Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAGY5M)

DME Name	Catalase-peroxidase (katG)
Synonyms	Peroxidase/catalase; Catalase peroxidase; katG; CP; Synpcc7942_1656
Gene Name	katG
UniProt ID	KATG_SYNE7
INTEDE ID	DME1301
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 1.11.1.21 Oxidoreductase Peroxidase Peroxidase EC: 1.11.1.21
Lineage	Species: Synechococcus elongatus Kingdom: Bacteria Phylum: Cyanobacteria Class: Synechococcales Order: Synechococcales Family: Synechococcaceae Genus: Synechococcus Species: Synechococcus elongatus Subspecies: Synechococcus elongatus PCC 7942 = FACHB-805
Tissue Distribution	Primarily distributed in human lung.
Sequence	MTATQGKCPVMHGGATTVNISTAEWWPKALNLDILSQHDRKTNPMGPDFNYQEEVKKLDV AALKQDLQALMTDSQDWWPADWGHYGGLMIRLTWHAAGTYRIADGRGGAGTGNQRFAPLN SWPDNTNLDKARRLLWPIKQKYGNKLSWADLIAYAGTIAYESMGLKTFGFAFGREDIWHP EKDIYWGPEKEWVPPSTNPNSRYTGDRELENPLAAVTMGLIYVNPEGVDGNPDPLKTAHD VRVTFARMAMNDEETVALTAGGHTVGKCHGNGNAALLGPEPEGADVEDQGLGWINKTQSG IGRNAVTSGLEGAWTPHPTQWDNGYFRMLLNYDWELKKSPAGAWQWEPINPREEDLPVDV EDPSIRRNLVMTDADMAMKMDPEYRKISERFYQDPAYFADVFARAWFKLTHRDMGPKARY IGPDVPQEDLIWQDPIPAGNRNYDVQAVKDRIAASGLSISELVSTAWDSARTYRNSDKRG GANGARIRLAPQKDWEGNEPDRLAKVLAVLEGIAAATGASVADVIVLAGNVGVEQAARAA GVEIVLPFAPGRGDATAEQTDTESFAVLEPIHDGYRNWLKQDYAATPEELLLDRTQLLGL TAPEMTVLIGGLRVLGTNHGGTKHGVFTDREGVLTNDFFVNLTDMNYLWKPAGKNLYEIC DRKTNQVKWTATRVDLVFGSNSILRAYSELYAQDDNKEKFVRDFVAAWTKVMNADRFDLD
Function	This enzyme is with both catalase and broad-spectrum peroxidase activity.
KEGG Pathway	Biosynthesis of secondary metabolites (syf01110 ) Metabolic pathways (syf01100 ) Phenylalanine metabolism (syf00360 ) Tryptophan metabolism (syf00380 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1]
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References

1	Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid. FEBS Lett. 2015 Jan 2;589(1):131-7.