 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Maltose DMH0ROP N. A. N. A. Phase 1/2 [1]

References

1 Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase. Protein Eng Des Sel. 2010 Oct;23(10):781-7.