Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAH3PE)
| DME Name | S-(hydroxymethyl)glutathione dehydrogenase (adh) | ||||
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| Synonyms |
NAD- and glutathione-dependent formaldehyde dehydrogenase; NAD-dependent formaldehyde dehydrogenase; NAD-linked formaldehyde dehydrogenase; Class III alcohol dehydrogenase; Formaldehyde dehydrogenase; Formaldehyde dehydrogenase (glutathione); Formic dehydrogenase; GD-FALDH; GS-FDH; adh
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| Gene Name | adh | ||||
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| EC Number | EC: 1.1.1.284 | ||||
| Lineage | Species: Vibrio cholerae | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MKSRAAVAFGPGLPLEIVEIDVAPPKKGEVLVKISHTGVCHTDAYTLSGDDPEGLFPVVL
GHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECDFCTSGKTNLCVAVRETQGKGVMPD GTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPQANAEQVCLLGCGVTTGIGAVHN TAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIFAIDTNPSKFELAKQFGATDCINPND YDKPVQQVLVEMTKWGVDHTFECIGNVNVMRSALESAHRGWGQSVIIGVAGAGKEISTRP FQLVTGRVWKGTAFGGVKGRTQLPGMVEDAMSGKIELAPFVTHTMELDKINEAFDLMHDG KSIRTVIHY |
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| Function | This enzyme specifically reduces S-(hydroxymethyl)glutathione. | ||||
Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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1 Investigative Drug(s) Metabolized by This DME
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