| DME Name |
UDP-glucuronosyltransferase 2B11 (UGT2B11)
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| Synonyms |
UDP-glucuronosyltransferase family 2 member B11; UDPGT 2B11; UGT2B11; UDPGT2B4; UDPGTH1; OMIM: 600067; HomoloGene: 130717 |
| Gene Name |
UGT2B11
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| UniProt ID |
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| INTEDE ID |
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| 3D Structure |
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| Gene ID |
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| EC Number |
EC: 2.4.1.17
- Transferase
- Glycosyltransferases
- Hexosyltransferase
- EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens
- Kingdom: Metazoa
- Phylum: Chordata
- Class: Mammalia
- Order: Primates
- Family: Hominidae
- Genus: Homo
- Species: Homo sapiens
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| Sequence |
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD
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| Function |
This enzyme is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. |
| KEGG Pathway |
- Ascorbate and aldarate metabolism (hsa00053 )
- Chemical carcinogenesis (hsa05204 )
- Drug metabolism - cytochrome P450 (hsa00982 )
- Drug metabolism - other enzymes (hsa00983 )
- Metabolic pathways (hsa01100 )
- Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
- Pentose and glucuronate interconversions (hsa00040 )
- Porphyrin and chlorophyll metabolism (hsa00860 )
- Retinol metabolism (hsa00830 )
- Steroid hormone biosynthesis (hsa00140 )
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| Reactome Pathway |
- Glucuronidation (R-HSA-156588 )
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