Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAMSKV)

DME Name Alpha-glucosidase (aglA)
Synonyms Oligo-1,6-glucosidase; 6-phospho-alpha-glucosidase 1; LSEI_0369; simA
Gene Name simA
UniProt ID
PAGL1_LACP3
INTEDE ID
DME1299
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
4421568
EC Number EC: 3.2.1.20
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.20
Lineage Species: Lactobacillus paracasei
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus paracasei
Tissue Distribution Primarily distributed in human gut.
Sequence
MDDRKFSVLIAGGGSTYTPGIVLTLLDHIQKFPLRKLKFYDIDGERQQRVADACEILVKE
RAPEVEFLATTDPEEAFTDVDFVMAQIRVGKYAMRSLDEKIPLKHGVVGQETTGPGGIAY
GLRSIPGVIGLVDYMEKYSPNAWMLNYSNPAAIVAEATRRLRPHSRIINICDMPIGIMDR
MAQIVGLKDRNDLVFRYYGLNHFGWWTDVRDKTGKDLMPALKQYVAKNGYWLGDKDKDTE
ASWVSTFKKAADVYALDPSTLPNTYLKYYLYPKYVVEHSDPNYTRTDEVEAYREKHVFDE
CDRIIAAGTAADTHFKSDDHATYIVDLCTAIAYDTKQRMLAIVPNDGAIENIDPEAMVEV
PCLFGANGAERLAMGKAATFQKGLITEQNCVEKLTVDAFEQQSYTKLWEAMSLCKIVPDA
SVAKEILDEMVVANKDYWPELK
Function
This enzyme is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). And it hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, i.e. trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphate. Moreover, it can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphate. However, it fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphate.
KEGG Pathway
Metabolic pathways (lca01100 )
Starch and sucrose metabolism (lca00500 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
D-glucose DMMG2TO Discovery agent N.A. Investigative [1]

References

1 Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice. Food Funct. 2018 Jul 17;9(7):3630-3639.