Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DE9TLVP)
| DME Name | Diol dehydratase (pddA) | ||||
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| Synonyms | Diol dehydrase; Propanediol dehydratase; Dioldehydrase; Dioldehydratase | ||||
| Gene Name | pddA | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| Gene ID | |||||
| EC Number | EC: 4.2.1.28 | ||||
| Lineage | Species: Roseburia inulinivorans | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFD
LIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHM NVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAP FNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPW SKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSV SCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFI SSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQ AVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQG GFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEE IKNIPGALDPNEID |
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| Function | This enzyme has two forms. One form requires a cobamide coenzyme which can dehydrate ethylene glycol to acetaldehyde, while the other is a glycyl radical enzyme. | ||||
| KEGG Pathway | |||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
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1 Investigative Drug(s) Metabolized by This DME
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