Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEA2SU9)

DME Name	D-psicose 3-epimerase (DPEase)
Synonyms	Psicose 3-epimerase; D-psicose-epimerase; Psicose epimerase; DPEase; Ccel_0941; dpe
Gene Name	DPEase
UniProt ID	DPES_RUMCH
INTEDE ID	DME1171
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 5.1.3.30 Isomerase Racemase/epimerase Carbohydrate racemase/epimerase EC: 5.1.3.30
Lineage	Species: Ruminiclostridium cellulolyticum Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Hungateiclostridiaceae Genus: Ruminiclostridium Species: Ruminiclostridium cellulolyticum Subspecies: Ruminiclostridium cellulolyticum H10
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKHGIYYAYWEQEWEADYKYYIEKVAKLGFDILEIAASPLPFYSDIQINELKACAHGNGI TLTVGHGPSAEQNLSSPDPDIRKNAKAFYTDLLKRLYKLDVHLIGGALYSYWPIDYTKTI DKKGDWERSVESVREVAKVAEACGVDFCLEVLNRFENYLINTAQEGVDFVKQVDHNNVKV MLDTFHMNIEEDSIGGAIRTAGSYLGHLHTGECNRKVPGRGRIPWVEIGEALADIGYNGS VVMEPFVRMGGTVGSNIKVWRDISNGADEKMLDREAQAALDFSRYVLECHKHS
Function	This enzyme catalyzes the reversible epimerization of D-fructose at the C3 position to yield D-psicose and it is highly specific for D-psicose and shows very low activity with D-tagatose.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-fructose	DMNX5VI	N. A.	N. A.	Investigative	[1], [2]
------------------------------------------------------------------------------------

References

1	Highly efficient production of Clostridium cellulolyticum H10 D-psicose 3-epimerase in Bacillus subtilis and use of these cells to produce D-psicose. Microb Cell Fact. 2018 Nov 28;17(1):188.
2	Anaerobic bacteria as producers of antibiotics. Appl Microbiol Biotechnol. 2012 Oct;96(1):61-7.