Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEASPQ0)

• DME Name: Beta-glycosidase (glyB)
• Synonyms: Isoflavonoid 7-O-beta-apiosyl-glucoside beta-glycosidase; Peptidoglycan hydrolase; CF162_08980
• Gene Name: glyB
• UniProt ID: A0A3D9A9X6_9BACT
• INTEDE ID: DME1677
• EC Number:
  EC: 3.2.1.-
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.-
• Lineage:
  Species: Parabacteroides distasonis
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Tannerellaceae
  Genus: Parabacteroides
  Species: Parabacteroides distasonis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MRTFSKKKKLPRLLTLCGAVAVSALLGGCGQSGVPAESFDRSDYYTRGIGSYPGDPGEDF
  SPSLRPDYSTYRNIALLRSAYNSSSYDYNLTAQLVTDGVISDKQPQYLDLSTQNGDIARR
  EREWMIDQGPYSRNAVTGEDAYFLFTLNNWKEKADKVQFRGSVAYDENKIKDGYEIVCEG
  SNDGNTWTELAALKGKGMPGKASKYKAHSDPNKNSWDPGTLPTRMLNETLTFDQPGEYAY
  YRMRLKMEGAAYWAFFEMNFYNQDKLIDLLPSKFFNSAWMSATTGEEWVYVDLGSQSEFD
  KVKLHWINKAIKGKIQVSDDAKQWVDIANLPGGDANLDEIKLKGKGRYVRVWMEQPANDG
  RYILSEIEVMGKGGLLAQPAAAPAATKDEIRLSGGNWKVQRASEVTASGEEISKPSFSPE
  NWIVATVPGTVLSSYKNIGAIPNPNYADNLMQISESFFNSNFWYRDEFEVPEGFKQDRLF
  LNFDGINWKANVYLNGNKIGRIEGAFIRGVFDVTDRVVPGKNVVAVEIIKNEHIGAIKEK
  CEKNTDFNGGILGADNPTFHASIGWDWISTIRGRNIGIWDDVYLTSTGKVTIQDPFVQVV
  LPLPDTTSATLTPEVIVKNHDAAPVKGVLTGKIGDITFEQPVELAANEEKTVTFDPNSFS
  QLKVQNPRLWWPKGYGSPYLYDANFTFKVGDKVSDSEDFKVGIRQMTFNENNSILSLFIN
  GRRFIGRGGNWGFGESNLNYRGREYDIAVAYHADMNFTMMRNWVGQIGDKELYEACDRHG
  IMIWQDFWLANPSDGPDPYDPEMFIANAEDYVKRFRNHASIGIYCGRNEGFPPEQIDKAL
  RRIVKEDHPGLHYISSSADEVVSGHGPYRALPVKEYFSLKNGSDKFHSERGMPNVMNYES
  LVRTFSPEALWPQNAQWGQHDYTMEGAQSCASFNAIIEKGFGKPNNAKEFADLAQWVNYD
  GYRGMFESRSLNRKGLLLWMTHPAWPSMVWQTYDYYFEPTAAYFGCKKASEPLHIQWNPV
  TDEIEVVNYSAGVRNGLTAKAQIINMDGSISWENEVSVDSKEDTTNKCMKLDFPASVSSA
  HFVKLTLTENGKIVSDNFYLRGVEEGNYQALREMPKVTLRSNVATNKGNDGTWTATATLE
  NTSSTPALMIRVNVIGEKDGQQFLPMFYSDNYFSLLPGEKKEINIHWKDVDTRGEAPKVV
  ISGYNVN
• Function: This enzyme catalyzes the hydrolysis of substrates containing beta-glycoside.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
K-6015	DMUKTBF	N. A.	N. A.	Investigative	[1]

References

• [1] Comparison of anti-Campylobacter activity of free thymol and thymol-beta-D-glucopyranoside in absence or presence of beta-glycoside-hydrolysing gut bacteria. Food Chem. 2015 Apr 15;173:92-8.