Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEB8PZ0)

• DME Name: Beta-glucuronidase (uidA)
• Synonyms: Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; uidA
• Gene Name: uidA
• UniProt ID: Q6W7J7_RUMGN
• INTEDE ID: DME1940
• EC Number:
  EC: 3.2.1.31
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.31
• Lineage:
  Species: Ruminococcus gnavus
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Blautia
  Species: Ruminococcus gnavus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MLEYSELYPIQNEYRMMQSLDGMWKFQFDPEEIGKKSGWENGLPAPVSMPVPSSFADFFT
  DHKERDYCGDFWYETEFYLPAEWRNKKIWLRFGSITHRGTVYCNGMEITSHEGGFLPVLA
  DISTVAKPGQVNQVVVKINNELNETSLPCGATKILNNGRKLAKPYFDFFNYSGLQRSVWV
  IALPEESVKDYSVDYELCGTDALVKYEVVTTGEHPVIVRLLDAEGELVAETEGKEGILQV
  ANARLWEVRNAYLYQIVILITDGNGVLDEYREKIGIRTVRIEGTKILLNDRPVYLKGFGK
  HEDFPILGRGFHWGIVKRDFECLKWTNANCFRTSHYPYAEEWYQFADEEGFLIIDEVPAV
  GMMRSTRNFVAAGSGNYTYFFEALTVPELLKSHIADTEEMITRDKNHPSVIAWSLFNEPE
  TITDYAYEYFKEVFAAAETYDFQSRPMTGAFEKNSKPELCKCYPLCDFICLNRYYGWYIS
  GGPEIEEAEELFRDEMDRWKAKELNVPFVFTEFGTDTMAGLHKLPSIMWSEEYQKEYLEM
  NFRVFDSYEFVQGELAWNFADFQTTEGIMRVDGNHKGVFTRDRQPKAAAVVFKDRWEKKN
  ELF
• Function: This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac glucuronide	DMWADLM	N. A.	N. A.	Investigative	[1]

References

• [1] tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.