Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE9VSLW)

• DME Name: Cardiac glycoside reductase 2 (cgr2)
• Synonyms: Cardiac glycoside reductase operon protein 2; Cardenolide reductase; Digoxin reductase; cgr2
• Gene Name: cgr2
• UniProt ID: CGR2_EGGLE
• INTEDE ID: DME1036
• Gene ID: 40923314
• EC Number:
  EC: 1.3.2.-
  Oxidoreductase
  CH-CH donor oxidoreductase
  Quinone acceptor oxidoreductase
  EC: 1.3.2.-
• Lineage:
  Species: Eggerthella lenta
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Coriobacteriia
  Order: Eggerthellales
  Family: Eggerthellaceae
  Genus: Eggerthella
  Species: Eggerthella lenta
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MEYGKCRGIERGMGRRDFLKAATLLGATAAGAGMLAGCAPKSASEAQAQTAPAATGGLDP
  ADVDWKYETDVVIVGSGSGGTCAAIEAAEAGADVVVFEKDKAMYGGNSALCGGYMLAAGW
  STQEEITGYAGDTGEAFANQMLRWSQGLGNQDMIREACLRSGEAVDWMMDTGRTYEGASP
  LPPVWSCGDTEADVVPRSVYNHNAYGATEGHMATLKKRAESLSNIEIEMGCEVAHILKNA
  EGSVIGVQLADGSFAKARKGVVMACASVDNNLEMSKDLGLMQNVWGLTLEGAGLLAPGNP
  DMDSNTGDGVRMLREIGAELCMQQAVCMNDSIYVGGISDWGMSEILGKDVNIHDSSNIDA
  ILVDKTGRRFCQDDAEWGYVMHECAQAAWKQGFTPDDPTTGYIFYVYDATGAPFFEMKGH
  TPDTCDTTFSADSVDGLAEFIGCDPTALASEVERWNSFCEAGLDADFGRRANMAPIATPP
  FYCDVVRPGPMGTFAGAKSNVEAEIIGLDGNPIPRLYGAGCIIGGNVSGAFYFGCGWSIT
  NTVVWGREAGRNVAALEPWE
• Function: This enzyme serves as the terminal electron reductase partner to Cardiac glycoside reductase 1 (Cgr1) by forming an complex with Cgr1 and receiving electrons from Cgr1 at the active site FAD redox cofactor.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[1]

References

• [1] Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8.