Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBK21A)

• DME Name: Alpha-galactosidase (melA)
• Synonyms: Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; melA
• Gene Name: melA
• UniProt ID: Q6IYF5_LACFE
• INTEDE ID: DME2080
• EC Number:
  EC: 3.2.1.22
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.22
• Lineage:
  Species: Lactobacillus fermentum
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus fermentum
  Subspecies: Lactobacillus fermentum subsp. cellobiosus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MPVFINEETKLFHLQTKNTSYIFQILANEAAGQVYYGAKVPVKPSYSNLMTMEEHDCTNT
  LSEENTSFQLELVKQEYATQGKGDFPGGRLRYPIPRRLPDQEFEYQVTKSKREKAPAGSA
  ILFDDEGTDATSLTLILKDRLYDLRMNLHYTFFNDDDVIVRSASFENKGDTVMIDRALSA
  QLDLPDDNYDLLQFSGTWAREPNLYRNHLRPGTQSVASRRIKLQPPRNPAIILARPKHRI
  IIRVKPLVLTIVYSGSFLDTVEVDQFNTTRVVTGIHPDDFSWQLEAGQSFQTPEAVLSYT
  NAGMNALSQQMGRFYRDHLINPHFAKEDRPILINNWEATFMDFTEEKLMKIVTKAKETGI
  EMFVLDDGWFGHRDNDLTSLGDWFVDQKKFLNGVGGFASRVHKLGMKFGLWFEPEMISID
  SKLYEDHPDWMIQTKGRLATPARHQFVLDMARQEVVDDIFNKMSAVIKDTKLDYIKWDMN
  RTITEAFTATLPANRQQEFAHRYILGVYQLYERLTQAFPSVLFESCASGGGRFDLGMMYY
  APQAWCSDDTDAVERIYIQDGTSYGYIPSMWGAHVSAVPNDQVGRVTSLNTRAKVAYFRC
  LWLRTGLKRTVRRRAGNGLKNKSPFTSSTATSSNTGPSTGLTVQTPLPITSTGWQVVNDD
  QSEAIAVRFQILNKPNPGYIRFYFTGLDPEKTYQVNDDEETYSGAELMNAGYFVARIMPR
  SASPKPLADFNATMFVVKAV
• Function: This enzyme hydrolyzes alpha-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[1]

References

• [1] Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.