Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBI60T)

DME Name	L-arabinose isomerase (araA)
Synonyms	Isomerase L-arabinose; D-arabinose aldose-ketose-isomerase; araA
Gene Name	araA
UniProt ID	D9ILD9_LACFE
INTEDE ID	DME1005
EC Number	EC: 5.3.1.4 Isomerase Intramolecular oxidoreductase Aldose/ketose isomerase EC: 5.3.1.4
Lineage	Species: Lactobacillus fermentum Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus fermentum Subspecies: Lactobacillus fermentum CGMCC 2921
Tissue Distribution	Primarily distributed in human gut.
Sequence	MRKMQDYKFWFVVGSQPLYGPEALAEVEKDARKLVDGLNKGGKLDYPVEFKLVATTADSI TKFMKEANYNDDVAGVITWMHTFSPAKNWIRGTELLQKPLLHLATQFLNNIPFDSIDMDY MNLHQSAHGDREYAYINSRLNVPAASVYGWWGDADVQEQIADWQHVAVAYNESFHIKIAR FGDTMRDVAVTEGDKVAAQIKLGWTVDYYPTNELVAVVNGIAEDEIDAAYKDLEANYDLV EGDNDHEKYVHNVRYQLREYLGIKKFLDDNGYDAFTDNFQDLEGLEQLPGLAVQLLMIDG YGFGPEGDFKMAGLTRLLKIAADNKQTALMEDYTLDLRHGHEAIMGSHMLEVDPTLASDK PRVEVHPLGIGGKDDPARLVFTGAEGKGYDITLSYFDDGYKFIGYPVDCKTPEAEMPKLP VAKQMWTPEIGLAEGAKQWMKYGGGHHTVLTLALSEEQLEQLARLFKVDFINIK
Function	This enzyme catalyzes the conversion of L-arabinose to L-ribulose. It requires a divalent metal ion and binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism. It can also convert D-galactose to D-tagatose with lower efficiency.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-l-arabinose	DM2I564	N. A.	N. A.	Investigative	[1]
------------------------------------------------------------------------------------

References

1	Protein purification, crystallization and preliminary X-ray diffraction analysis of L-arabinose isomerase from Lactobacillus fermentum CGMCC2921. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):28-33.