Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEA9TJ6)

• DME Name: Alkaline phosphatase (ALP)
• Synonyms: Alkaline p-nitrophenylphosphate phosphatase; Alkaline phenyl phosphatase; Alkaline phosphatase F I; Alkaline phosphatase F II; Alkaline phosphatase HaALP1; Alkaline phosphatase HaALP2; Alkaline phosphatase HvmALP 1; ALKP; ALPase; Alk Phos; Basic phosphatase; 86 kDa homodimeric protein enzyme; CGC50_00990
• Gene Name: ALP
• UniProt ID: A0A250FL93_9FLAO
• INTEDE ID: DME1774
• EC Number:
  EC: 3.1.3.1
  Hydrolases
  Ester bond hydrolase
  Phosphoric monoester hydrolase
  EC: 3.1.3.1
• Lineage:
  Species: Capnocytophaga gingivalis
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Flavobacteriia
  Order: Flavobacteriales
  Family: Flavobacteriaceae
  Genus: Capnocytophaga
  Species: Capnocytophaga gingivalis
• Tissue Distribution: Primarily distributed in human oral cavity.
• Sequence:
  MERRNFLKNSLLAGLGSLLVPSVAQAQASESFGRKRAKNIIYLVSDGMSIGTLVMADLYS
  KRILGRSSAWFSLYEQKLAVKASMDMQSASSVVTDSSAASSSWGSGHRIINGMINVGVNG
  EQYTPILQKFKKAGKKVGCVTTVPITHATPAGFCTNSKERKAQPKIAENYLDLRFDVMMG
  GGDNYFNAGKRKDKQDMYVKYLEKGFTVVKNVSQMNAAPKNVPLLGVFDKDALPYTLDEN
  NTTKNATIPTLAQMTQKAIDMMADHKQGFVLQVEGGKVDWAAHGNDIGALLFDQLAFDDA
  VRVAIDFAKKDGNTLVVITSDHGNANPGLIYGKECNKNFDNLAHFLHTNDFTLQSINLTD
  SVSQVRDLLTHNFGNIPFSQEEAKEILSFYTEGKQEDGLYNYKKLPYRLLAEIQKKHTSV
  GWISMDHSSDYTELAMYGPGSQNLPPFIENYKMHNFLLEAAEVDMLEKY
• Function: This enzyme can catalyse transphosphorylations and has wide specificity.
• KEGG Pathway:
  Folate biosynthesis (cgh00790)
  Metabolic pathways (cgh01100)
  Thiamine metabolism (cgh00730)
  Two-component system (cgh02020)

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan monophosphate	DMYB57J	N. A.	N. A.	Investigative	[1]

References

• [1] Hydrolysis of triclosan monophosphate by dental plaque and selected species of oral micro-organisms. J Dent Res. 1996 Aug;75(8):1578-84.