Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE9EXRN)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852582_00799; uidA
• Gene Name: uidA
• UniProt ID: A0A173S5S4_9FIRM
• INTEDE ID: DME1210
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Faecalibacterium prausnitzii
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Ruminococcaceae
  Genus: Faecalibacterium
  Species: Faecalibacterium prausnitzii
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MRSIAKLMKDWQFTGPDGVTAAVALPHTWNAVDGQDGGNDYWRGTCIYRTSFAAPAFDPA
  QQQVWLQFEGVNSSAAVLLNGQQLCTHDGGYSTFRAEITELLQAENQLTVRVDNSVNDRV
  YPQKADFTFYGGIYRDVSLLVVNKNHIALGHFGDTGVKITPDLKEGSADIQVETLVEGEG
  TVVVELLDAEGNSVARSEGAKASLHLDAPHLWNGVKDPYLYTCIVRLMQDGKPVDEVTTR
  VGLRSFSVDAKKGFFLNGKPYPLHGVSRHQDRKGLGNAITREMHDEDMALIRELGANTVR
  LAHYQHDQYFYDLCDKYGMVVWAEIPYISEHLPKGRENTISQMKELIHQNYNHPSIVCWG
  VSNEITISTKDKADMLDNHRVLNELCHKMDPTRLTTLACYAMCGPFNSVAHITDLVSWNL
  YLGWYVPGLFLNDLWMGFFHLVYPNRPLGFSEYGAEGMPNLHSAHPRRGDHTEEYQAKYH
  EYMLKCFDRHPWLWATHVWNMFDFAADARDQGGEPGMNHKGLVTFDRKTKKDSFYLYKAW
  WSEENFVHICSKRFTDRTEKEIEVKVYSNQKSVTLYADGKKLAEQTGEHIFKFRVPLHGK
  VELKAVAGDCIDTACFRSVAAPNPSYKLVKTKSKSANWV
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac glucuronide	DMWADLM	N. A.	N. A.	Investigative	[1]
PhIP glucuronide	DM7DWZC	N. A.	N. A.	Investigative	[2]

References

• [1] tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
• [2] Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.