Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAMEF2)
| DME Name | NADH dehydrogenase (nuoE) | ||||
|---|---|---|---|---|---|
| Synonyms |
DPNH-menadione reductase; FMN-dependent NADH-quinone reductase; D-diaphorase; Reduced nicotinamide adenine dinucleotide (quinone); FMN-dependent NADH:quinone oxidoreductase; H+(NA+)-translocating NADH-quinone oxidoreductase; NADH-dependent 1,4-benzoquinone reductase; NADH-Q oxidoreductase; NADH dehydrogenase subunit E; nuoE
|
||||
| Gene Name | nuoE | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.6.5.11 | ||||
| Lineage | Species: Streptomyces griseus | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MTDGQTSLGMPQLPAPDYPAEVRARLEADAEEIIARYPGSRSALLPLLHLVQSEEGHVTR
TGMKFCAEILGLTTAEVTAVATFYTMYRRKPSGDYQVGVCTNTLCAVMGGDAIFEELKEH LGVGNNETTEDGKVTLEHIECNAACDFAPVVMVNWEFFDNQTPDSAKKIVDDLRAGRPVE PTRGAPLCTYKETARILAGFPDEREGAVEATGGAGPASLVGLRLAKGETPHHKIVHPRGE SASGEGE |
||||
| Function | This enzyme is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. | ||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
1 Approved Drug(s) Metabolized by This DME
|
||||||||||||||||||||||||||||