General Information of Drug-Metabolizing Enzyme (DME) (ID: DE97F4R)

DME Name Arylamine N-acetyltransferase (NAT)
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; nat; PWN146_00756
Gene Name nat
UniProt ID
A0A1C3HAL9_SERMA
INTEDE ID
DME1100
EC Number EC: 2.3.1.5
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage Species: Shigella flexneri
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella flexneri
Tissue Distribution Primarily distributed in human gut.
Sequence
MDTQRYLQHIGFIGAARPDLPTLQQLHHRHMLSVPFENLSIIYHQGIRLAPEALFSKVVE
RNRGGFCYELNTLFALLLREIGFKVSFISGEIRARDGHFGPPYDHLALRVDLEDQAWLVD
VGFGDSFLTPLKIVVAEPQPQASGTFHLEQEGEYYLLERRNGDQRSHAKTLYRFTIQPRA
LHEFDEMCRFHSTSPQSHFTQRLVCSRPTDHGRVTLSDMKLIVTEDHQRHETTLHSEEER
RAALWQHFAIDLDR
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Asacolitin DM3WVPJ N. A. N. A. Investigative [1]

References

1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.